Adapting to the Cold: A Role for Endogenous Fibroblast Growth Factor 21 in Thermoregulation?

scientific article published on 02 July 2020

Adapting to the Cold: A Role for Endogenous Fibroblast Growth Factor 21 in Thermoregulation? is …
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scholarly articleQ13442814

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P356DOI10.3389/FENDO.2020.00389
P932PMC publication ID7343899
P698PubMed publication ID32714278

P2093author name stringSusanne Keipert
Marlou Klein Hazebroek
P2860cites workIdentification of a novel FGF, FGF-21, preferentially expressed in the liverQ22254289
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FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation responseQ24653481
BetaKlotho is required for metabolic activity of fibroblast growth factor 21Q24681531
The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of MitochondriaQ28115102
FGF21 requires βklotho to act in vivoQ28485347
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obeseQ28510931
FGF21 is an endocrine signal of protein restrictionQ28572009
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Serum FGF21 levels are associated with brown adipose tissue activity in humans.Q30374773
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 geneQ33199648
Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.Q33762194
FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.Q34315567
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Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male MiceQ35763646
High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator miceQ35865700
A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.Q36307444
Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis.Q36508902
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Interplay between FGF21 and insulin action in the liver regulates metabolismQ37524205
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FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent MechanismsQ38852382
Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokineQ39042458
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Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.Q40958865
Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpointsQ41421048
iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 TherapyQ41440576
Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretionQ41810632
Mild cold induced thermogenesis: are BAT and skeletal muscle synergistic partners?Q41948731
FGF-21/FGF-21 receptor interaction and activation is determined by betaKlothoQ42819634
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetesQ45834496
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeysQ46844955
A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21).Q47244001
The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity.Q47300790
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic SubjectsQ47319669
Long-Term Cold Adaptation Does Not Require FGF21 or UCP1.Q47813776
FGF21 Is an Exocrine Pancreas Secretagogue.Q51189900
Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.Q51421300
Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptationQ57797975
Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold ExposureQ61444357
Interaction between the amount of dietary protein and the environmental temperature on the expression of browning markers in adipose tissue of rats.Q64946008
UCP1 is essential for adaptive adrenergic nonshivering thermogenesisQ83092333
Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotypeQ88243697
The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and AlcoholQ88363823
Reduced adiposity by compensatory WAT browning upon iBAT removal in miceQ88727338
Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient miceQ89474341
A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to MetabolismQ90239463
Pegbelfermin (BMS-986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 StudyQ90300458
Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trialQ90566894
Circulating fibroblast growth factor 21 is reduced, whereas its production is increased in a fat depot-specific manner in cold-acclimated ratsQ90610388
Pegbelfermin (BMS-986036): an investigational PEGylated fibroblast growth factor 21 analogue for the treatment of nonalcoholic steatohepatitisQ92403525
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)389
P577publication date2020-07-02
P1433published inFrontiers in EndocrinologyQ27723680
P1476titleAdapting to the Cold: A Role for Endogenous Fibroblast Growth Factor 21 in Thermoregulation?
P478volume11

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