Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9

scientific article published on 21 August 2019

Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9 is …
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scholarly articleQ13442814

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P356DOI10.3390/CELLS8090948
P932PMC publication ID6770737
P698PubMed publication ID31438640

P2093author name stringHorng-Rong Chang
Shun-Fa Yang
Jen-Pi Tsai
Yi-Hsien Hsieh
Hui-Ling Chiou
Chia-Liang Lin
Min-Hong Hsieh
P2860cites workLicochalcone A inhibits the invasive potential of human glioma cells by targeting the MEK/ERK and ADAM9 signaling pathwaysQ93348122
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Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cellsQ33986266
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Fisetin inhibits growth, induces G₂ /M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activationQ37051658
Utilization of cytoreductive nephrectomy and patient survival in the targeted therapy era.Q37671681
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Fisetin suppresses ADAM9 expression and inhibits invasion of glioma cancer cells through increased phosphorylation of ERK1/2.Q38926832
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Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modelingQ39011116
Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cellsQ39635235
Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung cancer cell line A549.Q39804651
Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cellsQ40345970
The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activityQ40538936
YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetinQ40720588
Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathwayQ42726405
Prognostic impact of proteolytic factors (urokinase-type plasminogen activator, plasminogen activator inhibitor 1, and cathepsins B, D, and L) in primary breast cancer reflects effects of adjuvant systemic therapy.Q43736429
16-Hydroxycleroda-3, 13-dien-15, 16-olide inhibits the proliferation and induces mitochondrial-dependent apoptosis through Akt, mTOR, and MEK-ERK pathways in human renal carcinoma cellsQ46257765
Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells.Q46327293
Fisetin induces apoptosis and endoplasmic reticulum stress in human non-small cell lung cancer through inhibition of the MAPK signaling pathwayQ46606929
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.Q47100235
Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription ActivityQ47346980
Galangin increases ERK1/2 phosphorylation to decrease ADAM9 expression and prevents invasion in A172 glioma cellsQ47426288
Combination of etoposide and fisetin results in anti-cancer efficiency against osteosarcoma cell models.Q48360649
Sulforaphane suppresses oral cancer cell migration by regulating cathepsin S expression.Q54113625
Lysosomal cathepsin B: correlation with metastatic potentialQ70777196
Critical function for ADAM9 in mouse prostate cancerQ81362568
The origin, evolution and route to metastasis of clear cell RCCQ89014735
Timosaponin AIII inhibits metastasis of renal carcinoma cells through suppressing cathepsin C expression by AKT/miR-129-5p axisQ90861562
Fisetin Inhibited Growth and Metastasis of Triple-Negative Breast Cancer by Reversing Epithelial-to-Mesenchymal Transition via PTEN/Akt/GSK3β Signal PathwayQ90948102
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P921main subjectfisetinQ418384
renal cell carcinomaQ1164529
P577publication date2019-08-21
P1433published inCellsQ27724621
P1476titleFisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9
P478volume8