Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism

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Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism is …
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review articleQ7318358
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P356DOI10.1016/J.PHARMTHERA.2005.01.001
P3181OpenCitations bibliographic resource ID2592850
P932PMC publication ID1828602
P698PubMed publication ID15922018
P5875ResearchGate publication ID7819873

P2093author name stringDavid E Williams
Sharon K Krueger
P2860cites workThe flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional proteinQ22004271
In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamilyQ23916231
Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed proteinQ24292035
Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathioneQ24293146
Oxidation of caffeine to theobromine and theophylline is catalyzed primarily by flavin-containing monooxygenase in liver microsomesQ24314549
Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in HispanicsQ24539077
Crystal structure of a Baeyer-Villiger monooxygenaseQ24561935
Yeast flavin-containing monooxygenase generates oxidizing equivalents that control protein folding in the endoplasmic reticulumQ24673769
N-oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (form 3): role in bioactivation and detoxicationQ28137664
Immunoquantitation of FMO1 in human liver, kidney, and intestineQ28144175
Mild trimethylaminuria caused by common variants in FMO3 geneQ28144334
Two novel mutations of the FMO3 gene in a proband with trimethylaminuriaQ28144483
Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6)Q28182512
Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humansQ28184203
New metabolic pathways of alpha-lipoic acidQ28189129
Identification of novel variants of the flavin-containing monooxygenase gene family in African AmericansQ28203039
6-methylhydroxylation of the anti-cancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by flavin-containing monooxygenase 3Q28205470
Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011Q28207926
Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expressionQ28216584
The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenaseQ28217168
Chemical and biological evolution of nucleotide-binding proteinQ28240624
Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidineQ28249334
Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1'-oxideQ28250108
The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expressionQ28250605
Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndromeQ28256555
A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identitiesQ28259625
Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxicationQ28267159
Three-dimensional structure of glutathione reductase at 2 Å resolutionQ28281753
Expression and characterization of a modified flavin-containing monooxygenase 4 from humansQ28284425
The molecular biology of the flavin-containing monooxygenases of manQ28300051
Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humansQ28300061
Flavin-containing monooxygenase mediated metabolism of psychoactive drugs by human brain microsomesQ28301383
Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme systemQ28330781
New sequence motifs in flavoproteins: evidence for common ancestry and tools to predict structureQ28369348
Phenotypes of flavin-containing monooxygenase activity determined by ranitidine N-oxidation are positively correlated with genotypes of linked FM03 gene mutations in a Korean populationQ28374623
Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouseQ28507596
Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeastQ28577889
Cloning, sequencing and tissue distribution of rat flavin-containing monooxygenase 4: two different forms are produced by tissue-specific alternative splicingQ28579447
Multisubstrate flavin-containing monooxygenases: applications of mechanism to specificityQ28679232
Population distribution of human flavin-containing monooxygenase form 3: gene polymorphisms.Q30766881
Metabolism of ketoconazole and deacetylated ketoconazole by rat hepatic microsomes and flavin-containing monooxygenases.Q53968891
NADPH-dependent oxidation of reduced ebselen, 2-selenylbenzanilide, and of 2-(methylseleno)benzanilide catalyzed by pig liver flavin-containing monooxygenaseQ54066252
Effects of genetic or chemically induced diabetes on imipramine metabolism. Respective involvement of flavin monooxygenase and cytochrome P-450-dependent monooxygenases.Q54404822
Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria.Q54561055
Characterization of two human flavin-containing monooxygenase (form 3) enzymes expressed in Escherichia coli as maltose binding protein fusions.Q54561103
Prochiral sulfides as in vitro probes for multiple forms of the flavin-containing monooxygenase.Q54613648
Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: studies with rabbit FMO1, FMO2, FMO3, and FMO5 expressed in Escherichia coli.Q54632225
Functional characterization of flavin-containing monooxygenase 1B1 expressed in Saccharomyces cerevisiae and Escherichia coli and analysis of proposed FAD- and membrane-binding domains.Q54660502
Identification of a Baeyer-Villiger monooxygenase sequence motifQ56900855
A hydrophobic sequence motif common to N-hydroxylating enzymesQ57978321
Studies on the chirality of sulfoxidation catalyzed by bacterial flavoenzyme cyclohexanone monooxygenase and hog liver FAD-containing monooxygenaseQ58483904
Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese.Q64912692
Hepatic microsomal mixed-function amine oxidaseQ67358280
Covalent binding of 14C- and 35S-labeled thiocarbamides in rat hepatic microsomesQ67532333
Metabolism of benzimidazoline-2-thiones by rat hepatic microsomes and hog liver flavin-containing monooxygenaseQ67589138
Neurotoxins: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 1,2,3,4-tetrahydroisoquinoline and 1-methyl-6,7-dihydroxy-tetrahydroisoquinoline as substrates for FAD-containing monooxygenase of porcine liver microsomesQ67591976
The effect of Hg2+ on rabbit hepatic and pulmonary solubilized, partially purified N,N-dimethylaniline N-oxidasesQ67693457
Microsomal mixed-function oxidase-dependent renaturation of reduced ribonucleaseQ67707927
Thiobenzamide-induced hepatotoxicity: effects of substituents and route of administration on the nature and extent of liver injuryQ67768998
Metabolism of 7-(1,3-thiazolidin-2-ylmethyl)theophylline by rat liver microsomes. Evidence for a monooxygenase-dependent step in 1,3-thiazolidine ring cleavageQ67886851
Multiple forms of liver microsomal flavin-containing monooxygenases: complete covalent structure of form 2Q67981472
Protection of rats against the effects of alpha-naphthylthiourea (ANTU) by elevation of non-protein sulphydryl levelsQ67997594
Rat hepatic microsomal metabolism of ethylenethiourea. Contributions of the flavin-containing monooxygenase and cytochrome P-450 isozymesQ68001782
The role of cytochromes P-450 and flavin-containing monooxygenase in the metabolism of (S)-nicotine by rabbit lungQ68095471
Microsomal oxidation of dodecylthioacetic acid (a 3-thia fatty acid) in rat liverQ68294966
Stereoselective sulfoxidation of a series of alkyl p-tolyl sulfides by microsomal and purified flavin-containing monooxygenasesQ68783087
Contribution of N-oxygenation to the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparationsQ68794452
The N-oxidation of alkylhydrazines catalyzed by the microsomal mixed-function amine oxidaseQ69569248
The relative participation of liver microsomal amine oxidase and cytochrome P-450 in N-demethylation reactionsQ41278083
Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking.Q41315418
Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenasesQ41500976
Primary aromatic amines: their N-oxidative bioactivationQ41590929
Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomesQ41610819
Flavin-containing monooxygenase-dependent stereoselective S-oxygenation and cytotoxicity of cysteine S-conjugates and mercapturatesQ41636016
Population-specific polymorphisms of the human FMO3 gene: significance for detoxicationQ41714991
Size limits of thiocarbamides accepted as substrates by human flavin-containing monooxygenase 1.Q42056202
Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractionsQ42224865
Metabolism of phosphorus-containing compounds by pig liver microsomal FAD-containing monooxygenaseQ42227776
Rabbit lung flavin-containing monooxygenase is immunochemically and catalytically distinct from the liver enzymeQ42249402
Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: the role of flavin-containing mono-oxygenase and cytochrome P-450 systemsQ42250916
Guanethidine N-oxide formation as a measure of cellular flavin-containing monooxygenase activityQ42259495
Detoxication of tyramine by the flavin-containing monooxygenase: stereoselective formation of the trans oximeQ42547874
Studies on the discontinuous N-oxidation of trimethylamine among Jordanian, Ecuadorian and New Guinean populationsQ42550120
Isolation and structure of a third form of liver microsomal flavin monooxygenaseQ42603718
Pulmonary toxicity of thioureas in the rat.Q43227788
In vitro evaluation of the disposition of A novel cysteine protease inhibitor.Q43508454
Accumulation of the 1-methyl-4-phenylpyridinium ion in suncus (Suncus murinus) brain: implication for flavin-containing monooxygenase activity in brain microvesselsQ43547769
Trimethylaminuria: the fish malodor syndromeQ43548058
A novel deletion in the flavin-containing monooxygenase gene (FMO3) in a Greek patient with trimethylaminuriaQ43552028
Characterization of expressed full-length and truncated FMO2 from rhesus monkeyQ43575408
In vivo variability of TMA oxidation is partially mediated by polymorphisms of the FMO3 geneQ43680703
Mechanisms for the cytotoxicity of cysteamineQ43710220
Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activitiesQ43843786
Role of yeast flavin-containing monooxygenase in maintenance of thiol-disulfide redox potentialQ43909856
The association of microsomal epoxide hydrolase polymorphisms and lung cancer risk in African-Americans and Mexican-AmericansQ43997512
Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3.Q44047239
N-oxidation and demethylation of N,N-dimethylaniline by rabbit liver and lung microsomes. Effects of age and metalsQ44062607
Sulfoxides as urinary metabolites of S-allyl-L-cysteine in rats: evidence for the involvement of flavin-containing monooxygenasesQ44135081
Stereoselective N-oxygenation of zimeldine and homozimeldine by the flavin-containing monooxygenaseQ44178326
Effects of olopatadine, a new antiallergic agent, on human liver microsomal cytochrome P450 activitiesQ44217913
Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppressionQ44264790
Sulphoxidation of ethyl methyl sulphide, 4-chlorophenyl methyl sulphide and diphenyl sulphide by purified pig liver flavin-containing monooxygenaseQ44273092
Expression and characterization of functional dog flavin-containing monooxygenase 1.Q44278260
Deactivation of sulindac-sulphide by human renal microsomesQ44354370
Hepatotoxicity of ketoconazole in Sprague-Dawley rats: glutathione depletion, flavin-containing monooxygenases-mediated bioactivation and hepatic covalent bindingQ44440251
Involvement of cytochrome P450 and the flavin-containing monooxygenase(s) in the sulphoxidation of simple sulphides in human liver microsomesQ44448193
Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: comparative genetic and functional studiesQ44483223
In vitro metabolism of clindamycin in human liver and intestinal microsomesQ44483232
Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines. XII. Enantioselectivity and temperature dependence in microsomes and reconstituted cytochrome P-450 systems from rat liverQ44486694
Critical role of histidine residues in cyclohexanone monooxygenase expression, cofactor binding and catalysisQ44641672
Gene expression profiling of oxidative stress on atrial fibrillation in humansQ44674855
S-oxidation of S-methyl-esonarimod by flavin-containing monooxygenases in human liver microsomesQ44741194
Effect of total parenteral nutrition and choline on hepatic flavin-containing and cytochrome P-450 monooxygenase activity in ratsQ44743386
Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymesQ44771795
Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.Q44787991
Cysteamine alters redox state, HIF-1alpha transcriptional interactions and reduces duodenal mucosal oxygenation: novel insight into the mechanisms of duodenal ulcerationQ44816467
Comparative hepatic and extrahepatic enantioselective sulfoxidation of albendazole and fenbendazole in sheep and cattleQ44853297
The flavin-containing monooxygenase in mouse lung: evidence for expression of multiple formsQ44856453
The effect of detergents on the purified flavin-containing monooxygenase of mouse liver, kidney and lungsQ44857039
The flavin-containing monooxygenase of mouse kidney. A comparison with the liver enzymeQ44857922
Stereospecificity in the oxidation of phorate and phorate sulphoxide by purified FAD-containing mono-oxygenase and cytochrome P-450 isozymesQ44861567
Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase.Q44862826
Pulmonary flavin-containing monooxygenase (FMO) in rhesus macaque: expression of FMO2 protein, mRNA and analysis of the cDNA.Q36849602
Yeast flavin-containing monooxygenase is induced by the unfolded protein responseQ37143530
Genetic polymorphism of trimethylamine N-oxidationQ38140229
Purification and comparison of liver microsomal flavin-containing monooxygenase from normal and streptozotocin-diabetic ratsQ38346500
Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuriaQ38351957
Studies on the mechanism of toxicity and of development of tolerance to the pulmonary toxin, alpha-naphthylthiourea (ANTU)Q39107578
Microsomal mixed-function amine oxidase. Oxidation products of piperazine-substituted phenothiazine drugsQ39195831
Superoxide radical as an intermediate in the oxidation of hydroxylamines by mixed function amine oxidaseQ39240082
The liver microsomal FAD-containing monooxygenase. Spectral characterization and kinetic studiesQ39252752
Species, organ and cellular variation in the flavin-containing monooxygenaseQ39584079
Flavin-containing monooxygenases: catalytic mechanism and substrate specificitiesQ39654203
Studies on the Nature and Regulation of the Cellular Thiol:Disulphide PotentialQ39858903
The Metabolism of Insecticides: The Role of Monooxygenase EnzymesQ40179304
Toxicology of thiono-sulfur compoundsQ40331713
The FSSP database of structurally aligned protein fold familiesQ40401060
Potential role of the flavin-containing monooxygenases in the metabolism of endogenous compoundsQ40508481
Species differential stereoselective oxidation of a methylsulfide metabolite of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor dual agonistQ40540018
The olivacine derivative s 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-B)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary cultureQ40601665
Activation of molecular oxygen by flavins and flavoproteins.Q40697821
Baculovirus-mediated expression and purification of human FMO3: catalytic, immunochemical, and structural characterizationQ40890111
Recent studies on the structure and function of multisubstrate flavin-containing monooxygenasesQ40908165
The assessment of flavin-containing monooxygenase activity in intact animalsQ41197123
Trimethylamine N-oxygenation and N-demethylation in rat liver microsomesQ72870606
Flavin-containing monooxygenase-mediated N-oxidation of the M(1)-muscarinic agonist xanomelineQ73019162
Redox regulation of yeast flavin-containing monooxygenaseQ73079922
Oxidation of cysteine S-conjugates by rabbit liver microsomes and cDNA-expressed flavin-containing mono-oxygenases: studies with S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2,2-trichlorovinyl)-L-cysteine, S-allyl-L-cysteine, and S-benzyl-L-cysteineQ73128226
N-oxygenation of clozapine by flavin-containing monooxygenaseQ73234162
Effect of age and smoking on in vivo CYP1A2, flavin-containing monooxygenase, and xanthine oxidase activities in Koreans: determination by caffeine metabolismQ73604653
Determination of FAD-binding domain in flavin-containing monooxygenase 1 (FMO1)Q73728044
N-oxygenation of phenethylamine to the trans-oxime by adult human liver flavin-containing monooxygenase and retroreduction of phenethylamine hydroxylamine by human liver microsomesQ73746641
Can caffeine metabolism be used as an in-vivo probe for human flavin-containing monooxygenase activity?Q73769609
A novel mutation in the flavin-containing monooxygenase 3 gene, FM03, that causes fish-odour syndrome: activity of the mutant enzyme assessed by proton NMR spectroscopyQ74012004
Isoform specificity of N-deacetyl ketoconazole by human and rabbit flavin-containing monooxygenasesQ74197849
Expression of two different FMOs in sheep liverQ74279923
Abnormalities of flavin monooxygenase as an etiology for sideroblastic anemiaQ74342704
Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship studyQ74505817
Sequence variations in the flavin-containing mono-oxygenase 3 gene (FMO3) in fish odour syndromeQ77362948
Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3Q77425114
Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomesQ77752834
Phenotyping of flavin-containing monooxygenase using caffeine metabolism and genotyping of FMO3 gene in a Korean populationQ77905237
Methionine S-oxidation in human and rabbit liver microsomes: evidence for a high-affinity methionine S-oxidase activity that is distinct from flavin-containing monooxygenase 3Q77967658
Contribution of flavin-containing monooxygenase and cytochrome P450 to imipramine N-oxidation in rat hepatic microsomesQ78006903
Flavin-containing monooxygenase-mediated metabolism of N-deacetyl ketoconazole by rat hepatic microsomesQ78045180
Trimethylaminuria is caused by mutations of the FMO3 gene in a North American cohortQ78233196
FORMATION OF AN INTERMEDIATE N-OXIDE IN THE OXIDATIVE DEMETHYIATION OF N,N-DIMETHYIANILINE CATALYZED BY LIVER MICROSOMESQ86282699
The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrateQ31440452
Metabolism of a disulfiram metabolite, S-methyl N,N-diethyldithiocarbamate, by flavin monooxygenase in human renal microsomesQ31835723
Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates.Q31915842
Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5).Q32064467
Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters.Q33201366
Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases. Comparison of human liver and kidney microsomes and mammalian enzymesQ33901684
Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1.Q33910078
Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-AmericansQ33922383
Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patientsQ33976915
Alternative processing of the human FMO6 gene renders transcripts incapable of encoding a functional flavin-containing monooxygenaseQ34140161
PRINTS and its automatic supplement, prePRINTS.Q34169535
Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in miceQ34171361
Trimethylaminuria and a human FMO3 mutation databaseQ34225073
Structural and catalytic properties of the mammalian flavin-containing monooxygenaseQ34311922
Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit orthologQ34319637
Biotransformation of organophosphorus compoundsQ34360437
The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genesQ34493449
The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymesQ34502898
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.Q34614591
Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolismQ34673357
Reactions of the 4a-hydroperoxide of liver microsomal flavin-containing monooxygenase with nucleophilic and electrophilic substratesQ34694694
N-oxygenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by the rat liver flavin-containing monooxygenase expressed in yeast cellsQ34721316
Alpha-lipoic acid in liver metabolism and diseaseQ34747466
An overview of the mechanism, substrate specificities, and structure of FMOsQ34818980
Genetic polymorphisms of flavin-containing monooxygenase (FMO).Q34819029
Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variationQ34849013
Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria.Q35100379
The role of the flavin-containing monooxygenase (EC 1.14.13.8) in the metabolism and mode of action of agricultural chemicalsQ35533274
Lipoic acid as a potential therapy for chronic diseases associated with oxidative stressQ35768380
A nonsense mutation in the FMO3 gene underlies fishy off-flavor in cow's milkQ35806700
Steady-state pharmacokinetics and pharmacodynamics of cysteamine bitartrate in paediatric nephropathic cystinosis patientsQ35825821
In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoformsQ36055300
Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activityQ36055351
Cloning, sequencing, distribution, and expression in Escherichia coli of flavin-containing monooxygenase 1C1. Evidence for a third gene subfamily in rabbits.Q36782075
Xenobiotic biotransforming enzymes in the central nervous system: an isoform of flavin-containing monooxygenase (FMO4) is expressed in rabbit brainQ44866362
Molecular cloning, sequencing, and expression in Escherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): comparison with the human isoformQ44868855
Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidationQ44872457
Porcine FAD-containing monooxygenase metabolizes lidocaine, bupivacaine and propranolol in vitroQ44933848
Studies on the cytochrome P-450 catalyzed ring alpha-carbon oxidation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Q44963390
S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2.Q45007440
Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients.Q45009688
Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descentQ45050361
Identification and characterization of the FMO2 gene in Rattus norvegicus: a good model to study metabolic and toxicological consequences of the FMO2 polymorphism.Q45083439
Enantioselective N-oxygenation of verapamil by the hepatic flavin-containing monooxygenaseQ45106363
A mutation in the flavin-containing monooxygenase 3 gene and its effects on catalytic activity for N-oxidation of trimethylamine in vitroQ45201110
The effect of methimazole on thioamide bioactivation and toxicityQ45262503
Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxideQ45264840
Enantioselective N-oxygenation of chlorpheniramine by the flavin-containing monooxygenase from hog liverQ45385468
Enantioselective S-oxygenation of 2-aryl-1,3-dithiolanes by rabbit lung enzyme preparations.Q45982401
Properties of expressed and native flavin-containing monooxygenases: evidence of multiple forms in rabbit liver and lungQ46133044
S-oxidative cleavage of farnesylcysteine and farnesylcysteine methyl ester by the flavin-containing monooxygenaseQ46136040
Use of thiocarbamides as selective substrate probes for isoforms of flavin-containing monooxygenasesQ46209674
Formation of glutathionyl-spironolactone disulfide by rat liver cytochromes P450 or hog liver flavin-containing monooxygenases: a functional probe of two-electron oxidations of the thiosteroid?Q46216706
Glutathione S-transferase M1 polymorphism and lung cancer risk in African-AmericansQ46306966
Expression in Escherichia coli of the cloned flavin-containing monooxygenase from pig liverQ46315184
Quantitative analysis of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolism in isolated rat hepatocytesQ46496103
Liver microsome and flavin-containing monooxygenase catalyzed oxidation of organic selenium compoundsQ46716422
Estimation of flavin-containing monooxygenase activities in crude tissue preparations by thiourea-dependent oxidation of thiocholineQ46779434
Stereoselectivity in the N'-oxidation of nicotine isomers by flavin-containing monooxygenaseQ46806772
Tertiary amines related to brompheniramine: preferred conformations for N-oxygenation by the hog liver flavin-containing monooxygenaseQ46844193
Rabbit lung flavin-containing monooxygenase. Purification, characterization, and induction during pregnancyQ46899045
Substrate specificities of rabbit lung and porcine liver flavin-containing monooxygenases: differences due to substrate sizeQ47445222
Lung cancer risk and CYP1A1 genotype in African AmericansQ47943724
Effect of cysteamine hydrochloride on secretion of growth hormone in male swineQ48182934
The FMO2 gene of laboratory rats, as in most humans, encodes a truncated proteinQ48312846
Differences in enzymatic properties of flavin-containing monooxygenase in brain microsomes of rat, mouse, hamster, guinea pig and rabbit.Q48642976
Cerebral metabolism of imipramine and a purified flavin-containing monooxygenase from human brain.Q48952585
Effect of methimazole, an FMO substrate and competitive inhibitor, on the neurotoxicity of 3,3'-iminodipropionitrile in male rats.Q50509009
N-deacetyl ketoconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes.Q50530624
The flavin-containing monooxygenases in rat liver: evidence for the expression of a second form different from FMO1.Q50759706
Cytochrome P4502D and -2C enzymes catalyze the oxidative N-demethylation of the parkinsonism-inducing substance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in rat liver microsomes.Q50991255
Cerebral flavin-containing monooxygenase-mediated metabolism of antidepressants in brain: immunochemical properties and immunocytochemical localization.Q52033109
Sulfoxidation of thioether-containing pesticides by the flavin-adenine dinucleotide- dependent monooxygenase of pig liver microsomes.Q52530696
Flavin adenine dinucleotide--dependent monooxygenase: its role in the sulfoxidation of pesticides in mammals.Q52534815
Stereoselective sulfoxidation of the pesticide methiocarb by flavin-containing monooxygenase and cytochrome P450-dependent monooxygenases of rat liver microsomes. Anticholinesterase activity of the two sulfoxide enantiomers.Q52546979
S-oxygenation of thiourea results in the formation of genotoxic products.Q52564441
Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome.Q52585908
S-Oxygenation of N-substituted thioureas catalyzed by the pig liver microsomal FAD-containing monooxygenaseQ52770703
In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation.Q52846035
Purification of mixed-function amine oxidase from rat liver microsomes.Q53561036
Effect of inhibitors of the FAD-containing monooxygenase system from rat liver microsomes on monomethylhydrazine metabolism and activation to reactive metabolitesQ69585380
Substrate specificity of the rabbit lung flavin-containing monooxygenase for amines: oxidation products of primary alkylaminesQ69670742
Formation of hydrogen peroxide and N-hydroxylated amines catalyzed by pulmonary flavin-containing monooxygenases in the presence of primary alkylaminesQ69712670
Studies on substrate specificity of the hog liver flavin-containing monooxygenase. Anionic organic sulfur compoundsQ69714312
Loss of rat liver microsomal cytochrome P-450 during methimazole metabolism. Role of flavin-containing monooxygenaseQ69858815
Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbitQ69940104
Catalytic activity and substrate specificity of the flavin-containing monooxygenase in microsomal systems: characterization of the hepatic, pulmonary and renal enzymes of the mouse, rabbit, and ratQ69952739
Interaction of primary amines with a mixed-function amine oxidase isolated from pig liver microsomesQ70049974
Cytochrome P-450- and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene and its covalent binding to nuclear DNAQ70366802
Microsomal oxidase. IV. Properties of a mixed-function amine oxidase isolated from pig liver microsomesQ70378536
Studies of the mechanism of metabolism of thioacetamide s-oxide by rat liver microsomesQ70438506
Increased biliary GSSG efflux from rat livers perfused with thiocarbamide substrates for the flavin-containing monooxygenaseQ70490505
Characterization of the purified microsomal FAD-containing monooxygenase from mouse and pig liverQ70493110
Purification of macaque liver flavin-containing monooxygenase: a form of the enzyme related immunochemically to an isozyme expressed selectively in adult human liverQ70597169
Microsomal oxidation of thiobenzamide. A photometric assay for the flavin-containing monooxygenaseQ70719431
Comparative sulphoxidation of albendazole by sheep and cattle liver microsomes and the inhibitory effect of methimazoleQ70727973
The oxidation of hydrazine derivatives catalyzed by the purified liver microsomal FAD-containing monooxygenaseQ70730004
Further characterization of rat brain flavin-containing monooxygenase. Metabolism of imipramine to its N-oxideQ71077788
Oxidation of aldehydes catalyzed by pig liver flavin-containing monooxygenaseQ71215029
Selectivity of flavin-containing monooxygenase 5 for the (S)-sulfoxidation of short-chain aralkyl sulfidesQ71215054
S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeastQ71290712
Relative hepatotoxicity of substituted thiobenzamides and thiobenzamide-S-oxides in the ratQ71343506
Species differences in pulmonary N-oxidation of chlorpromazine and imipramineQ71370290
Role of the microsomal FAD-containing monooxygenase in the liver toxicity of thioacetamide S-oxideQ71373979
Metabolism of alpha-naphthylthiourea by rat liver and rat lung microsomesQ71506324
Characterization of the methionine S-oxidase activity of rat liver and kidney microsomes: immunochemical and kinetic evidence for FMO3 being the major catalystQ71530817
In vitro microsomal metabolism of hydrazineQ71546873
Discontinuous distribution of N-oxidation of dietary-derived trimethylamine in a British populationQ71728615
N-oxygenation of primary amines and hydroxylamines and retroreduction of hydroxylamines by adult human liver microsomes and adult human flavin-containing monooxygenase 3Q71746723
Trimethylamine N-oxidation in Turkish women with bacterial vaginosisQ71840310
In vitro-in vivo correlations of human (S)-nicotine metabolismQ71987568
Flavin-containing monooxygenase (FMO)-dependent metabolism of methionine and evidence for FMO3 being the major FMO involved in methionine sulfoxidation in rabbit liver and kidney microsomesQ72037168
Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomesQ72208998
Role of cytochromes P-450 and flavin-containing monooxygenase in the biotransformation of 4-fluoro-N-methylanilineQ72217162
Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-oxidationQ72232377
Metabolism-dependent toxicity of methimazole in the olfactory nasal mucosaQ72245630
A quantitative micro method for the estimation of amine oxidesQ72379928
Factors influencing the oxidation of cysteamine and other thiols: implications for hyperthermic sensitization and radiation protectionQ72399316
Oxidation of dimethylselenide to dimethylselenoxide by microsomes from rat liver and lung and by flavin-containing monooxygenase from pig liverQ72411623
Stereoselective S-oxidation of flosequinan sulfide by rat hepatic flavin-containing monooxygenase 1A1 expressed in yeastQ72425583
Inhibition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolic activity of porcine FAD-containing monooxygenase by selective monoamine oxidase-B inhibitorsQ72426791
Asymmetric metabolic N-oxidation of N-ethyl-N-methylaniline by purified flavin-containing monooxygenaseQ72520295
Tissue-specific expression of flavin-containing monooxygenase (FMO) forms 1 and 2 in the rabbitQ72633049
Mechanism of inactivation of thyroid peroxidase by thioureylene drugsQ72688827
Characteristic properties and kinetic analysis with neurotoxins of porcine FAD-containing monooxygenaseQ72773967
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectdrug metabolismQ1124842
P304page(s)357-87
P577publication date2005-06-01
P1433published inPharmacology & TherapeuticsQ3378596
P1476titleMammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism
P478volume106

Reverse relations

cites work (P2860)
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Q92229907Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs
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Q37425658Cytochrome P450 metabolism and inhibition: analysis for drug discovery
Q37189245D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis
Q45218281Development of a CD-MEKC method for investigating the metabolism of tamoxifen by flavin-containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA.
Q46304439Development of electrophoretically mediated microanalysis method for the kinetics study of flavin-containing monooxygenase in a partially filled capillary.
Q90594112Development of potent inhibitors of the human microsomal epoxide hydrolase
Q36545025Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3.
Q27002933Developmental pharmacokinetics in pediatric populations
Q53001535Dietary conjugated linoleic acid affects blood parameters, liver morphology and expression of selected hepatic genes in laying hens.
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Q51770720Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver.
Q36559863Different cucumber CsYUC genes regulate response to abiotic stresses and flower development
Q35596350Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice
Q37405059Differential RNA Expression Profile of Skeletal Muscle Induced by Experimental Autoimmune Myasthenia Gravis in Rats.
Q28567676Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes
Q34338686Dimethylsulphidemia: the significance of dimethyl sulphide in extra-oral, blood borne halitosis
Q98625321Discovery of a histidine-based scaffold as an inhibitor of gut microbial choline trimethylamine-lyase
Q50462011Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients.
Q38966423Drug metabolism by flavin-containing monooxygenases of human and mouse.
Q36435702Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice
Q38307386Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver
Q41618331Effect of human flavin-containing monooxygenase 3 polymorphism on the metabolism of aurora kinase inhibitors
Q28570562Effect of hyperosmotic conditions on flavin-containing monooxygenase activity, protein and mRNA expression in rat kidney
Q85317400Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers
Q35686503Effects of a Terrified-Sound Stress on Serum Proteomic Profiling in Mice
Q37038292Effects of ritonavir on adipocyte gene expression: evidence for a stress-related response
Q42360866Effects of salinity acclimation on the pesticide-metabolizing enzyme flavin-containing monooxygenase (FMO) in rainbow trout (Oncorhynchus mykiss).
Q36337990Emerging roles of flavin monooxygenase 3 in cholesterol metabolism and atherosclerosis
Q46089936Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms
Q33609122Environmental sensing and response genes in cnidaria: the chemical defensome in the sea anemone Nematostella vectensis.
Q40439693Escherichia coli Overexpressing a Baeyer-Villiger Monooxygenase from Acinetobacter radioresistens Becomes Resistant to Imipenem.
Q30763197Eureka-DMA: an easy-to-operate graphical user interface for fast comprehensive investigation and analysis of DNA microarray data
Q41830391Exploring nicotinamide cofactor promiscuity in NAD(P)H-dependent flavin containing monooxygenases (FMOs) using natural variation within the phosphate binding loop. Structure and activity of FMOs from Cellvibrio sp. BR and Pseudomonas stutzeri NF13.
Q45317495FMO oxidises nucleophiles
Q53033156First case of Currarino syndrome and trimethylaminuria: two rare diseases for a complex clinical presentation.
Q64084770Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity
Q95851909Flavin Containing Monooxygenases and Metabolism of Xenobiotics
Q89452333Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk
Q33631394Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes
Q47116870Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway.
Q37008890Flavin-containing monooxygenase 3 and human disease
Q48031007Flavin-containing monooxygenase 3 gene polymorphisms in Turkish population
Q39213310Flavin-containing monooxygenase 3 polymorphisms in 13 ethnic populations from Europe, East Asia and sub-Saharan Africa: frequency and linkage analysis
Q33946752Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones.
Q36316996Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development.
Q34005493Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver.
Q53204311Flavin-containing monooxygenases from Phanerochaete chrysosporium responsible for fungal metabolism of phenolic compounds.
Q39313594Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes
Q92229912Flavin-containing monooxygenases: new structures from old proteins
Q38648995Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health.
Q41857015Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria
Q38619177Genetic and Non-genetic Factors Associated with Protein Abundance of Flavin-containing Monooxygenase 3 in Human Liver
Q28305656Genetic polymorphisms of human flavin-containing monooxygenase 3: implications for drug metabolism and clinical perspectives
Q37187804Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects
Q36540437Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease
Q93223495Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline
Q24539077Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics
Q34433222Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli
Q35727337Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis
Q41763477Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide
Q41206250Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria
Q91802338Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation
Q40278415Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice
Q47143254Identification of novel gene expression signature in lung adenocarcinoma by using next-generation sequencing data and bioinformatics analysis
Q34510105Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis
Q37889234In vitro approaches to studying the metabolism of new psychoactive compounds
Q36662870Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics
Q33712363Isoform distinct time-, dose-, and castration-dependent alterations in flavin-containing monooxygenase expression in mouse liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Q27664240Joint Functions of Protein Residues and NADP(H) in Oxygen Activation by Flavin-containing Monooxygenase
Q28553912Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects
Q33976014Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide
Q39109460Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes
Q46305658Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin
Q36753612Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse
Q37060764Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes
Q53625601Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites.
Q36504395Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
Q27728081Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase
Q42596962Molecular cloning, sequence characterization, SNP detection, and tissue expression analysis of duck FMO3 gene
Q47584047Molecular phylogeny, long-term evolution, and functional divergence of flavin-containing monooxygenases
Q36642348Nicotinamide N-oxidation by CYP2E1 in human liver microsomes
Q58086982Nicotine-N'-oxidation by flavin monooxygenase enzymes
Q38929936Non-cytochrome P450-mediated bioactivation and its toxicological relevance.
Q42708412Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway.
Q36839694Osmotic regulation of a novel flavin-containing monooxygenase in primary cultured cells from rainbow trout (Oncorhynchus mykiss).
Q49397777Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer.
Q36870689Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3.
Q36414574Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells
Q38295313Pharmacogenetics of drug-metabolizing enzymes in Italian populations.
Q38127716Pharmacogenetics of olanzapine metabolism
Q34717044Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study
Q36245456Predicting the Metabolic Sites by Flavin-Containing Monooxygenase on Drug Molecules Using SVM Classification on Computed Quantum Mechanics and Circular Fingerprints Molecular Descriptors
Q90525391Production of drug metabolites by human FMO3 in Escherichia coli
Q46353725Protein kinase CK2 regulates redox homeostasis through NF-κB and Bcl-xL in cardiomyoblasts.
Q58838045Proteomic analysis of Bayvarol®resistance mechanisms in the honey bee parasiteVarroa destructor
Q35055301Quail FMO3 gene cloning, tissue expression profiling, polymorphism detection and association analysis with fishy taint in eggs
Q37062604Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny.
Q48192886Range of therapeutic prothipendyl and prothipendyl sulfoxide concentrations in clinical blood samples
Q36252867Regioselective oxidation of phospho-NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety
Q98566142Regulation of dynamic pigment cell states at single-cell resolution
Q37731862Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.
Q57730438Response to: “Prediction of Voriconazole Non-Linear Pharmacokinetics Using a Paediatric Physiologically Based Pharmacokinetic Modelling Approach”
Q27650474Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase
Q42180308Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes
Q52652398Selective Heteroaryl N-Oxidation of Amine-Containing Molecules.
Q44169005Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
Q38717340Specific features of pharmacokinetics in children.
Q51248022Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.
Q90582114Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria
Q46361393Subclade of flavin-monooxygenases involved in aliphatic glucosinolate biosynthesis
Q28504955Synchronous evolution of an odor biosynthesis pathway and behavioral response
Q33562137Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American
Q92511817Targeted ultra-deep sequencing of a South African Bantu-speaking cohort to comprehensively map and characterize common and novel variants in 65 pharmacologically-related genes
Q55082798Tetracycline-Inactivating Enzymes.
Q79734003The Arabidopsis flavin-dependent monooxygenase FMO1 is an essential component of biologically induced systemic acquired resistance
Q34176701The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility
Q38764871The Genetic Architecture of Coronary Artery Disease: Current Knowledge and Future Opportunities
Q92327987The Roles of Auxin Biosynthesis YUCCA Gene Family in Plants
Q54686050The association of cytochrome P450 genetic polymorphisms with sulfolane formation and the efficacy of a busulfan-based conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantation.
Q34079767The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent
Q35871695The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing
Q37772507The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism
Q37152243The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa
Q36473486The role of flavin-containing monooxygenase (FMO) in the metabolism of tamoxifen and other tertiary amines
Q34737067Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.
Q38709842Transcriptome profiling of 3D co-cultured cardiomyocytes and endothelial cells under oxidative stress using a photocrosslinkable hydrogel system
Q34626393Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity
Q37357727Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease.
Q40752459Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease
Q27670798Two Structures of an N-Hydroxylating Flavoprotein Monooxygenase: ORNITHINE HYDROXYLASE FROM PSEUDOMONAS AERUGINOSA
Q38167838Use of density functional theory in drug metabolism studies.
Q59153034Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population
Q37645239Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism
Q37514335Xenobiotic metabolizing enzymes and metabolism of anthelminthics in helminths.

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