Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism

scientific article published on 22 August 2020

Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.METOP.2020.100053
P932PMC publication ID7479356
P698PubMed publication ID32924003

P2093author name stringThomas P J Solomon
Flemming Dela
Kirk Pappan
Kristian Karstoft
Jonathan P Barlow
Jørn W Helge
Martin Gram
Andreas Vigelsø
Warwick Dunn
Donna O'Neil
P2860cites workAlanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteersQ24338511
Triggering and amplifying pathways of regulation of insulin secretion by glucoseQ27863677
Recent data on obesity research: β-aminoisobutyric acid.Q30854525
β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factorsQ33596037
Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretionQ33676670
Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humansQ34099337
The dynamic range of the human metabolome revealed by challengesQ34198882
β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetesQ36610832
Fatty acid-specific fluorescent probes and their use in resolving mixtures of unbound free fatty acids in equilibrium with albuminQ36844298
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Immobilization rapidly induces muscle insulin resistance together with the activation of MAPKs (JNK and p38) and impairment of AS160 phosphorylationQ37176715
Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2Q37345580
Effects of β-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesityQ37593132
Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiencyQ38356934
Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic isletsQ38815536
Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cellsQ38931580
Assessment of the metabolic pathways associated with glucose-stimulated biphasic insulin secretionQ39021394
Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cellsQ39085330
Measuring mitochondrial bioenergetics in INS-1E insulinoma cellsQ39854680
New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?Q41815752
Insulin action in human thighs after one-legged immobilizationQ41992749
Effects of training and detraining on dose-response relationship between glucose and insulin secretionQ42496890
Examining the effects of hyperglycemia on pancreatic endocrine function in humans: evidence for in vivo glucotoxicity.Q42513842
Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men.Q46124325
Seven days of bed rest decrease insulin action on glucose uptake in leg and whole bodyQ46970750
Do skeletal muscle-secreted factors influence the function of pancreatic beta-cells?Q47326695
Come on BAIBA light my fireQ47753455
β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor.Q50098019
BAIBA Does Not Regulate UCP-3 Expression in Human Skeletal Muscle as a Response to Aerobic Exercise.Q50789263
The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle.Q51553127
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.Q51598262
Two weeks of one-leg immobilization decreases skeletal muscle respiratory capacity equally in young and elderly men.Q51699384
One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation.Q53075975
Effect of 7 days of bed rest on dose-response relation between plasma glucose and insulin secretion.Q54350148
Studies in 3,523 Norwegians and Meta-Analysis in 11,571 Subjects Indicate That Variants in the Hepatocyte Nuclear Factor 4 (HNF4A) P2 Region Are Associated With Type 2 Diabetes in ScandinaviansQ57506511
Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid MetabolismQ64091161
The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-pointsQ89397680
Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in HumansQ90704854
Conditioned media from contracting skeletal muscle potentiates insulin secretion and enhances mitochondrial energy metabolism of pancreatic beta-cellsQ93174865
P304page(s)100053
P577publication date2020-08-22
P1433published inMetabolism openQ96319425
P1476titleBeta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism
P478volume7

Search more.