The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation

scientific article published on 18 December 2019

The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2147/DDDT.S230572
P932PMC publication ID6930391
P698PubMed publication ID31908414

P2093author name stringHui Wang
Wei Wang
Yongbin Wang
Feifei Feng
Huanan Zhang
Nannan Li
Peng Cheng
Yuxin Qi
P2860cites workSinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFβ signaling.Q53096604
Tanshinone‑IIA attenuates the deleterious effects of oxidative stress in osteoporosis through the NF‑κB signaling pathway.Q55033063
WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosisQ56378303
Nrf2-dependent antioxidant response mediated the protective effect of tanshinone IIA on doxorubicin-induced cardiotoxicityQ58767703
Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica DustQ61445119
Inhibition of NADPH Oxidase 4 (NOX4) Signaling Attenuates Tuberculous Pleural FibrosisQ61813528
Prevalence of pneumoconiosis among young adults aged 24-44 years in a heavily industrialized province of ChinaQ64131245
Modulation of miR-10a-mediated TGF-β1/Smads signaling affects atrial fibrillation-induced cardiac fibrosis and cardiac fibroblast proliferationQ64234079
The burden of silicosis in Michigan: 1988-2016.Q66475585
Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica-Induced Sterile InflammationQ88248480
Tanshinone IIA Inhibits High Glucose-Induced Collagen Synthesis via Nuclear Factor Erythroid 2-Related Factor 2 in Cardiac FibroblastsQ90408631
Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosisQ91112005
Asbestosis and silicosis hospitalizations in Italy (2001-2015): results from the National Hospital Discharge RegistryQ91501543
MiR-124 regulates transforming growth factor-β1 induced differentiation of lung resident mesenchymal stem cells to myofibroblast by repressing Wnt/β-catenin signalingQ91891539
Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by activating Nrf2/HO-1-mediated HIF1α/BNIP3 pathwayQ93070178
A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant CompoundsQ93080293
Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosisQ26779846
Reactive oxygen species and fibrosis: further evidence of a significant liaisonQ28077930
Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibriumQ33577258
Noblesse oblige: NRF2 functions in the airwaysQ33799768
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosisQ35146205
Basic pathogenetic mechanisms in silicosis: current understandingQ36034136
TGF-β/SMAD Pathway and Its Regulation in Hepatic FibrosisQ36737131
Targeting NOX enzymes in pulmonary fibrosisQ37008372
Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and DiseaseQ37088240
A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disordersQ37607440
Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiationQ38656832
TGF-β signaling in liver and gastrointestinal cancersQ38796618
TGF-β: the master regulator of fibrosisQ38816052
Transcriptional Control by the SMADsQ38906095
Nrf2 signaling pathway: Pivotal roles in inflammation.Q39003225
Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balanceQ39834982
Artificial stone-associated silicosis: a rapidly emerging occupational lung diseaseQ40052423
Smad3 mediates TGF-beta1-induced collagen gel contraction by human lung fibroblastsQ40349505
Metformin attenuates lung fibrosis development via NOX4 suppressionQ40984750
Lysyl Oxidase-like 1 Protein Deficiency Protects Mice from AdTGF-β1 Induced Pulmonary Fibrosis.Q46777765
Redox Imbalance in Intestinal Fibrosis: Beware of the TGFβ-1, ROS, and Nrf2 ConnectionQ47259299
Rapamycin protects against paraquat-induced pulmonary fibrosis: Activation of Nrf2 signaling pathwayQ47859696
Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivativeQ48887479
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P304page(s)4275-4290
P577publication date2019-12-18
P1433published inDrug Design, Development and TherapyQ2566724
P1476titleThe Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation
P478volume13