IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex

scientific article published on 22 September 2020

IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex is …
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scholarly articleQ13442814

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P819ADS bibcode2020NatCo..11.4775D
P356DOI10.1038/S41467-020-18594-3
P698PubMed publication ID32963221

P50authorNeeraj N PatwardhanQ57173341
Srinivasa R PenumutchuQ59677896
Amanda E HargroveQ61305064
Gary BrewerQ88623974
Blanton S TolbertQ91023065
Jesse Davila-CalderonQ99608330
Liang-Yuan ChiuQ99608332
P2093author name stringMei-Ling Li
Zhengguo Cai
Andrew Sugarman
Srinivasa R Penutmutchu
P2860cites workConformational inhibition of the hepatitis C virus internal ribosome entry site RNAQ27490279
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mRNA decay factor AUF1 binds the internal ribosomal entry site of enterovirus 71 and inhibits virus replicationQ35215921
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HuR and Ago2 Bind the Internal Ribosome Entry Site of Enterovirus 71 and Promote Virus Translation and ReplicationQ35801650
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High-affinity interaction of hnRNP A1 with conserved RNA structural elements is required for translation and replication of enterovirus 71.Q37360738
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HnRNP A1 Alters the Structure of a Conserved Enterovirus IRES Domain to Stimulate Viral Translation.Q40155463
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Local RNA flexibility perturbation of the IRES element induced by a novel ligand inhibits viral RNA translationQ41211794
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Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR.Q54156199
Characterization of Hepatitis C Virus IRES Quasispecies - From the Individual to the Pool.Q54217646
Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved.Q54378546
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P433issue1
P304page(s)4775
P577publication date2020-09-22
P1433published inNature CommunicationsQ573880
P1476titleIRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
P478volume11

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