Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells

scientific article published on 11 September 2020

Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells is …
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scholarly articleQ13442814

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P356DOI10.1038/S41598-020-70890-6
P698PubMed publication ID32917927

P50authorGaurav K. VarshneyQ52674137
Kathrin PfeiferQ59547322
Georg WolfstetterQ86314753
Patricia MendozaQ86314758
Ruth PalmerQ86314761
P2093author name stringAnne Uv
Sa Chen
Mattias Backman
Ezgi Uçkun
Hannah Sonnenberg
Sanjay K Sukumar
Tafheem A Masudi
P2860cites workMutations affecting the pattern of the larval cuticle inDrosophila melanogaster : II. Zygotic loci on the third chromosomeQ89559824
Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila ModelQ89967600
Cell competition in development: information from flies and vertebratesQ91405195
Cell competition: the winners and losers of fitness selectionQ91663956
Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic targetQ95780288
KSR, a novel protein kinase required for RAS signal transductionQ24310039
Identification of ALK as a major familial neuroblastoma predisposition geneQ24655923
CRISPR-Cas9 Genome Editing in DrosophilaQ26314632
The role of the ALK receptor in cancer biologyQ26738384
The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogasterQ27334109
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancerQ27851410
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphomaQ27851421
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitorsQ27851431
Activating mutations in ALK provide a therapeutic target in neuroblastomaQ27851452
FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinaseQ28118071
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphomaQ28250347
Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinasesQ28279211
Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivoQ28343689
The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resourceQ28756923
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancerQ29547564
The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogasterQ30478286
PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancementsQ31145457
Positive autoregulation of the transcription factor Pax6 in response to increased levels of either of its major isoforms, Pax6 or Pax6(5a), in cultured cellsQ33244708
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasionQ33715310
Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor modelQ33947948
Developmental and transcriptional consequences of mutations in Drosophila TAF(II)60Q34012433
The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learningQ34031191
A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue cultureQ34235097
The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formationQ34473183
TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survivalQ34541693
The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogasterQ34645091
Regulation of Drosophila melanogaster pro-apoptotic gene hid.Q34988884
Wallenda regulates JNK-mediated cell death in DrosophilaQ36346887
Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactionsQ36435120
Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation.Q36628886
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9.Q37340778
Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.Q37480414
TLX-Its Emerging Role for Neurogenesis in Health and DiseaseQ37569901
The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.Q37630688
A tale of taillessQ37814798
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biologyQ38141512
Neuroblastoma and Its Zebrafish ModelQ38831353
Targeting ALK: Precision Medicine Takes on Drug ResistanceQ39103431
JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in DrosophilaQ39121816
Oncogenic mutations of ALK kinase in neuroblastomaQ39928776
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastomaQ39928780
puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in DrosophilaQ40442820
NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3aQ40590126
Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila.Q40952650
EYA1 expression and subcellular localization in neuroblastoma and its association with prognostic markersQ40993139
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signalingQ40995001
Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell statusQ41124701
Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.Q41148199
Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap.Q42416237
The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathwayQ42598419
Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684.Q42727617
Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapyQ42818525
Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual systemQ43116979
Dissection and mounting of Drosophila pupal eye discsQ43180341
Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of DrosophilaQ43529155
The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamilyQ43983015
Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers.Q44605512
Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.Q44605515
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domainQ44689071
Krüppel requirement for knirps enhancement reflects overlapping gap gene activities in the Drosophila embryoQ45757474
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.Q46027909
The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferationQ46192247
Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genomeQ46518014
Star is required for neuronal differentiation in the Drosophila retina and displays dosage-sensitive interactions with Ras1.Q46650620
14-3-3 epsilon positively regulates Ras-mediated signaling in DrosophilaQ46702351
Ras promotes cell survival in Drosophila by downregulating hid expressionQ47070193
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development.Q47070908
Drosophila myc regulates organ size by inducing cell competitionQ47071644
DCP-1, a Drosophila cell death protease essential for developmentQ47071648
Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila.Q47071698
Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation.Q47071922
dMyc transforms cells into super-competitorsQ47072112
Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma MutationQ47135061
ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cellsQ47215739
The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila.Q47608409
Feedback amplification loop drives malignant growth in epithelial tissuesQ47741462
Anaplastic lymphoma kinase spares organ growth during nutrient restriction in DrosophilaQ48119750
Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk.Q50097689
Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth.Q50550167
Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway.Q52177955
Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye.Q52256862
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.Q52551521
Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways(mili(Alk)) as receptor for Jeb signalling.Q52553075
Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling.Q52594202
Highwire restrains synaptic growth by attenuating a MAP kinase signal.Q52669720
Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis.Q53829229
The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL).Q54117760
STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasetsQ60469724
High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumoursQ61696748
Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathwaysQ63804632
Pro-apoptotic and pro-proliferation functions of the JNK pathway of Drosophila: roles in cell competition, tumorigenesis and regenerationQ64058272
NeuroblastomaQ88730901
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinibQ89120437
P433issue1
P304page(s)14954
P577publication date2020-09-11
P1433published inScientific ReportsQ2261792
P1476titleIdentification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells
P478volume10

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