14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity

scientific article

14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/21.8.1889
P932PMC publication ID125975
P698PubMed publication ID11953308
P5875ResearchGate publication ID11414328

P2093author name stringYonathan F Melman
Thomas V McDonald
Anna Kagan
Andrew Krumerman
P2860cites workMiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmiaQ22009462
Modulation of A-type potassium channels by a family of calcium sensorsQ22253194
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complexQ24291117
The 14-3-3 protein binds its target proteins with a common site located towards the C-terminusQ48636298
Structure and sites of phosphorylation of 14-3-3 protein: role in coordinating signal transduction pathways.Q48667801
Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A.Q48909397
Modulation of the Ca(2+)-activated Cl(-) channel by 14-3-3epsilon.Q50719734
14-3-3 proteins double the number of outward-rectifying K+ channels available for activation in tomato cellsQ52171422
Identification of soluble protein phosphatases that dephosphorylate voltage-sensitive sodium channels in rat brainQ72132255
Protein phosphorylation and cardiac function: cholinergic-adrenergic interactionQ72722195
Glucocorticoid receptor interaction with 14-3-3 and Raf-1, a proposed mechanism for cross-talk of two signal transduction pathwaysQ73004180
A plethora of mechanisms in the HERG-related long QT syndrome. Genetics meets electrophysiologyQ73482820
The dominant negative LQT2 mutation A561V reduces wild-type HERG expressionQ73643302
Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2Q73693862
Cyclic AMP regulates the HERG K(+) channel by dual pathwaysQ73849628
Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and IIQ77932855
Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulationQ24291204
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channelQ24292184
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channelQ24316252
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserineQ24322674
Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippersQ24678432
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand bindingQ27619633
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathwaysQ27729753
Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97Q28200159
14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchangeQ28208614
A minK-HERG complex regulates the cardiac potassium current I(Kr)Q28244324
14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domainQ28246442
The complexity of Raf-1 regulationQ28305850
A structural basis for drug-induced long QT syndromeQ28344808
A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2Q28572706
KChAP as a chaperone for specific K(+) channelsQ28575980
The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2CQ28593847
The structural basis for 14-3-3:phosphopeptide binding specificityQ29547190
14-3-3 proteins: structure, function, and regulationQ29619100
Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage displayQ30776583
Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociationQ32061766
The molecular genetics of the long QT syndrome: genes causing fainting and sudden deathQ33175543
The long QT syndrome: ion channel diseases of the heartQ33175550
Modulation of ion channels: a "current" view of AKAPsQ33703246
The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypesQ33860370
The long QT syndromes: genetic basis and clinical implicationsQ33970623
Long QT syndrome: cellular basis and arrhythmia mechanism in LQT2.Q34150435
Regulation of the cardiac repolarizing HERG potassium channel by protein kinase A.Q34204693
I(Kr): the hERG channelQ34245075
14-3-3 proteins; bringing new definitions to scaffoldingQ34405540
Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association.Q39426606
14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activityQ39575866
A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP.Q40557820
Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neuronsQ40788634
Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS.Q40923240
HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defectsQ41018746
A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminalsQ47070572
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectPotassium voltage-gated channel subfamily H member 2Q905000
regulation of potassium ion transmembrane transportQ14905768
negative regulation of peptidyl-serine dephosphorylationQ21100618
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonQ21109282
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaQ21109299
positive regulation of peptidyl-serine dephosphorylationQ21111840
regulation of peptidyl-serine dephosphorylationQ22245333
P304page(s)1889-1898
P577publication date2002-04-01
P1433published inThe EMBO JournalQ1278554
P1476title14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity
P478volume21

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cites work (P2860)
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