Galectin-3: an emerging all-out player in metabolic disorders and their complications

scientific article

Galectin-3: an emerging all-out player in metabolic disorders and their complications is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1093/GLYCOB/CWU111
P698PubMed publication ID25303959
P5875ResearchGate publication ID266745262

P50authorGiuseppe PuglieseQ37382959
Stefano MeniniQ43252011
P2093author name stringCarla Iacobini
Carlo M Pesce
P2860cites workHuman galectin-3 is a novel chemoattractant for monocytes and macrophagesQ22254736
Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapseQ24309257
Expression of galectin-3 modulates T-cell growth and apoptosisQ24309392
Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cellsQ24530074
Galectin-3 regulates myofibroblast activation and hepatic fibrosisQ24546358
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3Q24624887
Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosisQ24649584
N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectinQ24651908
Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cellsQ28138960
Intracellular functions of galectinsQ28201120
SR proteins and galectins: what's in a name?Q28286108
Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver diseaseQ28534290
Epsilon BP, a beta-galactoside-binding animal lectin, recognizes IgE receptor (Fc epsilon RI) and activates mast cellsQ28572966
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3Q28574963
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesityQ29617380
Composition of the stable carotid plaque: insights from a multidetector computed tomography study of plaque volumeQ30434380
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylationQ32058522
Impaired retinal angiogenesis in diabetes: role of advanced glycation end products and galectin-3.Q45285377
Advanced lipoxidation end-products mediate lipid-induced glomerular injury: role of receptor-mediated mechanisms.Q46067855
Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophilsQ46320323
Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice.Q46323175
Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammationQ46442221
At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end productsQ46450292
A Role for galectin-3 in renal tissue damage triggered by ischemia and reperfusion injuryQ46461255
Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice.Q46471398
CD36 is not involved in scavenger receptor-mediated endocytic uptake of glycolaldehyde- and methylglyoxal-modified proteins by liver endothelial cellsQ46535587
The galectin-3/RAGE dyad modulates vascular osteogenesis in atherosclerosisQ47703344
Regulation of cellular adhesion to extracellular matrix proteins by galectin-3.Q47999828
Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms.Q48024001
Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant StressQ50180621
Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice.Q52574179
Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue.Q53576992
Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriersQ57274173
Grand challenges in chronic non-communicable diseasesQ59055681
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infectionQ59068486
Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention TrialQ44459441
Galectin-3 ablation protects mice from diet-induced NASH: a major scavenging role for galectin-3 in liver.Q45052723
N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cellsQ45178590
Galectin-3 is a new MerTK-specific eat-me signalQ33972695
Inflammation: the link between insulin resistance, obesity and diabetesQ34286695
Advanced protein glycosylation in diabetes and agingQ34298835
Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesisQ34316944
Galectins as modulators of cell adhesionQ34346487
Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunctionQ34364121
Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound studyQ34370169
Osteoblast and chondroblast differentiation.Q34373196
Galectins as modulators of tumour progressionQ34381235
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responsesQ34387881
Galectin-3: an open-ended storyQ34494555
Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosisQ34501897
Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cellsQ34563122
Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO miceQ34603941
T-cell growth, cell surface organization, and the galectin-glycoprotein latticeQ34691040
Identification of galectin-3 as a factor in pre-mRNA splicingQ34706659
The regulation of inflammation by galectin-3.Q34991925
Pathology of the thin-cap fibroatheroma: a type of vulnerable plaqueQ35151273
Critical role of galectin-3 in phagocytosis by macrophagesQ35169042
Role of galectin-3 in diabetic nephropathyQ35182376
Transcriptional analysis of the endothelial response to diabetes reveals a role for galectin-3.Q35553234
Regulation of cellular homeostasis by galectinsQ35646643
Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.Q35809897
Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammationQ36069797
Understanding RAGE, the receptor for advanced glycation end productsQ36245387
Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgroundsQ36296729
Galectin-3 gene inactivation reduces atherosclerotic lesions and adventitial inflammation in ApoE-deficient miceQ36357458
Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patientsQ36727795
In vivo analysis of Wnt signaling in boneQ36774960
Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors.Q36887564
The mucopolysaccharidoses: a success of molecular medicine.Q37059193
Oxidation-specific epitopes are important targets of innate immunityQ37138021
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.Q37400702
Adaptive regulation at the cell surface by N-glycosylation.Q37598972
Metabolism, cell surface organization, and diseaseQ37671886
A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?Q37995073
Epidemiology of diabetic kidney diseaseQ38071780
Cross-linking of galectin 3, a galactose-binding protein of mammalian cells, by tissue-type transglutaminaseQ38298480
S-type mammalian lectins in allergic inflammationQ38315519
Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory functionQ38317758
L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativityQ38322449
Galectin-3 stimulates cell proliferationQ38330513
Role of the carboxyl-terminal lectin domain in self-association of galectin-3.Q38338168
Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexesQ38346878
Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infectedQ38362263
Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-EpithelializationQ38978059
Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient miceQ39191329
A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in ratsQ39915429
Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV.Q39937520
111In-labeled galectin-3-targeting peptide as a SPECT agent for imaging breast tumorsQ39991883
Regulation of alternative macrophage activation by galectin-3.Q40016366
Contributions of galectin-3 and -9 to epithelial cell adhesion analyzed by single cell force spectroscopyQ40098307
Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.Q40147884
Implication of galectin-3 in Wnt signaling.Q40427814
Characterisation of the advanced glycation endproduct receptor complex in the retinal pigment epitheliumQ40477757
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.Q40508811
Galectin-3, a novel binding partner of beta-cateninQ40514776
Expression of galectin-3 in skeletal tissues is controlled by Runx2.Q40668407
The family of metazoan metal-independent beta-galactoside-binding lectins: structure, function and molecular evolutionQ40860039
Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic isletsQ40944709
Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproductsQ41009444
Galectin-3 gene (LGALS3) expression in experimental atherosclerosis and cultured smooth muscle cells.Q41020090
Hepatic expression of galectin-3 and receptor for advanced glycation end products in patients with liver diseaseQ41134548
Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function.Q42046253
Endocytic uptake of advanced glycation end products by mouse liver sinusoidal endothelial cells is mediated by a scavenger receptor distinct from the macrophage scavenger receptor class A.Q42158174
Galectin-3/AGE-receptor 3 knockout mice show accelerated AGE-induced glomerular injury: evidence for a protective role of galectin-3 as an AGE receptorQ42467384
The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression.Q42491067
Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes.Q42767408
Specific siRNA targeting the receptor for advanced glycation end products inhibits experimental hepatic fibrosis in ratsQ43187791
Serum galectin-3 is elevated in obesity and negatively correlates with glycosylated hemoglobin in type 2 diabetesQ43191933
Do advanced glycation end products contribute to the development of long-term diabetic complications?Q43458994
Efficacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto ratsQ43508619
Accelerated diabetic glomerulopathy in galectin-3/AGE receptor 3 knockout mice.Q43786750
Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis - amelioration by liver transplantation.Q43862536
Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathwaysQ44368608
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)136-150
P577publication date2014-10-09
P1433published inGlycobiologyQ5572596
P1476titleGalectin-3: an emerging all-out player in metabolic disorders and their complications
P478volume25

Reverse relations

cites work (P2860)
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