MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

scientific article

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI43008
P932PMC publication ID2912201
P698PubMed publication ID20644257

P50authorNahum SonenbergQ904654
Gianluigi CondorelliQ37839035
Daniele CatalucciQ53518460
Marcello CeciQ58881311
P2093author name stringKirk L Peterson
Kun-Liang Guan
Shigeki Miyamoto
Roberto Rizzi
Ju Chen
Nancy D Dalton
Yusu Gu
Joan Heller Brown
Jianlin Zhang
Katherine Huang
Michael V G Latronico
Riccardo Contu
Denghong Zhang
P2860cites workPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexQ24316314
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1Q24319851
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signallingQ24323370
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)Q24324148
Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repressionQ24554226
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentQ24563399
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cellsQ24564276
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanismQ24603034
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human diseaseQ24606673
TOR signaling in growth and metabolismQ27860757
Regulation of translation initiation in eukaryotes: mechanisms and biological targetsQ28111696
Selective requirement of myosin light chain 2v in embryonic heart functionQ28258434
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1Q28276788
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBQ28306356
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase CQ28587901
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologiesQ28590387
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivityQ29614241
MicroRNA-133 controls cardiac hypertrophyQ29616572
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complexQ29617214
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathyQ33589972
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic miceQ34156036
Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potencyQ34277370
MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failureQ34416947
Cardiac plasticityQ34764732
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophyQ34891582
mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complexQ34998143
Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophyQ35126646
Hypertrophy of the heart: a new therapeutic target?Q35739349
Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac functionQ36646353
Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycinQ37110578
Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability.Q37234352
The role of autophagy in the heart.Q37325466
Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.Q37376549
Targeting mTOR with rapamycin: one dose does not fit allQ37409171
Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunctionQ37467718
Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophyQ37596176
TOR complex 2: a signaling pathway of its own.Q37624179
Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathwayQ41884318
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.Q42511063
Cell biology. Burn out or fade away?Q43142725
Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarctionQ43190981
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre proteinQ43664631
ErbB2 is essential in the prevention of dilated cardiomyopathy.Q43976647
Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytesQ44201590
Rapamycin attenuates load-induced cardiac hypertrophy in miceQ44385669
Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overloadQ44927100
Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression.Q45022812
Adenoviral RB2/p130 gene transfer inhibits smooth muscle cell proliferation and prevents restenosis after angioplastyQ45863592
Transthoracic echocardiography in models of cardiac disease in the mouse.Q45963321
Effect of sirolimus on left ventricular hypertrophy in kidney transplant recipients: a 1-year nonrandomized controlled trialQ46514014
Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophyQ46946750
High-efficiency CAG-FLPe deleter mice in C57BL/6J background.Q48558901
Effects of protein phosphorylation on ubiquitination and stability of the translational inhibitor protein 4E-BP1.Q53538416
Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinaseQ73554710
New method to evaluate myocyte remodeling from formalin-fixed biopsy and autopsy materialQ77925507
Cardiac-specific overexpression of E40K active Akt prevents pressure overload-induced heart failure in mice by increasing angiogenesis and reducing apoptosisQ79610474
Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosisQ80027046
Akt1 is required for physiological cardiac growthQ83195147
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2805-2816
P577publication date2010-07-19
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleMTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.
P478volume120

Reverse relations

cites work (P2860)
Q2854646317ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling
Q267673315'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications
Q42116782A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin.
Q28570967A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy
Q36700031AMPK attenuates microtubule proliferation in cardiac hypertrophy
Q90735566ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb
Q39285312Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy
Q35789287Adaptive mechanisms to compensate for overnutrition-induced cardiovascular abnormalities
Q64374807Adenosine kinase attenuates cardiomyocyte microtubule stabilization and protects against pressure overload-induced hypertrophy and LV dysfunction
Q54373272Akt-mTOR Pathway Inhibits Apoptosis and Fibrosis in Doxorubicin-Induced Cardiotoxicity Following Embryonic Stem Cell Transplantation.
Q28535743Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade
Q41880723Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.
Q56975424Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes
Q27692538Autophagy and cardiovascular aging: lesson learned from rapamycin
Q38837178Autophagy in cardiac metabolic control: Novel mechanisms for cardiovascular disorders
Q37999635Autophagy, myocardial protection, and the metabolic syndrome.
Q42042549Blockade of the acute activation of mTOR complex 1 decreases hypertrophy development in rats with severe aortic valve regurgitation
Q64244738Blossoming 20: The Energetic Regulator's Birthday Unveils its Versatility in Cardiac Diseases
Q34808547Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?
Q96586585CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes
Q36061754Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart
Q52727269Cardiac Arrhythmias and Antiarrhythmic Drugs: An Autophagic Perspective.
Q37179335Cardiac Gab1 deletion leads to dilated cardiomyopathy associated with mitochondrial damage and cardiomyocyte apoptosis
Q36791996Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling
Q37421014Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice
Q35251097Cardiac insulin resistance and microRNA modulators
Q40284379Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy
Q36115340Cardiac mTOR protects the heart against ischemia-reperfusion injury
Q52309831Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington's Disease.
Q35657122Cardiomyocyte death: mechanisms and translational implications
Q58791389Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action
Q38130112Cardiovascular autophagy: concepts, controversies, and perspectives
Q36062316Cardiovascular disease and mTOR signaling
Q36842427Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress
Q40842721Clinical impact of myocardial mTORC1 activation in nonischemic dilated cardiomyopathy
Q36909237Contribution of mammalian target of rapamycin in the pathophysiology of cirrhotic cardiomyopathy.
Q38936784DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.
Q28267272Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation
Q36184207Diet and aging
Q41986027Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle
Q34216750Drosophila, genetic screens, and cardiac function
Q33792524Effect of lithium on ventricular remodelling in infarcted rats via the Akt/mTOR signalling pathways
Q57300947Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases
Q47252604Emerging roles of RNA-binding proteins in diabetes and their therapeutic potential in diabetic complications.
Q83226379Endothelial EphB4 maintains vascular integrity and transport function in adult heart
Q35663684Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia
Q34307302Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation
Q92826281For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors
Q38781072Fuel availability and fate in cardiac metabolism: A tale of two substrates
Q90725026GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4)
Q30417331Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart
Q38294246Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish
Q41627722High-density lipoprotein protects cardiomyocytes from oxidative stress via the PI3K/mTOR signaling pathway
Q34836259IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
Q40630534Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects
Q104111362Inhibiting the Pkm2/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI
Q36812158Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression
Q45012762Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling
Q39180915Insights for Oxidative Stress and mTOR Signaling in Myocardial Ischemia/Reperfusion Injury under Diabetes.
Q39284965Insights into the Mechanisms Involved in Protective Effects of VEGF-B in Dopaminergic Neurons.
Q30377910Insulin Signaling and Heart Failure.
Q42818693Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.
Q38261284Insulin regulation of myocardial autophagy.
Q37829489LKB1 loss of function studied in vivo
Q53516074Links between mTOR and the immunoproteasome: Therapeutic targets for cardiac hypertrophy?
Q92398990Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction
Q36171264Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation.
Q50435398MTOR controls genesis and autophagy of GABAergic interneurons during brain development
Q28593301Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice
Q37715817Mammalian target of rapamycin signaling in cardiac physiology and disease.
Q89823740Mechanical Regulation of Protein Translation in the Cardiovascular System
Q34450669Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid
Q63131766Mechanisms of physiological and pathological cardiac hypertrophy
Q27320013Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth
Q34039918Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage
Q39232032Metabolism in cardiomyopathy: every substrate matters
Q34473676MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1.
Q35579292MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis
Q27006868Molecular basis of physiological heart growth: fundamental concepts and new players
Q27009396Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle
Q43232684NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFκB signaling pathways
Q53193638Neuregulin-1β promotes glucose uptake via PI3K/Akt in neonatal rat cardiomyocytes.
Q48506350New Insights Into the Role of mTOR Signaling in the Cardiovascular System.
Q35243945New insights into insulin resistance in the diabetic heart
Q92704203Novel Role for Pleckstrin Homology-Like Domain Family A, Member 3 in the Regulation of Pathological Cardiac Hypertrophy
Q47136381Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway
Q28588831Nprl3 is required for normal development of the cardiovascular system
Q26800197Ongoing controversies surrounding cardiac remodeling: is it black and white-or rather fifty shades of gray?
Q42067604Overexpression of microRNA-99a attenuates heart remodelling and improves cardiac performance after myocardial infarction.
Q36432388Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade
Q91284093PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress
Q34429082PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection
Q36025665PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?
Q92008008Pathway analysis with genome-wide association study (GWAS) data detected the association of atrial fibrillation with the mTOR signaling pathway
Q36972415Pharmacological Strategies to Retard Cardiovascular Aging
Q37883418Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure
Q33602622Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice
Q38854987Physiological and pathological cardiac hypertrophy.
Q41628153Prenatal Mechanistic Target of Rapamycin Complex 1 (m TORC1) Inhibition by Rapamycin Treatment of Pregnant Mice Causes Intrauterine Growth Restriction and Alters Postnatal Cardiac Growth, Morphology, and Function.
Q92849644Pressure overload inhibits glucocorticoid receptor transcriptional activity in cardiomyocytes and promotes pathological cardiac hypertrophy
Q38497014Proteotoxicity and cardiac dysfunction
Q33908036Rag GTPases are cardioprotective by regulating lysosomal function.
Q36392865Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.
Q37619336Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis.
Q37999634Regulation of autophagy by metabolic and stress signaling pathways in the heart
Q37054943Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α
Q34328828Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period
Q41820920Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome.
Q87666167Role of Everolimus on Cardiac Functions in Kidney Transplant Recipients
Q39506406Saffron (Crocus sativus) pretreatment confers cardioprotection against ischemia-reperfusion injuries in isolated rabbit heart
Q34117251Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.
Q27015640Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin
Q91430120Signalling protein protects the heart muscle from pressure-related stress
Q34627013Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin
Q61801386Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury
Q99629087Substrate metabolism regulated by Sestrin2-mTORC1 alleviates pressure overload-induced cardiac hypertrophy in aged heart
Q29568312Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway
Q93005204TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
Q42562973Target of rapamcyin (TOR)-based therapeutics for cardiomyopathy: insights from zebrafish genetics
Q38030250Target of rapamycin (TOR)-based therapy for cardiomyopathy: evidence from zebrafish and human studies
Q93246442Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases
Q26864639Targeting disease through novel pathways of apoptosis and autophagy
Q93139745Targeting mTOR suppressed colon cancer growth through 4EBP1/eIF4E/PUMA pathway
Q36413143Targets, trafficking, and timing of cardiac autophagy
Q36979192Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation
Q36227198The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload
Q64256257The Cutting Edge: The Role of mTOR Signaling in Laminopathies
Q35936057The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction
Q39256900The mTOR Signaling Pathway in Myocardial Dysfunction in Type 2 Diabetes Mellitus
Q33437313The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study
Q36597976The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation
Q26996481The two faces of miR-29
Q36913719Therapeutic targeting of autophagy in cardiovascular disease
Q26830282Therapeutic targeting of autophagy: potential and concerns in treating cardiovascular disease
Q47633679Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes.
Q90480931Thioredoxin-1 maintains mitochondrial function via mTOR signaling in the heart
Q34969926Three 4-letter words of hypertension-related cardiac hypertrophy: TRPC, mTOR, and HDAC.
Q30833466Titin-truncating variants affect heart function in disease cohorts and the general population.
Q28571523Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy
Q90269368Translating Translation to Mechanisms of Cardiac Hypertrophy
Q51249206Unacylated ghrelin analog prevents myocardial reperfusion injury independently of permeability transition pore.
Q37952798Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction
Q37644376VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart.
Q36465550Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern β-amyloid apoptotic injury of microglia
Q35972916mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy
Q90400154mTOR as a Marker of Exercise and Fatigue in Octopus vulgaris Arm
Q91973686mTOR as a central regulator of lifespan and aging
Q34426387mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy
Q53110486mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis.
Q34999217mTOR regulates brain morphogenesis by mediating GSK3 signaling
Q38056232mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases
Q90185072mTORC1 Deficiency Modifies Volume Homeostatic Responses to Dietary Sodium in a Sex-Specific Manner
Q40182849mTORC2 regulates cardiac response to stress by inhibiting MST1.

Search more.