Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection

scientific article published on 22 April 2015

Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00587-15
P932PMC publication ID4468479
P698PubMed publication ID25903345

P50authorBao-Liang SongQ59691556
P2093author name stringYu Xiang
Jin Zhong
Jing-Jie Tang
Wanyin Tao
Xuezhi Cao
P2860cites workcDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolismQ22008532
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunityQ24296473
The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virusQ24307963
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunityQ24337582
Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanismsQ24548483
A diverse range of gene products are effectors of the type I interferon antiviral responseQ24626018
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNAQ24634416
Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexesQ24673768
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to InsigQ24683936
Robust hepatitis C virus infection in vitroQ27470013
Nonlinear partial differential equations and applications: Genomic analysis of the host response to hepatitis C virus infectionQ27473003
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteinsQ27478188
Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative StressQ27481013
Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptorQ27485871
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and productionQ27487550
Production of infectious hepatitis C virus in tissue culture from a cloned viral genomeQ27860899
Complete replication of hepatitis C virus in cell cultureQ27860934
The lipid droplet is an important organelle for hepatitis C virus productionQ28131709
Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterolQ28282311
Viral reorganization of the secretory pathway generates distinct organelles for RNA replicationQ28283814
Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteinsQ28646552
Genome-scale CRISPR-Cas9 knockout screening in human cellsQ29616044
Protein sensors for membrane sterolsQ29617313
Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic PlaquesQ30054591
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agentsQ31045004
Current and future therapies for hepatitis C virus infectionQ34036762
HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferonsQ34247460
Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferonsQ34378778
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanismsQ34616709
Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol.Q34698858
Listeria monocytogenes infection induces prosurvival metabolic signaling in macrophagesQ34740192
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylationQ34792600
Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesisQ35451879
Hepatitis C virus infection and liver steatosisQ35593064
Systematic identification of type I and type II interferon-induced antiviral factorsQ35837132
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infectionQ36402648
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral responseQ36567141
Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assemblyQ36913366
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A productionQ37377292
A novel strategy to develop a robust infectious hepatitis C virus cell culture system directly from a clinical isolateQ37547199
25-Hydroxycholesterols in innate and adaptive immunityQ38260971
MDA5 plays a critical role in interferon response during hepatitis C virus infectionQ38933210
HCV genomic RNA activates the NLRP3 inflammasome in human myeloid cellsQ39036528
A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles.Q39793262
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharideQ39841750
Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2.Q39990933
Promotion of microsatellite instability by hepatitis C virus core protein in human non-neoplastic hepatocyte cells.Q40588114
Hepatitis C virus NS3/4A protease blocks IL-28 production.Q42981120
Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication.Q42981451
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challengeQ43048336
Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and InsigsQ45081451
Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptakeQ46884435
P433issue13
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
Hepatitis C virusQ708693
P304page(s)6805-6816
P577publication date2015-04-22
P1433published inJournal of VirologyQ1251128
P1476titleIdentification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection
P478volume89

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cites work (P2860)
Q3753042225-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation
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Q33911258Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection.

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