Outcomes in patients with relapsed or refractory multiple myeloma in a phase I study of everolimus in combination with lenalidomide

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Outcomes in patients with relapsed or refractory multiple myeloma in a phase I study of everolimus in combination with lenalidomide is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/BJH.12909
P698PubMed publication ID24761838

P50authorKenneth C. AndersonQ28421846
Robert SchlossmanQ114300414
Noopur RajeQ114442101
Teru HideshimaQ114455520
Diana D CirsteaQ117224708
Anuj K MahindraQ117224745
Tyler A ScullenQ117224746
Parameswaran HariQ42118262
Raffaella MarcheselliQ57617104
Paul G. RichardsonQ87712102
Jacob P LaubachQ87769541
Irene GhobrialQ88032966
Scott RodigQ88034786
Nikhil V MunshiQ89228014
P2093author name stringAndrew J Yee
Edie A Weller
Jill N Burke
P2860cites workDEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survivalQ24311448
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyQ24632296
Defining the role of mTOR in cancerQ28235431
Current development of mTOR inhibitors as anticancer agentsQ28255366
mTOR and cancer therapyQ28268516
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progressionQ29617473
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trialQ29618031
c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.Q31047994
A phase 2 study of bortezomib in relapsed, refractory myelomaQ33348702
In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft modelQ33362103
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphomaQ33366976
Phase II trial of temsirolimus in patients with relapsed or refractory multiple myelomaQ33383550
Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation studyQ33394281
Elotuzumab in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myelomaQ33401018
Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/refractory multiple myeloma: a Phase I Multiple Myeloma Research Consortium studyQ33401457
U.s. Food and Drug Administration approval: carfilzomib for the treatment of multiple myelomaQ33408443
Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group studyQ33942495
International uniform response criteria for multiple myeloma.Q34549410
Lenalidomide plus dexamethasone for relapsed multiple myeloma in North AmericaQ34585268
Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow TransplantQ34753416
mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signalingQ35581650
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myelomaQ35915726
Identification and validation of novel therapeutic targets for multiple myelomaQ36254612
Improved survival in multiple myeloma and the impact of novel therapiesQ36478461
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptorQ37215171
Novel therapeutic targets for multiple myelomaQ37707383
Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous SclerosisQ37806773
Latest advances and current challenges in the treatment of multiple myelomaQ37986287
Towards effective immunotherapy of myeloma: enhanced elimination of myeloma cells by combination of lenalidomide with the human CD38 monoclonal antibody daratumumabQ39627268
Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.Q39718152
In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myelomaQ39768627
Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosisQ40314252
Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myelomaQ40524119
Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.Q40569009
Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myelomaQ43726973
Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myelomaQ43761443
Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.Q43901688
Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trialQ44442859
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.Q44732861
Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.Q46708758
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)401-409
P577publication date2014-04-25
P1433published inBritish Journal of HaematologyQ4970200
P1476titleOutcomes in patients with relapsed or refractory multiple myeloma in a phase I study of everolimus in combination with lenalidomide
P478volume166

Reverse relations

cites work (P2860)
Q35236076Activity of everolimus (RAD001) in relapsed and/or refractory multiple myeloma: a phase I study.
Q38630472Advances in targeted therapy for the treatment of patients with relapsed/refractory multiple myeloma
Q48110513Bone-Targeted Therapies in Cancer-Induced Bone Disease
Q93029473Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells
Q41694198Emerging drugs and combinations to treat multiple myeloma
Q38413040Front-line lenalidomide therapy in patients with newly diagnosed multiple myeloma.
Q41346803Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing
Q37697253Kinase inhibitors as potential agents in the treatment of multiple myeloma
Q92772115Metastatic bone disease: Pathogenesis and therapeutic options: Up-date on bone metastasis management
Q64230046NVP-BEZ235-induced autophagy as a potential therapeutic approach for multiple myeloma
Q48263465PI3K/AKT/mTOR pathway in multiple myeloma: from basic biology to clinical promise.
Q97681541Phase 1 safety and pharmacodynamic study of lenalidomide combined with everolimus in patients with advanced solid malignancies with efficacy signal in adenoid cystic carcinoma
Q38753307Signaling Pathways and Emerging Therapies in Multiple Myeloma
Q33429430TAK-228 (formerly MLN0128), an investigational oral dual TORC1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non-Hodgkin lymphoma, or Waldenström's macroglobulinemia
Q51170783The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma.
Q47107700VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim.
Q92492516Venous thromboembolism risk with contemporary lenalidomide-based regimens despite thromboprophylaxis in multiple myeloma: A systematic review and meta-analysis
Q39113506m-TOR inhibitors and their potential role in haematological malignancies
Q42430902mTOR pathway activation in multiple myeloma cell lines and primary tumour cells: pomalidomide enhances cytoplasmic-nuclear shuttling of mTOR protein
Q28087019mTOR: a potential therapeutic target in osteoarthritis?

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