Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells

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Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...729518Z
P356DOI10.1371/JOURNAL.PONE.0029518
P932PMC publication ID3250450
P698PubMed publication ID22235304
P5875ResearchGate publication ID221738633

P50authorWei WangQ59683485
P2093author name stringYan Zeng
Jian Ma
Mingxiong Guo
Wenxin Li
Xianguo Wang
P2860cites workFlow cytometric analysis of human bone marrow: I. Normal erythroid development.Q52259217
Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy.Q54510439
Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation.Q54658974
Changes in cell surface antigen expressions during proliferation and differentiation of human erythroid progenitorsQ68222512
Lineage-specific regulation of cell cycle control gene expression during haematopoietic cell differentiationQ74346570
[Cloning and characterization of two novel alternatively spliced transcripts of ZNF268]Q83876442
Cloning and characterization of a novel Krüppel-like zinc finger gene, ZNF268, expressed in early human embryoQ24291146
ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver developmentQ24315713
Gene expression in proliferating human erythroid cellsQ28139879
p53-mediated differentiation of the erythroleukemia cell line K562Q28141730
The proto-oncogene c-myc in hematopoietic development and leukemogenesisQ28200929
Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineageQ28214849
Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREXQ28219302
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiationQ28244293
Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancyQ28265885
Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosomeQ28287810
Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosisQ28505824
Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOGQ28506193
Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic developmentQ28506380
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1Q28508495
Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 geneQ28509754
Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cellsQ28510862
Development of hematopoietic cells lacking transcription factor GATA-1Q28590584
KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domainsQ33251629
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disordersQ33374851
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanismQ34490491
Transcription of human zinc finger ZNF268 gene requires an intragenic promoter elementQ34540354
MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cellsQ34883097
GATA-1-mediated proliferation arrest during erythroid maturation.Q35107812
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodelingQ35170832
Mechanisms involved in the induced differentiation of leukemia cellsQ35598922
The role of CREB as a proto-oncogene in hematopoiesisQ36227096
Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathwayQ36711127
Erythropoiesis: model systems, molecular regulators, and developmental programsQ37557458
GATA factor switching during erythroid differentiationQ37705916
MicroRNAs are involved in erythroid differentiation controlQ39863507
Human myeloid leukemia cell lines: a reviewQ40289632
Fos modulates myeloid cell survival and differentiation and partially abrogates the c-Myc block in terminal myeloid differentiationQ40585990
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectGATA binding protein 1Q5512896
positive regulation of cell differentiationQ14758939
Zinc finger protein 268Q21174449
P304page(s)e29518
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleKnockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells
P478volume7

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cites work (P2860)
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Q35499791ZNF300 knockdown inhibits forced megakaryocytic differentiation by phorbol and erythrocytic differentiation by arabinofuranosyl cytidine in K562 cells
Q35125016Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins
Q35081094hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562