Disruption of an active site hydrogen bond converts human heme oxygenase-1 into a peroxidase

scientific article published in 2000

Disruption of an active site hydrogen bond converts human heme oxygenase-1 into a peroxidase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M010349200
P698PubMed publication ID11121422

P50authorPierre Moenne-LoccozQ64349469
P2093author name stringH Huang
D J Schuller
T L Poulos
T M Loehr
L K Lightning
P R de Montellano
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)10612-10619
P577publication date2000-12-19
P1433published inJournal of Biological ChemistryQ867727
P1476titleDisruption of an active site hydrogen bond converts human heme oxygenase-1 into a peroxidase
P478volume276

Reverse relations

cites work (P2860)
Q372986781H NMR study of the effect of variable ligand on heme oxygenase electronic and molecular structure
Q42137143A model for the flexibility of the distal histidine in dehaloperoxidase-hemoglobin A based on X-ray crystal structures of the carbon monoxide adduct
Q36828818Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network
Q33237045Characterization of the spontaneous "aging" of the heme oxygenase from the pathological bacterium Neisseria meningitidis via cleavage of the C-terminus in contact with the substrate. Implications for functional studies and the crystal structure
Q44406359Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae.
Q24621015Comparison of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2
Q33511502Coupling of the distal hydrogen bond network to the exogenous ligand in substrate-bound, resting state human heme oxygenase
Q27641404Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate. Conformational change of the distal helix during the heme cleavage reaction
Q27639657Crystal structure of rat heme oxygenase-1 in complex with heme bound to azide. Implication for regiospecific hydroxylation of heme at the alpha-meso carbon
Q46428883Crystal structures of the G139A, G139A-NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity
Q27641460Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation
Q27641631Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications
Q24296465Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
Q40420040Extracting protein dynamics information from overlapped NMR signals using relaxation dispersion difference NMR spectroscopy.
Q38155721Heme oxygenation and the widening paradigm of heme degradation
Q41991304Heme utilization by pathogenic bacteria: not all pathways lead to biliverdin
Q57160362Immobilized cytochrome c bound to cardiolipin exhibits peculiar oxidation state-dependent axial heme ligation and catalytically reduces dioxygen
Q24310223Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase
Q42288774In silico analysis of heme oxygenase structural homologues identifies group-specific conservations
Q93363610Iron Acquisition in Mycobacterium tuberculosis
Q33802460Isocyanides inhibit human heme oxygenases at the verdoheme stage
Q24647688Isoporphyrin intermediate in heme oxygenase catalysis. Oxidation of alpha-meso-phenylheme
Q31039839Modulation of the axial water hydrogen-bonding properties by chemical modification of the substrate in resting state, substrate-bound heme oxygenase from Neisseria meningitidis; coupling to the distal H-bond network via ordered water molecules
Q90578621Recent Advances in the Understanding of the Reaction Chemistries of the Heme Catabolizing Enzymes HO and BVR Based on High Resolution Protein Structures
Q36318748Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy
Q36445749Role of propionates in substrate binding to heme oxygenase from Neisseria meningitidis: a nuclear magnetic resonance study
Q34433464Solution 1H NMR characterization of substrate-free C. diphtheriae heme oxygenase: pertinence for determining magnetic axes in paramagnetic substrate complexes
Q30754996Solution 1H NMR investigation of the active site molecular and electronic structures of substrate-bound, cyanide-inhibited HmuO, a bacterial heme oxygenase from Corynebacterium diphtheriae
Q41237558Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism.
Q37178924The orbital ground state of the azide-substrate complex of human heme oxygenase is an indicator of distal H-bonding: implications for the enzyme mechanism

Search more.