Emerging therapeutic targets associated with the immune system in patients with intracerebral haemorrhage (ICH): From mechanisms to translation

scientific article published on 14 June 2019

Emerging therapeutic targets associated with the immune system in patients with intracerebral haemorrhage (ICH): From mechanisms to translation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.EBIOM.2019.06.012
P932PMC publication ID6642355
P698PubMed publication ID31208948

P50authorAnwen ShaoQ85410594
P2093author name stringJianmin Zhang
Zhiyuan Zhu
Shizhong Zhang
Lingfei Li
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Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhageQ35935126
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Activated regulatory T cell regulates neural stem cell proliferation in the subventricular zone of normal and ischemic mouse brain through interleukin 10.Q36055850
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Treatment with FTY720 has no beneficial effects on short-term outcome in an experimental model of intracerebral hemorrhageQ36591931
GDF10 is a signal for axonal sprouting and functional recovery after stroke.Q36682829
Prospective validation of the ICH Score for 12-month functional outcomeQ37393402
Interleukin-23 Secreted by Activated Macrophages Drives γδT Cell Production of Interleukin-17 to Aggravate Secondary Injury After Intracerebral HemorrhageQ37434824
Intracerebral haemorrhage: mechanisms of injury and therapeutic targets.Q37448194
Transplanted neural stem cells modulate regulatory T, γδ T cells and corresponding cytokines after intracerebral hemorrhage in rats.Q37684073
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Fingolimod for the treatment of intracerebral hemorrhage: a 2-arm proof-of-concept studyQ38427210
Inhibition of neuronal ferroptosis protects hemorrhagic brainQ38730939
Mechanisms of Axonal Damage and Repair after Central Nervous System InjuryQ38938539
Hippocampal adult neurogenesis: Does the immune system matter?Q39006416
Programmed death (PD)-1 attenuates macrophage activation and brain inflammation via regulation of fibrinogen-like protein 2 (Fgl-2) after intracerebral hemorrhage in miceQ39310709
Toll-Like Receptor 4/MyD88-Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral Hemorrhage.Q39439180
Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI.Q39648552
Natural History of Perihematomal Edema and Impact on Outcome After Intracerebral HemorrhageQ40301146
Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and NecroptosisQ40312201
The immune modulator FTY720 targets sphingosine 1-phosphate receptorsQ40736684
Fingolimod alters inflammatory mediators and vascular permeability in intracerebral hemorrhageQ41465491
Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhageQ41475535
White Matter Injury after Intracerebral Hemorrhage: Pathophysiology and Therapeutic StrategiesQ41549073
Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhageQ41701180
Increased expression of T cell immunoglobulin and mucin domain 3 aggravates brain inflammation via regulation of the function of microglia/macrophages after intracerebral hemorrhage in miceQ42252156
Up-Regulation of Interferon Regulatory Factor 3 Involves in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult RatsQ42496679
Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhageQ42518240
FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice.Q43235313
Effects of celecoxib on volumes of hematoma and edema in patients with primary intracerebral hemorrhageQ43878727
Dysregulated expression of T cell immunoglobulin and mucin domain 3 is associated with the disease severity and the outcome of patients with spontaneous intracerebral hemorrhageQ44167679
Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell deathQ45055104
Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trialQ45854165
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and DiseaseQ46292537
Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhageQ46838344
Increased Expression of T Cell Immunoglobulin and Mucin Domain 3 on CD14+ Monocytes Is Associated with Systemic Inflammatory Reaction and Brain Injury in Patients with Spontaneous Intracerebral HemorrhageQ47223322
Tim-3 enhances brain inflammation by promoting M1 macrophage polarization following intracerebral hemorrhage in miceQ47651163
The diverse functions of the PD1 inhibitory pathwayQ47678849
Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized TrialQ48010831
Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophagesQ48189205
PD-L1 (Programmed Death Ligand 1) Protects Against Experimental Intracerebral Hemorrhage-Induced Brain Injury.Q48196965
Blockage of central sphingosine-1-phosphate receptor does not abolish the protective effect of FTY720 in early brain injury after experimental subarachnoid hemorrhageQ48524908
Complement inhibition attenuates brain edema and neurological deficits induced by thrombin.Q48658500
CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesisQ48696556
Leukocyte invasion of the brain after experimental intracerebral hemorrhage in mice.Q48721779
Selective Sphingosine-1-Phosphate Receptor 1 Modulation Attenuates Experimental Intracerebral Hemorrhage.Q48738957
Blocking B7-1/CD28 Pathway Diminished Long-Range Brain Damage by Regulating the Immune and Inflammatory Responses in a Mouse Model of Intracerebral Hemorrhage.Q48830300
Brain recovery mediated by toll-like receptor 4 in rats after intracerebral hemorrhageQ49161802
T lymphocytes infiltration promotes blood-brain barrier injury after experimental intracerebral hemorrhageQ50169325
Toll-like receptor 4 antagonist attenuates intracerebral hemorrhage-induced brain injuryQ50847957
Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke.Q52148100
Stroke-induced immunosuppression and poststroke infection.Q52620332
Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice.Q54965190
The role of high mobility group box 1 protein in acute cerebrovascular diseasesQ57120217
Intracerebral haemorrhage: current approaches to acute managementQ57482499
Complement activation in the brain after experimental intracerebral hemorrhageQ73853504
Potential mechanisms of efficacy and adverse effects in the use of fingolimod (FTY720)Q82668181
Increased expression of Toll-like receptors 2 and 4 is associated with poor outcome in intracerebral hemorrhageQ83874975
Dynamic Changes in Toll-Like Receptor 4 in Human Perihematoma Tissue after Intracerebral HemorrhageQ89499664
Siponimod (BAF312) Treatment Reduces Brain Infiltration but Not Lesion Volume in Middle-Aged Mice in Experimental StrokeQ90148338
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 InternationalQ24082749
P921main subjectbrain injuryQ3280669
cerebral edemaQ979168
cerebral hemorrhageQ1368943
P304page(s)615-623
P577publication date2019-06-14
2019-07-01
P1433published inEBioMedicineQ24912341
P1476titleEmerging therapeutic targets associated with the immune system in patients with intracerebral haemorrhage (ICH): From mechanisms to translation
P478volume45

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cites work (P2860)
Q92650728Activation of PPAR-β/δ Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model
Q92131916Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities
Q90680318Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage
Q92131905Programmed Cell Deaths and Potential Crosstalk With Blood-Brain Barrier Dysfunction After Hemorrhagic Stroke
Q90149173The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression
Q99414986The Updated Role of the Blood Brain Barrier in Subarachnoid Hemorrhage: From Basic and Clinical Studies

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