DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response

scientific article published on 01 October 2019

DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKZ694
P932PMC publication ID6765147
P698PubMed publication ID31396623

P2093author name stringAnthony J Davis
Huiming Lu
Eric A Hendrickson
Janapriya Saha
Pauline J Beckmann
P2860cites workPostreplicative Joining of DNA Double-Strand Breaks Causes Genomic Instability in DNA-PKcs–Deficient Mouse Embryonic FibroblastsQ59018430
The ATM protein kinase: regulating the cellular response to genotoxic stress, and moreQ38088935
Chromatin remodeling at DNA double-strand breaksQ38090114
The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activityQ38314660
Endogenous DNA Damage as a Source of Genomic Instability in CancerQ39130435
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage ResponseQ39378761
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damageQ39622746
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathwayQ40252252
DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent mannerQ40315391
Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitorsQ40511617
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiationQ40570996
Unraveling the complexities of DNA-dependent protein kinase autophosphorylationQ40603571
DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatusQ40892156
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaksQ42021074
Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repairQ47094825
Meta-analysis of DNA double-strand break response kineticsQ47154064
Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensorsQ49977725
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repairQ21145054
DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cellsQ24297891
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageQ24306743
KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesionsQ24337449
XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsQ24597771
The DNA-damage response in human biology and diseaseQ24606586
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsQ24608343
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytesQ24649590
Common mechanisms of PIKK regulationQ24653672
DNA-PK: a dynamic enzyme in a versatile DSB repair pathwayQ26866928
The DNA Damage Response: Making It Safe to Play with KnivesQ27861055
The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cellsQ28115800
Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunctionQ28118848
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signalsQ28292900
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sitesQ33589782
Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaksQ33602897
Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage responseQ33883063
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoiningQ33958394
BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycleQ34313012
The DNA damage response: implications for tumor responses to radiation and chemotherapyQ34449481
Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repairQ34759375
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repairQ34825234
The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaksQ34915507
Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functionsQ35171563
Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joiningQ35555378
Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phaseQ36627940
Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PKQ36963312
DNA double strand break repair via non-homologous end-joiningQ37135926
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cellsQ37264809
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.Q37347174
scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repairQ37404182
Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joiningQ38083939
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue18
P1104number of pages13
P304page(s)9467-9479
P577publication date2019-10-01
P1433published inNucleic Acids ResearchQ135122
P1476titleDNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response
P478volume47

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Q94474304DNA damage response signaling pathways and targets for radiotherapy sensitization in cancercites workP2860

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