Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells

scientific article published on 19 June 2019

Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41392-019-0050-0
P932PMC publication ID6582141
P698PubMed publication ID31240133

P2093author name stringØystein Bruserud
Elise Aasebø
Frode Selheim
Maria Hernandez-Valladares
Frode S Berven
Håkon Reikvam
Kristin Paulsen Rye
Kimberley Joanne Hatfield
Ina Nepstad
Ida Sofie Grønningsæter
Karen Marie Hagen
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The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.Q34024558
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Targeting of cell metabolism in human acute myeloid leukemia--more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling?Q38606849
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Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathwayQ40117414
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A combination of catalase and trehalose as additives to conventional freezing medium results in improved cryoprotection of human hematopoietic cells with reference to in vitro migration and adhesion propertiesQ40437077
Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia - identification of responders by gene expression profiling of pretreatment leukemic cellsQ41625772
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Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cellsQ41985108
Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effectQ43461214
Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities.Q44394415
IsobariQ: software for isobaric quantitative proteomics using IPTL, iTRAQ, and TMT.Q45841310
Resistance to the Antiproliferative In Vitro Effect of PI3K-Akt-mTOR Inhibition in Primary Human Acute Myeloid Leukemia Cells Is Associated with Altered Cell MetabolismQ48043104
Patients with acute myeloid leukemia can be subclassified based on the constitutive cytokine release of the leukemic cells; the possible clinical relevance and the importance of cellular iron metabolism.Q51102707
Therapeutic targeting of leukemic stem cells in acute myeloid leukemia - the biological background for possible strategies.Q51818965
Stem cell gene expression programs influence clinical outcome in human leukemia.Q51856192
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.Q53526869
Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention.Q53769196
Splenic tyrosine kinase (SYK) inhibitors and their possible use in acute myeloid leukemia.Q54118068
Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison.Q54976555
IGF1 receptor signaling pathways.Q54982190
The IGF2/IGF1R/Nanog Signaling Pathway Regulates the Proliferation of Acute Myeloid Leukemia Stem Cells.Q55709078
Secretion of IL-2, IL-3, IL-4, IL-6 and GM-CSF by CD4+ and CD8+ TCR alpha beta+ T-cell clones derived early after allogeneic bone marrow transplantationQ72822880
In vitro effects of insulin-like growth factor-1 (IGF-1) on proliferation and constitutive cytokine secretion by acute myelogenous leukemia blastsQ74630699
Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat shock protein 70 and 90Q83115248
Impact of insulin-like growth factor 1 and insulin-like growth factor binding proteins on outcomes in acute myeloid leukemiaQ86861698
Downregulation of monocarboxylate transporter 1 inhibits the invasion and migration through suppression of the PI3K/Akt signaling pathway in human nasopharyngeal carcinoma cellsQ89037283
P921main subjectacute myeloid leukemiaQ264118
P304page(s)20
P577publication date2019-06-19
P1433published inSignal Transduction and Targeted TherapyQ108821959
P1476titleEffects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells
P478volume4

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