Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention

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Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/MED.20055
P932PMC publication ID7168515
P698PubMed publication ID16521129

P2093author name stringNicholas A Meanwell
Kap-Sun Yeung
Gregory A Yamanaka
P2860cites workA human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidaseQ22254730
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9Q24290169
ACE2: from vasopeptidase to SARS virus receptorQ24294404
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirusQ24307914
pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGNQ24563490
The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core ComplexQ27477706
Structural basis for paramyxovirus-mediated membrane fusionQ27617867
Structural characterization of the human respiratory syncytial virus fusion protein coreQ27628799
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysisQ27643059
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirusQ28188496
The HIV Env-mediated fusion reactionQ28188544
Characterization of a novel coronavirus associated with severe acute respiratory syndromeQ28202401
Angiotensin-converting enzyme 2 is an essential regulator of heart functionQ28205840
Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infectionQ28588877
Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineageQ29615331
Mechanisms of viral membrane fusion and its inhibitionQ29616090
The Genome sequence of the SARS-associated coronavirusQ29619007
Immunological characterization of the spike protein of the severe acute respiratory syndrome coronavirusQ37421234
Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptorQ37423228
Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2.Q37511480
Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cellsQ37567824
Targeting a binding pocket within the trimer-of-hairpins: small-molecule inhibition of viral fusionQ37585515
Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoproteinQ39992400
Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike proteinQ40436586
Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodiesQ40437929
Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus spike glycoprotein produced from the mammalian expression system.Q40471278
Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccineQ40506063
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.Q40510688
Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expressionQ40517315
A DNA vaccine induces SARS coronavirus neutralization and protective immunity in miceQ40520942
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptorQ40546105
Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoproteinQ40548165
S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patientsQ40551623
Identification of an HLA-A*0201-restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike proteinQ40579430
Coronavirus-induced membrane fusion requires the cysteine-rich domain in the spike proteinQ40892854
Amino acids 1055 to 1192 in the S2 region of severe acute respiratory syndrome coronavirus S protein induce neutralizing antibodies: implications for the development of vaccines and antiviral agentsQ42716746
Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1.Q44000915
Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitorsQ44217290
Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoproteinQ44985460
Infectious diseases. One year after outbreak, SARS virus yields some secretsQ45637990
Structural basis for coronavirus-mediated membrane fusion. Crystal structure of mouse hepatitis virus spike protein fusion coreQ45643870
Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitorsQ45659807
Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal casesQ47242360
Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2).Q47278854
Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferretsQ47283945
The SARS-CoV S glycoprotein: expression and functional characterizationQ47346882
Identification of two antigenic epitopes on SARS-CoV spike proteinQ47378590
A molecular docking model of SARS-CoV S1 protein in complex with its receptor, human ACE2.Q47774466
The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: putative role during viral entryQ47863927
Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirusQ47902789
Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics.Q47924234
Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: implication for developing SARS diagnostics and vaccinesQ47930004
Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion coreQ47932220
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirusQ47957009
Structural characterization of the SARS-coronavirus spike S fusion protein core.Q48009341
Early events of SARS coronavirus infection in vero cells.Q51654795
Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoproteinQ56762915
Severe acute respiratory syndromeQ56775278
A model of the ACE2 structure and function as a SARS-CoV receptor.Q64924413
Oligomerization of the SARS-CoV S glycoprotein: dimerization of the N-terminus and trimerization of the ectodomainQ80457043
Epitope mapping and biological function analysis of antibodies produced by immunization of mice with an inactivated Chinese isolate of severe acute respiratory syndrome-associated coronavirus (SARS-CoV)Q81481064
Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein.Q30336102
Identification of the membrane-active regions of the severe acute respiratory syndrome coronavirus spike membrane glycoprotein using a 16/18-mer peptide scan: implications for the viral fusion mechanismQ30775494
Expression cloning of functional receptor used by SARS coronavirusQ31041420
Novel peptide inhibitors of angiotensin-converting enzyme 2.Q31133376
B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoproteinQ31149856
Potential for antiviral treatment of severe acute respiratory syndromeQ33195130
The life cycle of SARS coronavirus in Vero E6 cellsQ33203307
The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cellsQ33207348
Molecular and biological characterization of human monoclonal antibodies binding to the spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirusQ33210858
Structure of a proteolytically resistant core from the severe acute respiratory syndrome coronavirus S2 fusion proteinQ33581892
Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronavirusesQ33756740
Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variantsQ33780455
Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike proteinQ33788831
Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region.Q33834543
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entryQ33920306
T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS.Q34151667
Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides.Q34376025
Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in miceQ34385350
An exposed domain in the severe acute respiratory syndrome coronavirus spike protein induces neutralizing antibodiesQ34437463
Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodiesQ34438091
Structure of SARS coronavirus spike receptor-binding domain complexed with receptorQ34451350
Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus.Q34514760
Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infectionQ35124942
SARS coronavirus: a new challenge for prevention and therapyQ35143451
SARS--beginning to understand a new virusQ35701656
Molecular biology of severe acute respiratory syndrome coronavirusQ35883052
Cellular entry of the SARS coronavirusQ35894137
The SARS-CoV S glycoproteinQ35938995
Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitorQ36024617
Current status of anti-SARS agentsQ36058652
Development of antiviral therapy for severe acute respiratory syndrome.Q36119173
Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor associationQ36602721
Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of miceQ37010921
Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entryQ37356916
P433issue4
P304page(s)414-433
P577publication date2006-07-01
P1433published inMedicinal Research ReviewsQ2436033
P1476titleSevere acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention
P478volume26

Reverse relations

cites work (P2860)
Q81615402A second SARS-CoV S2 glycoprotein internal membrane-active peptide. Biophysical characterization and membrane interaction
Q40231729Computational characterization and design of SARS coronavirus receptor recognition and antibody neutralization
Q46287563Expression of SARS-coronavirus spike glycoprotein in Pichia pastoris
Q40030137Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors
Q35670097Impaired angiogenesis in aminopeptidase N-null mice
Q34009523Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans
Q58290652Interaction of a Peptide from the Pre-transmembrane Domain of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein with Phospholipid Membranes
Q37929687Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, and therapeutic potential
Q87461608Potential interventions for novel coronavirus in China: A systematic review
Q94589436Study of combining virtual screening and antiviral treatments of the Sars-CoV-2 (Covid-19)
Q33897964Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody
Q92053517Therapeutic strategies for critically ill patients with COVID-19

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