The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells

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The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/IJO.2015.2931
P932PMC publication ID4383025
P698PubMed publication ID25776829
P5875ResearchGate publication ID273703199

P2093author name stringRakesh K Singh
Clinton O Chichester
Richard G Moore
Yifei Wang
Nicholi Vorsa
Ajay P Singh
Eva Chen
Alex Han
P2860cites workNuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptorsQ37622619
Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2.Q38524840
Purified cranberry proanthocyanidines (PAC-1A) cause pro-apoptotic signaling, ROS generation, cyclophosphamide retention and cytotoxicity in high-risk neuroblastoma cellsQ39459020
A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell linesQ40549851
Inhibition of cell-proliferation by an adenovirus vector expressing the human wild type-p53 protein.Q41514934
Metallothionein gene expression and resistance to cisplatin in human ovarian cancerQ41740395
Isolation of Specific Cranberry Flavonoids for Biological Activity AssessmentQ41940121
Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblastsQ42811761
Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascadeQ44521641
Characterization of flavonols in cranberry (Vaccinium macrocarpon) powderQ44734953
Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell linesQ45198853
Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells.Q53219141
Structure, Recognition, and Processing of Cisplatin-DNA Adducts.Q55035583
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatmentQ24338426
p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells.Q25257047
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
Activation of Raf as a result of recruitment to the plasma membraneQ29618481
Progress and challenges in screening for early detection of ovarian cancerQ31041170
Retracted: Grape Seed Proanthocyanidins Inhibit the Invasiveness of Human HNSCC Cells by Targeting EGFR and Reversing the Epithelial-To-Mesenchymal TransitionQ31047791
Human glycemic response and phenolic content of unsweetened cranberry juiceQ33325240
Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatinQ33403233
A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coliQ33918797
p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblastsQ33986335
Histone H3 phosphorylation and cell divisionQ34290245
The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunitiesQ34399306
EGFR and cancer prognosisQ34399312
ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpressionQ34519896
Cranberry and its phytochemicals: a review of in vitro anticancer studiesQ34593432
Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).Q35063894
The cell cycle: a review of regulation, deregulation and therapeutic targets in cancerQ35157537
Ovarian cancer: strategies for overcoming resistance to chemotherapyQ35166813
Direct cellular responses to platinum-induced DNA damageQ36800400
Radiation-induced EGFR-signaling and control of DNA-damage repairQ37024025
P433issue5
P921main subjectovarian cancerQ172341
cisplatinQ412415
P304page(s)1924-1934
P577publication date2015-03-17
P1433published inInternational Journal of OncologyQ6051527
P1476titleThe cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells
P478volume46

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cites work (P2860)
Q99551767Antitumor effects and molecular mechanisms of action of natural products in ovarian cancer
Q26739912Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents
Q37213021Cranberry proanthocyanidins modulate reactive oxygen species in Barrett's and esophageal adenocarcinoma cell lines
Q46256497Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin.
Q47102500Dietary feeding of freeze-dried whole cranberry inhibits intestinal tumor development in Apcmin/+ mice
Q50038057Flavonoids from Chinese bayberry leaves induced apoptosis and G1 cell cycle arrest via Erk pathway in ovarian cancer cells
Q49629069In vitro study on reversal of ovarian cancer cell resistance to cisplatin by naringin via the nuclear factor-κB signaling pathway
Q26767372Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma
Q43811122Phenolic Compounds in Chilean Mistletoe (Quintral, Tristerix tetrandus) Analyzed by UHPLC-Q/Orbitrap/MS/MS and Its Antioxidant Properties.
Q90694592Phytochemical Composition, Antioxidant and Antiproliferative Activities of Defatted Sea Buckthorn (Hippophaë rhamnoides L.) Berry Pomace Fractions Consecutively Recovered by Pressurized Ethanol and Water
Q26777099Proteomic Analysis of Anticancer TCMs Targeted at Mitochondria
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Q37289470V8 induces apoptosis and the endoplasmic reticulum stress response in human multiple myeloma RPMI 8226 cells via the PERK-eIF2α-ATF4 signaling pathway
Q92556126Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway

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