ACE2: from vasopeptidase to SARS virus receptor

scientific article

ACE2: from vasopeptidase to SARS virus receptor is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.TIPS.2004.04.001
P953full work available at URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119032/
P932PMC publication ID7119032
P698PubMed publication ID15165741

P50authorNigel Mark HooperQ37376223
Julian HiscoxQ40004586
P2093author name stringAnthony J Turner
P2860cites workCounterregulatory actions of angiotensin-(1-7).Q41607078
Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitorsQ44162874
Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.Q44353743
Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2.Q44592757
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependenceQ44649919
The SARS-CoV S glycoprotein: expression and functional characterizationQ47346882
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidaseQ22254730
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9Q24290169
Crystal structure of the human angiotensin-converting enzyme-lisinopril complexQ24293072
Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexinsQ24321922
Human aminopeptidase N is a receptor for human coronavirus 229EQ24338168
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysisQ27643059
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidaseQ28115041
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirusQ28188496
A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2Q28191005
Characterization of a novel coronavirus associated with severe acute respiratory syndromeQ28202401
Angiotensin-converting enzyme 2 is an essential regulator of heart functionQ28205840
The Genome sequence of the SARS-associated coronavirusQ29619007
Novel peptide inhibitors of angiotensin-converting enzyme 2.Q31133376
Ace revisited: a new target for structure-based drug design.Q34282839
The angiotensin-converting enzyme gene family: genomics and pharmacologyQ34586915
The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replicationQ35201150
Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirusQ35607907
Enhanced Renal Immunocytochemical Expression of ANG-(1-7) and ACE2 During PregnancyQ57185045
A model of the ACE2 structure and function as a SARS-CoV receptor.Q64924413
Cardiac Angiotensin-(1-7) in Ischemic CardiomyopathyQ79096678
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpeptidaseQ212410
SARSr-CoVQ278567
angiotensin I converting enzyme 2Q301630
isozymeQ407801
peptide hormoneQ416997
blood vesselQ988343
viral entry into host cellQ4118894
virus receptorsQ66053321
SARS-CoV-1Q85438966
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)291-4
P577publication date2004-06-01
P1433published inTrends in Pharmacological SciencesQ2451474
P1476titleACE2: from vasopeptidase to SARS virus receptor
P478volume25

Reverse relations

cites work (P2860)
Q93166790ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models
Q24538811ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia
Q97551921ACE2, the Receptor that Enables the Infection by SARS-CoV-2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators
Q91703665Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System
Q90027115Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics
Q94587433Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019
Q97075901Angiotensin-Converting Enzyme 2 and the Resolution of Inflammation: In Support of Continuation of Prescribed Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers
Q51820362Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome.
Q46068140Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes
Q92070664COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities
Q92103416COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities
Q98779021COVID-19 and Central Nervous System: Entry Routes And
Q97636658COVID-19 and Myocarditis: What Do We Know So Far?
Q110566803COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation
Q97636279COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives
Q90092121COVID-19 and the cardiovascular system
Q99240645COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications
Q95276824COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches
Q91717735COVID-19: Risk Groups, Mechanistic Insights, and Challenges
Q99553587Can symptoms of anosmia and dysgeusia be diagnostic for COVID-19?
Q91931325Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?
Q98648527Canakinumab to reduce deterioration of cardiac and respiratory function in SARS-CoV-2 associated myocardial injury with heightened inflammation (canakinumab in Covid-19 cardiac injury: The three C study)
Q40329899Cardioprotective role for angiotensin-(1-7) and angiotensin converting enzyme 2 in the heart
Q97093986Cardiovascular disease management during the coronavirus disease 2019 pandemic
Q99631931Cardiovascular involvement in COVID-19: not to be missed
Q96612393Cardiovascular manifestations in severe and critical patients with COVID-19
Q91996603Characteristic Electrocardiographic Manifestations in Patients With COVID-19
Q98155172Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis
Q40231729Computational characterization and design of SARS coronavirus receptor recognition and antibody neutralization
Q94671925Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Q99597189Coronavirus disease-19 and cardiovascular disease: A risk factor or a risk marker?
Q52017432Developmental expression of ACE2 in the SHR kidney: a role in hypertension?
Q95300834Diabetes and metabolic syndrome as risk factors for COVID-19
Q36817565Enzymatic pathways of the brain renin-angiotensin system: unsolved problems and continuing challenges.
Q94562917Epidemiological analysis of the early 38 fatalities in Hubei, China, of the coronavirus disease 2019
Q92040628Epidemiology and clinical features of COVID-19: A review of current literature
Q98224247Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels
Q47752741Good ACE, bad ACE do battle in lung injury, SARS.
Q41786103Human recombinant ACE2 reduces the progression of diabetic nephropathy
Q35025287Hydrolysis of angiotensin peptides by human angiotensin I-converting enzyme and the resensitization of B2 kinin receptors
Q40399203Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis
Q91719430Inside the heart of COVID-19
Q93270479Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors-lessons from available evidence and insights into COVID-19
Q94602018Lipid-lowering therapy and renin-angiotensin-aldosterone system inhibitors in the era of the COVID-19 pandemic
Q35088385Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis
Q36935327Modulation of glomerulosclerosis
Q99630284Myocardial injury and COVID-19: Serum hs-cTnI level in risk stratification and the prediction of 30-day fatality in COVID-19 patients with no prior cardiovascular disease
Q96647283Neurological Manifestations of COVID-19 (SARS-CoV-2): A Review
Q37660786New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism
Q94460600Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far
Q96302226Outbreak of SARS-CoV2: Pathogenesis of infection and cardiovascular involvement
Q36846526PAI-1 and kidney fibrosis
Q94466083Perspectives for the use of therapeutic Botulinum toxin as a multifaceted candidate drug to attenuate COVID-19
Q34645944Preparative Purification of Linarin Extracts from Dendranthema indicum Flowers and Evaluation of Its Antihypertensive Effect
Q99202266Psychological, addictive, and health behavior implications of the COVID-19 pandemic
Q35011434Recently discovered human coronaviruses
Q38750210Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease
Q98771893Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review
Q37884450Role of ACE2 in diastolic and systolic heart failure.
Q37081415Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure
Q94547449SARS-CoV-2 and the Use of Chloroquine as an Antiviral Treatment
Q94492553SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications
Q44282005SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS.
Q36415424Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention
Q37089449Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibition
Q91977604The double burden of disease of COVID-19 in cardiovascular patients: overlapping conditions could lead to overlapping treatments
Q34010888The nucleocapsid protein of SARS-CoV induces transcription of hfgl2 prothrombinase gene dependent on C/EBP alpha.
Q93237239The pivotal link between ACE2 deficiency and SARS-CoV-2 infection
Q94656864The pulmonary-proteoliposome as a new therapeutic approach for Coronaviruses
Q36663074Type 1 angiotensin receptor pharmacology: signaling beyond G proteins.
Q36776835Virus-mediated modulation of the host endocrine signaling systems: clinical implications