Use of transgenic animals in biotechnology: prospects and problems

scientific article published on January 2013

Use of transgenic animals in biotechnology: prospects and problems is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3612824
P698PubMed publication ID23556129

P2093author name stringP G Georgiev
O G Maksimenko
Yu M Khodarovich
A V Deykin
P2860cites workDistal control of the pig whey acidic protein (WAP) locus in transgenic miceQ80782779
Purification and characterization of a recombinant version of human alpha-fetoprotein expressed in the milk of transgenic goatsQ81038309
Production of recombinant albumin by a herd of cloned transgenic cattleQ82713021
Production of human lactoferrin in animal milkQ83502637
The state of health and the reproductive potential of transgenic mice secreting recombinant human lactoferrin in milkQ84686010
Transmission of prionsQ24540228
Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoningQ24683895
Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genomeQ27324003
The protein CTCF is required for the enhancer blocking activity of vertebrate insulatorsQ28142800
Pigs expressing salivary phytase produce low-phosphorus manureQ28209995
Viable offspring derived from fetal and adult mammalian cellsQ28304072
Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for large-scale production of functional human lactoferrinQ28473868
Production of cattle lacking prion protein.Q30492928
Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeuticsQ30857760
N- and O-glycans of recombinant human C1 inhibitor expressed in the milk of transgenic rabbitsQ31003775
Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic miceQ31793558
VEZF1 elements mediate protection from DNA methylationQ33523011
Biopharmaceutical production in transgenic livestockQ33719380
Transgenic mice secreting coronavirus neutralizing antibodies into the milkQ33782648
Transgenic milk as a method for the production of recombinant antibodiesQ33825189
Is there a risk from not using GE animals?Q33833888
Production of transgenic mice by random recombination of targeted genes in female germline stem cells.Q34154413
Cloned transgenic cattle produce milk with higher levels of beta-casein and kappa-caseinQ34172919
The current state of GMO governance: are we ready for GM animals?Q34256621
Generating transgenic mice from bacterial artificial chromosomes: transgenesis efficiency, integration and expression outcomes.Q34468652
Preparation of recombinant proteins in milk to improve human and animal health.Q34581876
Transgenic alteration of sow milk to improve piglet growth and health.Q34617188
Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cellsQ34659480
Production of pharmaceutical proteins by transgenic animalsQ34744705
Expression and characterization of bioactive recombinant human alpha-lactalbumin in the milk of transgenic cloned cows.Q34889966
Antibody manufacture in transgenic animals and comparisons with other systemsQ35026023
Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expressionQ35031058
Making recombinant proteins in animals--different systems, different applications.Q35209242
Mammary expression of new genes to combat mastitisQ35682256
Prospects and implications of using chromatin insulators in gene therapy and transgenesisQ35819847
Use of the chicken lysozyme 5' matrix attachment region to generate high producer CHO cell lines.Q50768570
Production of recombinant human lysozyme in the milk of transgenic pigs.Q51559850
Adenoviral vector mediates high expression levels of human growth hormone in the milk of mice and goats.Q51604726
Expression of active recombinant human lactoferrin in the milk of transgenic goats.Q51725485
A mWAP-hLF hybrid gene locus gave extremely high level expression of human lactoferrin in the milk of transgenic mice.Q51819442
Detection of endoplasmic reticulum stress markers and production enhancement treatments in transgenic goats expressing recombinant human butyrylcholinesterase.Q52608297
High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow.Q53767961
Alteration of the quality of milk by expression of sheep β-lactoglobulin in transgenic miceQ59086278
Tissue-specific and expression of porcine growth hormone gene in BAC transgenic miceQ64463720
Production of the mouse whey acidic protein in transgenic pigs during lactationQ67706678
Casein genes and genetic engineering of the caseinsQ70139515
Induction of human tissue plasminogen activator in the mammary gland of transgenic goatsQ72273389
Expression of human lactoferrin in milk of transgenic miceQ72456336
Expression of active human blood clotting factor VIII in mammary gland of transgenic rabbitsQ73011515
Production of biologically active human granulocyte colony stimulating factor in the milk of transgenic goatQ73079768
Expression of bovine beta-lactoglobulin/human erythropoietin fusion protein in the milk of transgenic mice and rabbitsQ73341007
Production of active anti-CD6 mouse/human chimeric antibodies in the milk of transgenic miceQ73887021
Chicken beta-globin 5'HS4 insulators function to reduce variability in transgenic founder miceQ73983972
The potential benefits of insulators on heterologous constructs in transgenic animalsQ75232573
Production of recombinant antibodies in the milk of transgenic animalsQ77624476
Transgenic animal bioreactors in biotechnology and production of blood proteinsQ77798567
High level expression of a functional human/mouse chimeric anti-CD20 monoclonal antibody in milk of transgenic miceQ80467782
Analysis of the N-glycans of recombinant human Factor IX purified from transgenic pig milkQ35835707
Transgenic animals in medicine: integration and expression of foreign genes, theoretical and applied aspectsQ35929035
Characterization of the chicken beta-globin insulatorQ35956059
Employing epigenetics to augment the expression of therapeutic proteins in mammalian cellsQ36388110
Genetic modifications of pigs for medicine and agriculture.Q36466394
A generic intron increases gene expression in transgenic miceQ36695893
Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activityQ37368665
Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elementsQ37371658
Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathwayQ37387167
Production of recombinant proteins by microbes and higher organismsQ37509309
Animal-derived pharmaceutical proteins.Q37547045
Expression systems for therapeutic glycoprotein production.Q37627411
Recent advances in large-scale production of monoclonal antibodies and related proteinsQ37715488
Engineering mammalian cells in bioprocessing - current achievements and future perspectivesQ37730868
Recombinant plasma proteinsQ37822845
Advances in farm animal transgenesis.Q37878026
CTCF: insights into insulator function during developmentQ37987091
The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of proteinQ39918311
Functional recombinant human anti-HAV antibody expressed in milk of transgenic miceQ40011772
High-level expression of human lactoferrin in the milk of goats by using replication-defective adenoviral vectors.Q40185831
Transgenic mice can express mutant human coagulation factor IX with higher level of clotting activityQ40222400
The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicityQ40690773
Recombinant protein production in transgenic animalsQ41238612
Toward altering milk composition by genetic manipulation: current status and challengesQ41602609
Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic miceQ41653965
Recent Advances in Application of Male Germ Cell Transplantation in Farm AnimalsQ41843370
Chromatin Boundaries, Insulators, and Long-Range Interactions in the NucleusQ42837625
Chromosome integration of BAC (bacterial artificial chromosome): evidence of multiple rearrangementsQ43690878
Genetically enhanced cows resist intramammary Staphylococcus aureus infectionQ44213530
A 3,387 bp 5'-flanking sequence of the goat alpha-S1-casein gene provides correct tissue-specific expression of human granulocyte colony-stimulating factor (hG-CSF) in the mammary gland of transgenic mice.Q44357425
Phenotypic and genotypic stability of multiple lines of transgenic pigs expressing recombinant human protein C.Q45104933
Recruitment of histone modifications by USF proteins at a vertebrate barrier elementQ45138460
Large scale production of recombinant human lactoferrin in the milk of transgenic cowsQ45231378
Engineering passive immunity in transgenic mice secreting virus-neutralizing antibodies in milkQ45756684
Lysozyme transgenic goats' milk influences gastrointestinal morphology in young pigs.Q45933060
Human lysozyme expressed in the mammary gland of transgenic dairy goats can inhibit the growth of bacteria that cause mastitis and the cold-spoilage of milk.Q46027534
Expression of full-length human pro-urokinase in mammary glands of transgenic mice.Q46035661
Transgenic salmon: a final leap to the grocery shelf?Q46395760
Production and processing of milk from transgenic goats expressing human lysozyme in the mammary glandQ46523142
Expression of human lysozyme mRNA in the mammary gland of transgenic miceQ46666986
High expression level of recombinant human erythropoietin in the milk of non-transgenic goats.Q46842938
Transgenically produced human antithrombin: structural and functional comparison to human plasma-derived antithrombin.Q48004775
Identification of anti-repressor elements that confer high and stable protein production in mammalian cellsQ48252074
Expression of recombinant human factor VIII in milk of several generations of transgenic rabbitsQ48292669
Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth.Q48488820
The insulator effect of the 5'HS4 region from the beta-globin chicken locus on the rabbit WAP gene promoter activity in transgenic mice.Q50682512
P433issue1
P921main subjectbiotechnologyQ7108
P304page(s)33-46
P577publication date2013-01-01
P1433published inActa NaturaeQ27723435
P1476titleUse of transgenic animals in biotechnology: prospects and problems
P478volume5

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cites work (P2860)
Q61800268A Brief Reminder of Systems of Production and Chromatography-Based Recovery of Recombinant Protein Biopharmaceuticals
Q57285329Avian Bioreactor Systems: A Review
Q37138255Characterization of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori).
Q28829918Efficient delivery of DNA into bovine preimplantation embryos by multiwall carbon nanotubes
Q40271068Expression of Active Fluorophore Proteins in the Milk of Transgenic Pigs Bypassing the Secretory Pathway
Q37544868GMOs in Russia: Research, Society and Legislation
Q27345423Generation of Transgenic Porcine Fibroblast Cell Lines Using Nanomagnetic Gene Delivery Vectors.
Q58569006Production of Recombinant Proteins in the Milk of Transgenic Animals: Current State and Prospects
Q37602144Production of functional human nerve growth factor from the saliva of transgenic mice by using salivary glands as bioreactors.
Q92542772Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development
Q38611817Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins
Q98181154Structural and functional characterization of recombinant human growth hormone isolated from transgenic pig milk
Q41200519The Use of Transcription Terminators to Generate Transgenic Lines of Chinese Hamster Ovary Cells (CHO) with Stable and High Level of Reporter Gene Expression
Q37052505Transgenic bovine as bioreactors: Challenges and perspectives
Q57490374Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
Q35899473Virus-resistant pigs might help to stem next outbreak