Transmission-Blocking Vaccines: Old Friends and New Prospects

scientific article published on 21 May 2019

Transmission-Blocking Vaccines: Old Friends and New Prospects is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.00775-18
P932PMC publication ID6529669
P698PubMed publication ID30962400
P8602University of Ghana Digital Collections (UGSpace) ID34038

P50authorLinda E AmoahQ89635448
P2093author name stringKim C Williamson
Acquah, F.K.
Amoah, L.E.
Festus K Acquah
Williamson, K.C.
Adjah, J.
Joshua Adjah
P2860cites workSpread of artemisinin resistance in Plasmodium falciparum malariaQ21032481
Algae-produced Pfs25 elicits antibodies that inhibit malaria transmissionQ21134576
The cell biology of malaria infection of mosquito: advances and opportunitiesQ27024179
Naturally occurring antibodies to an epitope on Plasmodium falciparum gametes detected by monoclonal antibody-based competitive enzyme-linked immunosorbent assayQ27487442
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomesQ27860838
RIFINs are adhesins implicated in severe Plasmodium falciparum malariaQ27972159
Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparumQ27972160
The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune systemQ27973784
Plasmodium falciparum evades mosquito immunity by disrupting JNK-mediated apoptosis of invaded midgut cellsQ27973785
The March Toward Malaria VaccinesQ28084325
Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriersQ28482471
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Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytesQ29618254
A proteomic view of the Plasmodium falciparum life cycleQ29618807
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytesQ29618991
Targeting malaria virulence and remodeling proteins to the host erythrocyteQ29620631
Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparumQ30042317
Cloning and expression of the gene for Plasmodium falciparum transmission-blocking target antigen, Pfs230Q30042991
Differential ability of specific regions of Plasmodium falciparum sexual-stage antigen, Pfs230, to induce malaria transmission-blocking immunityQ30042993
A central role for P48/45 in malaria parasite male gamete fertilityQ30043154
Pfs47, paralog of the male fertility factor Pfs48/45, is a female specific surface protein in Plasmodium falciparumQ30043157
SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites and infected erythrocytesQ30043677
PEXEL-independent trafficking of Plasmodium falciparum SURFIN4.2 to the parasite-infected red blood cell and Maurer's cleftsQ30043679
Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of the Plasmodium falciparum Sexual Stage Protein Pfs230.Q30390705
SURFIN4.1, a schizont-merozoite associated protein in the SURFIN family of Plasmodium falciparumQ31161094
Sub-grouping and sub-functionalization of the RIFIN multi-copy protein familyQ33314965
Plasmodium falciparum antigens on the surface of the gametocyte-infected erythrocyteQ33338492
The Plasmodium falciparum STEVOR multigene family mediates antigenic variation of the infected erythrocyteQ33410790
A potent malaria transmission blocking vaccine based on codon harmonized full length Pfs48/45 expressed in Escherichia coliQ33485233
Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycleQ37582797
Revisiting the Plasmodium falciparum RIFIN family: from comparative genomics to 3D-model predictionQ33505456
Evidence for specific suppression of gametocytemia by Plasmodium falciparum in residents of hyperendemic Irian JayaQ33528315
Three members of the 6-cys protein family of Plasmodium play a role in gamete fertilityQ33553363
A region of Plasmodium falciparum antigen Pfs25 that is the target of highly potent transmission-blocking antibodiesQ33591209
Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrowQ33794320
New adenovirus-based vaccine vectors targeting Pfs25 elicit antibodies that inhibit Plasmodium falciparum transmissionQ33801989
Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugsQ33898575
Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparumQ33934212
Immunization of mice with DNA-based Pfs25 elicits potent malaria transmission-blocking antibodiesQ34000822
Antibodies to malaria vaccine candidates Pvs25 and Pvs28 completely block the ability of Plasmodium vivax to infect mosquitoesQ34005142
Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparumQ34086895
The Plasmodium bottleneck: malaria parasite losses in the mosquito vectorQ34142771
Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidatesQ34161839
Differential adhesive properties of sequestered asexual and sexual stages of Plasmodium falciparum on human endothelial cells are tissue independentQ34171103
Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and eliminationQ34177472
Plasmodium falciparum transmission stages accumulate in the human bone marrowQ34245311
Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytesQ34256662
CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparumQ34521530
Decoding the language of var genes and Plasmodium falciparum sequestrationQ34548667
Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and potential improvements for future assaysQ34618434
Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assayQ34995863
Malaria parasite Pfs47 disrupts JNK signaling to escape mosquito immunityQ35062675
Regulation of sexual development of Plasmodium by translational repressionQ35090746
Virulence and transmission success of the malarial parasite Plasmodium falciparumQ35132510
N-terminal prodomain of Pfs230 synthesized using a cell-free system is sufficient to induce complement-dependent malaria transmission-blocking activityQ35138720
A plant-produced Pfs230 vaccine candidate blocks transmission of Plasmodium falciparumQ35138735
Cytoadherence and sequestration in Plasmodium falciparum: defining the ties that bindQ35200263
Alga-produced malaria transmission-blocking vaccine candidate Pfs25 formulated with a human use-compatible potent adjuvant induces high-affinity antibodies that block Plasmodium falciparum infection of mosquitoesQ35439931
A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccinesQ35544571
Pfs230: from malaria transmission-blocking vaccine candidate toward functionQ35548285
Regulating the adaptive immune response to blood-stage malaria: role of dendritic cells and CD4⁺Foxp3⁺ regulatory T cellsQ35565165
Sequestration: causes and consequencesQ35666823
Comparative assessment of transmission-blocking vaccine candidates against Plasmodium falciparumQ35718341
Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?Q37625114
The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion ProteinQ37675742
Potent malaria transmission-blocking antibody responses elicited by Plasmodium falciparum Pfs25 expressed in Escherichia coli after successful protein refoldingQ37713285
Plasmodium falciparum gametocytes: with a view to a kill.Q38129536
The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identificationQ38520062
Development of vaccines for Plasmodium vivax malariaQ38597276
The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycleQ38789240
Transmission-blocking activity is determined by transmission-reducing activity and number of control oocysts in Plasmodium falciparum standard membrane-feeding assayQ38845963
Evidence of non-neutral polymorphism in Plasmodium falciparum gamete surface protein genes Pfs47 and Pfs48/45.Q38876779
The infectivity of gametocytes of Plasmodium falciparum from patients treated with artemisinin.Q38942070
Parasite infectivity and immunity to Plasmodium falciparum gametocytes in Gambian childrenQ38977779
Naturally acquired antibody responses to recombinant Pfs230 and Pfs48/45 transmission blocking vaccine candidatesQ39018502
Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions.Q39034766
Whole-Killed Blood-Stage Vaccine-Induced Immunity Suppresses the Development of Malaria Parasites in MosquitoesQ39141585
Limited polymorphism in Plasmodium falciparum sexual-stage antigensQ39304090
Dynamics of the Human Infectious Reservoir for Malaria Determined by Mosquito Feeding Assays and Ultrasensitive Malaria Diagnosis in Burkina FasoQ39331193
Variant proteins of the Plasmodium falciparum RIFIN family show distinct subcellular localization and developmental expression patternsQ39352490
Variant surface antigens of Plasmodium falciparum and their roles in severe malariaQ39365658
A model for sequestration of the transmission stages of Plasmodium falciparum: adhesion of gametocyte-infected erythrocytes to human bone marrow cells.Q39405774
A Plasmodium falciparum 48/45 single epitope R0.6C subunit protein elicits high levels of transmission blocking antibodiesQ39467691
Stevor transcripts from Plasmodium falciparum gametocytes encode truncated polypeptidesQ39500191
Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunizationQ39504399
Plasmodium falciparum sexual stage antigens: Immunogenicity and cell-mediated responsesQ39511780
A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stagesQ39520295
The N-terminal segment of Plasmodium falciparum SURFIN4.1 is required for its trafficking to the red blood cell cytosol through the endoplasmic reticulumQ39631308
Transmission blockade of Plasmodium falciparum malaria by anti-Pfs230-specific antibodies is isotype dependentQ39821154
Genetic diversity and antibody responses against Plasmodium falciparum vaccine candidate genes from Chhattisgarh, Central India: Implication for vaccine developmentQ40102169
Antibody responses to two new Lactococcus lactis-produced recombinant Pfs48/45 and Pfs230 proteins increase with age in malaria patients living in the Central Region of GhanaQ40110842
An N-terminal Pfs230 domain produced in baculovirus as a biological active transmission-blocking vaccine candidateQ40118467
New observations on gametogenesis, fertilization, and zygote transformation in Plasmodium gallinaceumQ41579335
Development of a malaria vaccineQ41662362
Evaluation of a Plasmodium-specific carrier protein to enhance production of recombinant Pfs25, a leading transmission-blocking vaccine candidateQ41989340
Recombinant Pfs25 protein of plasmodium falciparum elicits malaria transmission-blocking immunity in experimental animalsQ42006764
Development of a single-replicon miniBYV vector for co-expression of heterologous proteinsQ42184797
The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?Q42424857
Monoclonal antibodies against surface determinants on gametes of Plasmodium gallinaceum block transmission of malaria parasites to mosquitoesQ43032460
Induction of plasmodium falciparum transmission-blocking antibodies by recombinant vaccinia virusQ43409506
A vaccine candidate from the sexual stage of human malaria that contains EGF-like domainsQ43525538
Heterologous expression of the C-terminal antigenic domain of the malaria vaccine candidate Pfs48/45 in the green algae Chlamydomonas reinhardtiiQ43645737
A comparative study of the localization and membrane topology of members of the RIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infected erythrocytesQ35853627
Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine.Q35867612
Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigenQ35941338
Transmission-blocking activity induced by malaria vaccine candidates Pfs25/Pvs25 is a direct and predictable function of antibody titerQ35982771
The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitopeQ35989209
A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stagesQ36057631
Plasmodium falciparum Gametocyte-Specific Antibody Profiling Reveals Boosting through Natural Infection and Identifies Potential Markers of Gametocyte ExposureQ36138015
Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve AdultsQ36165265
Pexel/VTS: a protein-export motif in erythrocytes infected with malaria parasites.Q36208248
Target antigens of transmission-blocking immunity on gametes of plasmodium falciparumQ36348052
Sequential expression of antigens on sexual stages of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquitoQ36351262
Restricted or absent immune responses in human populations to plasmodium falciparum gamete antigens that are targets of malaria transmission-blocking antibodiesQ36355913
Pfs2400 can mediate antibody-dependent malaria transmission inhibition and may be the Plasmodium falciparum 11.1 gene productQ36361341
Plasmodium evasion of mosquito immunity and global malaria transmission: The lock-and-key theoryQ36371372
Small, clonally variant antigens expressed on the surface of the Plasmodium falciparum-infected erythrocyte are encoded by the rif gene family and are the target of human immune responsesQ36375576
Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technologyQ36442817
Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine AntigensQ36455757
Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametesQ36531224
Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidatesQ36539678
The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametesQ36585513
A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction.Q36595999
Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in miceQ36670217
Gamete vaccines and transmission-blocking immunity in malariaQ36674753
Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trialsQ36800842
Plasmodium falciparum variant STEVOR antigens are expressed in merozoites and possibly associated with erythrocyte invasionQ36853127
Malaria transmission-blocking immunity induced by natural infections of Plasmodium vivax in humansQ37016257
Assessment of Pfs25 expressed from multiple soluble expression platforms for use as transmission-blocking vaccine candidatesQ37170062
An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccinesQ37243605
A humanized mouse model for sequestration of Plasmodium falciparum sexual stages and in vivo evaluation of gametocytidal drugsQ37330567
Functional comparison of Plasmodium falciparum transmission-blocking vaccine candidates by the standard membrane-feeding assayQ37336089
Antibody responses to surface antigens of Plasmodium falciparum gametocyte-infected erythrocytes and their relation to gametocytaemiaQ37384816
Surface antigens of Plasmodium falciparum gametocytes--a new class of transmission-blocking vaccine targets?Q37487002
Antibodies to a single, conserved epitope in Anopheles APN1 inhibit universal transmission of Plasmodium falciparum and Plasmodium vivax malariaQ37546481
Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitroQ37549510
Early gametocytes of the malaria parasite Plasmodium falciparum specifically remodel the adhesive properties of infected erythrocyte surfaceQ43713662
High human malarial infectivity to laboratory-bred Anopheles gambiae in a village in Burkina Faso.Q43936049
Transmission-reducing immunity is inversely related to age in Plasmodium falciparum gametocyte carriersQ43946977
Estimates of the infectious reservoir of Plasmodium falciparum malaria in The Gambia and in TanzaniaQ43951299
Target antigens of malaria transmission blocking immunity exist as a stable membrane bound complexQ44027193
Association between anti-Pfs48/45 reactivity and P. falciparum transmission-blocking activity in sera from CameroonQ44137386
Properties of epitopes of pfs 48/45, a target of transmission blocking monoclonal antibodies, on gametes of different isolates of plasmodium falciparumQ44143594
The 230-kDa gamete surface protein of plasmodium falciparum is also a target for transmission-blocking antibodiesQ44146561
Antibodies to plasmodium falciparum gamete surface antigens in papua new guinea seraQ44150700
Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activityQ44156482
Plasmodium vivax gametocyte protein Pvs230 is a transmission-blocking vaccine candidateQ44161927
Transmission-blocking antibodies against multiple, non-variant target epitopes of the Plasmodium falciparum gamete surface antigen Pfs230 are all complement-fixingQ44168384
Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst productionQ44169388
Comparative functional potency of DNA vaccines encoding Plasmodium falciparum transmission blocking target antigens Pfs48/45 and Pfs25 administered alone or in combination by in vivo electroporation in rhesus macaquesQ44169836
The use of transgenic Plasmodium berghei expressing the Plasmodium vivax antigen P25 to determine the transmission-blocking activity of sera from malaria vaccine trialsQ44170388
Cytokine-mediated inactivation of malarial gametocytes is dependent on the presence of white blood cells and involves reactive nitrogen intermediatesQ44172461
Recombinant Pfs230, a Plasmodium falciparum gametocyte protein, induces antisera that reduce the infectivity of Plasmodium falciparum to mosquitoesQ44173322
Stage-specific processing of Pfs230, a Plasmodium falciparum transmission-blocking vaccine candidateQ44173710
Plasmodium P47: a key gene for malaria transmission by mosquito vectorsQ46243567
Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparumQ46246718
Advances in malaria vaccine development: report from the 2017 malaria vaccine symposiumQ47106697
Common trafficking pathway for variant antigens destined for the surface of the Plasmodium falciparum-infected erythrocyteQ47328565
Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum Surface Antigens and Possible Vaccine CandidatesQ47377549
Epitope analysis of the malaria surface antigen pfs48/45 identifies a subdomain that elicits transmission blocking antibodies.Q47829675
Immunisation against gametes and asexual erythrocytic stages of a rodent malaria parasiteQ47836839
Identification of additional members define a Plasmodium falciparum gene superfamily which includes Pfs48/45 and Pfs230.Q47850151
CD36-dependent adhesion and knob expression of the transmission stages of Plasmodium falciparum is stage specific.Q47850905
Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometryQ47915916
Role of T cells in preventing transmission of rodent malariaQ47925772
A glycosylphosphatidylinositol anchor signal sequence enhances the immunogenicity of a DNA vaccine encoding Plasmodium falciparum sexual-stage antigen, Pfs230.Q47930799
Evidence for cyclic development and short-lived maturity in the gametocytes of Plasmodium falciparumQ47956702
Minimal variation in the transmission-blocking vaccine candidate Pfs48/45 of the human malaria parasite Plasmodium falciparum.Q48003662
Production, purification and immunogenicity of a malaria transmission-blocking vaccine candidate: TBV25H expressed in yeast and purified using nickel-NTA agaroseQ48004480
Production of non-glycosylated recombinant proteins in Nicotiana benthamiana plants by co-expressing bacterial PNGase F.Q48007592
Strain polymorphism of Plasmodium falciparum transmission-blocking target antigen Pfs230.Q48014503
Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria TransmissionQ48021662
Cloning and expression of the gene coding for the transmission blocking target antigen Pfs48/45 of Plasmodium falciparumQ48103837
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunityQ49732059
Detecting gametocytes: how sensitive is sensible?Q50138673
Immune Response and Evasion Mechanisms of Plasmodium falciparum Parasites.Q54978998
Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent period.Q55381231
Antibody targeting of a specific region of Pfs47 blocks Plasmodium falciparum malaria transmission.Q55563437
Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adultsQ56337991
Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adultsQ56342219
Regulation of Sexual Commitment and Gametocytogenesis in Malaria ParasitesQ56365794
Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibodyQ57154118
Characterization of Plasmodium falciparum sexual stage antigens and their biosynthesis in synchronised gametocyte culturesQ68897064
Gametocytogenesis of Plasmodium falciparum in vitro: an electron microscopic studyQ70221465
P433issue6
P921main subjectTransmission-blocking vaccines.Q34680152
Plasmodium falciparumQ90813889
gametocytogenesisQ60586439
P577publication date2019-01-01
2019-05-21
P1433published inInfection and ImmunityQ6029193
P1476titleTransmission-Blocking Vaccines: Old Friends and New Prospects
P478volume87

Reverse relations

cites work (P2860)
Q92669430A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system
Q90699157Antibody response of a particle-inducing, liposome vaccine adjuvant admixed with a Pfs230 fragment
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