| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1003100696 |
| P356 | DOI | 10.1038/356718A0 |
| P698 | PubMed publication ID | 1533274 |
| P2093 | author name string | J R Parnes | |
| R H Seong | |||
| J W Chamberlain | |||
| P2860 | cites work | Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site | Q24321802 |
| The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck | Q28506433 | ||
| Structure of the mouse gene encoding CD4 and an unusual transcript in brain | Q34360014 | ||
| A human beta-actin expression vector system directs high-level accumulation of antisense transcripts | Q34638492 | ||
| On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? | Q36340069 | ||
| Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules | Q36356209 | ||
| Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways | Q36356927 | ||
| Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice | Q37586973 | ||
| Molecular and cellular events of T cell development | Q38220900 | ||
| The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression | Q39634636 | ||
| Cloned T Lymphocytes and Monoclonal Antibodies as Probes for Cell Surface Molecules Active in T Cell-Mediated Cytolysis | Q40105231 | ||
| In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells | Q40658124 | ||
| Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity | Q42703870 | ||
| Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo. | Q44368136 | ||
| Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes | Q44851100 | ||
| Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. | Q45999974 | ||
| Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor | Q46155874 | ||
| Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. | Q50800754 | ||
| Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. | Q51161910 | ||
| Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells | Q58991849 | ||
| Positive selection of antigen-specific T cells in thymus by restricting MHC molecules | Q59080081 | ||
| P433 | issue | 6371 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell differentiation | Q210861 |
| CD4 molecule | Q412587 | ||
| transmembrane protein | Q424204 | ||
| regulation of T cell activation | Q14865404 | ||
| CD4 antigen | Q14865413 | ||
| P304 | page(s) | 718-20 | |
| P577 | publication date | 1992-04-23 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail | |
| P478 | volume | 356 |
| Q40801692 | A challenge to the instructive model of positive selection |
| Q24336028 | A mutation in zap-70 protein tyrosine kinase results in a selective immunodeficiency |
| Q36402496 | An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4 |
| Q35769448 | CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision |
| Q40994026 | CD4/CD8 lineage commitment: back to instruction? |
| Q51093044 | CD4/CD8 lineage commitment: matching fate with competence. |
| Q35824059 | CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals |
| Q33938606 | CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx |
| Q36487614 | Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins |
| Q58134165 | Chimeric protein of CD8a extracellular domain and CD4 transmembrane and cytoplasmic domain binds more efficiently to p56lck than CD8a |
| Q36382781 | Commitment issues: linking positive selection signals and lineage diversification in the thymus |
| Q36363187 | Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice |
| Q44271114 | Constitutive expression of high levels of soluble mouse CD4 in transgenic mice does not interfere with their immune function |
| Q36659847 | Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes |
| Q33203664 | Detailed analysis of gene expression during development of T cell lineages in the thymus. |
| Q35595964 | From antilymphocyte serum to therapeutic monoclonal antibodies: first experiences with a chimeric CD4 antibody in the treatment of autoimmune disease |
| Q28288372 | Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation |
| Q36362299 | Functional GATA-3 binding sites within murine CD8 alpha upstream regulatory sequences |
| Q51137998 | Generation of mature T cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation. |
| Q60065823 | Helper T-cell development in the absence of CD4-p56 Ick association |
| Q41475916 | Human CD4 restores normal T cell development and function in mice deficient in murine CD4. |
| Q40567149 | Human immunodeficiency virus type 1-associated CD4 downmodulation. |
| Q41729181 | Lck activity controls CD4/CD8 T cell lineage commitment. |
| Q34831201 | Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice |
| Q44762315 | Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage |
| Q73259593 | Multiple negative and positive cis-acting elements control the expression of the murine CD4 gene |
| Q34547220 | New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision |
| Q36565800 | Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages |
| Q24680530 | Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer |
| Q40872594 | Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. |
| Q24309394 | Role of CD4 and CD8 in T cell activation and differentiation |
| Q37636556 | Role of coreceptors in positive selection and lineage commitment |
| Q51103780 | Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus. |
| Q34927276 | Stochastic component to development of class I major histocompatibility complex-specific T cells |
| Q42265829 | Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway |
| Q73835287 | Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes |
| Q34659128 | T-cell development and the CD4-CD8 lineage decision |
| Q35076682 | The Ras/MAPK cascade and the control of positive selection |
| Q36365908 | The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells |
| Q46118331 | The function of the CD4 coreceptor in the development of T cells |
| Q53653317 | The influence of the thymic environment on the CD4-versus-CD8 T lineage decision. |
| Q36670501 | Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages |
| Q36370932 | Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells |
| Q36401327 | Visualization of CD4/CD8 T cell commitment |
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