Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

scientific article published on 28 May 2008

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1046728140
P356DOI10.1038/NATURE07017
P698PubMed publication ID18509335
P5875ResearchGate publication ID5342333

P50authorPernille R. JensenQ44902421
Ferdia A GallagherQ57192026
Magnus KarlssonQ58830664
Mathilde Hauge LercheQ58830674
Mikko KettunenQ40248990
Jan Henrik Ardenkjær-LarsenQ42676450
P2093author name stringKevin M Brindle
De-En Hu
Klaes Golman
René in 't Zandt
Sam E Day
P2860cites workNon-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agentQ43786944
In vivo measurement of brain tumor pH using [11C]DMO and positron emission tomographyQ44976557
31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate.Q55481907
An assessment of31P MRS as a method of measuring pH in rat tumoursQ60536737
In Vivo Magnetic Resonance Imaging of Tissue pH Using a Novel pH-Sensitive Contrast Agent, GdDOTA-4AmPQ61703277
In vivo imaging of extracellular pH using1H MRSIQ61703297
The rates of fast reactions of carbon dioxide and bicarbonate in human erythrocytes measured by carbon-13 NMRQ70330700
Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosisQ79362737
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMRQ24683340
Carbonic anhydrase. Its preparation and propertiesQ28264990
Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantroneQ28345658
Enhancement of chemotherapy by manipulation of tumour pH.Q30578111
Administration and (1)H MRS detection of histidine in human brain: application to in vivo pH measurementQ30595496
Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST).Q30619398
Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI.Q30813015
Imaging of brain tissue pH and metabolites. A new approach for the validation of volume-selective NMR spectroscopyQ31063825
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.Q34007874
pH imaging. A review of pH measurement methods and applications in cancers.Q35964389
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR.Q36288856
Regulation of cytoplasmic pH in phagocytic cell function and dysfunctionQ36414477
Metabolic imaging and other applications of hyperpolarized 13C1.Q36537521
Regulation of tumor pH and the role of carbonic anhydrase 9.Q36784373
Management of life-threatening acid-base disorders. First of two partsQ41670821
The effect of blood flow modification on intra- and extracellular pH measured by 31P magnetic resonance spectroscopy in murine tumoursQ41840462
P433issue7197
P407language of work or nameEnglishQ1860
P921main subjectmagnetic resonance imagingQ161238
hyperpolarizationQ1641079
P304page(s)940-943
P577publication date2008-05-28
P1433published inNatureQ180445
P1476titleMagnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate
P478volume453

Reverse relations

cites work (P2860)
Q30445519(13)C NMR spectroscopy applications to brain energy metabolism
Q36060672(13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging
Q4253072715N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH.
Q304981702D luminescence imaging of pH in vivo
Q356293802H-DNP-enhanced 2H-13C solid-state NMR correlation spectroscopy
Q336908963D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer
Q38613732A New Horizon of DNP technology: Application to In-vivo 13C Magnetic Resonance Spectroscopy and Imaging
Q89658833A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer Based upon Its Hydrogen Ion Dynamics
Q28554531A Potential Magnetic Resonance Imaging Technique Based on Chemical Exchange Saturation Transfer for In Vivo γ-Aminobutyric Acid Imaging
Q60961340A Role of Tumor-Released Exosomes in Paracrine Dissemination and Metastasis
Q50671030A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure.
Q89116418A Transistor-like pH Nanoprobe for Tumour Detection and Image-guided Surgery
Q36404477A comparison of iopromide and iopamidol, two acidoCEST MRI contrast media that measure tumor extracellular pH.
Q36802166A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate
Q47681445A fluorescent pH probe for acidic organelles in living cells.
Q48622963A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol.
Q34694247A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent.
Q51652789A hypoxia efficient imidazole-based Ru(II) arene anticancer agent resistant to deactivation by glutathione.
Q48862174A multisample dissolution dynamic nuclear polarization system for serial injections in small animals.
Q46583035A nanospherical polymer as an MRI sensor without paramagnetic or superparamagnetic species.
Q37153837A new direction for polarized carbon-13 MRI.
Q36491638A novel perfused Bloch-McConnell simulator for analyzing the accuracy of dynamic hyperpolarized MRS.
Q37213034A novel technology for the imaging of acidic prostate tumors by positron emission tomography
Q51330634A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy.
Q30991020A peripheral component interconnect express-based scalable and highly integrated pulsed spectrometer for solution state dynamic nuclear polarization
Q42643016A platform for designing hyperpolarized magnetic resonance chemical probes
Q28540556A polymer-based magnetic resonance tracer for visualization of solid tumors by 13C spectroscopic imaging
Q47447443A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer
Q61179862A ratiometric NMR pH sensing strategy based on a slow-proton-exchange (SPE) mechanism
Q88964560Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Q39156478Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity
Q38846154Acidic tumor microenvironment in human melanoma
Q39222206Acidosis blocks CCAAT/enhancer-binding protein homologous protein (CHOP)- and c-Jun-mediated induction of p53-upregulated mediator of apoptosis (PUMA) during amino acid starvation
Q35067955Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway
Q91770161Acquisition strategies for spatially resolved magnetic resonance detection of hyperpolarized nuclei
Q50012069Advanced Contrast Agents for Multimodal Biomedical Imaging Based on Nanotechnology
Q96128425Advanced biomimetic nanoreactor for specifically killing tumor cells through multi-enzyme cascade
Q28830010Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection
Q38186073Agents described in the Molecular Imaging and Contrast Agent Database for imaging carbonic anhydrase IX expression
Q42643265Amplifying dynamic nuclear polarization of frozen solutions by incorporating dielectric particles
Q36360672An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment.
Q34551523Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.
Q34599128Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S
Q37711198Anilinomethylrhodamines: pH sensitive probes with tunable photophysical properties by substituent effect
Q26745461Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect
Q37706150Antitumor effect of combination of the inhibitors of two new oncotargets: proton pumps and reverse transcriptase.
Q28833660Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI
Q35977263Application of hyperpolarized [1-¹³C]lactate for the in vivo investigation of cardiac metabolism.
Q56703053Application of magnetic resonance imaging in zoology
Q36849513Applications of NMR spectroscopy to systems biochemistry
Q33600827Beyond Warburg effect--dual metabolic nature of cancer cells
Q33848102Bimodal MR-PET agent for quantitative pH imaging.
Q59789349Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement
Q40914549Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.
Q47162047Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy
Q88994421Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology
Q30985593Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Q41772016Cardiovascular Applications of Hyperpolarized MRI.
Q37304956Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research
Q49504547Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group
Q33680025Challenges for molecular neuroimaging with MRI
Q39135714Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging
Q43197434Chemical reaction-induced multi-molecular polarization (CRIMP).
Q56041128Chemical robotics — chemotactic drug carriers
Q40237426Chemical shift encoded imaging of hyperpolarized (13) C pyruvate
Q27023363Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization
Q89534107Clinical Cardiovascular Applications of Hyperpolarized Magnetic Resonance
Q27025172Clinical implications of cardiac hyperpolarized magnetic resonance imaging
Q33840708Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate.
Q42956769Continuous (1)H AND (13)C signal enhancement in NMR spectroscopy and MRI using parahydrogen and hollow-fiber membranes
Q34493834Correcting surface coil excitation inhomogeneities in single-shot SPEN MRI
Q34030346Correlation of the EPR properties of perchlorotriphenylmethyl radicals and their efficiency as DNP polarizers
Q35216268Could 13C MRI assist clinical decision-making for patients with heart disease?
Q30460977Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy.
Q37644820Current opportunities and challenges of magnetic resonance spectroscopy, positron emission tomography, and mass spectrometry imaging for mapping cancer metabolism in vivo
Q38644547Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response
Q37148195Design and characterization of a W-band system for modulated DNP experiments.
Q31132701Detecting tumor progression in glioma: Current standards and new techniques.
Q46218802Detecting tumor responses to treatment using hyperpolarized 13C magnetic resonance spectroscopic imaging
Q33772430Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy
Q47911382Deuteration of Hyperpolarized 13 C-Labeled Zymonic Acid Enables Sensitivity-Enhanced Dynamic MRI of pH.
Q28818324Developing imidazoles as CEST MRI pH sensors
Q57494938Development of a Symmetric Echo-Planar Spectroscopy Imaging Framework for Hyperpolarized C Imaging in a Clinical PET/MR Scanner
Q46815726Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging.
Q38844369Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein.
Q42317306Doxorubicin-loaded poly (lactic-co-glycolic acid) nanoparticles coated with chitosan/alginate by layer by layer technology for antitumor applications
Q37682657Dual-function pH and oxygen phosphonated trityl probe
Q64069789Dynamic Imaging of Glucose and Lactate Metabolism by C-MRS without Hyperpolarization
Q36894057Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging
Q34307070Dynamic nuclear polarization with a rigid biradical
Q53669024Dynamic nuclear polarization with photoexcited triplet electrons in a glassy matrix.
Q45255109Dysregulated pH: a perfect storm for cancer progression.
Q89658673Effects of Andrographolide on Intracellular pH Regulation, Cellular Migration, and Apoptosis in Human Cervical Cancer Cells †
Q51541689Effects of pyruvate dose on in vivo metabolism and quantification of hyperpolarized ¹³C spectra.
Q38892159Efficient Synthesis of Nicotinamide-1-¹⁵N for Ultrafast NMR Hyperpolarization Using Parahydrogen
Q46814869Efficient production of hyperpolarized bicarbonate by chemical reaction on a DNP precursor to measure pH.
Q42076524Electron paramagnetic resonance-based pH mapping using spectral-spatial imaging of sequentially scanned spectra
Q37849727Engineering Nanocarriers for siRNA Delivery.
Q58558620Esterase-Catalyzed Production of Hyperpolarized C-Enriched Carbon Dioxide in Tissues for Measuring pH
Q28821895Evaluating pH in the Extracellular Tumor Microenvironment Using CEST MRI and Other Imaging Methods
Q64076126Evaluation of the sensitivity of Rρ MRI to pH and macromolecular density
Q36935816Evaluations of Tumor Acidosis Within In Vivo Tumor Models Using Parametric Maps Generated with Acido CEST MRI
Q33663027Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI
Q35728529Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis
Q52542413Extracellular Acid-Base Balance and Ion Transport Between Body Fluid Compartments.
Q89624673Fast Imaging for Hyperpolarized MR Metabolic Imaging
Q28818747Fast Padé Transform Accelerated CSI for Hyperpolarized MRS
Q85312110Field dependence of T1 for hyperpolarized [1-13C]pyruvate
Q90677006Functional In Vivo Imaging of Tumors
Q33726910Functional and molecular imaging with MRI: potential applications in paediatric radiology
Q53267611Functional imaging for head and neck cancer.
Q30462527Functional photoacoustic microscopy of pH.
Q30667477Gd-labeled glycol chitosan as a pH-responsive magnetic resonance imaging agent for detecting acidic tumor microenvironments
Q36692671Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions.
Q47985359High-resolution hyperpolarized in vivo metabolic 13C spectroscopy at low magnetic field (48.7mT) following murine tail-vein injection
Q37287105Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized (13)C Magnetic Resonance Spectroscopy.
Q51578728Hyperpolarised organic phosphates as NMR reporters of compartmental pH.
Q30364782Hyperpolarization MRI: Preclinical Models and Potential Applications in Neuroradiology.
Q35642084Hyperpolarization of "Neat" Liquids by NMR Signal Amplification by Reversible Exchange
Q91709877Hyperpolarization of 15N-pyridinium and 15N-aniline derivatives by using parahydrogen: new opportunities to store nuclear spin polarization in aqueous media
Q41900087Hyperpolarized (1)H NMR employing low gamma nucleus for spin polarization storage.
Q84597943Hyperpolarized (13) C-labelled anhydrides as DNP precursors of metabolic MRI agents
Q26781659Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs
Q36803260Hyperpolarized (13)C-lactate to (13)C-bicarbonate ratio as a biomarker for monitoring the acute response of anti-vascular endothelial growth factor (anti-VEGF) treatment.
Q38088398Hyperpolarized (13)C-pyruvate magnetic resonance imaging in cancer diagnostics.
Q35146434Hyperpolarized 13C MR for molecular imaging of prostate cancer
Q90175339Hyperpolarized 13C MRI: A novel approach for probing cerebral metabolism in health and neurological disease
Q92137259Hyperpolarized 13C MRI: State of the Art and Future Directions
Q90455861Hyperpolarized 13C Magnetic Resonance Imaging Can Detect Metabolic Changes Characteristic of Penumbra in Ischemic Stroke
Q38722689Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Q35132644Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism.
Q43782046Hyperpolarized 13C NMR studies of glucose metabolism in living breast cancer cell cultures
Q42415330Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor.
Q36545086Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas
Q35179690Hyperpolarized 15N-pyridine derivatives as pH-sensitive MRI agents.
Q33765358Hyperpolarized 89Y complexes as pH sensitive NMR probes.
Q49805653Hyperpolarized Amino Acid Derivatives as Multivalent Magnetic Resonance pH Sensor Molecules.
Q59812714Hyperpolarized C MRI: Path to Clinical Translation in Oncology
Q37588737Hyperpolarized NMR probes for biological assays.
Q42844062Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo
Q37486490Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging.
Q43016797Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart
Q41993594Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents
Q27000332Hyperpolarized magnetic resonance as a sensitive detector of metabolic function
Q35298233Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease.
Q50640829Hyperpolarizing gases via dynamic nuclear polarization and sublimation.
Q36573025Hypoxic stress and cancer: imaging the axis of evil in tumor metastasis
Q89402906Imaging biomarkers in oncology: Basics and application to MRI
Q43983077Imaging mouse cancer models in vivo using reporter transgenes
Q42228440Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models.
Q33829737Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
Q37609813Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for the examination of cardiac and renal function
Q37851075Imaging pH and metastasis
Q37910840Imaging pH with hyperpolarized 13C.
Q49592815Imaging the Tumor Microenvironment.
Q33908856Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents
Q42878391Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy
Q36004030Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO.
Q38781585Implantable Sensors for Regenerative Medicine
Q28833257Improved pH measurements with a single PARACEST MRI contrast agent
Q47698844In Vivo Assessment of Ovarian Tumor Response to Tyrosine Kinase Inhibitor Pazopanib by Using Hyperpolarized 13C-Pyruvate MR Spectroscopy and 18F-FDG PET/CT Imaging in a Mouse Model
Q33766020In situ detection of PHIP at 48 mT: demonstration using a centrally controlled polarizer
Q34432372In situ high-field dynamic nuclear polarization--direct and indirect polarization of 13C nuclei
Q90060755In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance
Q46021262In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy.
Q42108457In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate
Q42713182In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma
Q39981457In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate
Q36459091In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance
Q58100282In vivo extracellular pH mapping of tumors using electron paramagnetic resonance
Q57183803In vivo magnetic resonance imaging of hyperpolarized silicon particles
Q35834783In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors.
Q41905714In vivo pH imaging with (99m)Tc-pHLIP
Q42292503In vivo pH mapping of injured lungs using hyperpolarized [1-13 C]pyruvate
Q37694499In vivo proton-electron double-resonance imaging of extracellular tumor pH using an advanced nitroxide probe.
Q41539796In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging
Q28828600In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding
Q38370504In vivo tumour extracellular pH monitoring using electron paramagnetic resonance: the effect of X-ray irradiation
Q48143196Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate
Q37228743Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-.
Q57363419Intelligent nucleic acid delivery systems based on stimuli-responsive polymers
Q33749103Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI.
Q50065686In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors
Q33719676Iopamidol as a responsive MRI‐chemical exchange saturation transfer contrast agent for pH mapping of kidneys: In vivo studies in mice at 7 T
Q33572874Joint spatial-spectral reconstruction and k-t spirals for accelerated 2D spatial/1D spectral imaging of 13C dynamics
Q37416630Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells
Q48841689Labelling of mammalian cells for visualisation by MRI.
Q30815291Lanthanide ion (III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS)
Q57351863Long-decay near-infrared-emitting doped quantum dots for lifetime-based in vivo pH imaging
Q37413544Long-lived states to sustain hyperpolarized magnetization.
Q64960280Longitudinal Measurements of Intra- and Extracellular pH Gradient in a Rat Model of Glioma.
Q30364608MR Imaging Biomarkers in Oncology Clinical Trials
Q31137181MR Molecular Imaging of Brain Cancer Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy
Q37851076MR evaluation of response to targeted treatment in cancer cells.
Q37875004MRI & MRS assessment of the role of the tumour microenvironment in response to therapy.
Q37951603MRI of metastasis-permissive microenvironments
Q36170731Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis
Q38734065Magnetic resonance imaging with hyperpolarized agents: methods and applications.
Q33883070Magnetic resonance in the era of molecular imaging of cancer
Q33881902Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer
Q30489329Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate.
Q30842171Mathematical Modeling and Data Analysis of NMR Experiments using Hyperpolarized (13)C Metabolites
Q36610934Measuring in vivo tumor pHe with CEST-FISP MRI
Q33718324Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study
Q84084993Meeting for clinician scientists in training
Q91718463Metabolic alterations in acute myocardial ischemia-reperfusion injury and necrosis using in vivo hyperpolarized [1-13C] pyruvate MR spectroscopy
Q37871191Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy
Q37686102Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor
Q36713482Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging
Q41869171Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor
Q35746099Metabolic tumor imaging using magnetic resonance spectroscopy
Q39288397Metabolite-selective hyperpolarized (13)C imaging using extended chemical shift displacement at 9.4T.
Q37732704Molecular imaging and targeted therapies
Q37999206Molecular imaging for personalized cancer care
Q30367515Molecular imaging of the tumor microenvironment for precision medicine and theranostics.
Q26782151Molecular magnetic resonance imaging in cancer
Q37033902Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo
Q41886872Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate.
Q42606243Multi-chromatic pH-activatable 19F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes
Q33913684Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo
Q28828814Multimodality pH imaging in a mouse dorsal skin fold window chamber model
Q35565451NMR hyperpolarization techniques for biomedicine
Q38049124NMR of hyperpolarised probes
Q57095843NMR-based structural biology enhanced by dynamic nuclear polarization at high magnetic field
Q37406855NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells
Q37558594Nanoparticles for multimodal in vivo imaging in nanomedicine
Q38094240New frontiers and developing applications in 19F NMR.
Q42681260Nile Blue-based nanosized pH sensors for simultaneous far-red and near-infrared live bioimaging
Q58357710Nitroxide Radicals: Properties, Synthesis and Applications
Q37511779Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes
Q35700192Novel Approaches to Imaging Tumor Metabolism
Q41530333Open-Source Automated Parahydrogen Hyperpolarizer for Molecular Imaging Using (13)C Metabolic Contrast Agents.
Q48344652Oxidation of [U-13 C]glucose in the human brain at 7T under steady state conditions
Q42558014PASADENA hyperpolarized 13C phospholactate
Q86448569ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate
Q87892601Parahydrogen-Based Hyperpolarization for Biomedicine
Q35618777Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of 13C imaging of atheroma in mice
Q50796311Parameterization of hyperpolarized (13)C-bicarbonate-dissolution dynamic nuclear polarization.
Q34430691Pericellular proteolysis in cancer
Q37695857Phosphonated trityl probes for concurrent in vivo tissue oxygen and pH monitoring using electron paramagnetic resonance-based techniques.
Q39251086Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis
Q51108235Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner.
Q53454564Placental physiology monitored by hyperpolarized dynamic 13C magnetic resonance.
Q26865576Polarizing agents and mechanisms for high-field dynamic nuclear polarization of frozen dielectric solids
Q46445148Poly(N-phenylglycine)-Based Nanoparticles as Highly Effective and Targeted Near-Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma
Q26750864Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate
Q37126735Probe for the measurement of cell surface pH in vivo and ex vivo
Q103042980Probing Microenvironmental Acidity in Lyophilized Protein and Vaccine Formulations Using Solid-state NMR Spectroscopy
Q37446412Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors
Q46319560Progress in hyperpolarized ultrafast 2D NMR spectroscopy
Q39664958Proton magnetic resonance imaging with para-hydrogen induced polarization
Q34715470Proton-Electron Double-Resonance Imaging of pH using phosphonated trityl probe
Q55260053Pulsed Magnetic Resonance to Signal-Enhance Metabolites within Seconds by utilizing para-Hydrogen.
Q53495756Quantified pH imaging with hyperpolarized (13) C-bicarbonate.
Q64096467Quantifying normal human brain metabolism using hyperpolarized [1-C]pyruvate and magnetic resonance imaging
Q38681155Quantifying reaction kinetics of the non-enzymatic decarboxylation of pyruvate and production of peroxymonocarbonate with hyperpolarized 13C-NMR.
Q30756115Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons
Q34803587Quantum mechanical theory of dynamic nuclear polarization in solid dielectrics
Q34311896Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers
Q55311662Rational design of dinitroxide biradicals for efficient cross-effect dynamic nuclear polarization.
Q45228057Real-time DNP NMR observations of acetic acid uptake, intracellular acidification, and of consequences for glycolysis and alcoholic fermentation in yeast
Q42062389Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
Q35185962Real-time cardiac metabolism assessed with hyperpolarized [1-(13) C]acetate in a large-animal model
Q44902345Real-time detection of central carbon metabolism in living Escherichia coli and its response to perturbations.
Q36658324Recent Advances in Targeting Tumor Energy Metabolism with Tumor Acidosis as a Biomarker of Drug Efficacy
Q38156683Recent advances in metabolic imaging
Q44228110Reproducibility study for free-breathing measurements of pyruvate metabolism using hyperpolarized (13) C in the heart
Q26781245Research into cancer metabolomics: Towards a clinical metamorphosis
Q39021076Research progress of hydroxychloroquine and autophagy inhibitors on cancer.
Q48552373Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy
Q33694498Room temperature hyperpolarization of nuclear spins in bulk
Q38784480SABRE hyperpolarisation of vitamin B3 as a function of pH.
Q50057844Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
Q38577489Screening of CEST MR contrast agents.
Q57962471Self-assembled trityl radical capsules – implications for dynamic nuclear polarization
Q30662281Shape-changing magnetic assemblies as high-sensitivity NMR-readable nanoprobes
Q89717277Simultaneous T1 and T2 mapping of hyperpolarized 13C compounds using the bSSFP sequence
Q37385796Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI.
Q42067957Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo
Q30434273Sonophoric nanoprobe aided pH measurement in vivo using photoacoustic spectroscopy
Q92082059Spatiotemporal pH Heterogeneity as a Promoter of Cancer Progression and Therapeutic Resistance
Q89327404Spin-Lattice Relaxation of Hyperpolarized Metronidazole in Signal Amplification by Reversible Exchange in Micro-Tesla Fields
Q24629149Stable isotope-resolved metabolomics and applications for drug development
Q55516462Synthesis of Unsaturated Precursors for Parahydrogen-Induced Polarization and Molecular Imaging of 1-13C-Acetates and 1-13C-Pyruvates via Side Arm Hydrogenation.
Q41292105Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical
Q33937080T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate
Q38707574T1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13 C.
Q93075188Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma
Q30372356Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo.
Q36733474Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates
Q90242473Targeting metabolic dysregulation for fibrosis therapy
Q37229190Targeting the metabolic microenvironment of tumors
Q41367767Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH.
Q34182706The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor
Q36392626The Potential of Metabolic Imaging.
Q34297931The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
Q47314287The key role of extracellular vesicles in the metastatic process.
Q40817371The magnetic field dependence of cross-effect dynamic nuclear polarization under magic angle spinning.
Q37663377The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer
Q42254342The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion
Q50062142The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer
Q28477272The spatial organization of proton and lactate transport in a rat brain tumor
Q38947519The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging
Q30354655Theranostic Probes for Targeting Tumor Microenvironment: An Overview.
Q88502315Theranostics and metabolotheranostics for precision medicine in oncology
Q37315243Toward 13C hyperpolarized biomarkers produced by thermal mixing with hyperpolarized 129Xe.
Q60021754Toward Cleavable Metabolic/pH Sensing "Double Agents" Hyperpolarized by NMR Signal Amplification by Reversible Exchange
Q38677354Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen
Q53911762Translating imaging biomarkers into clinical practice.
Q37299318Transmembrane exchange of hyperpolarized 13C-urea in human erythrocytes: subminute timescale kinetic analysis.
Q36488080Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells
Q92945803Tubulin Polarizability in Aqueous Suspensions
Q47761233Tumor Microenvironment-Enabled Nanotherapy.
Q41667100Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells
Q34722734Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability--an implication in aneuploid human tumors
Q37775810Tumor pH and its measurement
Q96765503Ultrafast diffusion exchange nuclear magnetic resonance
Q37087726Use of a Multi-compartment Dynamic Single Enzyme Phantom for Studies of Hyperpolarized Magnetic Resonance Agents.
Q26865120Using magnetic resonance imaging and spectroscopy in cancer diagnostics and monitoring: preclinical and clinical approaches
Q99233800VDR-SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment
Q36326284Watching tumours gasp and die with MRI: the promise of hyperpolarised 13C MR spectroscopic imaging
Q41042280Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls
Q30980317pH imaging of mouse kidneys in vivo using a frequency-dependent paraCEST agent.
Q21129239pH sensing and regulation in cancer
Q41312049pH-Sensitive MR Responses Induced by Dendron-Functionalized SPIONs
Q39781678pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity
Q34061003pH-titratable superparamagnetic iron oxide for improved nanoparticle accumulation in acidic tumor microenvironments

Search more.