Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

scientific article published on 09 July 2020

Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7150/THNO.45922
P932PMC publication ID7381741
P698PubMed publication ID32724473

P2093author name stringBo Liu
Jie Liu
Yi Chen
Jin Zhang
Rong-Rong He
Honggang Xiang
P2860cites workSirtuins in Renal Health and DiseaseQ94073889
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activityQ22010164
Acetylation-dependent regulation of Skp2 functionQ24292805
SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stressQ24313709
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70Q24645120
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylaseQ24671306
Sirtuin 1 and sirtuin 3: physiological modulators of metabolismQ26828607
SIRT3 regulates progression and development of diseases of agingQ26864656
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismQ27679007
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3Q27684389
Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanismQ27687467
On the Origin of Cancer CellsQ27861025
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative diseaseQ28068499
Fighting neurodegeneration with rapamycin: mechanistic insightsQ28243647
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complexQ28249855
SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growthQ28258574
Conserved metabolic regulatory functions of sirtuinsQ28267340
Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathwayQ28468627
Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3Q28512747
SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat ModelQ28817614
Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric RestrictionQ29619949
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasisQ29620243
Docking and binding free energy calculations of sirtuin inhibitorsQ30316719
Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathwayQ30419038
A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer CellsQ33636551
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathwayQ33661644
Sirtuin regulation of mitochondria: energy production, apoptosis, and signalingQ34024056
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndromeQ34209480
The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signalingQ34556111
Old enzymes, new tricks: sirtuins are NAD(+)-dependent de-acylasesQ41953666
Correction for Papa and Germain, "SirT3 Regulates a Novel Arm of the Mitochondrial Unfolded Protein Response".Q41954145
SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose ControlQ41980114
SIRT3 reverses aging-associated degenerationQ42029936
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.Q42202731
Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling PathwayQ42373717
Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.Q42792585
Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapyQ42872858
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderlyQ44633411
Sesamin Protects Against Cardiac Remodeling Via Sirt3/ROS PathwayQ46238115
Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factorQ46254405
SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's diseaseQ46262918
Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cellsQ46267074
SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrityQ46274273
Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunctionQ46303141
Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathwayQ46306810
Does Metformin Protect Diabetic Patients from Oxidative Stress and Leukocyte-Endothelium Interactions?Q46372529
Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced DysfunctionQ46390320
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.Q47230286
2-Methoxyestradiol Affects Mitochondrial Biogenesis Pathway and Succinate Dehydrogenase Complex Flavoprotein Subunit A in Osteosarcoma Cancer CellsQ47257443
Polydatin protects cardiomyocytes against myocardial infarction injury by activating Sirt3.Q47389936
Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repairQ47404584
MicroRNA-210 Modulates the Cellular Energy Metabolism Shift During H2O2-Induced Oxidative Stress by Repressing ISCU in H9c2 CardiomyocytesQ47651944
miR-195 Regulates Metabolism in Failing Myocardium via Alterations in SIRT3 Expression and Mitochondrial Protein Acetylation.Q47657886
Metformin and insulin impact on clinical outcome in patients with advanced hepatocellular carcinoma receiving sorafenib: Validation study and biological rationale.Q47686470
Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosisQ48148630
Sirt3 protects dopaminergic neurons from mitochondrial oxidative stressQ48233603
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.Q48365119
LncRNA TUG1 sponges miR-145 to promote cancer progression and regulate glutamine metabolism via Sirt3/GDH axisQ48523033
A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutaseQ48720966
Building and decoding ubiquitin chains for mitophagyQ49864965
Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.Q49999953
Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapyQ50126710
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.Q51246484
Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring Nε-thioacetyl-lysine.Q51427110
SIRT3 deficiency impairs mitochondrial and contractile function in the heart.Q51632304
Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress and toxic environment and restores blood flow in critical limb ischemia area in mice.Q51760185
SIRT3 deficiency exacerbates p53/Parkin‑mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts.Q51763649
Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment.Q52347992
NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole-body metabolism.Q52596649
SIRT3 restricts HBV transcription and replication via epigenetic regulation of cccDNA involving SUV39H1 and SETD1A histone methyltransferases.Q52602564
Parkinson's diseaseQ54072241
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway.Q55315757
NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism.Q55395460
SIRT3 activator honokiol ameliorates surgery/anesthesia-induced cognitive decline in mice through anti-oxidative stress and anti-inflammatory in hippocampusQ57192027
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesisQ58115601
DNA-Encoded Dynamic Chemical Library and Its Applications in Ligand DiscoveryQ58565356
Non-mitotic effect of albendazole triggers apoptosis of human leukemia cells via SIRT3/ROS/p38 MAPK/TTP axis-mediated TNF-α upregulationQ58592592
Mitochondria as a therapeutic target for common pathologiesQ58611546
Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome InhibitionQ58764473
SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial HomeostasisQ59132734
Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis suppression of sirtuin 3 in pancreatic cancerQ59328828
Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axisQ34598059
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilizationQ34729713
4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.Q35041432
Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injuryQ35056744
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS productionQ35100923
SnapShot: Mammalian Sirtuins.Q35111981
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species productionQ35197888
Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studiesQ35252505
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cellsQ35568870
Mouse SIRT3 attenuates hypertrophy-related lipid accumulation in the heart through the deacetylation of LCADQ35573153
Energy metabolism in heart failureQ35602060
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3Q35636476
SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed MiceQ35973881
High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 lossQ35995078
NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.Q36038362
trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington DiseaseQ36098005
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylationQ36099753
SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatoninQ36111628
Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesionsQ36270948
Sirtuin Inhibition: Strategies, Inhibitors, and Therapeutic PotentialQ36340474
Are sirtuins viable targets for improving healthspan and lifespan?Q36385747
The Emerging Hallmarks of Cancer MetabolismQ36468964
Loss of SIRT3 Provides Growth Advantage for B Cell MalignanciesQ36573949
LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathwaysQ36574347
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β.Q36597265
Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3Q36632410
Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in miceQ36634376
SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with ObesityQ36713609
Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiologyQ36728778
Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinomaQ36809567
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expressionQ36868674
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surfaceQ36887547
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylationQ37193340
Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimuriumQ37257178
SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2Q37296133
Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in miceQ37330537
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.Q37343700
Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancerQ37620630
Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activityQ37695433
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitorsQ37727564
Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney InjuryQ37737807
The SirT3 divining rod points to oxidative stressQ37887129
The Role of p53 in Metabolic RegulationQ37903700
Sirtuins mediate mammalian metabolic responses to nutrient availabilityQ37976307
Metabolic regulation by SIRT3: implications for tumorigenesisQ38022918
Mitochondrial cytopathies and cardiovascular diseaseQ38180688
SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease ProtectionQ38665115
SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation.Q38674686
Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway.Q38704383
The expression of SIRT3 in primary hepatocellular carcinoma and the mechanism of its tumor suppressing effectsQ38710818
A small-molecule activator induces ULK1-modulating autophagy-associated cell death in triple negative breast cancerQ38760946
Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicityQ38822588
Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathwayQ38881949
NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In VivoQ38927795
Sirtuin 3: A Janus face in cancer (Review).Q39007460
Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complexQ39028348
Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress.Q39123771
Sirt3 is a tumor suppressor in lung adenocarcinoma cellsQ39127721
MicroRNA therapeutics: towards a new era for the management of cancer and other diseasesQ39139786
Mitochondrial Sirtuins and Molecular Mechanisms of Aging.Q39174949
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.Q39307719
Pharmacological modulation of autophagy: therapeutic potential and persisting obstaclesQ39321120
SIRT3: Oncogene and Tumor Suppressor in Cancer.Q39433144
SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathwayQ41364227
Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing AngiogenesisQ41628391
Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.Q41636426
Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-β/Smad3 pathwayQ41665102
FOXO3A directs a protective autophagy program in haematopoietic stem cells.Q41894710
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype.Q41913346
Sirtuin 3 deficiency aggravates contrast-induced acute kidney injuryQ59336990
The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancerQ60044742
Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagyQ61816619
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in VitiligoQ64093305
SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repairQ64115640
SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolismQ64266460
SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapyQ64277468
Therapeutic approaches to Huntington disease: from the bench to the clinicQ64859904
miR-494-3p modulates the progression of in vitro and in vivo Parkinson's disease models by targeting SIRT3Q64920897
Color-Mediated Contrast Sensitivity in Disabled ReadersQ67916777
Alzheimer's diseaseQ79264357
Human SIRT3 tripeptidic inhibitors containing N(ε)-thioacetyl-lysineQ85666749
An inhibitor of oxidative phosphorylation exploits cancer vulnerabilityQ89070252
Suppression of Endothelial-to-Mesenchymal Transition by SIRT (Sirtuin) 3 Alleviated the Development of Hypertensive Renal InjuryQ89143412
Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3Q89143446
MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3Q89285073
SIRT3 Inactivation Promotes Acute Kidney Injury Through Elevated Acetylation of SOD2 and p53Q90014679
SIRT2: Controversy and multiple roles in disease and physiologyQ90035223
SIRT3 inhibited the formation of calcium oxalate-induced kidney stones through regulating NRF2/HO-1 signaling pathwayQ90479829
Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagyQ90591742
Celastrol protects human retinal pigment epithelial cells against hydrogen peroxide mediated oxidative stress, autophagy, and apoptosis through sirtuin 3 signal pathwayQ90933575
Biological Functions of Autophagy Genes: A Disease PerspectiveQ91003224
SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthaseQ91063764
Protective effects of polydatin against sulfur mustard-induced hepatic injuryQ91199036
MiR-708-5p inhibits the progression of pancreatic ductal adenocarcinoma by targeting Sirt3Q91227731
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cellsQ91272499
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene TransferQ91589126
A novel metadherinΔ7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFĸB-SIRT3 axisQ91736468
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid LeukemiaQ91744014
MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinomaQ91760955
4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogrammingQ91778758
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and MetabolismQ91851871
SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylationQ92010137
Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cellsQ92048358
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activityQ92461921
LncRNA DYNLRB2-2 inhibits THP-1 macrophage foam cell formation by enhancing autophagyQ92569158
Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathwayQ92583059
Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κBTGF-β1/Smad Signaling PathwayQ92634138
Non-oncogene Addiction to SIRT3 Plays a Critical Role in LymphomagenesisQ92658293
Inhibition of Mitochondrial Oxidative Damage Improves Reendothelialization Capacity of Endothelial Progenitor Cells via SIRT3 (Sirtuin 3)-Enhanced SOD2 (Superoxide Dismutase 2) Deacetylation in HypertensionQ92687993
Impaired SIRT3 activity mediates cardiac dysfunction in endotoxemia by calpain-dependent disruption of ATP synthesisQ92764730
Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat DietQ92862803
SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylationQ93006989
Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemiaQ93017932
Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in MiceQ93047072
ABT737 enhances ovarian cancer cells sensitivity to cisplatin through regulation of mitochondrial fission via Sirt3 activationQ93076729
Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activationQ93156536
IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignanciesQ93222571
P433issue18
P304page(s)8315-8342
P577publication date2020-07-09
P1433published inTheranosticsQ21051383
P1476titleMitochondrial Sirtuin 3: New emerging biological function and therapeutic target
P478volume10

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