The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation

scientific article published on 03 September 2019

The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.RA119.010160
P932PMC publication ID6816099
P698PubMed publication ID31481468

P50authorScott B RothbartQ62070938
Bradley M DicksonQ87153165
Robert M VaughanQ61161389
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Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1Q27651995
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A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivoQ27666611
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The recognition domain of the methyl-specific endonuclease McrBC flips out 5-methylcytosineQ27678979
Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITEQ27684672
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S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenanceQ35979210
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UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinomaQ37632823
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Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation MaintenanceQ47425745
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Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenanceQ52673715
Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger-containing 1 (UHRF1) for anti-cancer drug development.Q55129550
UHRF1 mediates cell migration and invasion of gastric cancerQ57795809
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Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1Q58784398
P4510describes a project that usesPyMOLQ1373457
P433issue43
P407language of work or nameEnglishQ1860
P304page(s)15724-15732
P577publication date2019-09-03
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation
P478volume294

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