Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway

scientific article published on 12 August 2019

Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway is …
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scholarly articleQ13442814

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P356DOI10.12659/MSM.913829
P932PMC publication ID6703084
P698PubMed publication ID31402794

P2093author name stringFeng Xing
Lijin Feng
Ning Luo
Cong Sun
Zhongping Cheng
Mengmeng Chen
Siyu Ding
Chenghua Liu
Yuanying He
P2860cites workThe PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challengesQ26851852
Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.Q33960065
NVP-BEZ235, a dual PI3K/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cellsQ34000632
Cisplatin in cancer therapy: molecular mechanisms of actionQ34098163
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.Q34184917
Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcomeQ35032772
Synergistic inhibitory effect of wogonin and low-dose paclitaxel on gastric cancer cells and tumor xenograftsQ35047380
The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cellsQ35247181
Inhibition of nuclear factor κB transcription activity drives a synergistic effect of cisplatin and oridonin on HepG2 human hepatocellular carcinoma cellsQ35878495
AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancersQ36788196
mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovaryQ37346570
SEOM Clinical Guideline in ovarian cancer (2016)Q37475168
Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expressionQ38789527
Wogonin increases doxorubicin sensitivity by down-regulation of IGF-1R/AKT signaling pathway in human breast cancerQ38814180
Curcumin reverses cisplatin resistance in cisplatin-resistant lung caner cells by inhibiting FA/BRCA pathwayQ38925256
Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cellsQ39047050
Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathwayQ39125279
Cisplatin nephrotoxicity: a review of the literatureQ39223600
Activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway overcomes cisplatin resistance in ovarian carcinoma cellsQ39336106
Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen speciesQ39337101
JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cellsQ39384513
Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicalsQ39651374
Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathwayQ40051078
Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cellsQ46914709
Reversal of cisplatin resistance by inhibiting PI3K/Akt signal pathway in human lung cancer cells.Q53795106
Ovarian cancer statistics, 2018Q88890110
Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathwaysQ89407909
P921main subjectovarian cancerQ172341
wogoninQ409606
P304page(s)6007-6014
P577publication date2019-08-12
P1433published inMedical Science MonitorQ15756323
P1476titleWogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
P478volume25