Galectin-3 gene deletion results in defective adipose tissue maturation and impaired insulin sensitivity and glucose homeostasis

scientific article published on 18 November 2020

Galectin-3 gene deletion results in defective adipose tissue maturation and impaired insulin sensitivity and glucose homeostasis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41598-020-76952-Z
P932PMC publication ID7675972
P698PubMed publication ID33208796

P2093author name stringSaverio Cinti
Giuseppe Pugliese
Stefano Menini
Martina Vitale
Andrea Giaccari
Carla Iacobini
Claudia Blasetti Fantauzzi
Teresa Mezza
Gian Pio Sorice
P2860cites workAdipose tissue plasticity: how fat depots respond differently to pathophysiological cuesQ26753066
Role of Galectin-3 in Obesity and Impaired Glucose HomeostasisQ26771826
Galectin-3 is a new MerTK-specific eat-me signalQ33972695
Effect of 8 weeks of overfeeding on ectopic fat deposition and insulin sensitivity: testing the "adipose tissue expandability" hypothesisQ34219418
Molecular insights into the role of white adipose tissue in metabolically unhealthy normal weight and metabolically healthy obese individualsQ34448725
Inflammation, metaflammation and immunometabolic disordersQ34550852
Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO miceQ34603941
Subcutaneous adipose cell size and distribution: relationship to insulin resistance and body fatQ35130591
Critical role of galectin-3 in phagocytosis by macrophagesQ35169042
Role of galectin-3 in diabetic nephropathyQ35182376
Abdominal obesity: a marker of ectopic fat accumulationQ35720154
Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetesQ35842591
Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis.Q37076498
Interleukin-6 and insulin resistanceQ37403996
Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanismQ37413810
What we talk about when we talk about fat.Q37601812
Adiposopathy is "sick fat" a cardiovascular disease?Q37890583
Adipogenesis: from stem cell to adipocyteQ37998565
Ectopic fat and cardiometabolic and vascular risk.Q38142395
Galectin-3: an emerging all-out player in metabolic disorders and their complicationsQ38258947
Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory functionQ38317758
Expression of interleukin-6 is greater in preadipocytes than in adipocytes of 3T3-L1 cells and C57BL/6J and ob/ob miceQ38335831
Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitusQ39197051
Inflammation in subcutaneous adipose tissue: relationship to adipose cell size.Q39940257
Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic isletsQ40944709
Time course of histomorphological changes in adipose tissue upon acute lipoatrophyQ42042214
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscleQ42135596
Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance.Q42805774
Galectin-3 activates PPARγ and supports white adipose tissue formation and high-fat diet-induced obesity.Q42834230
Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetesQ43143653
Galectin-3 ablation protects mice from diet-induced NASH: a major scavenging role for galectin-3 in liver.Q45052723
How obesity causes diabetes: not a tall taleQ45232061
FL-926-16, a novel bioavailable carnosinase-resistant carnosine derivative, prevents onset and stops progression of diabetic nephropathy in db/db miceQ46279581
Relative contribution of glycogenolysis and gluconeogenesis to hepatic glucose production in control and diabetic rats. A re-examination in the presence of euglycaemia.Q51570788
The advanced glycation end-product Nϵ -carboxymethyllysine promotes progression of pancreatic cancer: implications for diabetes-associated risk and its prevention.Q51740842
Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue.Q53576992
Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytesQ80010792
Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesisQ80430041
Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for ManagementQ88182023
Adipose Organ Development and RemodelingQ91446295
P433issue1
P304page(s)20070
P577publication date2020-11-18
P1433published inScientific ReportsQ2261792
P1476titleGalectin-3 gene deletion results in defective adipose tissue maturation and impaired insulin sensitivity and glucose homeostasis
P478volume10

Search more.