Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β

scientific article published on 29 April 2019

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/ALL.13801
P932PMC publication ID6850072
P698PubMed publication ID30937919

P50authorAchilleas FloudasQ88313635
Luke A. J. O'NeillQ24209151
Andrew N. J. McKenzieQ30106734
Christian SchwartzQ57090701
Graham OggQ60327610
Gabriel NúñezQ63409996
Alan D. IrvineQ39066910
Padraic G. FallonQ42944857
Jocelyne DemengeotQ47410059
Sean P. SaundersQ55948319
Patrick T WalshQ56246146
Yoichiro IwakuraQ56564114
P2093author name stringJoana Bom
Tara Moran
Agnieszka Kaszlikowska
P2860cites workGenetic variation determines mast cell functions in experimental asthmaQ84102352
Cytokine modulation of atopic dermatitis filaggrin skin expressionQ84498043
Atopic dermatitisQ86174273
Dupilumab treatment in adults with moderate-to-severe atopic dermatitisQ87371931
Dupilumab: A review of its use in the treatment of atopic dermatitisQ87853471
Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial KillingQ88055796
Key component of inflammasome, NLRC4, was identified in the lesional epidermis of psoriatic patientsQ88804115
Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α releaseQ91626434
Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymaseQ24336387
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunityQ24630261
Topographical and temporal diversity of the human skin microbiomeQ24647583
Gout-associated uric acid crystals activate the NALP3 inflammasomeQ28131797
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitisQ28255158
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitisQ28259055
Differential activation of the inflammasome by caspase-1 adaptors ASC and IpafQ28266417
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitisQ28303063
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivoQ28506160
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjectsQ28511427
RAG-1-deficient mice have no mature B and T lymphocytesQ28592133
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesQ29614469
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cellsQ30612542
A two-step process for cytokine production revealed by IL-4 dual-reporter miceQ33677827
IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cellsQ33869215
Eosinophils increase neuron branching in human and murine skin and in vitro.Q33979626
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsionQ34106637
Basophils promote innate lymphoid cell responses in inflamed skinQ34218677
Filaggrin mutations associated with skin and allergic diseases.Q34223419
An in vitro culture model to study the dynamics of colonic microbiota in Syrian golden hamsters and their susceptibility to infection with Clostridium difficileQ35002637
Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) lociQ35155640
Mast cell secretory granules: armed for battleQ35182662
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.Q35350543
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesityQ35660131
Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' MiceQ35975739
IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.Q36102435
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17.Q36121354
Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 proteinQ36137849
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammationQ36291657
Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretionQ36400734
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunityQ36526371
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophagesQ36694157
Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency.Q36770768
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammationQ36798825
The prevalence of mutations in the gene encoding filaggrin in the population of Polish patients with atopic dermatitisQ36946174
Evidence of innate lymphoid cell redundancy in humansQ37357543
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.Q37397800
IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammationQ37397810
TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cellsQ56671802
Possible Pathogenic Role of Th17 Cells for Atopic DermatitisQ56772998
Dupilumab progressively improves systemic and cutaneous abnormalities in atopic dermatitis patientsQ56889179
Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell-related immunity and angiogenesisQ57167945
IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis ModelsQ62735563
Tissue signals imprint ILC2 identity with anticipatory function.Q64969347
Mast cells in atopic dermatitisQ69802044
An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitisQ73431465
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1Q73748033
In activated mast cells, IL-1 up-regulates the production of several Th2-related cytokines including IL-9Q73812151
A distinct role for interleukin-13 in Th2-cell-mediated immune responsesQ74344715
Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostainingQ77331786
Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalphaQ77677370
Persistent central memory phenotype of circulating Fel d 1 peptide/DRB1*0101 tetramer-binding CD4+ T cellsQ79396285
Fate mapping reveals separate origins of T cells and myeloid lineages in the thymusQ83371591
Cellular and molecular mechanisms in atopic dermatitisQ37499326
Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 yearQ37552637
Filaggrin Mutation in Korean Patients with Atopic Dermatitis.Q37622167
Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitisQ37709681
Inflammasome-independent regulation of IL-1-family cytokinesQ38286016
The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapiesQ38733182
The Role of the Skin Microbiome in Atopic Dermatitis: A Systematic ReviewQ38756577
Atopic dermatitis phenotypes and the need for personalized medicineQ39352185
The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis.Q39402846
IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.Q40058815
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.Q40118341
IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation.Q40172237
A mouse model for the human pathogen Salmonella typhiQ40346083
Opposing functions of thymic stromal lymphopoietin-responsive basophils and dendritic cells in a mouse model of atopic dermatitis.Q40627439
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1betaQ41457693
Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitisQ41719738
TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis.Q41877936
Type 2 helper T-cell cytokines induce morphologic and molecular characteristics of atopic dermatitis in human skin equivalentQ42010436
Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodelingQ43183078
Mutations analysis in filaggrin gene in northern China patients with atopic dermatitisQ43567219
Association of single nucleotide polymorphisms of interleukin-1 family with atopic dermatitis.Q43592353
Defective NK cell activity and Th1 response in IL-18-deficient miceQ43595287
Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responsesQ44158655
The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flg(ft/ft) miceQ46799597
Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP PathwayQ48205671
IL-1β induces thymic stromal lymphopoietin and an atopic dermatitis-like phenotype in reconstructed healthy human epidermisQ48247956
Divergent Roles of Interferon-γ and Innate Lymphoid Cells in Innate and Adaptive Immune Cell-Mediated Intestinal Inflammation.Q49205651
The human skin microbiomeQ50051002
Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin.Q51459379
Dupilumab for Moderate-to-Severe Atopic Dermatitis.Q51791317
Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis.Q52033316
Of Mouse Models of Mast Cell Deficiency and Metabolic Syndrome.Q52859997
Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin.Q54319446
P433issue10
P921main subjectatopic dermatitisQ268667
P304page(s)1920-1933
P577publication date2019-04-29
P1433published inAllergyQ2699825
P1476titleSpontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β
P478volume74