Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation (scientific article)

cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism

Q22008532

Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment

Q24337128

A diverse range of gene products are effectors of the type I interferon antiviral response

Q24626018

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A

Q24632380

Regulation of hepatic innate immunity by hepatitis C virus

Q26824743

Innate and adaptive immune responses in HCV infections

Q26851685

Global epidemiology and genotype distribution of the hepatitis C virus infection

Q27001240

Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication

Q27339861

Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication

Q27472912

Interferon-inducible antiviral effectors

Q27486790

Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor

Q27490234

The enzymes, regulation, and genetics of bile acid synthesis

Q28204726

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

Q28282311

Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H)

Q28730628

Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus

Q33400538

Explanted diseased livers - a possible source of metabolic competent primary human hepatocytes

Q33855523

25-Hydroxycholesterol acts as an amplifier of inflammatory signaling

Q33972004

A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus

Q34010288

Differential transcriptional responses to interferon-alpha and interferon-gamma in primary human hepatocytes

Q34163327

The dependence of viral RNA replication on co-opted host factors

Q34241671

Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons

Q34378778

OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation

Q34400001

Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication

Q34430077

Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2.

Q34593688

Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms

Q34616709

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein

Q35252021

Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection

Q35745376

Systematic identification of type I and type II interferon-induced antiviral factors

Q35837132

The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response

Q36567141

Oxysterol-binding protein family I is the target of minor enviroxime-like compounds.

Q36760237

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

Q37377292

The antiviral potentials of Mx proteins

Q37384756

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

Q37710976

On the formation and possible biological role of 25-hydroxycholesterol.

Q38021545

Novel therapies for hepatitis C - one pill fits all?

Q38117549

Interferon-stimulated genes and their role in controlling hepatitis C virus

Q38128136

Lipids in innate antiviral defense

Q38153910

Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web.

Q38195556

25-Hydroxycholesterols in innate and adaptive immunity

Q38260971

Hepatitis C virus RNA replication and assembly: living on the fat of the land

Q38294573

Mx GTPases: dynamin-like antiviral machines of innate immunity

Q38312100

Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection

Q38901568

Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells

Q39117420

DNA sensing unchained

Q39192403

Cholesterol biosynthesis modulation regulates dengue viral replication

Q39856050

Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics

Q40211546

Hepatitis C: the clinical spectrum of disease

Q41598735

IFITM1 is a tight junction protein that inhibits hepatitis C virus entry

Q41844055

Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment

Q41851727

Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection.

Q42237257

All-oral HCV therapies near approval

Q42992684

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus

Q43038816

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

Hepatitis C virus

Q708693

P304

page(s)

702-714

P577

publication date

2015-05-22

P1433

published in

Hepatology

Q15724398

P1476

title

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation

P478

volume

Reverse relations

cites work (P2860)

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