Multivalent endosome targeting by homodimeric EEA1

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Multivalent endosome targeting by homodimeric EEA1 is …
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scholarly articleQ13442814

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P356DOI10.1016/S1097-2765(01)00385-9
P8608Fatcat IDrelease_33q4vevhjzcctdzqlcsnbq24ne
P3181OpenCitations bibliographic resource ID3967467
P698PubMed publication ID11741531
P5875ResearchGate publication ID11614296

P2093author name stringD G Lambright
D Lawe
D Rajamani
E Merithew
E Sudharshan
J J Dumas
S Corvera
S Hayes
P2860cites workThe Rab5 effector EEA1 interacts directly with syntaxin-6Q22010591
EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motifQ24320229
EEA1 links PI(3)K function to Rab5 regulation of endosome fusionQ24322668
Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.Q24515230
Signal-dependent membrane targeting by pleckstrin homology (PH) domainsQ24532099
Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteinsQ24532611
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cellsQ24599234
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27pQ27618582
Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transductionQ27621560
Structural mechanism of endosome docking by the FYVE domainQ27630275
Raster3D: photorealistic molecular graphicsQ27860557
The CCP4 suite: programs for protein crystallographyQ27861090
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domainsQ27933286
Signalling through phosphoinositide 3-kinases: the lipids take centre stageQ28141934
Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13Q28142791
FYVE fingers bind PtdIns(3)PQ28279043
Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE fingerQ28289331
The Rab5 effector EEA1 is a core component of endosome dockingQ29620568
The role of phosphoinositide 3-kinase lipid products in cell functionQ33543235
Regulation of endosome fusion.Q33637955
Phosphoinositides in membrane trafficQ33712456
Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.Q36655286
The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimerQ38328008
Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes. Role of conserved residuesQ40880319
Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes.Q41016003
Using structure to define the function of phosphoinositide 3-kinase family membersQ41554112
The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localizationQ42806047
High-affinity binding of a FYVE domain to phosphatidylinositol 3-phosphate requires intact phospholipid but not FYVE domain oligomerizationQ43676993
A functional PtdIns(3)P-binding motifQ47713511
[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.Q55059918
Phosphatidylinositol 3-Phosphate Recognition by the FYVE DomainQ57800410
Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomesQ73413820
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transductionQ77686452
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectEarly endosome antigen 1Q4037784
protein homodimerization activityQ14762996
P304page(s)947-58
P577publication date2001-11-01
P1433published inMolecular CellQ3319468
P1476titleMultivalent endosome targeting by homodimeric EEA1
P478volume8

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