SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia

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SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1022210268
P356DOI10.1038/SJ.ONC.1206367
P698PubMed publication ID12743605
P5875ResearchGate publication ID7296903

P50authorAlex J BowersQ73385956
P2093author name stringSheila Scully
John F Boylan
P2860cites workNormal Fibroblasts Induce the C/EBPβ and ATF-4 bZIP Transcription Factors in Response to AnoxiaQ72035109
Apoptosis in human adenocarcinoma HT29 cells induced by exposure to hypoxiaQ72134553
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screeningQ22253364
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligaseQ24290903
The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)Q24291499
Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4)Q24310920
ZIP kinase, a novel serine/threonine kinase which mediates apoptosisQ24314699
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response elementQ24561653
Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificityQ24562832
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspectsQ28200181
Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cellsQ28252331
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaQ28512201
cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding proteinQ28513830
Identification of a novel kinase-like gene induced during neuronal cell deathQ28565461
Hidden Markov modelsQ29622874
Presence of activating transcription factor 4 (ATF4) in the porcine anterior pituitaryQ30785198
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulationQ33939961
The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasisQ34085639
Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding proteinQ34439052
C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elementsQ36311629
Regulation of c-jun expression during hypoxic and low-glucose stressQ36662280
Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxiaQ36665401
Chromosomal localization and promoter analysis of the adenomatous polyposis coli binding protein RP1.Q40775821
Fundamental principles of in situ hybridizationQ40782339
Amplification of hypoxia-inducible factor 1alpha gene in prostate cancerQ40792488
Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2.Q42448867
Transcriptional response to hypoxia in human tumorsQ43727979
Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysisQ47070956
A genetic link between morphogenesis and cell division during formation of the ventral furrow in DrosophilaQ47071048
Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulationQ51996119
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.Q52545083
P433issue18
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
DrosophilaQ312154
kinase activityQ14863082
Tribbles pseudokinase 3Q21131683
overexpressionQ61643320
P304page(s)2823-2835
P577publication date2003-05-01
P1433published inOncogeneQ1568657
P1476titleSKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia
P478volume22

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cites work (P2860)
Q45029434A Xenopus tribbles orthologue is required for the progression of mitosis and for development of the nervous system
Q42412062A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor
Q36655003ATF4-dependent transcription mediates signaling of amino acid limitation
Q39776400Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosis
Q37349289Activating transcription factor 4 is translationally regulated by hypoxic stress
Q37715756Activation transcription factor-4 and the acute vascular response to injury.
Q39742473An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels.
Q39119312Arsenic trioxide induces unfolded protein response in vascular endothelial cells
Q36493230Atorvastatin up-regulates TRIB3 independent of ATF4-CHOP pathway in atherosclerotic patients
Q38121189Biochemistry of cardiomyopathy in the mitochondrial disease Friedreich's ataxia.
Q57483447Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cells
Q39423655Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer
Q24293712Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion
Q26828448Developmental roles of tribbles protein family members
Q24307557Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia
Q39601327Emodin-induced microglial apoptosis is associated with TRB3 induction
Q36225299Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats
Q43025133Global gene expression reveals a set of new genes involved in the modification of cells during erythroid differentiation
Q34548034High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.
Q24300663Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
Q34988108Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells
Q38962089Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation.
Q28386347Luteolin modulates 6-hydroxydopamine-induced transcriptional changes of stress response pathways in PC12 cells
Q33727391Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance
Q37481737Mammalian tribbles homologs at the crossroads of endoplasmic reticulum stress and Mammalian target of rapamycin pathways
Q33697043Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression
Q39992392Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4.
Q39226865Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases
Q36313167Regulation of the Akt kinase by interacting proteins
Q39517528Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress
Q37198294Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease
Q27324556Stress-inducible caspase substrate TRB3 promotes nuclear translocation of procaspase-3
Q24311973TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta
Q36176636TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity
Q41954447TRB3 function in cardiac endoplasmic reticulum stress.
Q38633290TRB3 is elevated in psoriasis vulgaris lesions and mediates HaCaT cells proliferation in vitro
Q42365354TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1
Q30663340TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations
Q38985277TRB3 mediates renal tubular cell apoptosis associated with proteinuria
Q40091713TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4.
Q24298384TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
Q42365292TRB3: an oxidant stress-induced pseudokinase with a potential to negatively modulate MCP-1 cytokine in diabetic nephropathy
Q61809291TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway
Q90208491TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ
Q48215925The Drosophila melanogaster tribbles pseudokinase is necessary for proper memory formation
Q38122246The functionally diverse roles of tribbles
Q38954583The integrated stress response.
Q39273700The role of TRB3 in mast cells sensitized with monomeric IgE.
Q34450702Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding
Q37462633Trb3 regulates LR axis formation in zebrafish embryos.
Q35147735Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet
Q24627314Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia
Q35608727Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response.
Q37845436Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation
Q26777715Tribbles in normal and malignant haematopoiesis
Q26777717Tribbles-1: a novel regulator of hepatic lipid metabolism in humans
Q36978650Upregulation of CHOP/GADD153 during coronavirus infectious bronchitis virus infection modulates apoptosis by restricting activation of the extracellular signal-regulated kinase pathway
Q34446954miR-511 and miR-1297 inhibit human lung adenocarcinoma cell proliferation by targeting oncogene TRIB2.

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