TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription

scientific article published on 16 December 2019

TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2019NatCo..10.5720Y
P356DOI10.1038/S41467-019-13700-6
P932PMC publication ID6915745
P698PubMed publication ID31844113

P50authorBing CuiQ55444983
Jin-Mei YuQ85322473
Xiao-Wei ZhangQ90431741
Fang HuaQ92024822
Xue-Ying HouQ117281385
P2093author name stringWei Sun
Feng Wang
Ke Li
Bo Huang
Xiao Liang
Ping-Ping Li
Xiao-Xi Lv
Zhuo-Wei Hu
Yu-Ying Liu
Shan-Shan Liu
Zhen-He Wang
Jiao-Jiao Yu
Shuang Shang
Chen-Xi Zhao
Zhao-Na Yang
P2860cites workAkt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Hallmarks of Cancer: The Next GenerationQ22252312
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell deathQ24298384
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumorsQ24300043
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liverQ24304147
Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemiaQ24627314
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypesQ24647928
Latent bone metastasis in breast cancer tied to Src-dependent survival signalsQ24648828
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?Q26824147
Diverse mechanisms of AKT pathway activation in human malignancyQ26851604
The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseasesQ27002724
MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemiaQ28241703
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumorsQ29615393
TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradationsQ30663340
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patientsQ33519584
FOXO1 is an essential regulator of pluripotency in human embryonic stem cellsQ33740977
Triple-negative breast cancer: challenges and opportunities of a heterogeneous diseaseQ33769821
Cisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activityQ33815839
Animal research: reporting in vivo experiments: the ARRIVE guidelinesQ34116755
SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells.Q34269756
Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotencyQ44553011
SOX2 expression associates with stem cell state in human ovarian carcinoma.Q46004424
Homology Modeling and Virtual Screening to Discover Potent Inhibitors Targeting the Imidazole Glycerophosphate Dehydratase Protein in Staphylococcus xylosusQ47094626
Cancer stem cells revisitedQ49557760
Overexpression of TRIB3 promotes angiogenesis in human gastric cancer.Q51543984
TRB3 interacts with SMAD3 promoting tumor cell migration and invasion.Q53221284
Expression of Sox2 in human cervical carcinogenesis.Q53296336
Cancer stem cells (CSCs): metabolic strategies for their identification and eradication.Q55254924
Sox2: masterminding the root of cancer.Q55460821
SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity.Q55465654
TRIB3 Interacts with Beta-catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and TumorigenesisQ58574154
Prognostic significance of NANOG and KLF4 for breast cancerQ83975592
Sox2 expression in breast tumours and activation in breast cancer stem cellsQ84709308
Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal nicheQ88721108
Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapyQ34448718
Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and DiseaseQ34546438
High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.Q34548034
Regulation of FOXO protein stability via ubiquitination and proteasome degradationQ35032366
One-step zero-background IgG reformatting of phage-displayed antibody fragments enabling rapid and high-throughput lead identification.Q35047152
Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced dietQ35147735
Breast cancer stem cells, cytokine networks, and the tumor microenvironmentQ35571904
Tumor twitter: cellular communication in the breast cancer stem cell nicheQ35575679
Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response.Q35608727
Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast CancerQ36030226
Soft fibrin gels promote selection and growth of tumorigenic cells.Q36117097
Metabolic stress induces a Wnt-dependent cancer stem cell-like state transitionQ36293834
Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excessQ36312457
Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.Q36731080
Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cellsQ36787443
OCT4 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells by miR-125b/BAK1 pathwayQ37148223
Isolation of Mouse and Human Tumor-Associated Macrophages.Q37258360
Control of p53 multimerization by Ubc13 is JNK-regulatedQ37293253
Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis.Q37320359
Cervical cancer cells with positive Sox2 expression exhibit the properties of cancer stem cellsQ37525522
Forkhead box proteins: tuning forks for transcriptional harmony.Q38116309
Clinical management of breast cancer heterogeneityQ38431284
Breast cancer stem cells: current advances and clinical implicationsQ38514871
TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence.Q38704195
BCL6 induces EMT by promoting the ZEB1-mediated transcription repression of E-cadherin in breast cancer cells.Q38866778
SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinomaQ38947301
The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer.Q39111034
Cellular stress induces TRB3/USP9x-dependent Notch activation in cancerQ39423655
Sox2 maintains self renewal of tumor-initiating cells in osteosarcomasQ39472160
Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosisQ39776400
The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia.Q39903788
Preclinical study on induction of pluripotent stem cells from urine of dilated cardiomyopathy patientsQ40763262
SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cellsQ42092920
The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatumQ42708314
A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neuronsQ42844976
Oct4 and Nanog expression is associated with early stages of pancreatic carcinogenesis.Q43154857
Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axisQ44063727
P433issue1
P304page(s)5720
P577publication date2019-12-16
P1433published inNature CommunicationsQ573880
P1476titleTRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
P478volume10

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Q98289234Functional roles of E3 ubiquitin ligases in gastric cancercites workP2860

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