Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation

scientific article

Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1093/GLYCOB/CWI053
P8608Fatcat IDrelease_ftyzyyxklndc7gj3qaetbboaoy
P698PubMed publication ID15764591

P50authorKevan C HeroldQ87494800
Ann Marie SchmidtQ89261684
P2093author name stringRavichandran Ramasamy
Shi Fang Yan
Susan J Vannucci
Shirley Shi Du Yan
P2860cites workAge-dependent accumulation of advanced glycation end-products in adult Drosophila melanogaster.Q52563298
A redox-triggered ras-effector interaction. Recruitment of phosphatidylinositol 3'-kinase to Ras by redox stress.Q54582355
Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastasesQ59084980
Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathwaysQ22010208
RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptidesQ22010236
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosisQ22254188
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's diseaseQ24314906
Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infectionQ24317377
Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamilyQ24558912
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) GroupQ27860882
HMG-1 as a late mediator of endotoxin lethality in miceQ28139166
S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE)Q28184570
Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycationQ28187673
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamineQ28189831
The S100 family of EF-hand calcium-binding proteins: functions and pathologyQ28284255
The S100 protein family: history, function, and expressionQ28293937
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteinsQ28378989
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsQ28509783
The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous systemQ28567291
Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cellsQ28570142
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytesQ28574795
N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expressionQ28645594
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathyQ29012485
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein EQ29615236
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageQ29616101
S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional rolesQ29620465
Randomized trial of an inhibitor of formation of advanced glycation end products in diabetic nephropathyQ30312025
In vitro formation of N(epsilon)-(carboxymethyl)lysine and imidazolones under conditions similar to continuous ambulatory peritoneal dialysisQ31856845
Role of advanced glycation end products in aging collagen. A scanning force microscope study.Q32056302
Protein glycation, diabetes, and agingQ32120059
Neurotoxicity of advanced glycation end-products for cultured cortical neuronsQ33181556
The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammationQ33853348
S100 proteins in Corpora amylacea from normal human brain.Q33904267
How does glucose generate oxidative stress in peripheral nerve?Q34146338
Relation between serum 3-deoxyglucosone and development of diabetic microangiopathyQ34199766
The role of AGEs in aging: causation or correlationQ34348813
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathyQ34388076
Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female miceQ34430361
Increased risk of type 2 diabetes in Alzheimer diseaseQ44745172
N epsilon-carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease.Q44863326
Evidence of preferential protein targets for age-related modifications in peripheral blood lymphocytesQ44972982
Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injuryQ46535314
Blockade of late stages of autoimmune diabetes by inhibition of the receptor for advanced glycation end productsQ47231228
Advanced glycation end products modulate the maturation and function of peripheral blood dendritic cellsQ47433201
High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritisQ47850293
Age associated changes of AGE-receptor expression: RAGE upregulation is associated with human heart dysfunctionQ47908374
Stroke and the risk of Alzheimer diseaseQ48115889
Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant StressQ50180621
Hyperinsulinemia and risk of Alzheimer disease.Q51526824
Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic miceQ34432623
Advanced glycoxidation end products in commonly consumed foodsQ34549688
The Maillard hypothesis on aging: time to focus on DNA.Q34614549
Central role of RAGE-dependent neointimal expansion in arterial restenosisQ34890522
The biology of senescence: potential for prevention of diseaseQ34993296
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular diseaseQ35039895
Glycation products and the pathogenesis of diabetic complicationsQ35594899
Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stressQ35664175
Crosslink breakers: a new approach to cardiovascular therapyQ35817743
Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetesQ35838612
Protein glycation: a firm link to endothelial cell dysfunctionQ35857303
Fructose-mediated non-enzymatic glycation: sweet coupling or bad modificationQ35877294
Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.Q37308593
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.Q37363088
Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diaQ38292287
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive functionQ38422040
The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amylQ39770000
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic miceQ40251711
Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end productsQ40304611
Glycation-induced inactivation of NADP(+)-dependent isocitrate dehydrogenase: implications for diabetes and agingQ40495631
Binding of receptor for advanced glycation end products (RAGE) ligands is not sufficient to induce inflammatory signals: lack of activity of endotoxin-free albumin-derived advanced glycation end productsQ40558928
Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell linesQ40605303
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 proteinQ40609759
Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous systemQ40668935
Improved arterial compliance by a novel advanced glycation end-product crosslink breakerQ40684856
Receptor for advanced glycation end products (RAGE) signaling induces CREB-dependent chromogranin expression during neuronal differentiationQ40712159
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune responseQ40899986
Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproductsQ41009444
Beta 2-microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblastsQ41045340
Diabetes and cardiovascular disease. The Framingham studyQ41509493
Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutaseQ41815238
RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-alpha and NF-kappaBQ41853060
Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice.Q41893958
The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitmentQ42037633
RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathyQ42263637
Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end productsQ42440103
N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reactionQ42555798
Evidence for non-enzymatic glycosylation in Escherichia coliQ43544090
Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E-null mice.Q43633661
RAGE and arthritis: the G82S polymorphism amplifies the inflammatory responseQ44032299
Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse.Q44043194
Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's diseaseQ44059260
Plasma 3-deoxyglucosone elevation in chronic renal failure is associated with increased aldose reductase in erythrocytesQ44117979
Accumulation of imidazolone, pentosidine and N(epsilon)-(carboxymethyl)lysine in hippocampal CA4 pyramidal neurons of aged human brainQ44198123
RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice.Q44228474
Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementiaQ44260190
Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patientsQ44321459
The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic controlQ44545480
Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell deathQ44559324
Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administrationQ44745040
P433issue7
P921main subjectneurodegenerationQ1755122
P304page(s)16R-28R
P577publication date2005-03-10
P1433published inGlycobiologyQ5572596
P1476titleAdvanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation
P478volume15

Reverse relations

cites work (P2860)
Q482742806-Nitroazolo[1,5-a]pyrimidin-7(4H)-ones as Antidiabetic Agents.
Q40516938A monoclonal antibody against the receptor for advanced glycation end products attenuates inflammatory and neuropathic pain in the mouse
Q38056179A review of recent advances and current hypotheses on the pathogenesis of acute laminitis
Q64946819A study on hepatopathic, dyslipidemic and immunogenic properties of fructosylated-HSA-AGE and binding of autoantibodies in sera of obese and overweight patients with fructosylated-HSA-AGE.
Q38766433AGE-RAGE interaction in the TGFβ2-mediated epithelial to mesenchymal transition of human lens epithelial cells
Q36427785AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression
Q33886522AGEs decrease insulin synthesis in pancreatic β-cell by repressing Pdx-1 protein expression at the post-translational level
Q53542852Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.
Q52091458Accumulation of methylglyoxal increases the advanced glycation end-product levels in DRG and contributes to lumbar disk herniation-induced persistent pain.
Q46319121Activation of AMPK is neuroprotective in the oxidative stress by advanced glycosylation end products in human neural stem cells
Q27667822Advanced Glycation End Product Recognition by the Receptor for AGEs
Q90139165Advanced Glycation End Products (AGEs), Receptor for AGEs, Diabetes, and Bone: Review of the Literature
Q36578536Advanced Glycation End Products Induce Obesity and Hepatosteatosis in CD-1 Wild-Type Mice
Q59662238Advanced Glycation End Products and Risks for Chronic Diseases: Intervening Through Lifestyle Modification
Q38254631Advanced Glycation End Products, Inflammation, and Chronic Metabolic Diseases: Links in a Chain?
Q28551744Advanced Glycation Endproducts and Bone Material Properties in Type 1 Diabetic Mice
Q36915810Advanced glycation and lipoxidation end products--amplifiers of inflammation: the role of food.
Q38995799Advanced glycation end products (AGE) potentiates cell death in p53 negative cells via upregulaion of NF-kappa B and impairment of autophagy
Q41682122Advanced glycation end products (AGEs) activate mast cells
Q35273098Advanced glycation end products (AGEs) and their receptor (RAGE) induce apoptosis of periodontal ligament fibroblasts
Q36996149Advanced glycation end products (AGEs) promote melanogenesis through receptor for AGEs.
Q58029351Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor
Q42180745Advanced glycation end products induce endothelial-to-mesenchymal transition via downregulating Sirt 1 and upregulating TGF-β in human endothelial cells
Q58805414Advanced glycation end products induce neural tube defects through elevating oxidative stress in mice
Q33686550Advanced glycation end products influence oral cancer cell survival via Bcl-xl and Nrf-2 regulation in vitro
Q43720885Advanced glycation end products inhibit the expression of collagens type I and III by human gingival fibroblasts
Q35093747Advanced glycation end products, soluble receptor for advanced glycation end products, and risk of colorectal cancer
Q36643573Advanced glycation end products: Key players in skin aging?
Q38405889Advanced glycation endproducts in horses with insulin-induced laminitis
Q34350918Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation.
Q28570411Age-related alterations in retinal neurovascular and inflammatory transcripts
Q49210690Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system.
Q34545820Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans
Q53763737Aliskiren attenuates bleomycin-induced pulmonary fibrosis in rats: focus on oxidative stress, advanced glycation end products, and matrix metalloproteinase-9.
Q92346511Almond-supplemented diet improves sexual functions beyond Phosphodiesterase-5 inhibition in diabetic male rats
Q54474275Altered bone material properties in HLA-B27 rats include reduced mineral to matrix ratio and altered collagen cross-links.
Q52680307Ameliorative effects of taurine against diabetes: a review.
Q45776839Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging
Q28581962An aqueous orally active vaccine targeted against a RAGE/AB complex as a novel therapeutic for Alzheimer's disease
Q43099572Antiglycative activity of sulforaphane: a new avenue to counteract neurodegeneration?
Q35881127Arg354 in the catalytic centre of bovine liver catalase is protected from methylglyoxal-mediated glycation.
Q37315520Association of diabetes with amnestic and nonamnestic mild cognitive impairment
Q54417809Association of polymorphisms in the RAGE gene with serum CRP levels and coronary artery disease in the Chinese Han population.
Q45004079Association of the glycoxidative stress marker pentosidine with equine laminitis.
Q39149192Attenuation of Diabetic Conditions by Sida rhombifolia in Moderately Diabetic Rats and Inability to Produce Similar Effects in Severely Diabetic in Rats
Q92438095Attenuation of diabetic kidney injury in DPP4-deficient rats; role of GLP-1 on the suppression of AGE formation by inducing glyoxalase 1
Q39727356Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia.
Q37266352Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats
Q92545350Brain microstructural abnormalities in type 2 diabetes mellitus: A systematic review of diffusion tensor imaging studies
Q64903301C. elegans-An Emerging Model to Study Metal-Induced RAGE-Related Pathologies.
Q52939905CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction.
Q91780151Cardiac Autonomic Neuropathy in Diabetes Mellitus
Q37598878Cardiac autonomic neuropathy in patients with diabetes mellitus.
Q40361355Cardiovascular dementia - a different perspective
Q64271593Carnosine improves diabetic retinopathy via the MAPK/ERK pathway
Q58723324Case-control studies of gene-environment interactions. When a case might not be the case
Q37934954Cell signaling and receptors in toxicity of advanced glycation end products (AGEs): α-dicarbonyls, radicals, oxidative stress and antioxidants
Q36687957Cellular mechanisms and signalling pathways activated by high glucose and AGE-albumin in the aortic endothelium
Q89551719Characterization and Antioxidant Activity of Collagen, Gelatin, and the Derived Peptides from Yellowfin Tuna (Thunnus albacares) Skin
Q36431831Characterization of blood oxidative stress in type 2 diabetes mellitus patients: increase in lipid peroxidation and SOD activity.
Q41335123Characterization of stress and methylglyoxal inducible triose phosphate isomerase (OscTPI) from rice
Q40100612Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling
Q36735682Clinical study of advanced glycation end products in egyptian diabetic obese and non-obese patients
Q55003432Comparative metabolomics of aging in a long-lived bat: Insights into the physiology of extreme longevity.
Q52647791Conflicting Effects of Methylglyoxal and Potential Significance of miRNAs for Seizure Treatment.
Q36458415Contribution of dietary advanced glycation end products (AGE) to circulating AGE: role of dietary fat
Q38034382Corn silk (Stigma maydis) in healthcare: a phytochemical and pharmacological review.
Q38261279Coumarin derivatives: an updated patent review (2012-2014).
Q38150990Critical role of RAGE in lung physiology and tumorigenesis: a potential target of therapeutic intervention?
Q37602130Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease
Q30575300D-ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation
Q35558632DAMPs, ageing, and cancer: The 'DAMP Hypothesis'.
Q36724350Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology
Q38430098Deoxycholic acid-modified polyethylenimine based nanocarriers for RAGE siRNA therapy in acute myocardial infarction
Q34607563Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens
Q35053820Diabetes and periodontitis
Q43039163Diabetic maculopathy and retinopathy. Functional and sociomedical significance
Q37405521Diabetic myopathy: impact of diabetes mellitus on skeletal muscle progenitor cells
Q52658260Diabetic neuropathy and the sensory neuron: New aspects of pathogenesis and their treatment implications.
Q33554384Diabetic neuropathy: mechanisms to management
Q39344658Diabetic retinopathy and dysregulated innate immunity
Q39427655Dietary Advanced Glycation End Products and Cardiometabolic Risk
Q33616732Dietary Metabolites and Chronic Kidney Disease
Q34706565Dietary consumption of advanced glycation end products and pancreatic cancer in the prospective NIH-AARP Diet and Health Study
Q30484885Dissociation of functional status from accrual of CML and RAGE in the aged mouse brain.
Q34609989Does senescence give rise to disease?
Q85893933Dual effect of advanced glycation end products in pancreatic islet apoptosis
Q40765921Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats
Q57165904Effect of a Shoulder Movement Intervention on Joint Mobility, Pain, and Disability in People With Diabetes: A Randomized Controlled Trial
Q42547772Effect of advanced glycation end products on oxidative stress and senescence of trabecular meshwork cells
Q35600704Effect of advanced glycosylation end products on apoptosis in human adipose tissue-derived stem cells in vitro
Q36495940Effect of high advanced glycation end-product diet on pulmonary inflammatory response and pulmonary function following gastric aspiration
Q46363812Effect of long-term maternal smoking on the offspring's lung health
Q46810886Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats
Q36360786Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome.
Q34987953Evidence that serum levels of the soluble receptor for advanced glycation end products are inversely associated with pancreatic cancer risk: a prospective study
Q38125149Exercise and type 1 diabetes (T1DM).
Q36826961Expression and function of psoriasin (S100A7) and koebnerisin (S100A15) in the brain
Q36494499Feeding our immune system: impact on metabolism
Q50249544Formation and elimination of pyrraline in the Maillard reaction in a saccharide-lysine model system
Q38258947Galectin-3: an emerging all-out player in metabolic disorders and their complications
Q51766190Gene and protein expression of CXCR4 in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations.
Q34868867Glycation and oxidative stress in the failure of dental implants: a case series
Q36724696Glycation does not modify bovine serum albumin (BSA)-induced reduction of rat aortic relaxation: the response to glycated and nonglycated BSA is lost in metabolic syndrome.
Q92017934Glycation in Huntington's Disease: A Possible Modifier and Target for Intervention
Q39666734Glycolaldehyde-modified β-lactoglobulin AGEs are unable to stimulate inflammatory signaling pathways in RAGE-expressing human cell lines
Q46665032Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in experimental rat model
Q38448137Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia
Q28829321Highlighting the impact of aging on type I collagen: label-free investigation using confocal reflectance microscopy and diffuse reflectance spectroscopy in 3D matrix model
Q33928779Hyperinsulinemia Down-Regulates TLR4 Expression in the Mammalian Heart.
Q37305013IL-1β, RAGE and FABP4: targeting the dynamic trio in metabolic inflammation and related pathologies
Q57110548Immunomodulation by Processed Animal Feed: The Role of Maillard Reaction Products and Advanced Glycation End-Products (AGEs)
Q39368611Impact of Non-Enzymatic Glycation in Neurodegenerative Diseases: Role of Natural Products in Prevention.
Q92820179Impact of mesenchymal stem cell senescence on inflammaging
Q45893258Impaired slow axonal transport in diabetic peripheral nerve is independent of RAGE.
Q24337632In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE)
Q42786914In-vivo evidence that high mobility group box 1 exerts deleterious effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and Parkinson's disease which can be attenuated by glycyrrhizin
Q41819713Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide
Q41539966Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives
Q38736612Inhibition of tumor suppressor p53 preserves glycation-serum induced pancreatic beta-cell demise
Q35607690Inhibitory effect of Clitoria ternatea flower petal extract on fructose-induced protein glycation and oxidation-dependent damages to albumin in vitro
Q46799102Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages
Q41789363Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy
Q34728267Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies
Q84987537Is there any association between GLY82 ser polymorphism of rage gene and Turkish diabetic and non diabetic patients with coronary artery disease?
Q38004236Ischemia-induced hyperglycemia: consequences, neuroendocrine regulation, and a role for RAGE.
Q46468830Key role of Src kinase in S100B-induced activation of the receptor for advanced glycation end products in vascular smooth muscle cells
Q50993769Levetiracetam ameliorates ovarian function in streptozotocin-induced diabetic rats.
Q33680171Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging
Q41367811Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway
Q42089443Measurement of Lens Autofluorescence for Diabetes Screening
Q80675900Measurement of advanced glycation endproducts in skin of patients with rheumatoid arthritis, osteoarthritis, and dialysis-related spondyloarthropathy using non-invasive methods
Q35687287Mechanisms of brain aging regulation by insulin: implications for neurodegeneration in late-onset Alzheimer's disease
Q34553052Mechanisms of disease: the oxidative stress theory of diabetic neuropathy
Q51074865Mesenchymal stem cells protects hyperoxia-induced lung injury in newborn rats via inhibiting receptor for advanced glycation end-products/nuclear factor κB signaling.
Q39313466Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells
Q35063131Methylglyoxal, the dark side of glycolysis
Q48178370Methylglyoxal-induced cytotoxicity in neonatal rat brain: a role for oxidative stress and MAP kinases
Q38253187MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis
Q27315179Microglial AGE-albumin is critical in promoting alcohol-induced neurodegeneration in rats and humans
Q35163077Modeling the interaction between quinolinate and the receptor for advanced glycation end products (RAGE): relevance for early neuropathological processes
Q87939347Modified Si-Miao-San ameliorates pancreatic B cell dysfunction by inhibition of reactive oxygen species-associated inflammation through AMP-kinase activation
Q48622926Molecular mechanisms of the antiglycative and cardioprotective activities of Psidium guajava leaves in the rat diabetic myocardium
Q38096444Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products.
Q35165597Morphological Changes and Immunohistochemical Expression of RAGE and its Ligands in the Sciatic Nerve of Hyperglycemic Pig (Sus Scrofa)
Q36139958Mouse RAGE Variant 4 Is a Dominant Membrane Receptor that Does Not Shed to Generate Soluble RAGE.
Q37459539Musculoskeletal Impairments Are Often Unrecognized and Underappreciated Complications From Diabetes
Q35865399Natural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets.
Q54944546Networks of blood proteins in the neuroimmunology of schizophrenia.
Q38246170New insights in (inter)cellular mechanisms by heart failure with preserved ejection fraction
Q51186905Nitrite-induced cross-linking alters remodeling and mechanical properties of collagenous engineered tissues.
Q38700889Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation.
Q37217856Novel potential mechanisms for diabetic macular edema: leveraging new investigational approaches
Q37729841Nutrients and the Pancreas: An Epigenetic Perspective
Q37261237Oat Protects against Diabetic Nephropathy in Rats via Attenuating Advanced Glycation End Products and Nuclear Factor Kappa B.
Q53066000Overexpression of RAGE contributes to cigarette smoke-induced nitric oxide generation in COPD.
Q35833994Oxidative stress in aging human skin
Q89579244PANEV: an R package for a pathway-based network visualization
Q34592806PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability
Q26796268Parainflammation, chronic inflammation, and age-related macular degeneration
Q37108641Periodontal disease: associations with diabetes, glycemic control and complications
Q91949654Persistent organic pollutants (POPs) increase rage signaling to promote downstream cardiovascular remodeling
Q41880812Pharmacokinetics and lung distribution of a humanized anti-RAGE antibody in wild-type and RAGE-/-mice
Q43685598Phytochemical constituents of Mongolian traditional medicinal plants, Chamaerhodos erecta and C. altaica, and its constituents prevents the extracellular matrix degradation factors
Q49117467Plasma carnosine, but not muscle carnosine, attenuates high-fat diet-induced metabolic stress
Q35670850Polyphenols and human health: prevention of disease and mechanisms of action
Q38698313Potential of Dietary Non-Provitamin A Carotenoids in the Prevention and Treatment of Diabetic Microvascular Complications
Q33608632Precursor of advanced glycation end products mediates ER-stress-induced caspase-3 activation of human dermal fibroblasts through NAD(P)H oxidase 4
Q51246577Predictors for Gingival Index in Middle-Aged Asian Indians with Type 2 Diabetes from South India: A Cross-Sectional Observational Study.
Q36825616Protection effect of endomorphins on advanced glycation end products induced injury in endothelial cells
Q64099255Protective Effects of Kaempferol on D-Ribose-Induced Mesangial Cell Injury
Q43049148Protective role of salidroside against aging in a mouse model induced by D-galactose.
Q28578850Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: potential vulnerability to oxidative stress
Q33301686Proteomics in pediatric research and practice
Q37152947RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation.
Q26744630RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
Q60732952RAGE Gene Polymorphisms in Patients with Multiple Sclerosis
Q89484239RAGE and Its Ligands: Molecular Interplay Between Glycation, Inflammation, and Hallmarks of Cancer-a Review
Q37199673RAGE mRNA expression and its correlation with nuclear factor kappa beta mRNA expression in inflamed human periradicular tissues
Q33520403RAGE supports parathyroid hormone-induced gains in femoral trabecular bone
Q37384331Receptor for AGE (RAGE) and its ligands-cast into leading roles in diabetes and the inflammatory response
Q37685213Receptor for advanced glycation end as drug targets in diabetes-induced skin lesion
Q38234624Receptor for advanced glycation end products (RAGE) and its ligands: focus on spinal cord injury
Q33841564Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer's disease
Q41926813Receptor for advanced glycation end products: fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis
Q39397658Rehmannia glutinosa suppresses inflammatory responses elicited by advanced glycation end products
Q54060443Relationship between RAGE gene polymorphisms and cardiovascular disease prognosis in the Chinese Han population.
Q54889072Relationship of shoulder activity and skin intrinsic fluorescence with low level shoulder pain and disability in people with type 2 diabetes.
Q90633592Relationships of diabetes and hyperglycaemia with intraocular pressure in a Japanese population: the JPHC-NEXT Eye Study
Q35896615Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy
Q27004644Role of methylglyoxal in Alzheimer's disease
Q37219745Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice
Q54311344Rosiglitazone modulates the behaviors of diabetic host-derived fibroblasts in a carboxymethyllysine-modified collagen model.
Q33595290Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end products
Q37354472S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis
Q42866173STR/ort mice, a model for spontaneous osteoarthritis, exhibit elevated levels of both local and systemic inflammatory markers
Q39015617Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis
Q42859517Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo
Q43217889Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers
Q35601343Selective Inhibition on RAGE-binding AGEs Required by Bioactive Peptide Alpha-S2 Case in Protein from Goat Ethawah Breed Milk: Study of Biological Modeling
Q37300540Senescence-dependent impact of anti-RAGE antibody on endotoxemic liver failure
Q37663816Sequential abnormalities in type 1 diabetic encephalopathy and the effects of C-Peptide
Q51127315Serum Fluorescent Advanced Glycation End (F-AGE) products in gestational diabetes patients.
Q50624062Severity of Type 2 Diabetes, Cognitive Function, and Self-Care.
Q35071085Skin autofluorescence is associated with the progression of chronic kidney disease: a prospective observational study
Q45090317Soluble receptor for advanced glycation end products alleviates nephritis in (NZB/NZW)F1 mice
Q51700919Soluble receptor for advanced glycation end products in multiple sclerosis: a potential marker of disease severity.
Q37865409Special issues in the management and selection of the donor for lung transplantation
Q24322846Structural and functional insights into RAGE activation by multimeric S100B
Q38904883Sweet old memories: a review of the experimental models of the association between diabetes, senility and dementia
Q39018573Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation
Q36154554Targeting AGEs Signaling Ameliorates Central Nervous System Diabetic Complications in Rats
Q55088424Targeting glucose metabolism for healthy aging.
Q38686477Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective.
Q36970069The Association of -429T>C and -374T>A Polymorphisms in the RAGE Gene with Polycystic Ovary Syndrome.
Q37785150The Drosophila 7-pass transmembrane glycoprotein BOSS and metabolic regulation: What Drosophila can teach us about human energy metabolism
Q64240851The Effect of Vitamin D on Cellular Pathways of Diabetic Nephropathy
Q38126643The Maillard reaction and pet food processing: effects on nutritive value and pet health.
Q49169179The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.
Q37444372The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence
Q42226832The Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications
Q36132723The Receptor for Advanced Glycation End Products (RAGE) Is Associated with Persistent Atrial Fibrillation
Q46569717The anti-hepatic fibrosis activity of ergosterol depended on upregulation of PPARgamma in HSC-T6 cells
Q33615012The attenuation of Moutan Cortex on oxidative stress for renal injury in AGEs-induced mesangial cell dysfunction and streptozotocin-induced diabetic nephropathy rats
Q36787569The biology of RAGE and its ligands: uncovering mechanisms at the heart of diabetes and its complications
Q34644417The biology of aging and frailty
Q35617622The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1.
Q33278821The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function
Q48951906The interaction of amyloid β and the receptor for advanced glycation endproducts induces matrix metalloproteinase-2 expression in brain endothelial cells
Q36454454The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer's disease pathogenesis
Q39678954The novel function of advanced glycation end products in regulation of MMP-9 production
Q38025026The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome
Q59329530The role of advanced glycation end-products in the development of coronary artery disease in patients with and without diabetes mellitus: a review
Q39394561The role of receptor for advanced glycation end products (RAGE) in neuronal differentiation
Q35160764The role of receptor for advanced glycation end products in airway inflammation in CF and CF related diabetes.
Q37254561The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE.
Q92343798Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy
Q51487967Toxicological evaluation of advanced glycation end product Nε-(carboxymethyl)lysine: Acute and subacute oral toxicity studies.
Q35859768Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging.
Q92635133UV Fluorescence-Based Determination of Urinary Advanced Glycation End Products in Patients with Chronic Kidney Disease
Q43521840Up-regulation of the inflammatory-reparative phenotype in human prostate carcinoma
Q36860811Update on the protective molecular pathways improving pancreatic beta-cell dysfunction
Q36514906Uremic Toxicity of Advanced Glycation End Products in CKD.
Q46044501Vascular biomarkers in the metabolic syndrome
Q37636453Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms
Q28393488Vibrational spectroscopic imaging for the evaluation of matrix and mineral chemistry
Q39220959Vibrational spectroscopic techniques to assess bone quality
Q64973366Vitamin D suppresses cellular pathways of diabetes complication in liver.
Q83130963[The influence of diabetes mellitus on male reproductive function: a poorly investigated aspect of male infertility]
Q38792762miR-223 contributes to the AGE-promoted apoptosis via down-regulating insulin-like growth factor 1 receptor in osteoblasts
Q54979238miR-5591-5p regulates the effect of ADSCs in repairing diabetic wound via targeting AGEs/AGER/JNK signaling axis.
Q36867450sRAGE and risk of diabetes, cardiovascular disease, and death
Q35777756siRNA Screening Identifies the Host Hexokinase 2 (HK2) Gene as an Important Hypoxia-Inducible Transcription Factor 1 (HIF-1) Target Gene in Toxoplasma gondii-Infected Cells
Q35056697wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death

Search more.