Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.

scientific article published on June 1996

Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/0306-3623(95)02054-3
P698PubMed publication ID8853285

P50authorPaul J ThornalleyQ56810389
P2093author name stringThornalley PJ
P433issue4
P921main subjectpharmacologyQ128406
chemotherapyQ974135
P304page(s)565-573
P577publication date1996-06-01
P1433published inGeneral PharmacologyQ27710984
P1476titlePharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy
P478volume27

Reverse relations

cites work (P2860)
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Q28596604Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification
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Q45231085Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells
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Q46958365Glycoxidative damage to human DNA: Neo-antigenic epitopes on DNA molecule could be a possible reason for autoimmune response in type 1 diabetes
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Q36488619Identification of the Elusive Pyruvate Reductase of Chlamydomonas reinhardtii Chloroplasts
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Q37183276Molecular enzymology of the glyoxalase system
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Q46808025New aspects of diabetes
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Q44083491Novel glyoxalases from Arabidopsis thaliana
Q39445103Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease
Q60935673Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype
Q35843484Overexpression of Semicarbazide-Sensitive Amine Oxidase in Smooth Muscle Cells Leads to an Abnormal Structure of the Aortic Elastic Laminas
Q24564718Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis
Q37731347Oxidative stress and aging: is methylglyoxal the hidden enemy?
Q37390287Oxidative stress and anxiety: relationship and cellular pathways
Q34452521Oxidative stress as a mechanism of added sugar-induced cardiovascular disease
Q41883018Perturbation of human coronary artery endothelial cell redox state and NADPH generation by methylglyoxal
Q34317801Pharmacological prevention of diabetic cataract
Q39427090Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway
Q39886675Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB.
Q42118514Polymorphic glutathione S-transferase subunit 3 of rat liver exhibits different susceptibilities to carbon tetrachloride: differences in their interactions with heat-shock protein 90.
Q36432375Presence of unique glyoxalase III proteins in plants indicates the existence of shorter route for methylglyoxal detoxification
Q42803262Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells
Q37112969Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease
Q36183850Protein-bound advanced glycation endproducts (AGEs) as bioactive amino acid derivatives in foods
Q37502060Proteomic Analysis Reveals the Positive Roles of the Plant-Growth-Promoting Rhizobacterium NSY50 in the Response of Cucumber Roots to Fusarium oxysporum f. sp. cucumerinum Inoculation
Q33289842Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice
Q33874206Proteomic analysis of peach endocarp and mesocarp during early fruit development.
Q46611353Proteomics of juvenile senegal sole (Solea senegalensis) affected by gas bubble disease in hyperoxygenated ponds.
Q43712674Purification and partial characterization of glyoxalase I from bovine brain
Q43280193Purification of glyoxalase I from onion bulbs and molecular cloning of its cDNA.
Q30424520Reactive intermediates: molecular and MS-based approaches to assess the functional significance of chemical-protein adducts
Q38656989Regulation of cellular redox signaling by matricellular proteins in vascular biology, immunology, and cancer
Q40212285Ribose utilization with an excess of mutarotase causes cell death due to accumulation of methylglyoxal
Q36283681Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae
Q34336935Role for glyoxalase I in Alzheimer's disease.
Q27003423Role of advanced glycation end products in cellular signaling
Q35896615Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy
Q43774403Role of iron in the interaction of red blood cells with methylglyoxal. Modification of L-arginine by methylglyoxal is catalyzed by iron redox cycling.
Q27004644Role of methylglyoxal in Alzheimer's disease
Q28588521Role of the glyoxalase system in astrocyte-mediated neuroprotection
Q39599235Salt stress-induced alterations in the root proteome of barley genotypes with contrasting response towards salinity
Q44615951Scavenging system efficiency is crucial for cell resistance to ROS-mediated methylglyoxal injury
Q53620385Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation.
Q92893292Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAAV6 to Inflamed Endothelium
Q34487152Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
Q46500567Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.
Q46834409Sub-lethal effects of acetone on Daphnia magna.
Q41550398Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway
Q91853544The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum
Q45116939The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway
Q49363984The influence of glyoxalase 1 gene polymorphism on its expression at different stages of breast cancer in Egyptian women
Q33853348The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation
Q44041434The plastid transcription kinase from mustard (Sinapis alba L.). A nuclear-encoded CK2-type chloroplast enzyme with redox-sensitive function
Q41852765The role of glyoxalases for sugar stress and aging, with relevance for dyskinesia, anxiety, dementia and Parkinson's disease
Q30386079The sour side of neurodegenerative disorders: the effects of protein glycation.
Q46927087The structural modification of DNA nucleosides by nonenzymatic glycation: an in vitro study based on the reactions of glyoxal and methylglyoxal with 2'-deoxyguanosine
Q28211259Therapeutic potential of breakers of advanced glycation end product–protein crosslinks
Q37979691Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs
Q44525676Triosephosphates are toxic to superoxide dismutase-deficient Escherichia coli.
Q34221728Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes
Q33829548Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents
Q24682276Trypanothione-dependent glyoxalase I in Trypanosoma cruzi
Q33894738Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE
Q42155901Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I.
Q36514906Uremic Toxicity of Advanced Glycation End Products in CKD.
Q34647287Urinary d-lactate levels reflect renal function in aristolochic acid-induced nephropathy in mice.
Q46462935Use of capillary electrophoresis to evaluate protective effects of methylglyoxal scavengers on the activity of creatine kinase
Q38113107What is under the hump? Mass spectrometry based analysis of complex mixtures in processed food--lessons from the characterisation of black tea thearubigins, coffee melanoidines and caramel
Q81393241[Maillard reaction products in food as pro-inflammatory and pro-arteriosclerotic factors of degenerative diseases]
Q46013155[The unsolved problem of diabetes mellitus type 2 and associated complications].

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