Chitinase-3 like-protein-1 function and its role in diseases

scientific article published on 14 September 2020

Chitinase-3 like-protein-1 function and its role in diseases is …
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scholarly articleQ13442814

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P356DOI10.1038/S41392-020-00303-7
P932PMC publication ID7490424
P698PubMed publication ID32929074

P50authorQiang YouQ87845746
P2093author name stringTing Zhao
Xiaoren Zhang
Yingchang Li
Zhongping Su
P2860cites workChitinase 3-like 1 deficiency ameliorates liver fibrosis by promoting hepatic macrophage apoptosisQ93095797
N-Glycosylation Regulates Chitinase 3-like-1 and IL-13 Ligand Binding to IL-13 Receptor α2Q94660156
Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathologyQ95721129
A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicryQ36884006
Plasma YKL-40: a BMI-independent marker of type 2 diabetesQ36943769
YKL-40 tissue expression and plasma levels in patients with ovarian cancerQ21260376
Hallmarks of Cancer: The Next GenerationQ22252312
Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycansQ24291240
Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastomaQ24295370
Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathwayQ24298961
Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytesQ24303575
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 systemQ24310081
The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1Q24310131
Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophagesQ24315996
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung functionQ24319020
Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein familyQ24319994
The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathwaysQ24534189
A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancersQ24595527
Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancerQ24604176
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3Q24624887
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
Potential association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancerQ26853189
Chitin is endogenously produced in vertebratesQ27316365
Inhibitory activity of YKL-40 in mammary epithelial cell differentiation and polarization induced by lactogenic hormones: a role in mammary tissue involutionQ27317208
Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39Q27641650
Matrix elasticity directs stem cell lineage specificationQ27860761
Immunity, Inflammation, and CancerQ27861048
Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridizationQ28142346
Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasionQ28142815
Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activityQ28142936
gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cellsQ28178254
High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survivalQ28190695
CD44: from adhesion molecules to signalling regulatorsQ28201701
Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the diseaseQ28205002
YKL-40 is a differential diagnostic marker for histologic subtypes of high-grade gliomasQ48956095
Detection of major histocompatibility complex/human cartilage gp-39 complexes in rheumatoid arthritis synovitis as a specific and independent histologic markerQ49145962
Chitinase 3 like 1 (CHI3L1) promotes vasculogenic mimicry formation in cervical cancer.Q49920011
Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malariaQ49962999
Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cellsQ50083808
Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky-Pudlak Syndrome Lung Disease.Q50088162
Changes in serum chitinase 3-like 1 levels correlate with changes in liver fibrosis measured by two established quantitative methods in chronic hepatitis B patients following antiviral therapyQ50142277
Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of MyofibroblastsQ50231479
Relationship between β-Secretase, inflammation and core cerebrospinal fluid biomarkers for Alzheimer's diseaseQ50471605
The cell wall polysaccharide metabolism of the brown alga Ectocarpus siliculosus. Insights into the evolution of extracellular matrix polysaccharides in EukaryotesQ50570948
Plasma level of chitinase 3-like 1 protein increases in patients with early Alzheimer's diseaseQ50802846
Clinical Utility of YKL-40 in Polymyositis/dermatomyositis-associated Interstitial Lung Disease.Q50888668
Serum YKL-40 as predictor of outcome in hypersensitivity pneumonitisQ51067922
The serum YKL-40 level is associated with vascular injury and predicts proteinuria in nephrotic syndrome patients.Q51315323
Serum levels of YKL-40 and interleukin-18 and their relationship to disease severity in patients with preeclampsia.Q51834726
YKL-40, a biomarker of inflammation, is elevated in patients with type 2 diabetes and is related to insulin resistance.Q51943807
Early detection and prognosis of ovarian cancer using serum YKL-40.Q52088111
Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells.Q52176115
Serum YKL-40 as a biomarker for liver fibrosis in chronic hepatitis B patients with normal and mildly elevated ALT.Q52619982
Chitinase-3-like protein 1 protects skeletal muscle from TNFα-induced inflammation and insulin resistance.Q53067238
Faecal chitinase 3-like 1 is a reliable marker as accurate as faecal calprotectin in detecting endoscopic activity in adult patients with inflammatory bowel diseases.Q53208202
Serum YKL-40 as a marker for cervical adenocarcinoma.Q53209904
Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility.Q53319037
The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation.Q53622506
Serum YKL-40 and bone marrow angiogenesis in multiple myeloma.Q55465518
YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas.Q55469339
Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.Q55469941
Plasma level of YKL-40 correlates with the severity of coronary atherosclerosis assessed with SYNTAX scoreQ57286231
An association between YKL-40 and type 2 diabetes in psychotic disordersQ57452552
Endogenous HLA–DR–restricted presentation of the cartilage antigens human cartilage gp-39 and melanoma inhibitory activity in the inflamed rheumatoid jointQ57752656
Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancerQ57975577
YKL-40 levels and atrial fibrillation in the general populationQ58007561
A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infectionQ58098412
High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survivalQ58175683
Clusterin plays an important role in hepatocellular carcinoma metastasisQ58321603
Chitinase 3-like 1 protein plays a critical role in RSV-induced airway inflammationQ58591824
Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancerQ58777985
YKL-40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosisQ58778146
K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expressionQ58788519
Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1Q58796710
Chitinase 3-like 1 protein plays a critical role in respiratory syncytial virus-induced airway inflammationQ60153688
Genetic variants inCHI3L1influencing YKL-40 levels: resequencing 900 individuals and genotyping 9000 individuals from the general populationQ60585747
Serum YKL-40 concentrations in patients with early rheumatoid arthritis: relation to joint destructionQ61912598
High YKL-40 levels predict mortality in patients with type 2 diabetesQ61948374
Progression of fibrosis in hepatitis C with and without schistosomiasis: Correlation with serum markers of fibrosisQ63432590
Diurnal, Weekly, and Long-Time Variation in Serum Concentrations of YKL-40 in Healthy SubjectsQ63727810
Serum YKL-40 in Risk Assessment for Colorectal Cancer: A Prospective Study of 4,496 Subjects at Risk of Colorectal CancerQ63753441
Decreased Lung Tumor Development in SwAPP Mice through the Downregulation of CHI3L1 and STAT 3 Activity via the Upregulation of miRNA342-3pQ64242366
Functional study of the association of polymorphisms with asthma susceptibility in the Southwest Chinese Han populationQ64262448
Tumor AngiogenesisQ69374811
Localization of MHC class II/human cartilage glycoprotein-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodiesQ28205489
High serum YKL-40 level after surgery for colorectal carcinoma is related to short survivalQ28215091
YKL-40--a novel biomarker in clinical practice?Q28244771
Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiationQ28245478
A perspective on cancer cell metastasisQ28307891
Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cellsQ28586972
Tissue cells feel and respond to the stiffness of their substrateQ29547613
Macrophage diversity enhances tumor progression and metastasisQ29615847
Vasculogenic mimicry and tumor angiogenesisQ30498765
miR-24 limits aortic vascular inflammation and murine abdominal aneurysm developmentQ30596758
YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factorQ33343967
The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor geneQ33546894
Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell TherapyQ33561644
Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitisQ33576348
Functions of hyaluronan in wound repairQ33609847
Resveratrol represses YKL-40 expression in human glioma U87 cellsQ33732189
Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomicsQ33769278
Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicryQ33874221
YKL-40 as a novel factor associated with inflammation and catabolic mechanisms in osteoarthritic jointsQ34012380
Elevated YKL40 is associated with advanced prostate cancer (PCa) and positively regulates invasion and migration of PCa cellsQ34052057
Antibiotics that inhibit fungal cell wall developmentQ34059193
Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patientsQ34088928
Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer.Q34165054
The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury.Q34269049
Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogelQ34287664
Serum YKL-40 independently predicts outcome after transcatheter arterial chemoembolization of hepatocellular carcinomaQ34412656
YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's diseaseQ34447497
Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesionQ34451438
Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart diseaseQ34468219
Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathwayQ34505974
A chitinase-like protein in the lung and circulation of patients with severe asthmaQ34713773
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.Q34733220
Circulating YKL-40 level, but not CHI3L1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery diseaseQ34834538
Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processingQ34945220
Serum YKL-40 and interleukin 6 levels in Hodgkin lymphomaQ37036167
YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuriaQ37067140
Chitin-binding domains of Escherichia coli ChiA mediate interactions with intestinal epithelial cells in mice with colitisQ37126258
Serum YKL-40 Levels in Patients with Gastric CancerQ37218917
IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responsesQ37264739
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosisQ37273123
YKL-40-A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients?Q37334247
Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver diseaseQ37339883
Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's DiseaseQ37345484
Vasculogenic mimicry in small cell lung cancerQ37408684
Exploring the role of CHI3L1 in "pre-metastatic" lungs of mammary tumor-bearing mice.Q37413102
Anti-YKL-40 antibody and ionizing irradiation synergistically inhibit tumor vascularization and malignancy in glioblastomaQ37537572
YKL-40 Level and Hypertension Incidence: A Population-Based Nested Case-Control Study in ChinaQ37556137
Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.Q37599022
Combination of a STAT3 Inhibitor and an mTOR Inhibitor Against a Temozolomide-resistant Glioblastoma Cell LineQ37607921
Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 proteinQ37618668
YKL-40--an emerging biomarker in cardiovascular disease and diabetesQ37636543
Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis.Q37705125
Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor α2Q37705711
Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunityQ37734258
Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.Q37807414
Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodelingQ38294459
Increased expression of chitinase 3-like 1 in aorta of patients with atherosclerosis and suppression of atherosclerosis in apolipoprotein E-knockout mice by chitinase 3-like 1 gene silencingQ38367958
Role of chitinase-like proteins in cancer.Q38687563
YKL-40 promotes the migration and invasion of prostate cancer cells by regulating epithelial mesenchymal transitionQ38693620
YKL-40 protein in osteosarcoma tumor tissueQ38785342
CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysisQ38805517
Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression ProfilesQ38895007
MicroRNA-24 Modulates Staphylococcus aureus-Induced Macrophage Polarization by Suppressing CHI3L1.Q38902190
Diagnostic function of the neuroinflammatory biomarker YKL-40 in Alzheimer's disease and other neurodegenerative diseasesQ38915171
Role of chitinase 3-like-1 and semaphorin 7a in pulmonary melanoma metastasisQ38928339
YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell lineQ38993594
Evaluation of serum biomarkers of fibrosis and injury in Egyptian patients with chronic hepatitis C.Q38995256
Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular eventsQ35021964
IL-13Rα2 mediates PNR-induced migration and metastasis in ERα-negative breast cancerQ35064635
Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergyQ35083970
Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosisQ35121499
YKL-40 levels are independently associated with albuminuria in type 2 diabetesQ35130280
Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasiaQ35168063
Breast cancer expression of YKL-40 correlates with tumour grade, poor differentiation, and other cancer markersQ35527112
Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation.Q35530893
Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional studyQ35548928
Raised human cartilage glycoprotein-39 plasma levels in patients with rheumatoid arthritis and other inflammatory conditionsQ35549462
Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritisQ35549775
Two closely related human members of chitinase-like family, CHI3L1 and CHI3L2, activate ERK1/2 in 293 and U373 cells but have the different influence on cell proliferationQ35578736
YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancerQ35746711
Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasisQ35763932
Induction of proinflammatory mediators by CHI3L1 is reduced by chitin treatment: decreased tumor metastasis in a breast cancer modelQ35783730
Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancerQ35791353
CHI3L1 Is a Liver-Enriched, Noninvasive Biomarker That Can Be Used to Stage and Diagnose Substantial Hepatic FibrosisQ35802388
YKL-40 genetic polymorphisms and the risk of liver disease progression in patients with advanced fibrosis due to chronic hepatitis CQ35823055
Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.Q35828331
Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung diseaseQ36040475
Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohortQ36071742
Relationship of YKL-40 and adiponectin and subclinical atherosclerosis in asymptomatic patients with type 1 diabetes mellitus from a European Mediterranean population.Q36071889
Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytesQ36276352
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapyQ36414978
Role of Chitinase 3-Like-1 in Interleukin-18-Induced Pulmonary Type 1, Type 2, and Type 17 Inflammation; Alveolar Destruction; and Airway Fibrosis in the Murine LungQ36549088
Urinary chitinase 3-like protein 1 for early diagnosis of acute kidney injury: a prospective cohort study in adult critically ill patientsQ36570193
Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft functionQ36574753
Serum YKL-40 and colorectal cancer.Q36619099
Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancerQ36646351
The signaling mechanism of ROS in tumor progressionQ36679538
Is YKL-40 a new therapeutic target in cancer?Q36709555
YKL-40 expression in chronic obstructive pulmonary disease: relation to acute exacerbations and airway remodelingQ36725097
Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responsesQ36731284
Gene Encoding Chitinase 3-Like 1 Protein (CHI3L1) is a Putative OncogeneQ36735677
Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell lineQ38995753
Chitinase 3 like 1 is associated with tumor angiogenesis in cervical cancer.Q39009341
The chitinase-like protein YKL-40 increases mucin5AC production in human bronchial epithelial cellsQ39102021
The expression of chitinase 3-like 1: a novel prognostic predictor for hepatocellular carcinomaQ39176294
YKL-40 induces IL-8 expression from bronchial epithelium via MAPK (JNK and ERK) and NF-κB pathways, causing bronchial smooth muscle proliferation and migrationQ39235588
High expression of IL-13 receptor α2 in colorectal cancer is associated with invasion, liver metastasis, and poor prognosisQ39364301
Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.Q39497650
Silencing IL-13Rα2 promotes glioblastoma cell death via endogenous signalingQ39539596
Association between YKL-40 and adult primary astrocytomaQ39700712
YKL-40, a secreted glycoprotein, promotes tumor angiogenesisQ39797155
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responsesQ39797207
Diagnostic accuracy of serum hyaluronic acid, FIBROSpect II, and YKL-40 for discriminating fibrosis stages in chronic hepatitis C.Q39840925
YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophagesQ39938215
Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2.Q39950004
Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding proteinQ39980523
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinomaQ40252227
CHI3L1 overexpression is associated with metastasis and is an indicator of poor prognosis in papillary thyroid carcinomaQ40410464
CHI3L1 nuclear localization in monocyte derived dendritic cells.Q40432115
Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.Q40443893
Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary DiseaseQ40537192
YKL-40 as marker of severe lung disease in cystic fibrosis patients.Q40829237
Observationally and Genetically High YKL-40 and Risk of Venous Thromboembolism in the General Population: Cohort and Mendelian Randomization StudiesQ40847064
Serum YKL-40 in young patients with β-thalassemia major: Relation to hepatitis C virus infection, liver stiffness by transient elastography and cardiovascular complicationsQ40896469
Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1.Q40994644
YKL-40 acts as an angiogenic factor to promote tumor angiogenesisQ41073254
Human ovarian-carcinoma cell lines express IL-4 and IL-13 receptors: comparison between IL-4- and IL-13-induced signal transductionQ41133816
The Role of MicroRNA, miR-24, and Its Target CHI3L1 in Osteomyelitis Caused by Staphylococcus aureusQ41229601
The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alphaQ42050319
Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects.Q42241520
Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort studyQ42318966
Circulating miRNA-24 and its target YKL-40 as potential biomarkers in patients with coronary heart disease and type 2 diabetes mellitusQ42362647
The glial marker YKL-40 is decreased in synucleinopathiesQ42441318
Purification of guinea pig YKL40 and modulation of its secretion by cultured articular chondrocytesQ42456377
Serum YKL-40 Predicts Adverse Clinical Outcomes in Patients With Chronic Heart FailureQ42833961
Serum fibrosis markers can predict rapid fibrosis progression after liver transplantation for hepatitis C.Q42981171
Elevated pretreatment serum concentration of YKL-40-An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancerQ43011817
CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells.Q43053159
Increased YKL-40 expression in patients with carotid atherosclerosisQ43116827
YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes.Q43519963
Regulation of YKL-40 production by human articular chondrocytesQ43584273
Isolation and characterization of a Mr = 38,000 protein from differentiating smooth muscle cells.Q43669802
YKL-40 (cartilage gp-39) induces proliferative events in cultured chondrocytes and synoviocytes and increases glycosaminoglycan synthesis in chondrocytesQ43684361
Protective role of bortezomib in steatotic liver ischemia/reperfusion injury through abrogation of MMP activation and YKL-40 expression.Q43753094
Autoimmunity against YKL-39, a human cartilage derived protein, in patients with osteoarthritis.Q44076085
Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease.Q44520884
Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation.Q44559401
Identification of proteins secreted by human osteoblastic cells in cultureQ46128068
YKL-40 identified by proteomic analysis as a biomarker of sepsisQ46131458
Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cellsQ46383598
YKL-40 protein expression is not a prognostic marker in patients with primary breast cancer.Q46834467
Isolation and characterization of a novel 39 kilodalton whey protein from bovine mammary secretions collected during the nonlactating periodQ70372737
Serum YKL-40: A new potential marker of prognosis and location of métastases of patients with recurrent breast cancerQ71784066
Plasma YKL‐40, as a prognostic tumor marker in recurrent ovarian cancerQ73267495
YKL-40 in giant cells and macrophages from patients with giant cell arteritisQ73313545
The relationship between serum levels of YKL-40 and disease progression in patients with early rheumatoid arthritisQ73332383
Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritisQ73414197
Serum YKL-40 is increased in patients with hepatic fibrosisQ74012591
Chondrex: new marker of joint diseaseQ74338979
Expression of matrix metalloproteinases (MMP-2, MMP-9, MT1-MMP) and their inhibitors (TIMP-1, TIMP-2) in common epithelial tumors of the ovaryQ74339345
YKL-39, a human cartilage-related protein, induces arthritis in miceQ74423906
Serum YKL-40 levels in rheumatoid arthritis: correlations between clinical and laborarory parametersQ77489800
IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responsesQ77899699
The distribution of YKL-40 in osteoarthritic and normal human articular cartilageQ77918676
High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancerQ79157507
A CHI3L1 gene polymorphism is associated with serum levels of YKL-40, a novel sarcoidosis markerQ79607597
Intranasal administration of recombinant human cartilage glycoprotein-39. A phase I escalating cohort study in patients with rheumatoid arthritisQ80231508
Changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer are related to survivalQ80421964
Increased expression of the inflammatory protein YKL-40 in precancers of the breastQ80471046
Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasiaQ80482812
High serum YKL-40 level in patients with small cell lung cancer is related to early deathQ80997430
Determination of serum levels of YKL-40 and hyaluronic acid in patients with hepatic fibrosis due to schistosomiasis japonica and appraisal of their clinical valueQ81270235
High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemiaQ81639135
Expression of YKL-40 by peritumoral macrophages in human small cell lung cancerQ81648019
Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinomaQ82056996
Serum YKL-40 predicts relapse-free and overall survival in patients with American Joint Committee on Cancer stage I and II melanomaQ82161711
Increased serum YKL-40 and C-reactive protein levels are associated with angiographic lesion progression in patients with coronary artery diseaseQ82427800
YKL-40, a new biomarker of endothelial dysfunction, is independently associated with albuminuria in type 2 diabetic patientsQ82894776
Role of YKL-40 in bronchial smooth muscle remodeling in asthmaQ83334872
Increased expression of YKL-40, a chitinase-like protein, in serum and lung of patients with idiopathic pulmonary fibrosisQ83936030
YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin EQ83964900
YKL-40 secreted from adipose tissue inhibits degradation of type I collagenQ84375015
Faecal chitinase 3-like-1: a novel biomarker of disease activity in paediatric inflammatory bowel diseaseQ84781540
Elevated serum YKL-40 level predicts poor prognosis in hepatocellular carcinoma after surgeryQ84809583
Comparative study of YKL-40, S-100B and LDH as monitoring tools for Stage IV melanomaQ84943604
YKL‐40 and mast cells are associated with detrusor fibrosis in patients diagnosed with bladder pain syndrome/interstitial cystitis according to the 2008 criteria of the European Society for the Study of Interstitial CystitisQ85029171
A repertoire of biomarkers helps in detection and assessment of therapeutic response in epithelial ovarian cancerQ86558470
Allergen induced pulmonary inflammation enhances mammary tumor growth and metastasis: Role of CHI3L1Q86916023
Elevated Serum Concentration of Chitinase 3-Like 1 is an Independent Prognostic Biomarker for Poor Survival in Lung Cancer PatientsQ87192810
Elevated plasma YKL-40 as a prognostic indicator in patients with idiopathic pulmonary arterial hypertensionQ87579958
YKL-40 levels increase with declining ankle-brachial index and are associated with long-term cardiovascular mortality in peripheral arterial disease patientsQ88758492
Urine Markers of Kidney Tubule Cell Injury and Kidney Function Decline in SPRINT Trial Participants with CKDQ89947074
Prognosis and Reclassification by YKL-40 in Stable Coronary Artery DiseaseQ89958702
Chitinase-3-Like-1 Promotes M2 Macrophage Differentiation and Induces Choroidal Neovascularization in Neovascular Age-Related Macular DegenerationQ91054498
Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancerQ91236192
Serum YKL-40 level is associated with severity of interstitial lung disease and poor prognosis in dermatomyositis with anti-MDA5 antibodyQ91438069
Chitinase-3-like-1 deficiency attenuates ethanol-induced liver injury by inhibition of sterol regulatory element binding protein 1-dependent triglyceride synthesisQ92764096
Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanomaQ46926442
YKL-40 is elevated in morbidly obese patients and declines after weight loss.Q47176179
A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40.Q47254535
Chitinase 3-like-1 Promotes Intrahepatic Activation of Coagulation Through Induction of Tissue Factor in Mice.Q47291910
Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypassQ47410039
Mortality prediction in stable hemodialysis patients is refined by YKL-40, a 40-kDa glycoprotein associated with inflammation.Q47754245
YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophilsQ47756516
Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apneaQ47795736
Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic miceQ47855094
Interleukin-8 in cancer pathogenesis, treatment and follow-upQ47864505
Diagnostic and prognostic values of preoperative serum levels of YKL-40, HE-4 and DKK-3 in endometrial cancerQ47956315
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.Q48102914
Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human gliomaQ48523844
Diagnostic and prognostic value of preoperative combined GFAP, IGFBP-2, and YKL-40 plasma levels in patients with glioblastomaQ48595349
The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failureQ48736245
YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastomaQ48904499
CSF YKL-40 and pTau181 are related to different cerebral morphometric patterns in early AD.Q48939866
Chi3l1 regulates APAP-induced liver injury by promoting macrophage infiltrationQ92835126
Elevated plasma YKL-40 and risk of infectious disease: a prospective study of 94665 individuals from the general populationQ92877141
Comparison of chitinase-3-like protein 1, aspartate aminotransferase-to-platelet ratio index, and fibrosis-4 index with shear-wave elastographyQ93092398
P433issue1
P304page(s)201
P577publication date2020-09-14
P1433published inSignal Transduction and Targeted TherapyQ108821959
P1476titleChitinase-3 like-protein-1 function and its role in diseases
P478volume5

Reverse relations

Q106464187Multi-organ proteomic landscape of COVID-19 autopsiescites workP2860

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