MTXPK.org: A clinical decision support tool evaluating high-dose methotrexate pharmacokinetics to inform post-infusion care and use of glucarpidase

scientific article published on 19 June 2020

MTXPK.org: A clinical decision support tool evaluating high-dose methotrexate pharmacokinetics to inform post-infusion care and use of glucarpidase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CPT.1957
P932PMC publication ID7484917
P698PubMed publication ID32558929

P2093author name stringJesper Heldrup
Laura B Ramsey
William Shuman
Alexander A Vinks
Tomoyuki Mizuno
Nieko C Punt
Zachary L Taylor
Adriana Navarro Sainz
Balaji Baskaran
Nicholas Felicelli
P2860cites workGlucarpidase to combat toxic levels of methotrexate in patientsQ24605014
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Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cellsQ28476416
Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemiaQ31103489
Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome.Q34131794
Resumption of high-dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patientsQ34247793
Polyglutamation of methotrexate. Is methotrexate a prodrug?Q34552178
Evaluating performance of a decision support system to improve methotrexate pharmacotherapy in children and young adults with cancerQ34780653
Application of pharmacokinetic modelling to the routine therapeutic drug monitoring of anticancer drugsQ35060593
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate dispositionQ35634476
Integration of modeling and simulation into hospital-based decision support systems guiding pediatric pharmacotherapyQ36478646
Genome-wide study of methotrexate clearance replicates SLCO1B1.Q36595293
Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustmentsQ37034349
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effectsQ37474395
Glucarpidase following high-dose methotrexate: update on developmentQ37635158
Evaluation of incidence and risk factors for high-dose methotrexate-induced nephrotoxicityQ38543699
High-dose methotrexate in adults with osteosarcoma: a population pharmacokinetics study and validation of a new limited sampling strategyQ40086721
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The pharmacology and clinical use of methotrexateQ40158601
Prophylactic Trimethoprim-Sulfamethoxazole Does Not Affect Pharmacokinetics or Pharmacodynamics of MethotrexateQ41846508
Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicityQ42556608
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemiaQ43221788
Establishing best practices and guidance in population modeling: an experience with an internal population pharmacokinetic analysis guidance.Q44108202
Carboxypeptidase-G2 rescue in cancer patients with delayed methotrexate elimination after high-dose methotrexate therapyQ44281596
High-dose methotrexate: on the relationship of methotrexate elimination time vs renal function and serum methotrexate levels in 1164 courses in 264 Swedish children with acute lymphoblastic leukaemia (ALL)Q44423326
Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemiaQ44473547
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Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate ClearanceQ46446111
Hypoalbuminemia is significantly associated with increased clearance time of high dose methotrexate in patients being treated for lymphoma or leukemia.Q47165422
Results of NOPHO ALL2008 treatment for patients aged 1-45 years with acute lymphoblastic leukemia.Q50501063
Successful carboxypeptidase G2 rescue in delayed methotrexate elimination due to renal failure.Q50752200
Delayed elimination of high-dose methotrexate and use of carboxypeptidase G2 in pediatric patients during treatment for acute lymphoblastic leukemia.Q51012681
Population pharmacokinetic study of methotrexate in children with acute lymphoblastic leukemia.Q51763283
Population pharmacokinetics of high-dose methotrexate in children with acute lymphoblastic leukaemia.Q51928567
Glucarpidase Intervention for Delayed Methotrexate ClearanceQ87702034
Population pharmacokinetic analysis of high-dose methotrexate in pediatric and adult oncology patientsQ90498370
Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in NeonatesQ90746848
Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinibQ91197807
NONMEM Tutorial Part I: Description of Commands and Options, with Simple Examples of Population AnalysisQ91773221
The Population Pharmacokinetics of High-Dose Methotrexate in Infants with Acute Lymphoblastic Leukemia Highlight the Need for Bedside Individualized Dose Adjustment: A Report from the Children's Oncology GroupQ91960784
Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in OncologyQ92473070
P921main subjectpharmacokineticsQ323936
decision support systemQ330268
methotrexateQ422232
P577publication date2020-06-19
P1433published inClinical Pharmacology & TherapeuticsQ1101529
P1476titleMTXPK.org: A clinical decision support tool evaluating high-dose methotrexate pharmacokinetics to inform post-infusion care and use of glucarpidase

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