| P2093 | author name string | Jun Ren | |
| | Yingmei Zhang | |
| P2860 | cites work | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice | Q24647805 |
| | Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol | Q24654272 |
| | Autophagy and cardiovascular aging: lesson learned from rapamycin | Q27692538 |
| | Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan | Q28244634 |
| | The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging | Q28276378 |
| | Haploinsufficiency of akt1 prolongs the lifespan of mice | Q28296350 |
| | Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression | Q28297737 |
| | Overexpression of Atg5 in mice activates autophagy and extends lifespan | Q29038178 |
| | The role of autophagy during the early neonatal starvation period | Q29547489 |
| | Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity | Q29614241 |
| | Autophagy and aging | Q29616002 |
| | Rapamycin extends murine lifespan but has limited effects on aging | Q30541884 |
| | Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice | Q33678212 |
| | Metabolic Stress, Autophagy, and Cardiovascular Aging: from Pathophysiology to Therapeutics | Q91140698 |
| | Myocardial stress and autophagy: mechanisms and potential therapies. | Q39210684 |
| | Resveratrol is a class IA phosphoinositide 3-kinase inhibitor | Q39253076 |
| | Autophagy and Mitophagy in Cardiovascular Disease | Q39331287 |
| | Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses | Q39335276 |
| | Role of Kallistatin Treatment in Aging and Cancer by Modulating miR-34a and miR-21 Expression | Q39458426 |
| | Rapamycin decelerates cellular senescence | Q39846812 |
| | Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states | Q40250572 |
| | Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway | Q40988610 |
| | Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function | Q41089202 |
| | Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-β/Smad3 pathway | Q41665102 |
| | AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction | Q42154599 |
| | Spermine and spermidine reversed age-related cardiac deterioration in rats | Q42371471 |
| | Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in male experimental rats | Q42705162 |
| | FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging | Q42705331 |
| | Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action | Q42816507 |
| | Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice | Q43263000 |
| | Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study | Q44802551 |
| | Hexosamine pathway metabolites enhance protein quality control and prolong life. | Q45905618 |
| | Biomedicine. A putative antiaging drug takes a step from mice to men. | Q46418325 |
| | Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. | Q47190780 |
| | HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila | Q47718594 |
| | Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment | Q47851530 |
| | Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy | Q48022125 |
| | Spermidine in health and disease. | Q48163525 |
| | Spermidine to the rescue for an aging heart | Q48178309 |
| | Cellular senescence: Implications for metabolic disease | Q49069786 |
| | Autophagy and Longevity | Q49224153 |
| | mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review | Q49486147 |
| | Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction | Q49794039 |
| | NAD+ in Aging: Molecular Mechanisms and Translational Implications | Q50128435 |
| | Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. | Q51385394 |
| | Visceral Adipose Tissue Drives Cardiac Aging Through Modulation of Fibroblast Senescence by Osteopontin Production. | Q51745075 |
| | Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. | Q51765157 |
| | The Role of Autophagy in the Heart. | Q51788753 |
| | Strategies for Optimal Cardiovascular Aging. | Q52590083 |
| | Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit(+) cardiac progenitor cells by promoting miR-675. | Q53125918 |
| | Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging. | Q53293313 |
| | Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy. | Q54115866 |
| | Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells. | Q54384741 |
| | Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. | Q54562272 |
| | Oxidative stress, aging, and diseases. | Q54944008 |
| | A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD Decline | Q56595074 |
| | Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice | Q57246062 |
| | Autophagy as a promoter of longevity: insights from model organisms | Q60198552 |
| | Targeting autophagy in obesity: from pathophysiology to management | Q88447728 |
| | Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats | Q88881645 |
| | The aging heart | Q89479694 |
| | Mitochondrial quality control mechanisms as molecular targets in cardiac ageing | Q90452942 |
| | Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart | Q33692414 |
| | Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 | Q33790225 |
| | Late-life rapamycin treatment reverses age-related heart dysfunction. | Q33903651 |
| | MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice | Q34028756 |
| | Metformin improves healthspan and lifespan in mice | Q34360789 |
| | Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents | Q34533772 |
| | Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy | Q34535472 |
| | Cardioprotection and lifespan extension by the natural polyamine spermidine. | Q34544613 |
| | Autophagy and aging: the importance of maintaining "clean" cells | Q34552013 |
| | Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy | Q34626193 |
| | The coming acceleration of global population ageing | Q34737999 |
| | Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans | Q35316092 |
| | Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts | Q35678633 |
| | Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome: implications for normal aging and age-dependent neurodegenerative disorders | Q35911400 |
| | Resveratrol as a calorie restriction mimetic: therapeutic implications | Q36291200 |
| | β-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy | Q36410000 |
| | Hypertension and aging | Q36623143 |
| | Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts. | Q36681450 |
| | HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation. | Q36768592 |
| | AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation | Q36863748 |
| | Mitonuclear protein imbalance as a conserved longevity mechanism | Q36873369 |
| | Aging and Autophagy in the Heart | Q36909023 |
| | Pharmacological Strategies to Retard Cardiovascular Aging | Q36972415 |
| | Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. | Q37460057 |
| | Metformin: do we finally have an anti-aging drug? | Q37530252 |
| | Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline | Q37592017 |
| | Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways | Q37592020 |
| | Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress | Q37643511 |
| | The Aging Heart | Q38578328 |
| | Novel strategies for anti-aging drug discovery | Q38659532 |
| | Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation | Q38691645 |
| | Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults. | Q38741510 |
| | Berberine alleviates postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice | Q38759945 |
| | Targeting chromatin aging - The epigenetic impact of longevity-associated interventions. | Q39041807 |
| P433 | issue | 12 | |
| P921 | main subject | autophagy | Q288322 |
| P304 | page(s) | 1064-1076 | |
| P577 | publication date | 2018-10-26 | |
| P1433 | published in | Trends in Pharmacological Sciences | Q2451474 |
| P1476 | title | Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases | |
| P478 | volume | 39 | |