Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis

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Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis is …
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scholarly articleQ13442814

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P356DOI10.1172/JCI119885
P3181OpenCitations bibliographic resource ID1304728
P932PMC publication ID508666
P698PubMed publication ID9486985

P50authorPaul J ThornalleyQ56810389
P2093author name stringI Giardino
M Brownlee
M Shinohara
S R Thorpe
J Onorato
P Beisswenger
P2860cites workThe glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological lifeQ24527362
Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetesQ24627259
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedureQ24634002
In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sitesQ28305676
Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complicationsQ28319032
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteinsQ28378989
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoterQ29614259
Advanced protein glycosylation in diabetes and agingQ34298835
Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucoseQ34321118
S-(N-aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II.Q34330523
3-Deoxyfructose concentrations are increased in human plasma and urine in diabetesQ34332726
Cloning and characterization of human colon glyoxalase-I.Q34361639
Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptorQ36397586
Two asialoglycoprotein receptor polypeptides in human hepatoma cellsQ36427390
Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic gangliaQ36851040
BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cellsQ37353111
Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidaseQ37689072
Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complicationsQ39506963
Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.Q40730866
Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitusQ40759611
Hyperglycemic pseudohypoxia and diabetic complications.Q40908737
Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.Q41148677
Functional characterization of the rat GAP-43 promoterQ41486257
N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reactionQ42555798
Probing the active site of glyoxalase I from human erythrocytes by use of the strong reversible inhibitor S-p-bromobenzylglutathione and metal substitutionsQ45233851
Measurement of acetol in serum.Q51637439
High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions.Q54140931
Negative Association between Erythrocyte Reduced Glutathione Concentration and Diabetic ComplicationsQ60786668
Molecular characteristics of methylglyoxal-modified bovine and human serum albumins. Comparison with glucose-derived advanced glycation endproduct-modified serum albuminsQ60786677
Glyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic ComplicationsQ60786679
Modification of the glyoxalase system in streptozotocin-induced diabetic ratsQ60786696
The assay of methylglyoxal in biological systems byderivatization with 1,2-diamino-4,5-dimethoxybenzeneQ60786717
Amadori rearrangement potential of hemoglobin at its glycation sites is dependent on the three-dimensional structure of proteinQ67974305
Sensitive determination of D-lactic acid in biological samples by high-performance liquid chromatographyQ68062678
Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active formQ69208934
Glyoxalase I from mouse liverQ70548265
Increased endocytosis in retinal vascular endothelial cells grown in high glucose medium is modulated by inhibitors of nonenzymatic glycosylationQ70953748
The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactionsQ71070390
Method for determination of free intracellular and extracellular methylglyoxal in animal cells grown in cultureQ71138879
Early atherosclerosis is retarded by improved long-term blood glucose control in patients with IDDMQ71442189
Pathways of Formation of Glycoxidation Products during Glycation of CollagenQ71786493
Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reactionQ72108149
Retinal vascular endothelial cell endocytosis increases in early diabetesQ72171952
Receptor-mediated endocytic uptake of methylglyoxal-modified serum albumin. Competition with advanced glycation end product-modified serum albumin at the advanced glycation end product receptorQ72352184
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmacromoleculeQ178593
endocytosisQ189814
hyperglycemiaQ271993
overexpressionQ61643320
P304page(s)1142-1147
P577publication date1998-03-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleOverexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis
P478volume101

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cites work (P2860)
Q42862729A Diverse Series of Substituted Benzenesulfonamides as Aldose Reductase Inhibitors with Antioxidant Activity: Design, Synthesis, and in Vitro Activity
Q53811353A bis-Schiff base of isatin improves methylglyoxal mediated insulin resistance in skeletal muscle cells.
Q37094883A high-salt diet further impairs age-associated declines in cognitive, behavioral, and cardiovascular functions in male Fischer brown Norway rats
Q37003623AGE restriction in diabetes mellitus: a paradigm shift
Q51747235AGE-RAGE Stress, Stressors, and Antistressors in Health and Disease.
Q40940923Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicity
Q38197337Activity, regulation, copy number and function in the glyoxalase system
Q36965274Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes.
Q37149382Advanced glycation end products and diabetic foot disease
Q37930514Advanced glycation end products and diabetic retinopathy
Q46613227Advanced glycation end products in human cancer tissues: detection of Nepsilon-(carboxymethyl)lysine and argpyrimidine
Q36643573Advanced glycation end products: Key players in skin aging?
Q38081119Advanced glycation end products: role in pathology of diabetic cardiomyopathy
Q46542915Advanced glycosylation end products in skin, serum, saliva and urine and its association with complications of patients with type 2 diabetes mellitus
Q34387932Aldolase B knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells.
Q47721742Aldose reductase: a window to the treatment of diabetic complications?
Q40346041Amelioration of oxidant stress by the defensin lysozyme
Q36492859An advanced glycation end product (AGE)-receptor for AGEs (RAGE) axis restores adipogenic potential of senescent preadipocytes through modulation of p53 protein function
Q42326942Analysis of Methylglyoxal Metabolism in CHO Cells Grown in Culture
Q35568131Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice
Q34441960Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2
Q37181170Arabidopsis thaliana GLX2-1 contains a dinuclear metal binding site, but is not a glyoxalase 2.
Q38199486Association of oxidative stress to the genesis of anxiety: implications for possible therapeutic interventions
Q84520313Association of two glyoxalase I gene polymorphisms with nephropathy and retinopathy in Type 2 diabetes
Q40802125Below the radar: advanced glycation end products that detour "around the side". Is HbA1c not an accurate enough predictor of long term progression and glycaemic control in diabetes?
Q29012485Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
Q28131781Biochemistry and molecular cell biology of diabetic complications
Q52939905CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction.
Q34355343Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function
Q36687957Cellular mechanisms and signalling pathways activated by high glucose and AGE-albumin in the aortic endothelium
Q42583958Characterisation of glyoxalase I in a streptozocin-induced mouse model of diabetes with painful and insensate neuropathy
Q46817492Common polymorphisms in the glyoxalase-1 gene and their association with pro-thrombotic factors
Q57073373Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes
Q36283819Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition
Q33267290Critical role of methylglyoxal and AGE in mycobacteria-induced macrophage apoptosis and activation
Q38070906Current therapeutic interventions in the glycation pathway: evidence from clinical studies
Q43593904Cytotoxic action of methylglyoxal on insulin-secreting cells
Q47105930Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes
Q35172873Diabetes and cancer: Looking at the multiligand/RAGE axis.
Q38070160Diabetes-related adduct formation and retinopathy.
Q79291119Diabetic hepatosclerosis: a novel entity or a rare form of nonalcoholic fatty liver disease?
Q33921581Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene
Q37072018Diabetic threesome (hyperglycaemia, renal function and nutrition) and advanced glycation end products: evidence for the multiple-hit agent?
Q89552373Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations
Q92084106Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging
Q46613111Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin
Q47632182Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle.
Q42273415Dicarbonyl stress in clinical obesity
Q37156152Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics
Q40047034Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress
Q37733102Dietary hyperglycemia, glycemic index and metabolic retinal diseases
Q39725004Dietary phenolic acids attenuate multiple stages of protein glycation and high-glucose-stimulated proinflammatory IL-1beta activation by interfering with chromatin remodeling and transcription in monocytes
Q44367856Different influences of hyperglycemic duration on phosphorylated extracellular signal-regulated kinase 1/2 in rat heart
Q36824440Distribution of glyoxalase I polymorphism among Zuni Indians: the Zuni Kidney Project
Q35809946Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics
Q91727269Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models
Q48479771Employing in vitro analysis to test the potency of methylglyoxal in inducing the formation of amyloid-like aggregates of caprine brain cystatin
Q49787990Endothelial Cell Metabolism.
Q34324055Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal
Q38082465Endothelial dysfunction in (pre)diabetes: characteristics, causative mechanisms and pathogenic role in type 2 diabetes
Q41964977Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?
Q46427869Enhanced Aerobic Glycolysis by S-Nitrosoglutathione via HIF-1α Associated GLUT1/Aldolase A Axis in Human Endothelial Cells
Q90655613Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic rats
Q55104216Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney.
Q35673589Evaluation of potential flavonoid inhibitors of glyoxalase-I based on virtual screening and in vitro studies
Q24630049GLO1 overexpression in human malignant melanoma
Q85210614Genetics of diabetes complications
Q36861036Glucolipotoxicity: fuel excess and beta-cell dysfunction.
Q90632374Glucose and Blood Pressure-Dependent Pathways-The Progression of Diabetic Kidney Disease
Q46717230Glycation-induced inactivation of aspartate aminotransferase, effect of uric acid.
Q64071600Glycine Suppresses AGE/RAGE Signaling Pathway and Subsequent Oxidative Stress by Restoring Glo1 Function in the Aorta of Diabetic Rats and in HUVECs
Q92066220Glycine increases glyoxalase-1 function by promoting nuclear factor erythroid 2-related factor 2 translocation into the nucleus of kidney cells of streptozotocin-induced diabetic rats
Q35813624Glycoxidation and diabetic complications: modern lessons and a warning?
Q51345459Glyoxalase 1 enzyme activity in erythrocytes and Ala111Glu polymorphism in type 1-diabetes patients.
Q24613178Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal
Q92646117Glyoxalase 1, regulated by LncRNA MALAT1, promotes malignant development of esophageal squamous cell carcinoma
Q42362227Glyoxalase 1-knockdown in human aortic endothelial cells - effect on the proteome and endothelial function estimates
Q36576306Glyoxalase I activity and immunoreactivity in the aging human lens
Q46966682Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions
Q39884842Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats
Q38311623Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family
Q53085119Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.
Q46790327Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans
Q46951415Heat-shock protein 27 is a major methylglyoxal-modified protein in endothelial cells
Q35436475High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature
Q36233220Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme
Q33773237Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
Q37120159Hyperglycemia and prostate cancer recurrence in men treated for localized prostate cancer
Q39331191Hypoxia driven glycation: Mechanisms and therapeutic opportunities.
Q45712472Identification of alpha-dicarbonyl scavengers for cellular protection against carbonyl stress
Q57110548Immunomodulation by Processed Animal Feed: The Role of Maillard Reaction Products and Advanced Glycation End-Products (AGEs)
Q43674559In situ kinetic analysis of glyoxalase I and glyoxalase II in Saccharomyces cerevisiae.
Q39451237Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose
Q92783034Indole-4-carboxaldehyde Isolated from Seaweed, Sargassum thunbergii, Attenuates Methylglyoxal-Induced Hepatic Inflammation
Q33816297Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation
Q36001244Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
Q42699855Inhibition of Methylglyoxal-Mediated Protein Modification in Glyoxalase I Overexpressing Mouse Lenses
Q38563967Inhibitory effects and actions of pentacyclic triterpenes upon glycation
Q34248342Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.
Q39854329Legacy effects from DCCT and UKPDS: what they mean and implications for future diabetes trials
Q39107278Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells
Q43117950Low-dose erythropoietin inhibits oxidative stress and early vascular changes in the experimental diabetic retina
Q37857087Macrovascular angiopathy in children and adolescents with type 1 diabetes.
Q47303198Maillard Proteomics: Opening New Pages
Q73040201Maillard reactions by alpha-oxoaldehydes: detection of glyoxal-modified proteins
Q48667618Mangiferin Upregulates Glyoxalase 1 Through Activation of Nrf2/ARE Signaling in Central Neurons Cultured with High Glucose
Q33229504Mass spectrometry of advanced glycation end products
Q43272240Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice
Q44631210Metabolism, not autoxidation, plays a role in alpha-oxoaldehyde- and reducing sugar-induced erythrocyte GSH depletion: relevance for diabetes mellitus
Q43249355Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells.
Q54357761Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo.
Q34389881Methylglyoxal induces mitochondrial dysfunction and cell death in liver
Q39314131Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation
Q46325452Methylglyoxal mediates vascular inflammation via JNK and p38 in human endothelial cells
Q40329542Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription
Q37183293Methylglyoxal, diabetes mellitus and diabetic complications
Q35063131Methylglyoxal, the dark side of glycolysis
Q39042002Modulation of GSH with exogenous agents leads to changes in glyoxalase 1 enzyme activity in VL-17A cells exposed to chronic alcohol plus high glucose
Q43720970Modulation of glyoxalase, glutathione S-transferase and antioxidant enzymes in the liver, spleen and erythrocytes of mice by dietary administration of fenugreek seeds
Q42590459Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan.
Q38096444Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products.
Q37530715NAD+ availability and proteotoxicity
Q37903708Naturally occurring inhibitors against the formation of advanced glycation end-products
Q33849766Negative consequences of glycation.
Q29616101Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Q34489018Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats
Q38111707Pathophysiology of the diabetic kidney.
Q55454896Phytate Decreases Formation of Advanced Glycation End-Products in Patients with Type II Diabetes: Randomized Crossover Trial.
Q37401263Pregabalin in the treatment of chronic pain: an overview
Q42013303Proanthocyanidin Attenuation of Oxidative Stress and NF- κ B Protects Apolipoprotein E-Deficient Mice against Diabetic Nephropathy
Q82814955Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology
Q42803262Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells
Q37112969Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease
Q37230025Proteome wide reduction in AGE modification in streptozotocin induced diabetic mice by hydralazine mediated transglycation
Q33289842Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice
Q42048767Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry
Q34110891Reduced fructosamine-3-kinase activity and its mRNA in human distal colorectal carcinoma
Q37400729Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue
Q34336935Role for glyoxalase I in Alzheimer's disease.
Q36407601Role of Glyoxalase 1 (Glo1) and methylglyoxal (MG) in behavior: recent advances and mechanistic insights
Q35896615Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy
Q28588521Role of the glyoxalase system in astrocyte-mediated neuroprotection
Q34055011Role of vascular risk factors and vascular dysfunction in Alzheimer's disease
Q28545019S100A8/A9 stimulates keratinocyte proliferation in the development of squamous cell carcinoma of the skin via the receptor for advanced glycation-end products
Q43776154Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats
Q30317530Temporal dynamics of glyoxalase 1 in secondary neuronal injury
Q24338430The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II
Q56760512The aldo-keto reductase superfamily and its role in drug metabolism and detoxification
Q46743346The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of alpha-oxoaldehyde plasma protein adducts in Fischer 344 rats
Q36716401The glucose metabolite methylglyoxal inhibits expression of the glucose transporter genes by inactivating the cell surface glucose sensors Rgt2 and Snf3 in yeast.
Q34436018The maillard reaction in eye diseases
Q84735970The metal ion requirements of Arabidopsis thaliana Glx2-2 for catalytic activity
Q46026413The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1.
Q38200957The pathobiology of diabetic vascular complications--cardiovascular and kidney disease
Q37801857The pathogenic role of Maillard reaction in the aging eye.
Q37661644The proinflammatory cytokine high-mobility group box-1 mediates retinal neuropathy induced by diabetes
Q40797864The protection conferred against ischemia-reperfusion injury in the diabetic brain by N-acetylcysteine is associated with decreased dicarbonyl stress
Q34348813The role of AGEs in aging: causation or correlation
Q35649410The role of advanced glycation end products in the development of atherosclerosis
Q38394355The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases
Q36916418Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
Q44525676Triosephosphates are toxic to superoxide dismutase-deficient Escherichia coli.
Q36245387Understanding RAGE, the receptor for advanced glycation end products
Q44590355Unusual susceptibility of heme proteins to damage by glucose during non-enzymatic glycation
Q83047854Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses
Q36514906Uremic Toxicity of Advanced Glycation End Products in CKD.
Q39008557Vascular AGE-ing by methylglyoxal: the past, the present and the future
Q41660334Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms
Q83105602[Current concepts of diabetic atherogenesis]
Q34440949α-Lipoic acid protects diabetic apolipoprotein E-deficient mice from nephropathy

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