Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

scientific article published on 29 May 2020

Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.57127
P698PubMed publication ID32469312

P50authorElena ContiQ16787491
Fabien BonneauQ52653880
Lukas M LangerQ92265647
Yair GatQ95941524
P2860cites workCloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance proteinQ24291181
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decayQ24291647
Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2Q24297542
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7Q24300529
Emerging common themes in regulation of PIKKs and PI3KsQ24647293
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Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for CatalysisQ27667818
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Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6Q27684654
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Features and development of CootQ27861079
Nonsense-mediated mRNA decay in humans at a glanceQ28077157
Substrate specificities and identification of putative substrates of ATM kinase family membersQ28141080
Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopyQ29547579
Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTipsQ29614831
Analysis of membrane and surface protein sequences with the hydrophobic moment plotQ29618183
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Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.Q30868748
A hyperactive piggyBac transposase for mammalian applicationsQ33785567
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.Q33928657
PIKKs--the solenoid nest where partners and kinases meetQ34666765
A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylationQ36002424
piggyBac transposase tools for genome engineeringQ36950347
Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decayQ37181245
Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decayQ38077285
Making new contacts: the mTOR network in metabolism and signalling crosstalkQ38189969
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Addressing preferred specimen orientation in single-particle cryo-EM through tilting.Q38696835
mTOR Signaling in Growth, Metabolism, and Disease.Q38747508
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage ResponseQ39378761
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motifQ40405852
Control of p70 s6 kinase by kinase activity of FRAP in vivoQ41284168
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CTFFIND4: Fast and accurate defocus estimation from electron micrographs.Q50866431
Architecture and activation of phosphatidylinositol 3-kinase related kinases.Q52329787
FAT: a novel domain in PIK-related kinasesQ57444244
New tools for automated high-resolution cryo-EM structure determination in RELION-3Q58563641
Nonsense-Mediated mRNA Decay Begins Where Translation EndsQ89068594
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in PhenixQ90549021
Cryo-EM structure of SMG1-SMG8-SMG9 complexQ91292192
Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP StateQ91327255
Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated MutationsQ91327261
New insights into the evolutionary conservation of the sole PIKK pseudokinase Tra1/TRRAPQ91459893
InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complexQ91621722
P4510describes a project that usesPyMOLQ1373457
P577publication date2020-05-29
P1433published ineLifeQ2000008
P1476titleStructure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity
P478volume9

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cites work (P2860)
Q98220565Structural Insights into TOR Signaling
Q101469869Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs
Q104691194Structure of an activated DNA-PK and its implications for NHEJ

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