Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet

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Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...994691O
P356DOI10.1371/JOURNAL.PONE.0094691
P932PMC publication ID3986210
P698PubMed publication ID24732777
P5875ResearchGate publication ID261735010

P50authorKersti LilleväliQ60582062
Eero VasarQ12361167
Jürgen InnosQ12365793
Sulev KõksQ16408409
P2093author name stringTriin Tekko
Silva Sütt
Daima Örd
Tiit Örd
Tõnis Örd
P2860cites workTribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulationQ51996119
Trib3 is regulated by IL-3 and affects bone marrow-derived mast cell survival and function.Q53128120
TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway.Q53565028
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell deathQ24298384
SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxiaQ24301730
Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibitionQ24622825
Emotion circuits in the brainQ27860733
Normal neuroanatomical variation in the human brain: an MRI-volumetric studyQ28215097
Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditionsQ28240970
TRB3 is a PI 3-kinase dependent indicator for nutrient starvationQ28269574
Myg1-deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differencesQ28504882
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivoresQ28511717
Identification of a novel kinase-like gene induced during neuronal cell deathQ28565461
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2Q28587149
Mouse NIPK interacts with ATF4 and affects its transcriptional activityQ28594970
Place navigation impaired in rats with hippocampal lesionsQ29547869
Coping with stress: eIF2 kinases and translational controlQ29619787
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.Q30465575
eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.Q30493570
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memoryQ30586619
Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathwayQ33784832
Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cellsQ34700334
Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cellsQ36176444
Mechanisms of food intake repression in indispensable amino acid deficiencyQ36747460
Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling.Q37245857
Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elementsQ37372007
Cell death during development of the nervous systemQ37716922
Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformationQ37845436
Variations in the size of the human brain. Influence of age, sex, body length, body mass index, alcoholism, Alzheimer changes, and cerebral atherosclerosis.Q39819256
Human TRB3 is upregulated in stressed cells by the induction of translationally efficient mRNA containing a truncated 5'-UTR.Q39841309
TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4.Q40091713
Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cellsQ41522239
Diets deficient in indispensable amino acids rapidly decrease the concentration of the limiting amino acid in the anterior piriform cortex of ratsQ42466713
A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neuronsQ42844976
Analysis of gene expression changes in a cellular model of Parkinson diseaseQ45223326
Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.Q46012978
Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.Q46386380
Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysisQ47070956
A genetic link between morphogenesis and cell division during formation of the ventral furrow in DrosophilaQ47071048
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectspatial memoryQ3560550
P304page(s)e94691
P577publication date2014-04-14
P1433published inPLOS OneQ564954
P1476titleTrib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet
P478volume9

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cites work (P2860)
Q92024824TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
Q48215925The Drosophila melanogaster tribbles pseudokinase is necessary for proper memory formation
Q35897729Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models
Q34546438Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

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