| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Nagesh Tripathi | Q55190874 |
| P2093 | author name string | Ambuj Shrivastava | |
| P2860 | cites work | Microscale to manufacturing scale-up of cell-free cytokine production--a new approach for shortening protein production development timelines | Q24599175 |
| A Single-use Strategy to Enable Manufacturing of Affordable Biologics | Q26738464 | ||
| Combinatorial optimization of CRISPR/Cas9 expression enables precision genome engineering in the methylotrophic yeast Pichia pastoris | Q26750733 | ||
| Plants as Factories for Human Pharmaceuticals: Applications and Challenges | Q26775069 | ||
| Adventitious viruses in insect cell lines used for recombinant protein expression | Q47407694 | ||
| Multimodal Chromatography for Purification of Biotherapeutics - a Review | Q47414395 | ||
| Implementing CRISPR-Cas technologies in conventional and non-conventional yeasts: Current state and future prospects | Q47563830 | ||
| Expanding the CRISPR/Cas9 toolkit for Pichia pastoris with efficient donor integration and alternative resistance markers | Q47578688 | ||
| One-step affinity capture and precipitation for improved purification of an industrial monoclonal antibody using Z-ELP functionalized nanocages | Q47593029 | ||
| Integrated continuous processing of proteins expressed as inclusion bodies: GCSF as a case study | Q47593816 | ||
| Systems biotechnology for protein production in Pichia pastoris. | Q47651199 | ||
| CRISPR-Cas9 vectors for genome editing and host engineering in the baculovirus-insect cell system. | Q47822735 | ||
| Trends in Upstream and Downstream Process Development for Antibody Manufacturing | Q47843398 | ||
| Fully Disposable Manufacturing Concepts for Clinical and Commercial Manufacturing and Ballroom Concepts | Q47860645 | ||
| Codon Optimization in the Production of Recombinant Biotherapeutics: Potential Risks and Considerations. | Q48118384 | ||
| Engineering the Pichia pastoris N-Glycosylation Pathway Using the GlycoSwitch Technology | Q49132367 | ||
| Human Embryonic Kidney 293 Cells: A Vehicle for Biopharmaceutical Manufacturing, Structural Biology, and Electrophysiology | Q49381322 | ||
| Modeling the Downstream Processing of Monoclonal Antibodies Reveals Cost Advantages for Continuous Methods for a Broad Range of Manufacturing Scales | Q50006101 | ||
| Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation | Q50133462 | ||
| Enhanced integration of large DNA into E. coli chromosome by CRISPR/Cas9. | Q50233059 | ||
| Commercial-scale biotherapeutics manufacturing facility for plant-made pharmaceuticals | Q26783099 | ||
| Cultivation strategies to enhance productivity of Pichia pastoris: A review | Q26849205 | ||
| Large-scale production of pharmaceutical proteins in plant cell culture-the Protalix experience | Q26862708 | ||
| Preparative purification of recombinant proteins: current status and future trends | Q27008176 | ||
| Recent advances in mammalian protein production | Q27008285 | ||
| Advances in cell culture: anchorage dependence | Q27015670 | ||
| Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production | Q28066032 | ||
| Biopharmaceuticals from microorganisms: from production to purification | Q28066997 | ||
| Production of Biopharmaceuticals in E. coli: Current Scenario and Future Perspectives | Q28083443 | ||
| Large-scale functional purification of recombinant HIV-1 capsid | Q28487670 | ||
| Evaluation of options for harvest of a recombinant E. Coli fermentation producing a domain antibody using ultra scale-down techniques and pilot-scale verification | Q28829630 | ||
| Molecular farming on rescue of pharma industry for next generations. | Q30252148 | ||
| Fundamentals of Expression in Mammalian Cells. | Q30387938 | ||
| Multimodal chromatography: an efficient tool in downstream processing of proteins | Q30423377 | ||
| Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor™. Part I. Effect of the cell density on the process. | Q30450136 | ||
| Cation-exchange chromatography of monoclonal antibodies: characterisation of a novel stationary phase designed for production-scale purification | Q33608532 | ||
| Refolding techniques for recovering biologically active recombinant proteins from inclusion bodies. | Q33649828 | ||
| Novel, versatile, and tightly regulated expression system for Escherichia coli strains | Q34045980 | ||
| N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli | Q34161971 | ||
| Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements | Q34247760 | ||
| An engineered eukaryotic protein glycosylation pathway in Escherichia coli. | Q34263550 | ||
| Production of biopharmaceutical proteins by yeast: advances through metabolic engineering | Q34311347 | ||
| Production of secretory IgA antibodies in plants | Q34376304 | ||
| Recombinant protein expression in Escherichia coli: advances and challenges | Q34421339 | ||
| Production of pharmaceutical proteins by transgenic animals | Q34744705 | ||
| Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins | Q35503548 | ||
| A folded and immunogenic IgE-hyporeactive variant of the major allergen Phl p 1 produced in Escherichia coli | Q35656998 | ||
| The rapid identification of elution conditions for therapeutic antibodies from cation-exchange chromatography resins using high-throughput screening | Q35902546 | ||
| Efficient expression of full-length antibodies in the cytoplasm of engineered bacteria. | Q36030124 | ||
| Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography. | Q36031060 | ||
| Optimization and scale up of industrial fermentation processes | Q36185230 | ||
| A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production | Q36233127 | ||
| SHuffle, a novel Escherichia coli protein expression strain capable of correctly folding disulfide bonded proteins in its cytoplasm | Q36478560 | ||
| Bioreactor systems for the production of biopharmaceuticals from animal cells | Q36501611 | ||
| Adapting viral safety assurance strategies to continuous processing of biological products. | Q38913337 | ||
| Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing | Q38918574 | ||
| Gene editing for cell engineering: trends and applications | Q38930453 | ||
| Plant-produced biopharmaceuticals: A case of technical developments driving clinical deployment | Q38955887 | ||
| Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactor | Q38966696 | ||
| Heterologous protein production in plant systems | Q38992414 | ||
| Renaissance of protein crystallization and precipitation in biopharmaceuticals purification. | Q39026374 | ||
| Transfer of a three step mAb chromatography process from batch to continuous: Optimizing productivity to minimize consumable requirements | Q39113158 | ||
| Continuous Manufacturing of Recombinant Therapeutic Proteins: Upstream and Downstream Technologies | Q39164854 | ||
| Very-large-scale production of antibodies in plants: The biologization of manufacturing. | Q39203194 | ||
| Therapeutic glycoprotein production in mammalian cells | Q39279123 | ||
| Glycoengineering of CHO Cells to Improve Product Quality | Q39298073 | ||
| CRISPR/Cas system for yeast genome engineering: advances and applications | Q39307074 | ||
| Host cell protein adsorption characteristics during protein A chromatography. | Q39324525 | ||
| Microscale disruption of microorganisms for parallelized process development | Q39385858 | ||
| Expression systems and species used for transgenic animal bioreactors | Q39468670 | ||
| Continuous precipitation of process related impurities from clarified cell culture supernatant using a novel coiled flow inversion reactor (CFIR). | Q39570618 | ||
| High-throughput methods for miniaturization and automation of monoclonal antibody purification processes | Q39633803 | ||
| Reconceptualizing cancer immunotherapy based on plant production systems | Q40051873 | ||
| An N-terminal Pfs230 domain produced in baculovirus as a biological active transmission-blocking vaccine candidate | Q40118467 | ||
| Design and operation of a continuous integrated monoclonal antibody production process. | Q40129818 | ||
| Improving the baculovirus expression vector system with vankyrin-enhanced technology | Q40158347 | ||
| Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin | Q40211655 | ||
| Metabolic engineering of CHO cells for the development of a robust protein production platform. | Q41200443 | ||
| A novel system for stable, high-level expression from the T7 promoter. | Q42150961 | ||
| Analytical QbD: development of a native gel electrophoresis method for measurement of monoclonal antibody aggregates | Q43737258 | ||
| Causes of proteolytic degradation of secreted recombinant proteins produced in methylotrophic yeast Pichia pastoris: case study with recombinant ovine interferon-tau | Q45174362 | ||
| Long-term adaptation of Saccharomyces cerevisiae to the burden of recombinant insulin production | Q45324768 | ||
| Production and Purification of Filovirus Glycoproteins in Insect and Mammalian Cell Lines | Q45346814 | ||
| From laboratory to pilot plant E. coli fed-batch cultures: optimizing the cellular environment for protein maximization | Q45740028 | ||
| A strategic crossflow filtration methodology for the initial purification of promegapoietin from inclusion bodies. | Q46018405 | ||
| Identification of novel factors enhancing recombinant protein production in multi-copy Komagataella phaffii based on transcriptomic analysis of overexpression effects | Q47108638 | ||
| Continuous processing of recombinant proteins: integration of refolding and purification using simulated moving bed size-exclusion chromatography with buffer recycling | Q47178757 | ||
| Glycoengineering in CHO cells: Advances in systems biology. | Q47189041 | ||
| Continuous integrated manufacturing of therapeutic proteins | Q47242303 | ||
| On-Line Control of Glucose Concentration in High-Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements | Q47244159 | ||
| Heterologous Protein Expression in Pichia pastoris: Latest Research Progress and Applications | Q47255058 | ||
| Impact of host cell line choice on glycan profile | Q47269842 | ||
| Integrated Chromatographic Platform for Simultaneous Separation of Charge Variants and Aggregates from Monoclonal Antibody Therapeutic Products | Q47322550 | ||
| Engineering strategies for enhanced production of protein and bio-products in Pichia pastoris: A review | Q47356914 | ||
| A practical approach in bioreactor scale-up and process transfer using a combination of constant P/V and vvm as the criterion. | Q47387197 | ||
| Vectors for Expression of Signal Peptide-Dependent Proteins in Baculovirus/Insect Cell Systems and Their Application to Expression and Purification of the High-Affinity Immunoglobulin Gamma Fc Receptor I in Complex with Its Gamma Chain. | Q47397603 | ||
| Production of Recombinant Proteins in the Milk of Transgenic Animals: Current State and Prospects | Q58569006 | ||
| An ultra scale-down method to investigate monoclonal antibody processing during tangential flow filtration (TFF) using ultrafiltration membranes | Q58575761 | ||
| Glycosylation control technologies for recombinant therapeutic proteins | Q58604840 | ||
| Engineering the protein secretory pathway of enables improved protein production | Q58612190 | ||
| Virus study for continuous low pH viral inactivation inside a coiled flow inverter (CFI) | Q59350661 | ||
| Continuous Virus Inactivation: How to Generate a Plug Flow | Q59352819 | ||
| Vaccine and antibody production in plants: developments and computational tools | Q59357462 | ||
| Continuous In-Line Virus Inactivation for Next Generation Bioprocessing | Q59360541 | ||
| The expression of a nopaline synthase ? human growth hormone chimaeric gene in transformed tobacco and sunflower callus tissue | Q60543519 | ||
| Evaluation of scFv protein recovery from E. coli by in vitro refolding and mild solubilization process | Q60909388 | ||
| Construction of Mini-Chemostats for High-throughput Strain Characterization | Q61444850 | ||
| Use of a design of experiments approach to optimise production of a recombinant antibody fragment in the periplasm of Escherichia coli: selection of signal peptide and optimal growth conditions | Q61450552 | ||
| Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Synthesis | Q61553875 | ||
| A Brief Reminder of Systems of Production and Chromatography-Based Recovery of Recombinant Protein Biopharmaceuticals | Q61800268 | ||
| FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing | Q64100947 | ||
| MultiBac: Baculovirus-Mediated Multigene DNA Cargo Delivery in Insect and Mammalian Cells | Q64103530 | ||
| Aeration and Shear Stress Are Critical Process Parameters for the Production of Oncolytic Measles Virus | Q64104893 | ||
| CRISPR/Cas9-Mediated Knockout of MicroRNA-744 Improves Antibody Titer of CHO Production Cell Lines | Q64387776 | ||
| Kinetic model for adherent Vero cell growth and poliovirus production in batch bioreactors. | Q64892091 | ||
| Reproduction of Large-Scale Bioreactor Conditions on Microfluidic Chips. | Q64902984 | ||
| Application of Continuous Culture Methods to Recombinant Protein Production in Microorganisms. | Q64906573 | ||
| Large-scale microcarrier culture of HEK293T cells and Vero cells in single-use bioreactors. | Q64946053 | ||
| Hybrid optimization of preparative chromatography for a ternary monoclonal antibody mixture. | Q64946347 | ||
| High-throughput screening of chromatographic separations: I. Method development and column modeling | Q81321385 | ||
| Scale-up methodologies for Escherichia coli and yeast fermentation processes | Q81369104 | ||
| The metabolic burden of cellulase expression by recombinant Saccharomyces cerevisiae Y294 in aerobic batch culture | Q83968690 | ||
| A methodological approach to scaling up fermentation and primary recovery processes to the manufacturing scale for vaccine production | Q84171657 | ||
| Two step capture and purification of IgG2 using multicolumn countercurrent solvent gradient purification (MCSGP) | Q84631111 | ||
| Economic comparison of diagnostic antibody production in perfusion stirred tank and in hollow fiber bioreactor processes | Q85003771 | ||
| A novel multimodal chromatography based single step purification process for efficient manufacturing of an E. coli based biotherapeutic protein product | Q86030855 | ||
| Twin-column CaptureSMB: a novel cyclic process for protein A affinity chromatography | Q86883468 | ||
| Preparative crystallization of a single chain antibody using an aqueous two-phase system | Q88006737 | ||
| Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles | Q88037357 | ||
| Main Strategies of Plant Expression System Glycoengineering for Producing Humanized Recombinant Pharmaceutical Proteins | Q88293797 | ||
| Affinity chromatography for vaccines manufacturing: Finally ready for prime time? | Q88298494 | ||
| Single Pass Diafiltration Integrated into a Fully Continuous mAb Purification Process | Q88336873 | ||
| Proteomic analysis of micro-scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform | Q88544151 | ||
| Implementation of Fully Integrated Continuous Antibody Processing: Effects on Productivity and COGm | Q88575885 | ||
| Perfusion mammalian cell culture for recombinant protein manufacturing - A critical review | Q88605307 | ||
| A brief practical review of size exclusion chromatography: Rules of thumb, limitations, and troubleshooting | Q88734773 | ||
| Expression of recombinant proteins in insect and mammalian cells | Q88737148 | ||
| Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition | Q88749398 | ||
| A Stable, Autonomously Replicating Plasmid Vector Containing Pichia pastoris Centromeric DNA | Q88867083 | ||
| Use of HPLC as an Enabler of Process Analytical Technology in Process Chromatography | Q88921269 | ||
| Perfusion Cell Culture Decreases Process and Product Heterogeneity in a Head-to-Head Comparison With Fed-Batch | Q88931786 | ||
| Nutrient Optimization Reduces Phosphorylation and Hydroxylation Level on an Fc-Fusion Protein in a CHO Fed-Batch Process | Q89020466 | ||
| Polyionic Tags as Enhancers of Protein Solubility in Recombinant Protein Expression | Q89040356 | ||
| E. coli strain engineering for the production of advanced biopharmaceutical products | Q89458028 | ||
| CRISPR-Cas9-assisted native end-joining editing offers a simple strategy for efficient genetic engineering in Escherichia coli | Q90007332 | ||
| Posttranslational Targeting of a Recombinant Protein Promotes Its Efficient Secretion into the Escherichia coli Periplasm | Q90024187 | ||
| Use of transgenic animals in biotechnology: prospects and problems | Q36730328 | ||
| Microtiter plates as mini-bioreactors: miniaturization of fermentation methods | Q36962828 | ||
| Upstream processes in antibody production: evaluation of critical parameters | Q36963368 | ||
| Comparison of DNA extraction methods in analysis of salivary bacterial communities | Q36981163 | ||
| Transgenic bovine as bioreactors: Challenges and perspectives | Q37052505 | ||
| Efficient Production of a Bioactive Bevacizumab Monoclonal Antibody Using the 2A Self-cleavage Peptide in Transgenic Rice Callus | Q37159302 | ||
| Microbial factories for recombinant pharmaceuticals | Q37160231 | ||
| Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview | Q37337268 | ||
| Several affinity tags commonly used in chromatographic purification | Q37486455 | ||
| Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives | Q37494846 | ||
| Production of recombinant proteins by microbes and higher organisms | Q37509309 | ||
| Comparative evaluation of recombinant protein production in different biofactories: the green perspective | Q37679720 | ||
| Recent advances in large-scale production of monoclonal antibodies and related proteins | Q37715488 | ||
| Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors | Q37831558 | ||
| The potential of hydrodynamic damage to animal cells of industrial relevance: current understanding | Q37904771 | ||
| Mammalian cell protein expression for biopharmaceutical production | Q37941925 | ||
| High-throughput process development of chromatography steps: advantages and limitations of different formats used | Q38022577 | ||
| Recent advances in technology supporting biopharmaceutical production from mammalian cells | Q38050998 | ||
| Single-use disposable technologies for biopharmaceutical manufacturing | Q38062254 | ||
| Recent advances in bioprocessing application of membrane chromatography | Q38077353 | ||
| Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells | Q38079490 | ||
| Continuous downstream processing of biopharmaceuticals. | Q38121251 | ||
| Statistical approaches to maximize recombinant protein expression in Escherichia coli: a general review | Q38161273 | ||
| Protein production using the baculovirus-insect cell expression system | Q38165127 | ||
| Purifying biopharmaceuticals: knowledge-based chromatographic process development | Q38196059 | ||
| The development and application of high throughput cultivation technology in bioprocess development. | Q38201927 | ||
| Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production. | Q38205379 | ||
| Understanding pharmaceutical quality by design | Q38214058 | ||
| Thirty years of baculovirus-insect cell protein expression: from dark horse to mainstream technology | Q38253350 | ||
| Recent developments in therapeutic protein expression technologies in plants. | Q38261152 | ||
| Continuous processing for production of biopharmaceuticals | Q38352753 | ||
| Large-scale crystallization of proteins for purification and formulation | Q38363126 | ||
| The baculovirus expression vector system: A commercial manufacturing platform for viral vaccines and gene therapy vectors | Q38388047 | ||
| Continuous downstream processing for high value biological products: A Review | Q38543755 | ||
| Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives | Q38572669 | ||
| A model-based framework for parallel scale-down fed-batch cultivations in mini-bioreactors for accelerated phenotyping | Q91979308 | ||
| Identification and CRISPR/Cas9 Inactivation of the C1s Protease Responsible for Proteolysis of Recombinant Proteins Produced in CHO Cells | Q92009419 | ||
| Optimized dual assay for the transgenes selection and screening in CHO cell line development for recombinant protein production | Q92010359 | ||
| Implementing Process Analytical Technology for the Production of Recombinant Proteins in Escherichia coli Using an Advanced Controller Scheme | Q92070639 | ||
| A Predictive Mathematical Model of Cell Cycle, Metabolism, and Apoptosis of Monoclonal Antibody-Producing GS-NS0 Cells | Q92070906 | ||
| [Strategies for Optimizing Recombinant Protein Synthesis in Plant Cells: Classical Approaches and New Directions] | Q92110694 | ||
| Membrane-Based Approach for the Downstream Processing of Influenza Virus-Like Particles | Q92151770 | ||
| An overview of mechanistic modeling of liquid chromatography | Q92152796 | ||
| Continuous precipitation for monoclonal antibody capture using countercurrent washing by microfiltration | Q92163972 | ||
| Small-molecule control of antibody N-glycosylation in engineered mammalian cells | Q92173365 | ||
| Validation and optimization of viral clearance in a downstream continuous chromatography setting | Q92186602 | ||
| Metaheuristic approaches in biopharmaceutical process development data analysis | Q92231759 | ||
| Expression of multidrug transporter P-glycoprotein in Pichia pastoris affects the host's methanol metabolism | Q92310973 | ||
| A bootstrap-aggregated hybrid semi-parametric modeling framework for bioprocess development | Q92379058 | ||
| A novel application of ion exchange chromatography in recombinant hepatitis B vaccine downstream processing: Improving recombinant HBsAg homogeneity by removing associated aggregates | Q92408262 | ||
| Cation exchange chromatography performed in overloaded mode is effective in removing viruses during the manufacturing of monoclonal antibodies | Q92426040 | ||
| Rapid screening and scale-up of ultracentrifugation-free, membrane-based procedures for purification of His-tagged membrane proteins | Q92454012 | ||
| High throughput process development workflow with advanced decision-support for antibody purification | Q92454839 | ||
| The Coming Age of Insect Cells for Manufacturing and Development of Protein Therapeutics | Q92461831 | ||
| A general platform for efficient extracellular expression and purification of Fab from Escherichia coli | Q92465944 | ||
| CRISPR/Cas9-mediated gfp gene inactivation in Arabidopsis suspension cells | Q92490076 | ||
| Fourier-transform infrared spectroscopy as a process analytical technology for near real time in-line estimation of the degree of PEGylation in chromatography | Q92506016 | ||
| Glucose-containing polymer rings enable fed-batch operation in microtiter plates with parallel online measurement of scattered light, fluorescence, dissolved oxygen tension, and pH | Q92507777 | ||
| Enhancing Recombinant Protein Yields in the E. coli Periplasm by Combining Signal Peptide and Production Rate Screening | Q92510993 | ||
| Barriers to genome editing with CRISPR in bacteria | Q92533426 | ||
| FeedER: a feedback-regulated enzyme-based slow-release system for fed-batch cultivation in microtiter plates | Q92536144 | ||
| Investigating the combination of single-pass tangential flow filtration and anion exchange chromatography for intensified mAb polishing | Q92554802 | ||
| Process for Continuous Fab Production by Digestion of IgG | Q92557501 | ||
| Improvement of baculovirus as protein expression vector and as biopesticide by CRISPR/Cas9 editing | Q92558499 | ||
| At-line multi-angle light scattering detector for faster process development in enveloped virus-like particle purification | Q92560991 | ||
| Production of protein-based polymers in Pichia pastoris | Q92562890 | ||
| Monitoring and control strategies for inclusion body production in E. coli based on glycerol consumption | Q92573657 | ||
| Soluble expression of single-chain variable fragment (scFv) in Escherichia coli using superfolder green fluorescent protein as fusion partner | Q92597094 | ||
| Control of antibody high and low molecular weight species by depth filtration-based cell culture harvesting | Q92653310 | ||
| Metabolomic profiling of CHO fed-batch growth phases at 10, 100, and 1,000 L | Q92653319 | ||
| QbD Based Media Development for the Production of Fab Fragments in E. coli | Q92702314 | ||
| Experimental Evaluation of the Impact of Intrinsic Process Parameters on the Performance of a Continuous Chromatographic Polishing Unit (MCSGP) | Q92712262 | ||
| Rational development of bioprocess engineering strategies for recombinant protein production in Pichia pastoris (Komagataella phaffii) using the methanol-free GAP promoter. Where do we stand? | Q92720763 | ||
| Escherichia coli "TatExpress" strains export several g/L human growth hormone to the periplasm by the Tat pathway | Q92724370 | ||
| Development of a novel, high-throughput screening tool for efficient perfusion-based cell culture process development | Q92740943 | ||
| CRISPR-Cas9-mediated genomic multiloci integration in Pichia pastoris | Q92755065 | ||
| Scale-down model qualification of ambr® 250 high-throughput mini-bioreactor system for two commercial-scale mAb processes | Q92808918 | ||
| Nonclinical immunogenicity risk assessment of therapeutic proteins | Q92817870 | ||
| A simplified techno-economic model for the molecular pharming of antibodies | Q92830653 | ||
| Novel, linked bioreactor system for continuous production of biologics | Q92867224 | ||
| Multistage continuous countercurrent diafiltration for formulation of monoclonal antibodies | Q92868936 | ||
| New tools for recombinant protein production in Escherichia coli: A 5-year update | Q92898209 | ||
| Minimizing the Influence of Fluorescent Tags on IgG Partition in PEG-Salt Aqueous Two-Phase Systems for Rapid Screening Applications | Q92922106 | ||
| Towards Self-Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture | Q92965578 | ||
| Optimizing the Performance of Chromatographic Separations Using Microfluidics: Multiplexed and Quantitative Screening of Ligands and Target Molecules | Q92974287 | ||
| Development of a Combined Genetic Engineering Vaccine for Porcine Circovirus Type 2 and Mycoplasma Hyopneumoniae by a Baculovirus Expression System | Q90040198 | ||
| Hydrophobic-interaction chromatography for purification of influenza A and B virus | Q90041276 | ||
| Scale-up of a Type I secretion system in E. coli using a defined mineral medium | Q90077174 | ||
| A scale-down model of 4000-L cell culture process for inactivated foot-and-mouth disease vaccine production | Q90099226 | ||
| Current state of the art in continuous bioprocessing | Q90141943 | ||
| Preparation and evaluation of dextran-grafted mixed-mode chromatography adsorbents | Q90211143 | ||
| Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation | Q90212011 | ||
| Affinity Chromatography: An Enabling Technology for Large-Scale Bioprocessing | Q90213173 | ||
| Hollow fiber countercurrent dialysis for continuous buffer exchange of high-value biotherapeutics | Q90300474 | ||
| Biopharmaceutical benchmarks 2018 | Q90302710 | ||
| New Developments in Pichia pastoris Expression System, Review and Update | Q90307091 | ||
| Larger Pore Size Hollow Fiber Membranes as a Solution to the Product Retention Issue in Filtration-Based Perfusion Bioreactors | Q90337047 | ||
| Scale-up of continuous multicolumn chromatography for the protein a capture step: From bench to clinical manufacturing | Q90346057 | ||
| Purification of Human Monoclonal Antibodies and Their Fragments | Q90420181 | ||
| Process analytical technology implementation for protein refolding: GCSF as a case study | Q90533599 | ||
| Multi-column displacement chromatography for separation of charge variants of monoclonal antibodies | Q90678766 | ||
| Glyco-Engineering of Plant-Based Expression Systems | Q90704137 | ||
| Investigation of fouling mechanisms of virus filters during the filtration of protein solutions using a high throughput filtration screening device | Q90984311 | ||
| Continuous integrated antibody precipitation with two-stage tangential flow microfiltration enables constant mass flow | Q91015715 | ||
| Control of IgG glycosylation by in situ and real-time estimation of specific growth rate of CHO cells cultured in bioreactor | Q91015890 | ||
| Integration of size-exclusion chromatography and ultracentrifugation for purification of recombinant hepatitis B surface antigen: An alternative method for immunoaffinity chromatography | Q91016891 | ||
| A fast and simple approach to optimize the unit operation high pressure homogenization - a case study for a soluble therapeutic protein in E. coli | Q91140780 | ||
| Current state-of-the-art in plant-based antibody production systems | Q91230399 | ||
| Model assisted comparison of Protein A resins and multi-column chromatography for capture processes | Q91232170 | ||
| Introducing substrate limitations to overcome catabolite repression in a protease producing Bacillus licheniformis strain using membrane-based fed-batch shake flasks | Q91319703 | ||
| Enhancing the functionality of a microscale bioreactor system as an industrial process development tool for mammalian perfusion culture | Q91319741 | ||
| MoCloFlex: A Modular Yet Flexible Cloning System | Q91369951 | ||
| Paving the way for the production of secretory proteins by yeast cell factories | Q91418081 | ||
| Improving bioreactor production of a recombinant glycoprotein in Escherichia coli: Effect of specific growth rate on protein glycosylation and specific productivity | Q91438577 | ||
| Challenging the workhorse: Comparative analysis of eukaryotic micro-organisms for expressing monoclonal antibodies | Q91438635 | ||
| Prediction of lab and manufacturing scale chromatography performance using mini-columns and mechanistic modeling | Q91440541 | ||
| Monitoring of antibody glycosylation pattern based on microarray MALDI-TOF mass spectrometry | Q91510918 | ||
| Transcription factor engineering in CHO cells for recombinant protein production | Q91574142 | ||
| Process design and development of a mammalian cell perfusion culture in shake-tube and benchtop bioreactors | Q91634092 | ||
| The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturing | Q91636522 | ||
| Assessing Carnivorous Plants for the Production of Recombinant Proteins | Q91639151 | ||
| Precultures Grown under Fed-Batch Conditions Increase the Reliability and Reproducibility of High-Throughput Screening Results | Q91703093 | ||
| Purification of yellow fever virus produced in Vero cells for inactivated vaccine manufacture | Q91705209 | ||
| Overcoming genetic heterogeneity in industrial fermentations | Q91723955 | ||
| A novel scale-down mimic of perfusion cell culture using sedimentation in an automated microbioreactor (SAM) | Q91724598 | ||
| Implementation of a Fully Automated Microbial Cultivation Platform for Strain and Process Screening | Q91823723 | ||
| Multi-omics profiling of CHO parental hosts reveals cell line-specific variations in bioprocessing traits | Q91841672 | ||
| Application of crossflow ultrafiltration for scaling up the purification of a recombinant ferritin | Q91847292 | ||
| Optimization of Protein Expression in Mammalian Cells | Q91847444 | ||
| Overexpression of endogenous stress-tolerance related genes in Saccharomyces cerevisiae improved strain robustness and production of heterologous cellobiohydrolase | Q91903392 | ||
| New developments in online OUR monitoring and its application to animal cell cultures | Q91911801 | ||
| Yeast Expression Systems: Overview and Recent Advances | Q91918638 | ||
| Continuous Solvent/Detergent Virus Inactivation Using a Packed-Bed Reactor | Q91955092 | ||
| Protein A chromatography: Challenges and progress in the purification of monoclonal antibodies | Q91967402 | ||
| Advanced technologies for improved expression of recombinant proteins in bacteria: perspectives and applications | Q38588987 | ||
| Countercurrent Staged Diafiltration for Formulation of High Value Proteins. | Q38597015 | ||
| Industrial systems biology and its impact on synthetic biology of yeast cell factories | Q38622373 | ||
| Towards systems metabolic engineering in Pichia pastoris | Q38651140 | ||
| Sophisticated Cloning, Fermentation, and Purification Technologies for an Enhanced Therapeutic Protein Production: A Review | Q38654852 | ||
| Clarification of vaccines: An overview of filter based technology trends and best practices | Q38666316 | ||
| Continuous countercurrent tangential chromatography for mixed mode post-capture operations in monoclonal antibody purification | Q38683671 | ||
| Extraction and purification methods in downstream processing of plant-based recombinant proteins. | Q38689725 | ||
| Using transgenic plants and modified plant viruses for the development of treatments for human diseases. | Q38695088 | ||
| Principles and approach to developing mammalian cell culture media for high cell density perfusion process leveraging established fed-batch media | Q38709169 | ||
| The transgenic animal platform for biopharmaceutical production | Q38714835 | ||
| Process performance and product quality in an integrated continuous antibody production process. | Q38753473 | ||
| High-throughput screening and selection of mammalian cells for enhanced protein production | Q38765872 | ||
| Assembling Multi-subunit Complexes Using Mammalian Expression | Q38771893 | ||
| Hydrophobic interaction chromatography for the characterization of monoclonal antibodies and related products | Q38809710 | ||
| Alternating flow filtration as an alternative to internal spin filter based perfusion process: Impact on productivity and product quality | Q38818491 | ||
| Engineering the transposition-based baculovirus expression vector system for higher efficiency protein production from insect cells | Q38822411 | ||
| A novel method to recover inclusion body protein from recombinant E. coli fed-batch processes based on phage ΦX174-derived lysis protein E. | Q38827509 | ||
| Membrane Protein Production in E. coli for Applications in Drug Discovery | Q38831265 | ||
| Fundamentals of Baculovirus Expression and Applications | Q38831287 | ||
| The MultiBac Baculovirus/Insect Cell Expression Vector System for Producing Complex Protein Biologics | Q38831288 | ||
| Mixed-mode chromatography in pharmaceutical and biopharmaceutical applications | Q38847117 | ||
| Microbial platform technology for recombinant antibody fragment production: A review | Q38888751 | ||
| Microbioreactor Cultivations of Fab-Producing Escherichia coli Reveal Genome-Integrated Systems as Suitable for Prospective Studies on Direct Fab Expression Effects | Q92974338 | ||
| Decision Tree-PLS (DT-PLS) algorithm for the development of process: Specific local prediction models | Q92999179 | ||
| Feasible development of stable HEK293 clones by CRISPR/Cas9-mediated site-specific integration for biopharmaceuticals production | Q93006156 | ||
| A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins | Q93012106 | ||
| Genetic engineering approaches to improve posttranslational modification of biopharmaceuticals in different production platforms | Q93012134 | ||
| Current advances in engineering tools for Pichia pastoris | Q93014354 | ||
| Anxa2- and Ctsd-knockout CHO cell lines to diminish the risk of contamination with host cell proteins | Q93019564 | ||
| Analyzing the suitability of a baffled orbitally shaken bioreactor for cells cultivation using the computational fluid dynamics approach | Q93027346 | ||
| Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins | Q93062782 | ||
| Non-protein A purification platform for continuous processing of monoclonal antibody therapeutics | Q93089886 | ||
| Engineering protein production by rationally choosing a carbon and nitrogen source using E. coli BL21 acetate metabolism knockout strains | Q93104095 | ||
| Transcriptome and proteome analysis of steady-state in a perfusion CHO cell culture process | Q93173029 | ||
| Improvement of soluble expression of GM-CSF in the cytoplasm of Escherichia coli using chemical and molecular chaperones | Q93178783 | ||
| Purification of a conjugated polysaccharide vaccine using tangential flow diafiltration | Q93203875 | ||
| Low-cost customizable microscale toolkit for rapid screening and purification of therapeutic proteins | Q93204037 | ||
| Multi-Omics Study on the Impact of Cysteine Feed Level on Cell Viability and mAb Production in a CHO Bioprocess | Q93371066 | ||
| Mechanistic modeling based process analytical technology implementation for pooling in hydrophobic interaction chromatography | Q93371488 | ||
| A protocol to transfer a fed-batch platform process into semi-perfusion mode: The benefit of automated small-scale bioreactors compared to shake flasks as scale-down model | Q93385009 | ||
| Current perspectives on biosimilars | Q91977733 | ||
| Comparison of batch and continuous multi-column protein A capture processes by optimal design. | Q50688906 | ||
| A straightforward methodology for designing continuous monoclonal antibody capture multi-column chromatography processes. | Q50855496 | ||
| Scale-up of Escherichia coli growth and recombinant protein expression conditions from microwell to laboratory and pilot scale based on matched k(L)a. | Q50875506 | ||
| High-throughput process development for recombinant protein purification. | Q51300775 | ||
| Production of Recombinant CCN2 Protein by Mammalian Cells. | Q51400381 | ||
| Industrial implementation of in vitro production of monoclonal antibodies. | Q51435449 | ||
| An integrated practical implementation of continuous aqueous two-phase systems for the recovery of human IgG: From the microdevice to a multistage bench-scale mixer-settler device. | Q51534477 | ||
| Process Analytical Technology for Advanced Process Control in Biologics Manufacturing with the Aid of Macroscopic Kinetic Modeling. | Q51730411 | ||
| Glycoengineering of Mammalian Expression Systems on a Cellular Level. | Q51730448 | ||
| End-to-end integrated fully continuous production of recombinant monoclonal antibodies. | Q51742541 | ||
| Purification process of recombinant monoclonal antibodies with mixed mode chromatography. | Q51743909 | ||
| Use of disposable reactors to generate inoculum cultures for E. coli production fermentations | Q51772130 | ||
| Recent developments in chromatographic purification of biopharmaceuticals. | Q52559868 | ||
| Integrated continuous biomanufacturing platform with ATF perfusion and one column chromatography operation for optimum resin utilization and productivity. | Q52672183 | ||
| Optimizing recombinant protein production in the E. coli periplasm alleviates stress. | Q52719509 | ||
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| Model based adaptive control of a continuous capture process for monoclonal antibodies production. | Q53620974 | ||
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| Cell-free prediction of protein expression costs for growing cells. | Q55000827 | ||
| Cell Line Techniques and Gene Editing Tools for Antibody Production: A Review. | Q55333943 | ||
| Comparison of Yeasts as Hosts for Recombinant Protein Production. | Q55717914 | ||
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| Cell culture media for recombinant protein expression in Chinese hamster ovary (CHO) cells: History, key components, and optimization strategies | Q56978826 | ||
| New tools for high-throughput expression of fungal secretory proteins in Saccharomyces cerevisiae and Pichia pastoris | Q56984092 | ||
| A Direct Approach for Process Development Using Single Column Experiments Results in Predictable Streamlined Multi Column Chromatography Bioprocesses | Q57024580 | ||
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| Synthetic biology toolkits and applications in Saccharomyces cerevisiae | Q57127530 | ||
| Comparative phenotypic analysis of CHO clones and culture media for lactate shift | Q57284494 | ||
| Model assisted process characterization and validation for a continuous two-column protein A capture process | Q57287528 | ||
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| An Integrated Approach to Aggregate Control for Therapeutic Bispecific Antibodies Using an Improved Three Column mAb Platform-Like Purification Process | Q57287555 | ||
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| In silico model-guided identification of transcriptional regulator targets for efficient strain design | Q57788170 | ||
| Scale-Down Model Development in ambr™ systems: An Industrial Perspective | Q57795826 | ||
| Optimized continuous multi-column chromatography enables increased productivities and cost savings by employing more columns | Q57795832 | ||
| N-glycan Remodeling Using Mannosidase Inhibitors to Increase High-mannose Glycans on Acid α-Glucosidase in Transgenic Rice Cell Cultures | Q58091852 | ||
| Engineering of the baculovirus expression system for optimized protein production | Q58100756 | ||
| Progression of continuous downstream processing of monoclonal antibodies: Current trends and challenges | Q58476110 | ||
| Hydrodynamics and mass transfer in miniaturized bubble column bioreactors | Q58552858 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P304 | page(s) | 420 | |
| P577 | publication date | 2019-12-20 | |
| P1433 | published in | Frontiers in Bioengineering and Biotechnology | Q21971197 |
| P1476 | title | Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development | |
| P478 | volume | 7 |
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