Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element

scientific article published on June 1, 1992

Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1992PNAS...89.4820K
P356DOI10.1073/PNAS.89.11.4820
P953full work available at URLhttps://europepmc.org/articles/PMC49179
https://europepmc.org/articles/PMC49179?pdf=render
P932PMC publication ID49179
P698PubMed publication ID1534408
P5875ResearchGate publication ID21622134

P2093author name stringJ. M. Leiden
M. D. Uhler
B. A. Karpinski
G. D. Morle
J. Huggenvik
P2860cites workParallel association of Fos and Jun leucine zippers juxtaposes DNA binding domainsQ57963273
Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cellsQ67286615
Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expressionQ70192276
Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growthQ24299049
Primary structure of the gene encoding rat preprosomatostatinQ24300788
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimersQ24302559
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brainQ24305269
A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brainQ24634609
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteinsQ27860587
Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNAQ28115365
A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequenceQ28247853
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNAQ29547801
CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcriptionQ33334154
Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expressionQ33556396
A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor alpha locusQ33560881
Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promotersQ33573484
A conserved sequence in the T-cell receptor beta-chain promoter regionQ33575084
mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response elementQ33841054
A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locusQ34301580
Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transferQ34314796
Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos proteinQ34711544
Structure and expression of the murine slow/cardiac troponin C geneQ36107558
Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genesQ36729503
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking regionQ36842600
Identification of a cyclic-AMP-responsive element within the rat somatostatin geneQ37398428
Regulation of the Human Enkephalin Promoter by Two Isoforms of the Catalytic Subunit of Cyclic Adenosine 3′,5′-Monophosphate-Dependent Protein KinaseQ38334613
Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancerQ38338362
A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a proteinQ38340347
The first intron of the 4F2 heavy-chain gene contains a transcriptional enhancer element that binds multiple nuclear proteinsQ38344412
Proto-oncogene fos: complex but versatile regulationQ39598189
Characterization of a bipartite activator domain in transcription factor CREB.Q41196823
A muscle-specific enhancer is located at the 3' end of the myosin light-chain 1/3 gene locusQ44531497
Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain.Q45933998
Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimersQ46196460
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectregulatory sequenceQ3238407
P304page(s)4820-4
P577publication date1992-06-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMolecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element
P478volume89

Reverse relations

cites work (P2860)
Q50421077A CREB2-targeting microRNA is required for long-term memory after single-trial learning
Q24608880A homeodomain protein related to caudal regulates intestine-specific gene transcription
Q36741717A novel POU domain protein which binds to the T-cell receptor beta enhancer
Q28208512ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase
Q33706914ATF3 and stress responses.
Q54217132ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming.
Q37562343ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression
Q24290903ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase
Q36640055ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo
Q39025634ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocytes
Q47135098ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish
Q35377107ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment
Q82468721ATF4 regulates lipid metabolism and thermogenesis
Q40514060ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells
Q37246226Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts.
Q44336479Activating transcription factor 4 overexpression inhibits proliferation and differentiation of mammary epithelium resulting in impaired lactation and accelerated involution
Q37715756Activation transcription factor-4 and the acute vascular response to injury.
Q39501012Adenoviral-mediated gene transfer of a constitutively active form of the retinoblastoma gene product attenuates neointimal thickening in experimental vein grafts
Q39899171Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways
Q28755664Atf2 transcription factor binds to the APP1 promoter in Cryptococcus neoformans: stimulatory effect of diacylglycerol
Q40877119Autoregulation of ZEB2 expression for zearalenone production in Fusarium graminearum.
Q36311629C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements
Q42470001CRE DNA binding proteins bind to the AP-1 target sequence and suppress AP-1 transcriptional activity in mouse keratinocytes
Q24655512CREB regulation of BK channel gene expression underlies rapid drug tolerance
Q32023470CREB-2, a cellular CRE-dependent transcription repressor, functions in association with Tax as an activator of the human T-cell leukemia virus type 1 promoter
Q34439052Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein
Q32141857Cloning of a T-cell receptor beta-chain enhancer binding protein
Q38326929Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response
Q24298557Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element
Q40401302Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression
Q42448867Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2.
Q36634401DISC1 genetics, biology and psychiatric illness
Q39378712DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription
Q28302106DISC1-binding proteins in neural development, signalling and schizophrenia
Q59064185Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB
Q41072629Degradation of the inducible cAMP early repressor (ICER) by the ubiquitin-proteasome pathway
Q40780164Differential transcription factor expression in human mononuclear cells in response to amphotericin B: identification with complementary DNA microarray technology
Q36540020Disrupted-in-schizophrenia-1 Gln31Leu polymorphism results in social anhedonia associated with monoaminergic imbalance and reduction of CREB and β-arrestin-1,2 in the nucleus accumbens in a mouse model of depression.
Q37973703Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals
Q42094437Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2
Q39105371Expression of a phosphorylated form of ATF4 in lung and non-small cell lung cancer tissues
Q48795033Expression of activating transcription factor-2 (ATF-2), one of the cyclic AMP response element (CRE) binding proteins, in Alzheimer disease and non-neurological brain tissues
Q28140720Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development
Q34634508G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes
Q35956277GABAB receptor complex as a potential target for tumor therapy
Q24643988General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
Q27009274Genes and signaling pathways involved in memory enhancement in mutant mice
Q64076011How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory
Q38314503Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene
Q30840384Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat GTP cyclohydrolase I gene
Q33939961Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation
Q33902078Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1.
Q28291920Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
Q38352377Inducible cAMP early repressor can modulate tyrosine hydroxylase gene expression after stimulation of cAMP synthesis
Q41947895Induction of nitric oxide synthase in cultured vascular smooth muscle cells: the role of cyclic AMP
Q34878914Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expression
Q55262733Integrated Stress Responses to Bacterial Pathogenesis Patterns.
Q36548273Lithium response and genetic variation in the CREB family of genes
Q38758523Liver-specific Gene Inactivation of the Transcription Factor ATF4 Alleviates Alcoholic Liver Steatosis in Mice
Q43566841Modular structure of cAMP response element binding protein 2 (CREB2).
Q33963343Molecular interactions involved in the transactivation of the human T-cell leukemia virus type 1 promoter mediated by Tax and CREB-2 (ATF-4).
Q28594970Mouse NIPK interacts with ATF4 and affects its transcriptional activity
Q40800435Negative regulation of transcription in eukaryotes
Q48540839Neurodegeneration: Keeping ATF4 on a Tight Leash
Q30489568Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.
Q36778180OHP1: a maize basic domain/leucine zipper protein that interacts with opaque2.
Q28084613Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity
Q89986670PERK-eIF2α-ATF4 signaling contributes to osteogenic differentiation of periodontal ligament stem cells
Q36513200Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression
Q74747032Positive and negative regulatory mechanisms that mediate long-term memory storage
Q30785198Presence of activating transcription factor 4 (ATF4) in the porcine anterior pituitary
Q92723713Quercetin Regulates the Integrated Stress Response to Improve Memory
Q28365839Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities
Q38343634Regulation of autophagy by ATF4 in response to severe hypoxia.
Q35944091Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells
Q48196721Regulation of transcription factor C/ATF by the cAMP signal activation in hippocampal neurons, and molecular interaction of C/ATF with signal integrator CBP/p300.
Q24301730SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia
Q24562305Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1
Q48044995Selection of down-regulated sequences along the monocytic differentiation of leukemic HL60 cells
Q36124985Serotonin-mediated synapsin expression is necessary for long-term facilitation of the Aplysia sensorimotor synapse
Q34557052Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells
Q27320825Specific downregulation of hippocampal ATF4 reveals a necessary role in synaptic plasticity and memory
Q38315116Temporal and tissue-specific interactions involving novel transcription factors and the proximal promoter of the mouse Pdha-2 gene
Q35857696The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression.
Q24673707The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx
Q44381511The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair
Q34988300The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators
Q24291499The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
Q34350825The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription
Q48875792The effect of glutamate on ghrelin release in mice
Q47261925The function of BTG3 in colorectal cancer cells and its possible signaling pathway
Q38954583The integrated stress response.
Q41545138The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families
Q28565267The metabotropic GABAB receptor directly interacts with the activating transcription factor 4
Q34925043The molecular and cellular biology of enhanced cognition
Q34085639The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis
Q24678306The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP
Q41860737The ubiquitin-proteasome system is necessary for long-term synaptic depression in Aplysia
Q41107800Tissue-specific methylation occurs in the essential promoter element of the tyrosine hydroxylase gene
Q34409226Toward a molecular definition of long-term memory storage
Q34757143Transcription of the human transferrin gene in neuronal cells
Q40614728Transcriptional control of gene expression by cAMP-response element binding proteins
Q21198897Transcriptional regulation of long-term memory in the marine snail Aplysia
Q37741390Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo
Q52595590Understanding of the functional role(s) of the Activating Transcription Factor 4(ATF4) in HIV regulation and production.
Q37099844Upregulation of human T-cell leukemia virus type 1 antisense transcription by the viral tax protein
Q40372635cAMP-dependent regulation of gene transcription by cAMP response element-binding protein and cAMP response element modulator
Q46485953cAMP-response elements in Aplysia creb1, creb2, and Ap-uch promoters: implications for feedback loops modulating long term memory
Q30493570eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.

Search more.