| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1047391109 |
| P356 | DOI | 10.1038/NCB3011 |
| P932 | PMC publication ID | 4249762 |
| P698 | PubMed publication ID | 25086747 |
| P5875 | ResearchGate publication ID | 264430205 |
| P50 | author | Joan Massagué Solé | Q462775 |
| Priscilla K Brastianos | Q57023902 | ||
| Franck Rapaport | Q79706422 | ||
| Christina S Leslie | Q87654951 | ||
| William C Hahn | Q88192808 | ||
| Robert L Bowman | Q101051385 | ||
| P2093 | author name string | Edi Brogi | |
| Johanna A Joyce | |||
| Daniela F Quail | |||
| Lisa Sevenich | |||
| Leslie J Holsinger | |||
| Benelita T Elie | |||
| Steven D Mason | |||
| P2860 | cites work | Bioconductor: open software development for computational biology and bioinformatics | Q21194861 |
| Genes that mediate breast cancer metastasis to the brain | Q24644008 | ||
| Astrocyte-endothelial interactions at the blood-brain barrier | Q28131675 | ||
| Cathepsin S required for normal MHC class II peptide loading and germinal center development | Q28611850 | ||
| affy--analysis of Affymetrix GeneChip data at the probe level | Q29547353 | ||
| Genes that mediate breast cancer metastasis to lung | Q29547479 | ||
| Metastasis: from dissemination to organ-specific colonization | Q29614295 | ||
| A multigenic program mediating breast cancer metastasis to bone | Q29614308 | ||
| The distribution of secondary growths in cancer of the breast. 1889 | Q29614314 | ||
| Microenvironmental regulation of tumor progression and metastasis | Q29615504 | ||
| Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease | Q29619726 | ||
| Matrix metalloproteinases: regulators of the tumor microenvironment | Q29619858 | ||
| Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins. | Q30321506 | ||
| Molecular characterization of the tumor microenvironment in breast cancer | Q31095898 | ||
| Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities | Q33235638 | ||
| Stromal gene expression predicts clinical outcome in breast cancer | Q33330931 | ||
| Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs | Q33609142 | ||
| IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion | Q33612349 | ||
| Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis. | Q33882549 | ||
| Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S. | Q34038556 | ||
| Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment. | Q34185886 | ||
| Breast carcinoma: Pattern of metastasis at autopsy | Q34256529 | ||
| Emerging principles in protease-based drug discovery | Q34282102 | ||
| Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration | Q34358711 | ||
| Distinct roles for cysteine cathepsin genes in multistage tumorigenesis | Q34471105 | ||
| Targeting proteases: successes, failures and future prospects | Q34563752 | ||
| Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood–brain barrier | Q35119354 | ||
| Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis | Q35409064 | ||
| Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors | Q35580568 | ||
| Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer | Q35624725 | ||
| The biology of brain metastases-translation to new therapies | Q35676602 | ||
| Genes that distinguish physiological and pathological angiogenesis | Q36087324 | ||
| Endosomal proteases in antigen presentation | Q36336164 | ||
| Matrix metalloproteinases as valid clinical targets | Q36741438 | ||
| Cysteine cathepsin proteases as pharmacological targets in cancer | Q37013943 | ||
| Cysteine cathepsin S as an immunomodulatory target: present and future trends. | Q37082769 | ||
| Metastatic patterns of cancers: results from a large autopsy study | Q37179275 | ||
| The ADAMs: signalling scissors in the tumour microenvironment | Q37324256 | ||
| Proteolytic networks in cancer | Q37343319 | ||
| Delineating protease functions during cancer development | Q37451007 | ||
| Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting | Q37641731 | ||
| Helminth-derived immunomodulators: can understanding the worm produce the pill? | Q37708009 | ||
| The regulatory crosstalk between kinases and proteases in cancer | Q37714303 | ||
| Cancer dissemination--lessons from leukocytes | Q37774092 | ||
| Does tumour dormancy offer a therapeutic target? | Q37806949 | ||
| Brain metastases as preventive and therapeutic targets | Q37862581 | ||
| The biology and therapeutic targeting of the proprotein convertases | Q38017196 | ||
| Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances | Q38017702 | ||
| Junctional adhesion molecules in cerebral endothelial tight junction and brain metastasis | Q38113200 | ||
| Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment | Q40131387 | ||
| A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging | Q40579830 | ||
| Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates | Q43203232 | ||
| Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. | Q46127843 | ||
| Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate | Q46570233 | ||
| Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization. | Q53109387 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| ggplot2 | Q326489 | ||
| limma | Q112236343 | ||
| P433 | issue | 9 | |
| P921 | main subject | proteolysis | Q33123 |
| P304 | page(s) | 876-888 | |
| P577 | publication date | 2014-08-03 | |
| P1433 | published in | Nature Cell Biology | Q1574111 |
| P1476 | title | Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S | |
| P478 | volume | 16 |
| Q42366169 | "Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma |
| Q92187139 | A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer |
| Q40430939 | A bioavailable cathepsin S nitrile inhibitor abrogates tumor development. |
| Q37217055 | Blood-brain barrier remodeling during brain metastasis formation |
| Q91099817 | Brain metastases |
| Q92134610 | Brain metastases in oncogene-driven non-small cell lung cancer |
| Q91526515 | Brain metastasis |
| Q52571424 | Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer. |
| Q30238959 | Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context. |
| Q57291657 | Breast cancer brain metastasis: molecular mechanisms and directions for treatment |
| Q38286205 | CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner. |
| Q92592414 | Cathepsin S as a target in gastric cancer |
| Q41634347 | Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer |
| Q38420668 | Cathepsin S: therapeutic, diagnostic, and prognostic potential. |
| Q38631861 | Cathepsin-S degraded decorin are elevated in fibrotic lung disorders - development and biological validation of a new serum biomarker |
| Q38728647 | Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness |
| Q33914741 | Cell-to-cell communication in cancer: workshop report |
| Q90637180 | Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers |
| Q26796326 | Clinical and molecular complexity of breast cancer metastases |
| Q48269323 | Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis |
| Q55012882 | Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy. |
| Q64069431 | Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment |
| Q36413686 | Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer |
| Q38644547 | Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response |
| Q26827307 | Cysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probes |
| Q38320736 | Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization |
| Q41644080 | Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells |
| Q34271356 | Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. |
| Q58763841 | Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis |
| Q35374807 | Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer |
| Q39130446 | Emerging Biological Principles of Metastasis |
| Q38925249 | Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation. |
| Q91899632 | Evaluating Magnetic Resonance Spectroscopy as a Tool for Monitoring Therapeutic Response of Whole Brain Radiotherapy in a Mouse Model for Breast-to-Brain Metastasis |
| Q33761570 | Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer |
| Q61812916 | Expression of Proteolytic Enzymes by Small Cell Lung Cancer Circulating Tumor Cell Lines |
| Q92784120 | Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9 |
| Q48108646 | Foe or friend? Janus-faces of the neurovascular unit in the formation of brain metastases |
| Q94953113 | Genes that Mediate Metastasis across the Blood-Brain Barrier |
| Q56883100 | HIF1A signaling selectively supports proliferation of breast cancer in the brain |
| Q47100235 | Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells. |
| Q93186392 | Immunological Regulation of Vascular Inflammation During Cancer Metastasis |
| Q47739102 | Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression |
| Q37715063 | Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways |
| Q64093580 | Innovative Therapeutic Strategies for Effective Treatment of Brain Metastases |
| Q104610112 | Insights into brain metastasis: Recent advances in circulating tumor cell research |
| Q38385463 | Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance |
| Q47771280 | Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development. |
| Q42315527 | Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells |
| Q52864120 | Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe. |
| Q52087016 | Lung cancer-associated brain metastasis: Molecular mechanisms and therapeutic options. |
| Q33744534 | Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies |
| Q36972901 | Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. |
| Q37624909 | Macrophages as Key Drivers of Cancer Progression and Metastasis. |
| Q90742690 | Melittin Induced G1 Cell Cycle Arrest and Apoptosis in Chago-K1 Human Bronchogenic Carcinoma Cells and Inhibited the Differentiation of THP-1 Cells into Tumour- Associated Macrophages |
| Q91823910 | Metastasis Organotropism: Redefining the Congenial Soil |
| Q55295930 | Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a. |
| Q28076164 | Metastatic colonization by circulating tumour cells |
| Q93192742 | MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer |
| Q92511346 | Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis |
| Q26800626 | Molecular and Genetic Predictors of Breast-to-Brain Metastasis: Review and Case Presentation |
| Q38776336 | Molecular insights into tumour metastasis: tracing the dominant events. |
| Q36039489 | Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk. |
| Q37691517 | Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer |
| Q38936710 | Novel Approaches to Apoptosis-Inducing Therapies |
| Q38665014 | Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF. |
| Q33915087 | Palmitoylation: a protein S-acylation with implications for breast cancer |
| Q38281325 | Pathogenesis of Breast Cancer Metastasis to Brain: a Comprehensive Approach to the Signaling Network |
| Q34430691 | Pericellular proteolysis in cancer |
| Q38743711 | Pre-metastatic niches: organ-specific homes for metastases. |
| Q49544395 | Predicting and Overcoming Chemotherapeutic Resistance in Breast Cancer |
| Q38773078 | Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors |
| Q38268345 | Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges |
| Q64988952 | Proteomic Analysis of the Breast Cancer Brain Metastasis Microenvironment. |
| Q47875808 | Reactive Astrocytes in Brain Metastasis |
| Q54962187 | Recent advances in the biology and treatment of brain metastases of non-small cell lung cancer: summary of a multidisciplinary roundtable discussion. |
| Q89940647 | Risk factors for breast cancer brain metastases: a systematic review |
| Q89070244 | STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis |
| Q47324967 | Site-specific and endothelial-mediated dysfunction of the alveolar-capillary barrier in response to lipopolysaccharides. |
| Q90481686 | Supportive roles of brain macrophages in CNS metastases and assessment of new approaches targeting their functions |
| Q90168508 | Synaptic proximity enables NMDAR signalling to promote brain metastasis |
| Q55724715 | TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. |
| Q34547374 | Targeting metastasis-initiating cells through the fatty acid receptor CD36 |
| Q26744019 | The Current and Future Treatment of Brain Metastases |
| Q52673453 | The Evolving Landscape of Brain Metastasis. |
| Q57166654 | The Interplay between Circulating Tumor Cells and the Immune System: From Immune Escape to Cancer Immunotherapy |
| Q39178065 | The Microenvironmental Landscape of Brain Tumors |
| Q59335820 | The Multifarious Role of Microglia in Brain Metastasis |
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| Q42378844 | Tissue and plasma levels of galectins in patients with high grade serous ovarian carcinoma as new predictive biomarkers |
| Q47398521 | Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding. |
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| Q64899538 | Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis. |
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| Q53639987 | [Tumor microenvironment--the critical element of tumor metastasis]. |
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