Drosophila glia: Few cell types and many conserved functions

scientific article published on 15 November 2018

Drosophila glia: Few cell types and many conserved functions is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/GLIA.23459
P698PubMed publication ID30443934

P2093author name stringChristian Klämbt
Johanna Petri
Kerem Yildirim
Rita Kottmeier
P2860cites workRapid Conduction and the Evolution of Giant Axons and Myelinated FibersQ22337352
Glial cells physiologically modulate clock neurons and circadian behavior in a calcium-dependent mannerQ24608506
Pericytes are required for blood-brain barrier integrity during embryogenesisQ24627396
Development, maintenance and disruption of the blood-brain barrierQ26829668
Glial processes at the Drosophila larval neuromuscular junction match synaptic growthQ27302104
A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axonsQ27318684
The glial regenerative response to central nervous system injury is enabled by pros-notch and pros-NFκB feedbackQ27321127
Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debrisQ27329462
The Drosophila blood-brain barrier as interface between neurons and hemolymphQ28082882
Brain barriers: Crosstalk between complex tight junctions and adherens junctionsQ28083498
Astrocyte-endothelial interactions at the blood-brain barrierQ28131675
Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizuresQ28268524
Pericytes regulate the blood-brain barrierQ29615840
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilizationQ29620724
Dynamic visualization of nervous system in live DrosophilaQ30478940
Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs largeQ30503127
Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLDQ30544252
Predetermined embryonic glial cells form the distinct glial sheaths of the Drosophila peripheral nervous systemQ30570990
Activity-dependent regulation of astrocyte GAT levels during synaptogenesisQ30588256
MANF silencing, immunity induction or autophagy trigger an unusual cell type in metamorphosing Drosophila brain.Q30644860
TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior.Q30832725
Glial chain migration requires pioneer cells.Q30850503
From nerve net to nerve ring, nerve cord and brain--evolution of the nervous systemQ33362129
Neuron-glial interactions in blood-brain barrier formation.Q33670796
The NG2 proteoglycan promotes oligodendrocyte progenitor proliferation and developmental myelinationQ33761196
Multifunctional glial support by Semper cells in the Drosophila retinaQ33797516
The tracheae defective gene encodes a bZIP protein that controls tracheal cell movement during Drosophila embryogenesisQ33887845
Blood barriers of the insectQ33889673
Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathwaysQ33943288
Electron-dense tracer evidence for a blood-brain barrier in the cuttlefish Sepia officinalisQ33986979
Organization and function of the blood-brain barrier in Drosophila.Q34009441
All vertebrates started out with a glial blood-brain barrier 4-500 million years ago.Q34010436
Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytesQ34014795
Oligodendroglia metabolically support axons and contribute to neurodegeneration.Q34032818
Glide2, a second glial promoting factor in Drosophila melanogasterQ34081588
The glucuronyltransferase GlcAT-P is required for stretch growth of peripheral nerves in DrosophilaQ34088150
Netrins guide migration of distinct glial cells in the Drosophila embryoQ34103525
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.Q34123789
MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genesQ34222706
The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.Q34439060
The origin and development of glial cells in peripheral nervesQ34447586
Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegenerationQ34458474
Accumulation of Laminin Monomers in Drosophila Glia Leads to Glial Endoplasmic Reticulum Stress and Disrupted Larval LocomotionQ48252677
Axonal wrapping in the Drosophila PNS is controlled by glia-derived neuregulin homolog VeinQ48287413
Remodeling of peripheral nerve ensheathment during the larval-to-adult transition in Drosophila.Q48305266
Freeze-fracture evidence for a novel restricting junction at the blood-brain barrier of the cuttlefish Sepia officinalisQ48496127
Innexins Ogre and Inx2 are required in glial cells for normal postembryonic development of the Drosophila central nervous systemQ48622172
A GAL4 driver resource for developmental and behavioral studies on the larval CNS of DrosophilaQ48622522
Organization and metamorphosis of glia in the Drosophila visual systemQ48650353
Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism.Q48682028
Midline axon guidance in the Drosophila embryonic central nervous systemQ49642667
Variant cell cycles regulated by Notch signaling control cell size and ensure a functional blood-brain barrier.Q50027298
Go and stop signals for glial regeneration.Q50069312
A transcriptional network controlling glial development in the Drosophila visual system.Q50585130
N-cadherin negatively regulates collective Drosophila glial migration through actin cytoskeleton remodeling.Q50601289
Interlocked loops trigger lineage specification and stable fates in the Drosophila nervous system.Q50645739
Loss of focal adhesions in glia disrupts both glial and photoreceptor axon migration in the Drosophila visual system.Q50646816
Transcriptional regulation of the Drosophila glial gene repo.Q52047804
Glia engulf degenerating axons during developmental axon pruning.Q52090523
Dpp and Hedgehog mediate neuron-glia interactions in Drosophila eye development by promoting the proliferation and motility of subretinal glia.Q52129050
gcm and pointed synergistically control glial transcription of the Drosophila gene loco.Q52170378
glide/gcm is expressed and required in the scavenger cell lineage.Q52192198
The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance.Q52448060
Defective glia induce neuronal apoptosis in the repo visual system of DrosophilaQ52538389
The Ets transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS.Q52542347
Pathfinding analysis in a glia-less gcm mutant in Drosophila.Q52587099
Time-lapse and cell ablation reveal the role of cell interactions in fly glia migration and proliferation.Q52652294
A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux.Q52662085
Glial cell migration in the eye disc.Q52685780
Homeostatic interactions at the front of migration control the integrity and the efficiency of a migratory glial chain.Q52728302
Regulation of neuroblast proliferation by surface glia in the Drosophila larval brain.Q52729996
Glial Glycolysis Is Essential for Neuronal Survival in Drosophila.Q52812695
The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing gliaQ58695763
Phosphatidylinositol 3-kinase and Akt nonautonomously promote perineurial glial growth in Drosophila peripheral nervesQ79535078
A role for Schwann cell-derived neuregulin-1 in remyelinationQ85637594
Regulation of Circadian Behavior by Astroglial MicroRNAs in DrosophilaQ87900485
Repulsive Epithelial Cues Direct Glial Migration along the NerveQ89025212
Differential expression of Öbek controls ploidy in the Drosophila blood-brain barrierQ90007176
The Drosophila Blood-Brain Barrier Adapts to Cell Growth by Unfolding of Pre-existing Septate JunctionsQ93348974
Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and functionQ38354320
Neurexin IV and Wrapper interactions mediate Drosophila midline glial migration and axonal ensheathment.Q38356082
Drosophila Central Nervous System GliaQ38365780
Comparison of larval and adult Drosophila astrocytes reveals stage-specific gene expression profilesQ38467154
Oligodendrocytes: Myelination and Axonal SupportQ38534982
The vascular niche in adult neurogenesisQ38535525
The early life of a fly glial cellQ38557259
Cyclin-dependent kinase 9 is required for the survival of adult Drosophila melanogaster gliaQ38654269
Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.Q38746156
ECM stiffness regulates glial migration in Drosophila and mammalian glioma modelsQ38971522
Regulation of Drosophila glial cell proliferation by Merlin-Hippo signalingQ38979328
The vasculature as a neural stem cell niche.Q38993011
Origins of glial cell populations in the insect nervous systemQ39035075
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrityQ39492965
Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in DrosophilaQ39871485
Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to WrapperQ39877219
Drosophila astrocytes cover specific territories of the CNS neuropil and are instructed to differentiate by Prospero, a key effector of NotchQ39985307
Subtypes of glial cells in the Drosophila embryonic ventral nerve cord as related to lineage and gene expressionQ40009510
The tumor suppressor, vitamin D3 up-regulated protein 1 (VDUP1), functions downstream of REPO during Drosophila gliogenesisQ40014882
In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons.Q40177119
The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in DrosophilaQ40193281
Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrityQ40423624
Distribution, classification, and development ofDrosophila glial cells in the late embryonic and early larval ventral nerve cord.Q40453156
Developmental dynamics of peripheral glia in Drosophila melanogasterQ40773676
Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki.Q40973062
Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volumeQ41260120
Crooked, coiled and crimpled are three Ly6-like proteins required for proper localization of septate junction componentsQ41268350
Drosophila PS2 and PS3 integrins play distinct roles in retinal photoreceptors-glia interactionsQ41322149
A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade.Q41476563
Guidance of neuronal growth cones in the grasshopper embryo. III. Recognition of specific glial pathwaysQ41477911
Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe.Q41488617
miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in DrosophilaQ41710228
Postembryonic development of transit amplifying neuroblast lineages in the Drosophila brainQ41869680
Glial enriched gene expression profiling identifies novel factors regulating the proliferation of specific glial subtypes in the Drosophila brain.Q41940803
Different isoforms of fasciclin II are expressed by a subset of developing olfactory receptor neurons and by olfactory-nerve glial cells during formation of glomeruli in the moth Manduca sextaQ42052060
Cell type-specific expression of fasciclin II isoforms reveals neuronal-glial interactions during peripheral nerve growthQ42054169
Different isoforms of fasciclin II play distinct roles in the guidance of neuronal migration during insect embryogenesisQ42055858
The claudin Megatrachea protein complex.Q42068888
Single-cell mapping of neural and glial gene expression in the developing Drosophila CNS midline cellsQ42124977
Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in DrosophilaQ42134280
Turtle interacts with borderless in regulating glial extension and axon ensheathmentQ42247979
Gap junction proteins in the blood-brain barrier control nutrient-dependent reactivation of Drosophila neural stem cells.Q42271735
miR-31 mutants reveal continuous glial homeostasis in the adult Drosophila brain.Q42289928
The glia of the adult Drosophila nervous systemQ42320097
Fine structure of the blood-brain interface in the cuttlefish Sepia officinalis (Mollusca, Cephalopoda)Q42460717
Migration of glia along photoreceptor axons in the developing Drosophila eye.Q42498111
Glial-derived prodegenerative signaling in the Drosophila neuromuscular systemQ42564559
Drosophila ebony activity is required in glia for the circadian regulation of locomotor activityQ42591240
Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion.Q42845643
APC/CFzr/Cdh1-dependent regulation of cell adhesion controls glial migration in the Drosophila PNSQ42871020
Increased energy metabolism rescues glia-induced pathology in a Drosophila model of Huntington's diseaseQ43010442
Glial cell regulation of neurotransmission and behavior in DrosophilaQ37307968
Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neuronsQ37313845
Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of DraperQ37343742
Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neuronsQ37488726
Astrocytes play a key role in Drosophila mushroom body axon pruningQ37500153
Neuromodulators signal through astrocytes to alter neural circuit activity and behaviourQ37510486
Macroglobulin complement-related encodes a protein required for septate junction organization and paracellular barrier function in DrosophilaQ37551618
The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formationQ37554316
Conserved miR-8/miR-200 defines a glial niche that controls neuroepithelial expansion and neuroblast transitionQ37597895
Axon degeneration induces glial responses through Draper-TRAF4-JNK signallingQ37637848
The eye imaginal disc as a model to study the coordination of neuronal and glial development.Q37693588
Astrocyte Ca2+ Influx Negatively Regulates Neuronal Activity.Q37697423
Comparing peripheral glial cell differentiation in Drosophila and vertebratesQ37785806
Glial solute carrier transporters in Drosophila and miceQ37898076
Nutrient control of neural stem cells.Q37935308
Microglial cell origin and phenotypes in health and diseaseQ37949246
Glial cells in amyotrophic lateral sclerosisQ38214532
Myelination of the nervous system: mechanisms and functionsQ38257393
New insights in the clockwork mechanism regulating lineage specification: Lessons from the Drosophila nervous system.Q38268538
The Drosophila blood-brain barrier: development and function of a glial endotheliumQ38276387
Expression profiling of glial genes during Drosophila embryogenesisQ38312524
The Drosophila surface glia transcriptome: evolutionary conserved blood-brain barrier processesQ34471851
Oligodendrocyte warsQ34478825
Astrocyte calcium signaling: the third waveQ34510958
Glial β-oxidation regulates Drosophila energy metabolismQ34965940
Physiologic and anatomic characterization of the brain surface glia barrier of DrosophilaQ35089539
Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila.Q35135150
The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structuresQ35210797
Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettesQ35216826
Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesisQ35577420
Integrins are necessary for the development and maintenance of the glial layers in the Drosophila peripheral nerveQ35681216
Tracheal development in the Drosophila brain is constrained by glial cellsQ35828917
A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal systemQ35885611
Origin and development of neuropil glia of the Drosophila larval and adult brain: Two distinct glial populations derived from separate progenitorsQ35889431
Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injuryQ35916532
Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extensionQ35935658
Sweet sixteen for ANLS.Q36079324
Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brainQ36084664
Glial TDP-43 regulates axon wrapping, GluRIIA clustering and fly motility by autonomous and non-autonomous mechanismsQ36142384
Antioxidant Role for Lipid Droplets in a Stem Cell Niche of DrosophilaQ36146773
Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiationQ36342117
Glia in mammalian development and diseaseQ36462699
Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migrationQ36692831
Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibilityQ36694046
Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligandQ36709333
Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila.Q36711549
Quantitative neuroanatomy for connectomics in DrosophilaQ36739757
Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signallingQ36804453
Astrocytic glutamate transport regulates a Drosophila CNS synapse that lacks astrocyte ensheathmentQ36883933
The diversity and pattern of glia during axon pathway formation in the drosophila embryoQ37085621
Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neuronsQ37114904
Gcm protein degradation suppresses proliferation of glial progenitorsQ37167678
Ensheathing glia function as phagocytes in the adult Drosophila brainQ37172039
Glial differentiation and the Gcm pathway.Q37218961
Macrophages and cellular immunity in Drosophila melanogasterQ37234530
Direct cell-cell contact with the vascular niche maintains quiescent neural stem cellsQ43110771
The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in DrosophilaQ43413543
Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain.Q44828380
Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis.Q44844568
A multilevel multimodal circuit enhances action selection in DrosophilaQ45012513
Downregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster.Q45900993
Glycosphingolipids control the extracellular gradient of the Drosophila EGFR ligand Gurken.Q45983546
Morphogenesis and proliferation of the larval brain glia in DrosophilaQ46154148
glial cells missing: a genetic switch that controls glial versus neuronal fateQ46183159
The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.Q46297739
Insect models of central nervous system energy metabolism and its links to behaviorQ46299096
Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and BehaviorQ46365946
Lineage, migration, and morphogenesis of longitudinal glia in the Drosophila CNS as revealed by a molecular lineage markerQ46534077
moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in DrosophilaQ46609827
Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in DrosophilaQ46851527
Switch in FGF signalling initiates glial differentiation in the Drosophila eye.Q47070039
Kinesin heavy chain function in Drosophila glial cells controls neuronal activity.Q47070218
Glia ECM interactions are required to shape the Drosophila nervous systemQ47070268
Spinster controls Dpp signaling during glial migration in the Drosophila eye.Q47070328
Role of DE-Cadherin in Neuroblast Proliferation, Neural Morphogenesis, and Axon Tract Formation inDrosophilaLarval Brain DevelopmentQ47070436
Identity, origin, and migration of peripheral glial cells in the Drosophila embryoQ47070551
Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factorsQ47070569
Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in DrosophilaQ47070993
The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axonsQ47071158
Antagonistic feedback loops involving Rau and Sprouty in the Drosophila eye control neuronal and glial differentiationQ47071181
GPCR signaling is required for blood-brain barrier formation in drosophilaQ47071337
Notch and Numb are required for normal migration of peripheral glia in DrosophilaQ47071424
glial cells missing: a binary switch between neuronal and glial determination in Drosophila.Q47071551
Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment.Q47071723
Reciprocal interactions between neurons and glia are required for Drosophila peripheral nervous system development.Q47071802
A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and functionQ47071954
RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia.Q47072127
Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier functionQ47072306
Organization and postembryonic development of glial cells in the adult central brain of Drosophila.Q47072439
Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis.Q47072646
Organization of the Drosophila larval visual circuit.Q47118167
The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and functionQ47402235
Glial Draper Rescues Aβ Toxicity in a Drosophila Model of Alzheimer's DiseaseQ47434009
Glial lipid droplets and neurodegeneration in a Drosophila model of complex I deficiency.Q47668492
Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and gliaQ47671000
Amyloid Precursor Protein in Drosophila Glia Regulates Sleep and Genes Involved in Glutamate RecyclingQ47753255
Chaski, a novel Drosophila lactate/pyruvate transporter required in glia cells for survival under nutritional stressQ47851075
The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous systemQ48007221
repo encodes a glial-specific homeo domain protein required in the Drosophila nervous systemQ48083343
Mactosylceramide prevents glial cell overgrowth by inhibiting insulin and fibroblast growth factor receptor signaling.Q48117996
Glia relay differentiation cues to coordinate neuronal development in Drosophila.Q48131660
Disruption of an EAAT-Mediated Chloride Channel in a Drosophila Model of Ataxia.Q48148082
Live imaging using a FRET glucose sensor reveals glucose delivery to all cell types in the Drosophila brainQ48184684
Segregation of postembryonic neuronal and glial lineages inferred from a mosaic analysis of the Drosophila larval brain.Q48251049
P433issue1
P921main subjectneurogliaQ177105
P304page(s)5-26
P577publication date2018-11-15
P1433published inGliaQ15716658
P1476titleDrosophila glia: Few cell types and many conserved functions
P478volume67

Reverse relations

cites work (P2860)
Q98288800Beyond Host Defense: Deregulation of Drosophila Immunity and Age-Dependent Neurodegeneration
Q91843560Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation
Q101051266Early lineage segregation of the retinal basal glia in the Drosophila eye disc
Q92237543Latrophilins: A Neuro-Centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily
Q89810573Meta-analysis of honey bee neurogenomic response links Deformed wing virus type A to precocious behavioral maturation
Q96342428Overexpression of H3K36 methyltransferase NSD in glial cells affects brain development in Drosophila
Q102152196Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity
Q92469487The astrocyte network in the ventral nerve cord neuropil of the Drosophila third-instar larva

Search more.