Berberine Improves Glucose and Lipid Metabolism in HepG2 Cells Through AMPKα1 Activation

scientific article published on 08 May 2020

Berberine Improves Glucose and Lipid Metabolism in HepG2 Cells Through AMPKα1 Activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2020.00647
P932PMC publication ID7225256
P698PubMed publication ID32457629

P2093author name stringGang Ren
Jian-Dong Jiang
Wei-Jia Kong
Jiang-Hong Guo
Yu-Zhen Qian
P2860cites workGastrodin Protects against Ethanol-Induced Liver Injury and Apoptosis in HepG2 Cells and Animal Models of Alcoholic Liver DiseaseQ54224802
Hexane-Isopropanolic Extract of Tungrymbai, a North-East Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP/FAS/ACC/HMGCR and PPARα/CPT1A/UCP2 pathways.Q55642037
Berberine activates thermogenesis in white and brown adipose tissueQ86052055
Learning from berberine: Treating chronic diseases through multiple targetsQ38156718
Current knowledge and pharmacological profile of berberine: An updateQ38532800
Berberine acutely activates the glucose transport activity of GLUT1Q39547455
Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK.Q40218653
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant statesQ40250572
Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytesQ42258667
The Compound of Mangiferin-Berberine Salt Has Potent Activities in Modulating Lipid and Glucose Metabolisms in HepG2 CellsQ42492483
Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytesQ42521110
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin actionQ46745033
Berberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein effluxQ46797385
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathwayQ47094365
TGF-β1/Smad3 Pathway Targets PP2A-AMPK-FoxO1 Signaling to Regulate Hepatic GluconeogenesisQ48364918
Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice.Q50220203
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemiaQ24290495
Berberine improves glucose metabolism through induction of glycolysisQ24642953
Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapyQ26798253
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver DiseaseQ27301440
Berberine Improves Glucose Metabolism in Diabetic Rats by Inhibition of Hepatic GluconeogenesisQ28477076
Berberine promotes glucose consumption independently of AMP-activated protein kinase activationQ28541332
Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activityQ34603754
Tissue distribution of berberine and its metabolites after oral administration in ratsQ35035856
Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling PathwayQ36216779
Metformin Regulates Glucose Transporter 4 (GLUT4) Translocation through AMP-activated Protein Kinase (AMPK)-mediated Cbl/CAP Signaling in 3T3-L1 Preadipocyte CellsQ36492756
Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesisQ37227111
AMPK in Health and DiseaseQ37543855
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)647
P577publication date2020-05-08
P1433published inFrontiers in PharmacologyQ2681208
P1476titleBerberine Improves Glucose and Lipid Metabolism in HepG2 Cells Through AMPKα1 Activation
P478volume11