The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma

scientific article published on 10 June 2020

The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41388-020-1345-X
P932PMC publication ID7329634
P698PubMed publication ID32523091

P50authorKrishnaraj RajalingamQ87655285
Lisa J CrawfordQ96303458
Roisin M McAveraQ96303460
P2093author name stringDharminder Chauhan
Andrew D Chantry
Alexandra E Irvine
David C Campbell
Michelle A Lawson
Aswini Krishnan
Claudia Hamilton
Jennifer M Down
Jonathan J Morgan
Treen C Morris
P2860cites workThe Influence of Metabolism on Drug Response in CancerQ59136910
Carfilzomib for relapsed and refractory multiple myelomaQ64083853
CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to TherapyQ64093247
Targeting MYC in multiple myelomaQ87842402
Ubiquitination: Friend and foe in cancerQ88976865
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53Q90352927
Bortezomib and other proteosome inhibitors-induced peripheral neurotoxicity: From pathogenesis to treatmentQ90919275
Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1α/β-mediated adaptive stress response pathway in skeletal muscle cellsQ92128904
Multiple myeloma: Every year a new standard?Q92675436
Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansionQ92761067
Ixazomib for the treatment of multiple myelomaQ93028409
The power of proteasome inhibition in multiple myelomaQ93067519
Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomasQ94452068
A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination ActivitiesQ27658641
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferationQ28280330
Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYCQ33828914
HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffoldQ34298040
HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitinQ34500475
NOD/SCID-GAMMA mice are an ideal strain to assess the efficacy of therapeutic agents used in the treatment of myeloma bone diseaseQ35175289
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligaseQ35275756
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.Q35679564
Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasmsQ36057221
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistanceQ36338365
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15Q36902911
HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiationQ37618001
Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistanceQ38743857
HUWE1 interacts with PCNA to alleviate replication stressQ38773179
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.Q38798189
The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular AspectsQ39221506
Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myelomaQ41971182
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasionQ42101475
Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosisQ42261427
A conformational switch regulates the ubiquitin ligase HUWE1.Q42321543
Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin SignalingQ42377050
Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation.Q45925019
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disabilityQ47093588
QuPath: Open source software for digital pathology image analysisQ47108040
E3 ubiquitin ligases in cancer and implications for therapiesQ47636038
HUWE1 variants cause dominant X-linked intellectual disability: a clinical study of 21 patients.Q48227714
The K48-K63 Branched Ubiquitin Chain Regulates NF-κB SignalingQ48964297
Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.Q50902450
Resistance to proteasome inhibitors and other targeted therapies in myeloma.Q53693372
Metabolic Features of Multiple Myeloma.Q53694850
Role of Proteasome Inhibitors in Relapsed and/or Refractory Multiple MyelomaQ57117709
Ubiquitination by HUWE1 in tumorigenesis and beyondQ57161316
Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumorQ57964092
Identification of novel mutational drivers reveals oncogene dependencies in multiple myelomaQ58792995
P577publication date2020-06-10
P1433published inOncogeneQ1568657
P1476titleThe E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma

Reverse relations

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