Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

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Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1027695431
P356DOI10.1038/NATURE12205
P3181OpenCitations bibliographic resource ID1153025
P698PubMed publication ID23698361
P5875ResearchGate publication ID236932292

P50authorAlfred WittinghoferQ110588
Herbert WaldmannQ1609256
Gemma TriolaQ30503863
Stephan HahnQ56850416
Shehab A IsmailQ59543248
P2093author name stringNachiket Vartak
Philippe I H Bastiaens
Anchal Chandra
Gunther Zimmermann
Björn Papke
Maike Hoffmann
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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activityQ27678097
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Imaging biochemistry inside cellsQ34228151
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The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteinsQ39426327
In situ analysis of tyrosine phosphorylation networks by FLIM on cell arraysQ39706047
Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activityQ40543716
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancerQ41454824
Multiple Cellular Proteins Modulate the Dynamics of K-ras Association with the Plasma MembraneQ42364777
Photoreceptor cGMP Phosphodiesterase δ Subunit (PDEδ) Functions as a Prenyl-binding ProteinQ44619466
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.Q52826734
RAS oncogenes: the first 30 years.Q55036584
Synthesis of the Rheb and K-Ras4B GTPasesQ57006918
P433issue7451
P407language of work or nameEnglishQ1860
P921main subjectKRAS proto-oncogene, GTPaseQ4042017
P304page(s)638-42
P577publication date2013-05-30
P1433published inNatureQ180445
P1476titleSmall molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
P478volume497

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