Understanding RAGE, the receptor for advanced glycation end products

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Understanding RAGE, the receptor for advanced glycation end products is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00109-005-0688-7
P8608Fatcat IDrelease_blalgjtqgzdilojhbygu3fjfum
P698PubMed publication ID16133426

P50authorPeter P NawrothQ88292204
Per M HumpertQ96350194
Angelika BierhausQ106836114
Triantafyllos ChavakisQ28054037
P2093author name stringBernd Arnold
Michael Morcos
David M Stern
Thoralf Wendt
P2860cites workCD36, serves as a receptor for advanced glycation endproducts (AGE)Q77712197
Antagonism of RAGE suppresses peripheral nerve regenerationQ81089325
RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathwaysQ81089332
Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathwaysQ22010208
RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptidesQ22010236
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosisQ22254188
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteinsQ24292994
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's diseaseQ24314906
Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamilyQ24558912
Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cellsQ24563997
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosisQ24564718
Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3Q28115196
Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cellsQ28138960
HMG-1 as a late mediator of endotoxin lethality in miceQ28139166
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaBQ28207628
Mini-review: The nuclear protein HMGB1 as a proinflammatory mediatorQ28263346
S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)Q28279641
Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEsQ28290998
Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing miceQ28344139
Purification and characterization of mouse soluble receptor for advanced glycation end products (sRAGE)Q28508886
The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous systemQ28567291
RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophagesQ28568915
Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cellsQ28570142
Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE bindingQ28579193
N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expressionQ28645594
The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking siteQ28645645
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseasesQ29547555
Function and activation of NF-kappa B in the immune systemQ29547790
Toll-like receptors: critical proteins linking innate and acquired immunityQ29615190
Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinomaQ30320422
Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathwayQ30445160
cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein.Q30791560
Negative consequences of glycation.Q33849766
The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammationQ33853348
LPS and cytokine-activated endotheliumQ34113215
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responsesQ34387881
Diabetes and advanced glycation endproductsQ34521835
Receptor for advanced glycation end products, inflammation, and accelerated periodontal disease in diabetes: mechanisms and insights into therapeutic modalitiesQ34557644
Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.Q34728855
RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic diseaseQ34836475
Central role of RAGE-dependent neointimal expansion in arterial restenosisQ34890522
CD40 contributes to lethality in acute sepsis: in vivo role for CD40 in innate immunityQ35011537
Pattern recognition receptors: doubling up for the innate immune responseQ35036522
Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disordersQ35563889
Chemical modification of proteins by lipids in diabetesQ35576075
HMGB1 in SepsisQ35585048
Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer diseaseQ36771851
Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayerQ37384492
High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromoleculesQ37529086
N -Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowthQ38290193
A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cellsQ38355620
Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injuryQ38359414
Role of Escherichia coli curli operons in directing amyloid fiber formationQ39620298
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic miceQ40251711
Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end productsQ40304611
S100B causes apoptosis in a myoblast cell line in a RAGE-independent manner.Q40574504
Advanced glycation end-products (AGEs) induce concerted changes in the osteoblastic expression of their receptor RAGE and in the activation of extracellular signal-regulated kinases (ERK).Q40636638
Role of megalin in endocytosis of advanced glycation end products: implications for a novel protein binding to both megalin and advanced glycation end products.Q40653176
Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous systemQ40668935
Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.Q40730866
The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cellsQ40766569
Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretionQ40803274
Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse lineQ40806119
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune responseQ40899986
Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproductsQ41009444
Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice.Q41893958
The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitmentQ42037633
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucoseQ42070713
RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathyQ42263637
Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end productsQ42440103
Expression of receptors for advanced glycation end products in peripheral occlusive vascular diseaseQ42790513
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE.Q43565214
Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E-null mice.Q43633661
Accelerated diabetic glomerulopathy in galectin-3/AGE receptor 3 knockout mice.Q43786750
Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCsQ44328949
The amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products, an interaction that may play a role in the development of diabetic complications.Q44432075
Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end productsQ44499434
Identification of the receptor for advanced glycation end products in synovial tissue of patients with rheumatoid arthritisQ44815233
High mobility group 1 B-box mediates activation of human endotheliumQ45182292
Blockade of late stages of autoimmune diabetes by inhibition of the receptor for advanced glycation end productsQ47231228
Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.Q47785594
AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE conceptQ47864019
Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaquesQ48584185
Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant StressQ50180621
Tissue-specific expression patterns of the RAGE receptor and its soluble forms—a result of regulated alternative splicing?Q53258066
Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism.Q53348339
Regulation of cell migration by amphoterin.Q55476224
Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasisQ57909992
Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastasesQ59084980
Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGEQ63433994
Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surfaceQ67854285
Expression of receptors for advanced glycosylated end-products in renal diseaseQ70894957
The dark side of glucoseQ71563592
The endothelial cell binding site for advanced glycation end products consists of a complex: an integral membrane protein and a lactoferrin-like polypeptideQ72331984
I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa BQ72571349
Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activationQ73010823
Differential expression of renal AGE-receptor genes in NOD mice: possible role in nonobese diabetic renal diseaseQ73108179
Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cellsQ73674097
Chemical modification of proteins by methylglyoxalQ77659598
P433issue11
P304page(s)876-886
P577publication date2005-08-24
P1433published inJournal of Molecular MedicineQ6295593
P1476titleUnderstanding RAGE, the receptor for advanced glycation end products
P478volume83

Reverse relations

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Q57175176Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration
Q36179583Genetic deficiency of neuronal RAGE protects against AGE-induced synaptic injury
Q45001439Genotyping of -374A/T, -429A/G, and 63 bp Ins/del polymorphisms of RAGE by rapid one-step hexaprimer amplification refractory mutation system polymerase chain reaction in breast cancer patients.
Q39397467Glucagon-like peptide 1: A potential anti-inflammatory pathway in obesity-related asthma.
Q36913552Glucitol-core containing gallotannins inhibit the formation of advanced glycation end-products mediated by their antioxidant potential
Q38953440Glycated albumin: from biochemistry and laboratory medicine to clinical practice.
Q37465801HMGB1 Promotes Intraoral Palatal Wound Healing through RAGE-Dependent Mechanisms
Q37199557HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease.
Q40058870HMGB1 as an autocrine stimulus in human T98G glioblastoma cells: role in cell growth and migration
Q92896599HMGB1 enhances AGE-mediated VSMC proliferation via an increase in 5-LO-linked RAGE expression
Q34622835HMGB1 in health and disease
Q36919024HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption
Q42347142HMGB1 regulates P-glycoprotein expression in status epilepticus rat brains via the RAGE/NF-κB signaling pathway
Q33381657HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk
Q41606893HMGB1/Advanced Glycation End Products (RAGE) does not aggravate inflammation but promote endogenous neural stem cells differentiation in spinal cord injury
Q36827934HMGB1: a signal of necrosis
Q92889825Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The CODAM Study
Q28577024High mobility group B1 protein interacts with its receptor RAGE in tumor cells but not in normal tissues
Q38210271High-mobility group box 1 (HMGB1) in childhood: from bench to bedside
Q37206315High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
Q34170847High-mobility group protein box-1 and its relevance to cerebral ischemia
Q47699459Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair
Q39700115Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction.
Q35562286Human muscle satellite cells show age-related differential expression of S100B protein and RAGE
Q41461919Hyperferritinemia and markers of inflammation and oxidative stress in the cord blood of HIV-exposed, uninfected (HEU) infants
Q53218782IL-1β enhances vascular smooth muscle cell proliferation and migration via P2Y2 receptor-mediated RAGE expression and HMGB1 release.
Q37305013IL-1β, RAGE and FABP4: targeting the dynamic trio in metabolic inflammation and related pathologies
Q89883961Identification of Candidate Genes and Therapeutic Agents for Light Chain Amyloidosis Based on Bioinformatics Approach
Q51031454Immune complexes activate human endothelium involving the cell-signaling HMGB1-RAGE axis in the pathogenesis of lupus vasculitis.
Q57110548Immunomodulation by Processed Animal Feed: The Role of Maillard Reaction Products and Advanced Glycation End-Products (AGEs)
Q51752708Immunomodulation by a combination of nitric oxide and glucocorticoids in a human endotoxin model
Q92059098Impact of RAGE polymorphisms on urothelial cell carcinoma clinicopathologic characteristics and long-term survival
Q50223052Impaired osteogenic differentiation and enhanced cellular receptor of advanced glycation end products sensitivity in patients with type 2 diabetes
Q47548856Impairment of Novel Object Recognition Memory and Brain Insulin Signaling in Fructose- but Not Glucose-Drinking Female Rats
Q57050209In Utero Heat Stress Alters the Offspring Epigenome
Q42235792Increased expression of the receptor for advanced glycation end-products in human peripheral neuropathies
Q42414162Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products
Q45274141Increased receptor for advanced glycation endproducts immunocontent in the cerebral cortex of vitamin A-treated rats
Q34364237Induction of RAGE shedding by activation of G protein-coupled receptors
Q37911285Inflammation and diabetic retinal microvascular complications
Q22241893Inflammation and insulin resistance
Q37705110Inflammation-associated S100 proteins: new mechanisms that regulate function.
Q59049799Inflammatory Response in Patients under Coronary Artery Bypass Grafting Surgery and Clinical Implications: A Review of the Relevance of Dexmedetomidine Use
Q36878348Inflammatory markers associated with osteoarthritis after destabilization surgery in young mice with and without Receptor for Advanced Glycation End-products (RAGE)
Q64056217Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation
Q52144777Inhibition of the Receptor for Advanced Glycation End-Products (RAGE) Attenuates Neuroinflammation While Sensitizing Cortical Neurons Towards Death in Experimental Subarachnoid Hemorrhage.
Q93024896Inhibition of the Receptor for Advanced Glycation End-Products in Acute Respiratory Distress Syndrome: A Randomised Laboratory Trial in Piglets
Q34043446Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]
Q89180802Inorganic Polyphosphate Amplifies High Mobility Group Box 1-Mediated Von Willebrand Factor Release and Platelet String Formation on Endothelial Cells
Q35582599Inorganic polyphosphate elicits pro-inflammatory responses through activation of the mammalian target of rapamycin complexes 1 and 2 in vascular endothelial cells
Q51043667Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone.
Q27001177Interaction between therapeutic interventions for Alzheimer's disease and physiological Aβ clearance mechanisms
Q28577725Internalization of the receptor for advanced glycation end products (RAGE) is required to mediate intracellular responses
Q42579440Intracellular and Extracellular Effects of S100B in the Cardiovascular Response to Disease
Q30317651Intraoperative sRAGE kinetics. A new age-related outcome predictor of cardiac surgery
Q37595925Investigating wild berries as a dietary approach to reducing the formation of advanced glycation endproducts: chemical correlates of in vitro antiglycation activity
Q38260264Investigation of phosphoproteome in RAGE signaling
Q28570305Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells
Q42277371Levels of S100B protein drive the reparative process in acute muscle injury and muscular dystrophy
Q40866184Levels of Soluble Receptor for Advanced Glycation End Products in Bronchoalveolar Lavage Fluid in Patients with Various Inflammatory Lung Diseases
Q46595652Limited role of the receptor for advanced glycation end products during Streptococcus pneumoniae bacteremia.
Q64883415Long-term administration of melatonin attenuates neuroinflammation in the aged mouse brain.
Q34311706Longistatin in tick saliva blocks advanced glycation end-product receptor activation
Q28276929Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell types
Q36575194Lung inflammation biomarkers and lung function in children chronically exposed to arsenic
Q92615014MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients
Q38776099Maillard reaction in food allergy: Pros and cons
Q38770084Markers of immune-mediated inflammation in the brains of young adults and adolescents with type 1 diabetes and fatal diabetic ketoacidosis. Is there a difference?
Q92163626Maternal Consumption of a Diet Rich in Maillard Reaction Products Accelerates Neurodevelopment in F1 and Sex-Dependently Affects Behavioral Phenotype in F2 Rat Offspring
Q42089443Measurement of Lens Autofluorescence for Diabetes Screening
Q36454380Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats
Q36864025Mechanisms of disease: a 'DAMP' view of inflammatory arthritis
Q38330759Mechanisms of distal axonal degeneration in peripheral neuropathies.
Q46813751Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model
Q35141196Mesona Chinensis Benth extract prevents AGE formation and protein oxidation against fructose-induced protein glycation in vitro
Q50482190Methylglyoxal concentrations differ in standard and washed neonatal packed red blood cells.
Q34854364Methylprednisolone stiffens aortas in lipopolysaccharide-induced chronic inflammation in rats
Q41014561Microglia function in Alzheimer's disease
Q46102290Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities (ARIC) Study
Q34557348Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy
Q38846666Molecular characterization of glycation-associated skin ageing: an alternative skin model to study in vitro antiglycation activity of topical cosmeceutical and pharmaceutical formulations.
Q38108373Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology.
Q100751507Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
Q38096444Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products.
Q45817707Morphological adaptation of muscle collagen and receptor of advanced glycation end product (RAGE) in osteoarthritis patients with 12 weeks of resistance training: influence of anti-inflammatory or glucosamine treatment.
Q37564063Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications
Q38140624Natural compounds with anti-ageing activity
Q50958699Neurodegenerative Markers are Increased in Postmortem BA21 Tissue from African Americans with Alzheimer's Disease.
Q91773901Neuroinflammation: friend and foe for ischemic stroke
Q37977251Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain
Q42870334Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice
Q35559895Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease
Q36330297Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease
Q35719575New screening technologies for type 2 diabetes mellitus appropriate for use in tuberculosis patients
Q37596871Nicousamide protects kidney podocyte by inhibiting the TGFβ receptor II phosphorylation and AGE-RAGE signaling
Q34604583Novel Inhibitory Effects of Glycyrrhizic Acid on the Accumulation of Advanced Glycation End Product and Its Receptor Expression
Q28286769Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function
Q24170228Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes
Q37070169Ovariectomy increases neuronal amyloid-beta binding alcohol dehydrogenase level in the mouse hippocampus
Q36084076Overexpression of human HSP27 protects sensory neurons from diabetes
Q33999811Overexpression of receptor for advanced glycation end products and high-mobility group box 1 in human dental pulp inflammation
Q37741560Oxidant/Antioxidant imbalance and the risk of Alzheimer's disease
Q29615423Oxidative Stress and Diabetic Complications
Q93126213Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?
Q55005264Oxidative stress and antioxidant treatment in patients with peripheral artery disease.
Q43201615Oxidative stress and glucose metabolism--is there a need to revisit effects of insulin treatment?
Q35833994Oxidative stress in aging human skin
Q37455830Oxidative stress in diabetes and Alzheimer's disease
Q36891939Oxidative stress, AGE, and atherosclerosis
Q35940134PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease
Q39223354Paradoxical Role of High Mobility Group Box 1 in Glioma: A Suppressor or a Promoter?
Q28087462Pathogenesis of diabetic cerebral vascular disease complication
Q26771860Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
Q38111707Pathophysiology of the diabetic kidney.
Q47803961Pattern-recognition receptors: Signaling pathways and dysregulation in canine chronic enteropathies-brief review
Q39332869Pentoxifylline alleviates high-fat diet-induced non-alcoholic steatohepatitis and early atherosclerosis in rats by inhibiting AGE and RAGE expression
Q26782422Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease
Q37858519Pharmacological treatment of diabetic neuropathic pain
Q47118391Pivotal neuroinflammatory and therapeutic role of high mobility group box 1 in ischemic stroke
Q37423137Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction
Q40200491Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes
Q37393702Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury
Q44504391Plasma sRAGE and N-(carboxymethyl) lysine in patients with CHF and/or COPD.
Q56888393Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data
Q37564791Polyphosphate amplifies proinflammatory responses of nuclear proteins through interaction with receptor for advanced glycation end products and P2Y1 purinergic receptor
Q38460480Postprandial Dysmetabolism and Oxidative Stress in Type 2 Diabetes: Pathogenetic Mechanisms and Therapeutic Strategies
Q37464262Postprandial hyperglycemia as an etiological factor in vascular failure
Q35607249Posttranslationally modified proteins as mediators of sustained intestinal inflammation
Q35539571Prenatal dietary load of Maillard reaction products combined with postnatal Coca-Cola drinking affects metabolic status of female Wistar rats.
Q90397894Prevention of Cognitive Decline in Alzheimer's Disease by Novel Antioxidative Supplements
Q33783947Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells
Q59790637Promoter methylation cooperates with SNPs to modulate transcription and alter UC risk
Q34456143Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension
Q92063917Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
Q41613567Proximate Mediators of Microvascular Dysfunction at the Blood-Brain Barrier: Neuroinflammatory Pathways to Neurodegeneration
Q35752436Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic
Q38873724Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells
Q37152947RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation.
Q36209840RAGE Deficiency Impairs Bacterial Clearance in Murine Staphylococcal Sepsis, but Has No Significant Impact on Staphylococcal Septic Arthritis
Q26744630RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage
Q60732952RAGE Gene Polymorphisms in Patients with Multiple Sclerosis
Q42285476RAGE Plays a Role in LPS-Induced NF-κB Activation and Endothelial Hyperpermeability
Q35888805RAGE and AGEs in Mild Cognitive Impairment of Diabetic Patients: A Cross-Sectional Study
Q37455857RAGE and Alzheimer's disease: a progression factor for amyloid-beta-induced cellular perturbation?
Q35970395RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells
Q36969021RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases
Q37860348RAGE biology, atherosclerosis and diabetes
Q43452286RAGE blockade and hepatic microcirculation in experimental endotoxaemic liver failure
Q34636067RAGE controls leukocyte adhesion in preterm and term infants
Q57466113RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr mice
Q36745763RAGE gene polymorphism and environmental factor in the risk of oral cancer
Q58714432RAGE in Cancer Lung: the End of a Long and Winding Road is in Sight
Q58597742RAGE in the pathophysiology of skeletal muscle
Q47325624RAGE influences obesity in mice. Effects of the presence of RAGE on weight gain, AGE accumulation, and insulin levels in mice on a high fat diet
Q41243867RAGE inhibition reduces acute lung injury in mice.
Q47867340RAGE mediates Aβ accumulation in a mouse model of Alzheimer's disease via modulation of β- and γ-secretase activity
Q34457327RAGE mediates S100A7-induced breast cancer growth and metastasis by modulating the tumor microenvironment
Q36502858RAGE signaling sustains inflammation and promotes tumor development
Q24658378RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
Q40385373RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis
Q39123617RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
Q30318035RAGE-dependent activation of gene expression of superoxide dismutase and vanins by AGE-rich extracts in mice cardiac tissue and murine cardiac fibroblasts
Q24315809RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction
Q55191109RAGE-specific single chain Fv for PET imaging of pancreatic cancer.
Q37599419RAGE: the beneficial and deleterious effects by diverse mechanisms of actions
Q64914593Radiological assessment of effectiveness of soluble RAGE in attenuating Angiotensin II-induced LVH mouse model using in vivo 9.4T MRI.
Q37665079Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling
Q36916192Reactive metabolites and AGE-RAGE-mediated inflammation in patients following liver transplantation
Q37801791Reactive metabolites and AGE/RAGE-mediated cellular dysfunction affect the aging process: a mini-review
Q57825328Receptor for Advanced Glycation End Products (RAGE)—Soluble Form (sRAGE) and Gene Polymorphisms in Patients with Breast Cancer
Q38182068Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases
Q37685213Receptor for advanced glycation end as drug targets in diabetes-induced skin lesion
Q38234624Receptor for advanced glycation end products (RAGE) and its ligands: focus on spinal cord injury
Q36842628Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes
Q21285070Receptor for advanced glycation end products and its involvement in inflammatory diseases
Q33841564Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer's disease
Q37373486Receptor for advanced glycation end-products (RAGE) and soluble RAGE (sRAGE): cardiovascular implications.
Q33873927Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke
Q37268198Receptor for advanced glycation endproducts signaling cascades are activated in pancreatic fibroblasts, but not in the INS1E insulinoma cell line: Are mesenchymal cells major players in chronic inflammation?
Q64087511Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept
Q36605862Reduced soluble RAGE is associated with disease severity of axonal Guillain-Barré syndrome
Q45970190Reference values of skin autofluorescence as an estimation of tissue accumulation of advanced glycation end products in a general Slovak population.
Q37586657Regulatory landscape of AGE-RAGE-oxidative stress axis and its modulation by PPARγ activation in high fructose diet-induced metabolic syndrome
Q35674689Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type 2 Diabetes Mellitus
Q33733145Research on the traditional Chinese medicine treating gastrointestinal motility in diabetic rats by improving biomechanical remodeling and neuroendocrine regulation
Q39561253Resveratrol-Dependent Down-regulation of Receptor for Advanced Glycation End-products and Oxidative Stress in Kidney of Rats With Diabetes
Q28535046Retracted: The Effect of Soluble RAGE on Inhibition of Angiotensin II-Mediated Atherosclerosis in Apolipoprotein E Deficient Mice
Q47133991Role of Galectin-3 in Bone Cell Differentiation, Bone Pathophysiology and Vascular Osteogenesis.
Q38547292Role of RAGE in Alzheimer's Disease
Q27003423Role of advanced glycation end products in cellular signaling
Q36673607Role of oxidative stress in arsenic-induced toxicity.
Q46555270Role of soluble receptor for advanced glycation end products on endotoxin-induced lung injury.
Q28387007S100A12 is up-regulated in pulmonary tuberculosis and predicts the extent of alveolar infiltration on chest radiography: an observational study
Q21135467S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)
Q28545019S100A8/A9 stimulates keratinocyte proliferation in the development of squamous cell carcinoma of the skin via the receptor for advanced glycation-end products
Q37629632S100A8/A9: a mediator of severe asthma pathogenesis and morbidity?
Q39150684S100A9 promotes human lung fibroblast cells activation through receptor for advanced glycation end-product-mediated extracellular-regulated kinase 1/2, mitogen-activated protein-kinase and nuclear factor-κB-dependent pathways
Q34106243S100B Protein, A Damage-Associated Molecular Pattern Protein in the Brain and Heart, and Beyond
Q35708432S100B Up-Regulates Macrophage Production of IL1β and CCL22 and Influences Severity of Retinal Inflammation
Q34821218S100B attenuates microglia activation in gliomas: possible role of STAT3 pathway
Q34140133S100B engages RAGE or bFGF/FGFR1 in myoblasts depending on its own concentration and myoblast density. Implications for muscle regeneration
Q37051646S100B promotes glioma growth through chemoattraction of myeloid-derived macrophages
Q48718934S100B protein activates a RAGE-dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis
Q36104103S100B protein expression in the heart of deceased individuals by overdose: a new forensic marker?
Q34606206S100B protein stimulates microglia migration via RAGE-dependent up-regulation of chemokine expression and release
Q37702852S100B: a multifunctional role in cardiovascular pathophysiology
Q37354472S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis
Q37300540Senescence-dependent impact of anti-RAGE antibody on endotoxemic liver failure
Q51342915Serum soluble receptor for advanced glycation end products (sRAGE) is independently associated with cigarette smoking in non-diabetic healthy subjects.
Q59354444Serum soluble receptor for advanced glycation end-products during acute bronchiolitis in infant: Prospective study in 93 cases
Q47390127Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study
Q91878595Shixiang Plaster, a Traditional Chinese Medicine, Promotes Healing in a Rat Model of Diabetic Ulcer Through the receptor for Advanced Glycation End Products (RAGE)/Nuclear Factor kappa B (NF-κB) and Vascular Endothelial Growth Factor (VEGF)/Vascular
Q35214629Skin autofluorescence as a novel marker of vascular damage in children and adolescents with chronic kidney disease
Q35949029Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies
Q35746399Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.
Q40126438Soluble RAGE blocks scavenger receptor CD36-mediated uptake of hypochlorite-modified low-density lipoprotein
Q37263827Soluble Receptor for Advanced Glycation End Product Ameliorates Chronic Intermittent Hypoxia Induced Renal Injury, Inflammation, and Apoptosis via P38/JNK Signaling Pathways.
Q50880511Soluble aggregates of the amyloid-beta protein activate endothelial monolayers for adhesion and subsequent transmigration of monocyte cells.
Q64912818Soluble receptor for AGE in diabetic nephropathy and its progression in Finnish individuals with type 1 diabetes.
Q47418383Soluble receptor for advanced glycation end products (sRAGE) in tracheobronchial aspirate fluid and cord blood of very low birth weight infants with chorioamnionitis and funisitis
Q39636114Soluble receptor for advanced glycation end products (sRAGE) is present at high concentrations in the lungs of children and varies with age and the pattern of lung inflammation.
Q45090317Soluble receptor for advanced glycation end products alleviates nephritis in (NZB/NZW)F1 mice
Q51620241Soluble receptor for advanced glycation end products and increased aortic stiffness in the general population.
Q35068413Soluble receptor for advanced glycation end products as an indicator of pulmonary vascular injury after cardiac surgery
Q34564061Soluble receptor for advanced glycation end products in critically ill patients and its associations with other clinical markers and 28-day mortality
Q55180476Soluble receptor for advanced glycation end products in male infertility.
Q84010026Soy protein prevents renal damage in a fructose-induced model of metabolic syndrome via inhibition of NF-kB in male rats
Q39106836Statins stimulate the production of a soluble form of the receptor for advanced glycation end products
Q24338271Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products
Q39347827Studies on the cardioprotective role of gallic acid against AGE-induced cell proliferation and oxidative stress in H9C2 (2-1) cells
Q37377678Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin
Q91819199Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy
Q85239968Systemic levels of the anti-inflammatory decoy receptor soluble RAGE (receptor for advanced glycation end products) are decreased in dogs with inflammatory bowel disease
Q33783975TRB3 mediates advanced glycation end product-induced apoptosis of pancreatic β-cells through the protein kinase C β pathway
Q38595544Targeting danger-associated molecular patterns after myocardial infarction
Q37691594Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease
Q47988381The -374T/A variant of the rage gene promoter is associated with clinical restenosis after coronary stent placement
Q27664995The 1.5 Å Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE) Ectodomains Reveals Unique Features Determining Ligand Binding
Q49299877The Association Between Variants of Receptor for Advanced Glycation End Products (RAGE) Gene Polymorphisms and Age-Related Macular Degeneration
Q41980641The Complexity of Sporadic Alzheimer's Disease Pathogenesis: The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction
Q37729333The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology
Q36134557The HMGB1 receptor RAGE mediates ischemic brain damage
Q33745462The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation
Q47176251The HMGB1/RAGE Pro-Inflammatory Axis in the Human Placenta: Modulating Effect of Low Molecular Weight Heparin.
Q30505780The IKKα-dependent NF-κB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1.
Q37141580The Immunoproteasome in oxidative stress, aging, and disease.
Q90221533The Impact of Diabetic Conditions and AGE/RAGE Signaling on Cardiac Fibroblast Migration
Q90440117The RAGE signaling pathway is involved in intestinal inflammation and represents a promising therapeutic target for Inflammatory Bowel Diseases
Q97519022The Receptor for Advanced Glycation Endproducts (RAGE) Contributes to Severe Inflammatory Liver Injury in Mice
Q36146033The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis.
Q36057340The Role of receptor for Advanced Glycation End Products (RAGE) in the proliferation of hepatocellular carcinoma
Q37066216The action of aminoguanidine on the liver of trained diabetic rats
Q38086654The beneficial role of thiamine in Parkinson disease.
Q33851482The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation
Q51887196The developmental aging and origins of health and disease hypotheses explained by different protein networks.
Q34335614The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
Q42849056The effects of the receptor for advanced glycation end products (RAGE) on bone metabolism under physiological and diabetic conditions
Q35617622The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1.
Q80517354The expression of the receptor for glycation endproducts (RAGE) in oral squamous cell carcinomas
Q45885546The functional -374T/A polymorphism of the receptor for advanced glycation end products may modulate Crohn's disease
Q21202840The generation and function of soluble apoE receptors in the CNS
Q34020798The glomerulus--a view from the outside--the podocyte
Q40112947The impact of RAGE inhibition in animal models of bacterial sepsis: a systematic review and meta-analysis
Q89584286The marine natural product Scalarin inhibits the receptor for advanced glycation end products (RAGE) and autophagy in the PANC-1 and MIA PaCa-2 pancreatic cancer cell lines
Q37158848The metal chelators, trientine and citrate, inhibit the development of cardiac pathology in the Zucker diabetic rat.
Q26801586The neurotoxic effects of vitamin A and retinoids
Q36800611The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice
Q57718003The possible role of esRAGE and sRAGE in the natural history of diabetic nephropathy in childhood
Q37212720The receptor RAGE: Bridging inflammation and cancer
Q38025026The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome
Q36199320The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice
Q93208374The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study
Q37140804The role of cell death in the pathogenesis of autoimmune disease: HMGB1 and microparticles as intercellular mediators of inflammation
Q94476127The role of innate immunity in the long-term outcome of lung transplantation
Q58701069The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease
Q38074422The role of vitamin D in Alzheimer's disease: possible genetic and cell signaling mechanisms
Q37307799Theories, types and treatments of diabetic neuropathy
Q92343798Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy
Q28582962Total and mitochondrial nitrosative stress, decreased brain-derived neurotrophic factor (BDNF) levels and glutamate uptake, and evidence of endoplasmic reticulum stress in the hippocampus of vitamin A-treated rats
Q37716694Trends in advanced glycation end products research in diabetes mellitus and its complications.
Q35137159Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis
Q57118512Up-regulated expression of advanced glycation end-products and their receptor in the small intestine and colon of diabetic rats
Q51863701Up-regulation of receptors for advanced glycation end-products by alveolar epithelium influences cytodifferentiation and causes severe lung hypoplasia.
Q33867705Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus
Q42330303Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway
Q43172749Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation.
Q38041671VEGF and podocytes in diabetic nephropathy
Q28081090Vascular Effects of Dietary Advanced Glycation End Products
Q37636453Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms
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