cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism

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cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.273.51.34316
P8608Fatcat IDrelease_aq2tbrjp6rcxbge6rabwzg3uji
P3181OpenCitations bibliographic resource ID409839
P698PubMed publication ID9852097
P5875ResearchGate publication ID13435870

P2093author name stringD W Russell
E G Lund
J Sakai
T A Kerr
W P Li
P2860cites workActivation of the nuclear receptor LXR by oxysterols defines a new hormone response pathwayQ24316367
Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologueQ24321668
Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterolQ24562932
Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expressionQ24596101
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPsQ28115918
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factorQ28238069
Resonance Raman evidence for an Fe-O-Fe center in stearoyl-ACP desaturase. Primary sequence identity with other diiron-oxo proteinsQ28239823
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alphaQ28273937
An oxysterol signalling pathway mediated by the nuclear receptor LXR alphaQ28294042
Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating proteinQ28295187
Primary structure of xylene monooxygenase: similarities to and differences from the alkane hydroxylation systemQ28334911
Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophagesQ28369414
Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenaseQ28564292
Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulationQ28613091
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segmentQ28644805
Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidaseQ28679167
42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoterQ34163055
5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcriptionQ34192670
A novel cytochrome P450 expressed primarily in brainQ34368296
Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA.Q34439033
Polyoma and hamster papovavirus large T antigen-mediated replication of expression shuttle vectors in Chinese hamster ovary cellsQ35909612
Bile acid biosynthesisQ36136767
Identification and characterization of a novel gene (neurorep 1) expressed in nerve cells and up-regulated after axotomyQ36880719
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1aQ37360326
Ecdysone-inducible gene expression in mammalian cells and transgenic mice.Q37651825
Impact of virus infection on host cell protein synthesisQ39596383
Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protectionQ41260355
Cellular cholesterol efflux mediated by cyclodextrinsQ41324065
Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolutionQ41344600
Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.Q42815198
Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activityQ48069962
Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.Q52519814
Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transportQ59307006
Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometryQ59307017
In vitro mutagenesisQ70121220
P433issue51
P407language of work or nameEnglishQ1860
P921main subjectmembrane proteinQ423042
lipid metabolismQ2792936
cholesterol 25-hydroxylaseQ21494903
Cholesterol 25-hydroxylaseQ22676906
P304page(s)34316-27
P577publication date1998-12-18
P1433published inJournal of Biological ChemistryQ867727
P1476titlecDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
P478volume273

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cites work (P2860)
Q5935801025-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection
Q3738879825-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages
Q4154414325-Hydroxycholesterol exerts both a cox-2-dependent transient proliferative effect and cox-2-independent cytotoxic effect on bovine endothelial cells in a time- and cell-type-dependent manner
Q9856494425-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor
Q3770699925-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis
Q3920533925-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line
Q3826097125-Hydroxycholesterols in innate and adaptive immunity
Q3738992325-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
Q4403923225-hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway.
Q52775785A New Frontier in Immunometabolism. Cholesterol in Lung Health and Disease.
Q38098775A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway
Q24675994A conserved ER targeting motif in three families of lipid binding proteins and in Opi1p binds VAP
Q46440479A simple and rapid method to measure cholesterol binding to P450s and other proteins
Q38293052ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Q36269130Activated immune response in an inherited leukodystrophy disease caused by the loss of oligodendrocyte gap junctions
Q57476231Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol
Q37731924Analysis by liquid chromatography-mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7(Δ3-5/T93M) mouse: a model of Smith-Lemli-Opitz syndrome.
Q36302794Analysis of bioactive oxysterols in newborn mouse brain by LC/MS.
Q34024015Analysis of hypoxia and hypoxia-like states through metabolite profiling
Q26800190Armand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunity
Q35127516Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature
Q33900004Biosynthesis of sterols and ecdysteroids in Ajuga hairy roots
Q38808601Cell interactions and genetic regulation that contribute to testicular Leydig cell development and differentiation.
Q39539780Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain?
Q45221777Changes in the expression of steroidogenic and antioxidant genes in the mouse corpus luteum during luteolysis
Q36064007Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing
Q63246525Chewing the Fat: The Conserved Ability of DNA Viruses to Hijack Cellular Lipid Metabolism
Q24629593Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain
Q40116058Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication through Enzyme Activity-Dependent and -Independent Mechanisms
Q99566670Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and coronaviruses by depleting membrane cholesterol
Q91447831Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways
Q34378778Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
Q39541370Cholesterol 25-hydroxylation activity of CYP3A.
Q38629851Cholesterol Oxidation in Fish and Fish Products.
Q41527256Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols
Q50294251Cholesterol is hydroxylated to 25-hydroxycholesterol
Q34116399Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration
Q24294873Cholesterol, hydroxycholesterols, and bile acids
Q92446302Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol
Q36971099Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice
Q90715120Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
Q28591006De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase
Q48363327Development of a novel method for quantification of sterols and oxysterols by UPLC-ESI-HRMS: application to a neuroinflammation rat model
Q41441969Distribution of cholesterol 24-hydroxylase in the monkey brain
Q24553299Do oxysterols control cholesterol homeostasis?
Q35809390Domestication Effects on Stress Induced Steroid Secretion and Adrenal Gene Expression in Chickens
Q27932476Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction
Q47874769Early transcriptome responses of the bovine midcycle corpus luteum to prostaglandin F2α includes cytokine signaling.
Q42335261Editorial: 25-Hydroxycholesterol: a new life in immunology
Q40524298Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum
Q36956223Effects of in vitro maturation on gene expression in rhesus monkey oocytes
Q88956014Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice
Q22253434Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
Q33612299Expression microarray identifies the unliganded glucocorticoid receptor as a regulator of gene expression in mammary epithelial cells
Q63246373Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry
Q36290974Five-aza-2'-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells
Q36293529G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition
Q28730628Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H)
Q44152594Good COP, bad COP: an unsolved murder. Are dietary cholesterol oxidation products guilty of atherogenicity?
Q64972531HIV-1 Envelope Glycoprotein at the Interface of Host Restriction and Virus Evasion.
Q38904547Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice
Q46348618Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.
Q34147831Human decidual NK cells from gravid uteri and NK cells from cycling endometrium are distinct NK cell subsets
Q38363101IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.
Q35745376Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection
Q24339407Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes
Q57998626Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease
Q46253871Increased 27-hydroxycholesterol production during luteolysis may mediate the progressive decline in progesterone secretion
Q42201187Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
Q64096241Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
Q33889087Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin
Q34616709Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms
Q40913679Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
Q38134169Involvement of free radicals and oxidative stress in NAFLD/NASH.
Q37002627Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver
Q38704327Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages
Q31431904Lipoproteins regulate expression of the steroidogenic acute regulatory protein (StAR) in mouse adrenocortical cells
Q34740192Listeria monocytogenes infection induces prosurvival metabolic signaling in macrophages
Q60045905Lucky, times ten: A career in Texas science
Q37788473Macrophages, Oxysterols and Atherosclerosis
Q39841750Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
Q36610465Mechanisms for cellular cholesterol transport: defects and human disease
Q40783838Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells
Q33945985Models of luteinization
Q33605990Murine cutaneous responses to the rocky mountain spotted fever vector, Dermacentor andersoni, feeding
Q33657925Nuclear orphan receptors control cholesterol catabolism.
Q35054306Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review).
Q35723425Oxysterol binding proteins: in more than one place at one time?
Q28510184Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses
Q43170223Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners
Q38133807Oxysterols and redox signaling in the pathogenesis of non-alcoholic fatty liver disease.
Q28505509Oxysterols direct B-cell migration through EBI2
Q37638753Oxysterols in biological systems: the gastrointestinal tract, liver, vascular wall and central nervous system
Q37572785Oxysterols in heart failure
Q91874779Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol
Q93190731PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells
Q92152941Porcine Reproductive and Respiratory Syndrome Virus E Protein Degrades Porcine Cholesterol 25-Hydroxylase via the Ubiquitin-Proteasome Pathway
Q59353420Porcine reproductive and respiratory syndrome virus nsp1β and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation
Q32023548Production of 25-hydroxycholesterol by testicular macrophages and its effects on Leydig cells
Q50930107Purification and identification of 25-hydroxycholesterol in a reptile: Seasonal variation and hormonal regulation.
Q33882753Regulation of cytochrome P450 (CYP) genes by nuclear receptors.
Q28391857Role for phospholipid acyl chains and cholesterol in pulmonary infections and inflammation
Q35032382Sequence diversity in genes of lipid metabolism
Q44615973Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.
Q33590851Signatures of Archaic Adaptive Introgression in Present-Day Human Populations
Q91654242Spermine synthesis inhibitor blocks 25-hydroxycholesterol-induced- apoptosis via SREBP2 upregulation in DLD-1 cell spheroids
Q57072613Sterol Metabolism and Transport in Atherosclerosis and Cancer
Q42813123Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol.
Q92904071The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis
Q24290489The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis
Q35793178The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease.
Q33815579The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes
Q36072482The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity.
Q38511726The genomic profile of the cerebral cortex after closed head injury in mice: effects of minocycline
Q33420098Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes
Q53261375[Oxysterols: metabolism, biological role and associated diseases].
Q22010155cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

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